C. Giannesini
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Therapeutic Management During Pregnancy and Relapse Risk in Women With Multiple Sclerosis Open
Importance In women with multiple sclerosis (MS), disease-modifying therapy (DMT) management during pregnancy might impact relapse risk. Objective To estimate the effect of DMT management during pregnancy on MS relapse rate and compare dif…
LymphoTEC: a Retrospective Real-World Study on Lymphocyte Reconstitution After Lymphopenia in Patients with Multiple Sclerosis Treated with Dimethyl Fumarate in France Open
ClinicalTrials.gov NCT04756687.
View article: High-Efficacy Therapy Discontinuation vs Continuation in Patients 50 Years and Older With Nonactive MS
High-Efficacy Therapy Discontinuation vs Continuation in Patients 50 Years and Older With Nonactive MS Open
Importance A recent randomized clinical trial concluded that discontinuing medium-efficacy therapy might be a reasonable option for older patients with nonactive multiple sclerosis (MS), but there is a lack of data on discontinuing high-ef…
View article: Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome
Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome Open
This study found that age younger than age 37 years, spinal cord involvement, and gadolinium-enhancing lesions on index MRI scan were associated with earlier clinical disease and relevant to the number of enrolled patients needed to detect…
View article: TNF-α inhibitors used as steroid-sparing maintenance monotherapy in parenchymal CNS sarcoidosis
TNF-α inhibitors used as steroid-sparing maintenance monotherapy in parenchymal CNS sarcoidosis Open
Objective To assess the efficacy of tumour necrosis factor-α (TNF-α) inhibitors used as steroid-sparing monotherapy in central nervous system (CNS) parenchymal sarcoidosis. Methods The French Multiple Sclerosis and Neuroinflammation Center…
Clinical Characteristics and Outcomes in Patients With Coronavirus Disease 2019 and Multiple Sclerosis Open
In this registry-based cohort study of patients with MS, age, EDSS, and obesity were independent risk factors for severe COVID-19; there was no association found between DMTs exposure and COVID-19 severity. The identification of these risk…
Evaluation of emotional disorders before and during treatment with interferon beta in patients with multiple sclerosis Open
Based on 24 months of prospective follow-up, the results of this study highlights a broad spectrum of emotional disorders in the MS population at the time of disease modifying drugs initiation but no major IFN-β-related emotional disorders…
View article: Comparative effectiveness of teriflunomide vs dimethyl fumarate in multiple sclerosis
Comparative effectiveness of teriflunomide vs dimethyl fumarate in multiple sclerosis Open
This study provides Class III evidence that for patients with RRMS, TRF and DMF have similar clinical effectiveness after 2 years of treatment.
Glatiramer acetate reduces infarct volume in diabetic mice with cerebral ischemia and prevents long-term memory loss Open
Stroke is currently the second leading cause of death in industrialized countries and the second cause of dementia after Alzheimer's disease. Diabetes is an independent risk factor for stroke that exacerbates the severity of lesions, disab…