Adriana C. C. Girardi
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View article: Physical association of NHE3 and SGLT2 mediated by accessory proteins in the renal proximal tubule
Physical association of NHE3 and SGLT2 mediated by accessory proteins in the renal proximal tubule Open
Proximal tubule NHE3 is tightly regulated by factors controlling extracellular volume homeostasis, blood pressure, and acid-base balance. Emerging evidence suggests that glycemic control-related factors also influence NHE3, supporting the …
View article: Unique Role of Proximal Tubule Dipeptidyl Peptidase 4 on Blood Pressure, Renal Sodium Handling, and Na <sup>+</sup> /H <sup>+</sup> Exchanger Isoform 3 Phosphorylation
Unique Role of Proximal Tubule Dipeptidyl Peptidase 4 on Blood Pressure, Renal Sodium Handling, and Na <sup>+</sup> /H <sup>+</sup> Exchanger Isoform 3 Phosphorylation Open
Background Dipeptidyl peptidase 4 (DPP4) is a transmembrane serine exopeptidase highly expressed in the proximal tubule (PT). While its enzymatic role is well characterized, its non‐enzymatic functions remain unclear. DPP4 physically assoc…
View article: Vascular effects of SGLT2 inhibitors: evidence and mechanisms
Vascular effects of SGLT2 inhibitors: evidence and mechanisms Open
Sodium–glucose cotransporter 2 inhibitors (SGLT2i) were initially developed as glucose-lowering agents for type 2 diabetes mellitus (T2DM). However, robust clinical evidence has demonstrated that their therapeutic benefits extend beyond gl…
View article: Association of urinary dipeptidyl peptidase 4 activity with clinical outcomes in people with chronic kidney disease
Association of urinary dipeptidyl peptidase 4 activity with clinical outcomes in people with chronic kidney disease Open
Experimental studies have shown that urinary dipeptidyl peptidase 4 (uDPP4), unlike serum DPP4 (sDPP4) activity, correlates with proteinuria, serum creatinine, and left ventricular (LV) hypertrophy in chronic kidney disease (CKD) models, s…
View article: Restoring lung renin-angiotensin system balance through blood pressure control
Restoring lung renin-angiotensin system balance through blood pressure control Open
Dysregulated renin-angiotensin system (RAS) signaling contributes to elevated blood pressure (BP), inflammation, and organ damage in systemic arterial hypertension (HTN). We have demonstrated that hypertensive humans and rats exhibit highe…
View article: Impact of Proximal Tubule-Specific Deletion of Dipeptidyl Peptidase 4 on Blood Pressure, Renal Sodium Handling, and NHE3 Phosphorylation
Impact of Proximal Tubule-Specific Deletion of Dipeptidyl Peptidase 4 on Blood Pressure, Renal Sodium Handling, and NHE3 Phosphorylation Open
Dipeptidyl peptidase 4 (DPP4) is a transmembrane serine exopeptidase abundantly expressed in the kidneys, predominantly in the proximal tubule (PT); however, its non-enzymatic functions in this nephron segment remain poorly understood. Whi…
View article: Association of urinary dipeptidyl peptidase 4 activity with clinical outcomes in people with chronic kidney disease
Association of urinary dipeptidyl peptidase 4 activity with clinical outcomes in people with chronic kidney disease Open
Background Experimental studies have shown that urinary dipeptidyl peptidase 4 (uDPP4), unlike serum DPP4 (sDPP4) activity, correlates with proteinuria, serum creatinine, and left ventricular (LV) hypertrophy in 5/6 nephrectomized rats, su…
View article: Empagliflozin’s role in reducing ventricular repolarization heterogeneity: insights into cardiovascular mortality decline from the EMPATHY-HEART trial
Empagliflozin’s role in reducing ventricular repolarization heterogeneity: insights into cardiovascular mortality decline from the EMPATHY-HEART trial Open
View article: Empagliflozin's role in reducing ventricular repolarization heterogeneity: Insights into cardiovascular mortality decline from the EMPATHY-HEART trial
Empagliflozin's role in reducing ventricular repolarization heterogeneity: Insights into cardiovascular mortality decline from the EMPATHY-HEART trial Open
Background: The incidence of myocardial infarction (MI) and sudden cardiac death (SCD) is significantly higher in individuals with Type 2 Diabetes Mellitus (T2DM) than in the general population. Strategies for the prevention of fatal arrhy…
View article: Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rat
Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rat Open
This study suggests that reduced NHE3-mediated sodium reabsorption in the renal proximal tubule may account, at least in part, for the BP-lowering effect of SGLT2 inhibitors in the setting of hypertension. It also demonstrates that chronic…
View article: Multiple electrolyte disorders triggered by proton pump inhibitor-induced hypomagnesemia: Case reports with a mini-review of the literature
Multiple electrolyte disorders triggered by proton pump inhibitor-induced hypomagnesemia: Case reports with a mini-review of the literature Open
Drug-induced hypomagnesemia is an adverse effect with the potential for serious and fatal outcomes. Although rare, chronic use of proton pump inhibitors (PPIs) can cause hypomagnesemia due to impaired intestinal absorption, mainly attribut…
View article: In memoriam: Gerhard Malnic
In memoriam: Gerhard Malnic Open
View article: Table of Contents
Table of Contents Open
View article: Empagliflozin reduces arrhythmogenic effects in rat neonatal and human iPSC-derived cardiomyocytes and improves cytosolic calcium handling at least partially independent of NHE1
Empagliflozin reduces arrhythmogenic effects in rat neonatal and human iPSC-derived cardiomyocytes and improves cytosolic calcium handling at least partially independent of NHE1 Open
The antidiabetic agent class of sodium-glucose cotransporter 2 (SGLT2) inhibitors confer unprecedented cardiovascular benefits beyond glycemic control, including reducing the risk of fatal ventricular arrhythmias. However, the impact of SG…
View article: Empagliflozin reduces arrhythmogenic effects in rat neonatal and human iPSC-derived cardiomyocytes and improves cytosolic calcium handling at least partially independent of NHE1
Empagliflozin reduces arrhythmogenic effects in rat neonatal and human iPSC-derived cardiomyocytes and improves cytosolic calcium handling at least partially independent of NHE1 Open
The antidiabetic agent class of sodium-glucose cotransporter 2 (SGLT2) inhibitors confer unprecedented cardiovascular benefits beyond glycemic control, including reducing the risk of fatal ventricular arrhythmias. However, the impact of SG…
View article: Relative Contribution of Blood Pressure and Renal Sympathetic Nerve Activity to Proximal Tubular Sodium Reabsorption via NHE3 Activity
Relative Contribution of Blood Pressure and Renal Sympathetic Nerve Activity to Proximal Tubular Sodium Reabsorption via NHE3 Activity Open
We examined the effects of an acute increase in blood pressure (BP) and renal sympathetic nerve activity (rSNA) induced by bicuculline (Bic) injection in the paraventricular nucleus of hypothalamus (PVN) or the effects of a selective incre…
View article: The Relative Contribution of Blood Pressure and Renal Sympa-Thetic Nerve Activity on Proximal Tubular Sodium Reabsorption through NHE3 Actions
The Relative Contribution of Blood Pressure and Renal Sympa-Thetic Nerve Activity on Proximal Tubular Sodium Reabsorption through NHE3 Actions Open
This study aimed to verify the effects of an acute increase in blood pressure (BP) and/or renal sympathetic nerve activity (rSNA) on the renal excretion of sodium and water and its potential effect on the regulation of NHE3 activity. Unine…
View article: Dipeptidyl Peptidase 4 Inhibition Rescues PKA-eNOS Signaling and Suppresses Aortic Hypercontractility in Rats with Heart Failure
Dipeptidyl Peptidase 4 Inhibition Rescues PKA-eNOS Signaling and Suppresses Aortic Hypercontractility in Rats with Heart Failure Open
View article: Sex differences in the lung ACE/ACE2 balance in hypertensive rats
Sex differences in the lung ACE/ACE2 balance in hypertensive rats Open
The angiotensin-converting enzyme (ACE)/Angiotensin II (Ang II) and angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) (Ang-(1-7)) pathways are coexpressed in most tissues. The balance between these pathways determines, at least in p…
View article: Editorial: The Tribute of Physiology for the Understanding of COVID-19 Disease
Editorial: The Tribute of Physiology for the Understanding of COVID-19 Disease Open
Georges Lefthériotis1*Susan Wray2Adriana Castello Costa Girardi3Emmanuelle Vidal-Petiot4Matthew A. Bailey5Deborah Schechtman6Nistala Ravi7Denis Noble8
View article: Antiproteinuric and Hyperkalemic Mechanisms Activated by Dual Versus Single Blockade of the RAS in Renovascular Hypertensive Rats
Antiproteinuric and Hyperkalemic Mechanisms Activated by Dual Versus Single Blockade of the RAS in Renovascular Hypertensive Rats Open
This study aimed to investigate the antiproteinuric and hyperkalemic mechanisms activated by dual renin-angiotensin system (RAS) blockade in renovascular hypertensive rats (2-kidney 1-clip model [2K-1C]). Six weeks after clipping the left …
View article: The Angiotensin II Type 1 Receptor-Associated Protein Attenuates Angiotensin II-Mediated Inhibition of the Renal Outer Medullary Potassium Channel in Collecting Duct Cells
The Angiotensin II Type 1 Receptor-Associated Protein Attenuates Angiotensin II-Mediated Inhibition of the Renal Outer Medullary Potassium Channel in Collecting Duct Cells Open
Adjustments in renal K + excretion constitute a central mechanism for K + homeostasis. The renal outer medullary potassium (ROMK) channel accounts for the major K + secretory route in collecting ducts during basal conditions. Activation of…
View article: Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure
Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure Open
Significance Statement SGLT2 inhibitors represent a class of drugs that were originally developed for improving glycemic control. Cardiovascular outcome trials designed to evaluate cardiovascular safety yielded unexpected and unprecedented…
View article: Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity
Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity Open
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a public health crisis of major proportions. Advanced age, male gender, and the presence of comorbidities have …
View article: Alterações da ECA2 e Fatores de Risco para Gravidade da COVID-19 em Pacientes com Idade Avançada
Alterações da ECA2 e Fatores de Risco para Gravidade da COVID-19 em Pacientes com Idade Avançada Open
ACE2, SARS-CoV-2 Infection and Aging Abnormalities induced by aging in metabolic pathways may partly explain the higher rate of COVID-19 morbidity and mortality in elderly patients. These include those belonging to the renin-angiotensin sy…
View article: Endogenous Activation of Glucagon-Like Peptide-1 Receptor Contributes to Blood Pressure Control
Endogenous Activation of Glucagon-Like Peptide-1 Receptor Contributes to Blood Pressure Control Open
The pharmacological administration of GLP-1R (glucagon-like peptide-1 receptor) agonists reduces blood pressure (BP) in type 2 diabetes mellitus and nondiabetic patients. This study tested the hypothesis that endogenous GLP-1R signaling in…
View article: Postprandial increase in glucagon-like peptide-1 is blunted in severe heart failure
Postprandial increase in glucagon-like peptide-1 is blunted in severe heart failure Open
The relationship between disturbances in glucose homeostasis and heart failure (HF) progression is bidirectional. However, the mechanisms by which HF intrinsically impairs glucose homeostasis remain unknown. The present study tested the hy…
View article: Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity
Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity Open
Invasive fungal infections (IFI) is a worldwide serious health problem and Amphotericin B (AmB) has been considered the drug of choice for IFI treatment. Despite its efficacy, clinical use of AmB has been associated with renal toxicity. So…
View article: Cardioprotection Conferred by Sitagliptin Is Associated with Reduced Cardiac Angiotensin II/Angiotensin-(1-7) Balance in Experimental Chronic Kidney Disease
Cardioprotection Conferred by Sitagliptin Is Associated with Reduced Cardiac Angiotensin II/Angiotensin-(1-7) Balance in Experimental Chronic Kidney Disease Open
Dipeptidyl peptidase IV (DPPIV) inhibitors are antidiabetic agents that exert renoprotective actions independently of glucose lowering. Cardiac dysfunction is one of the main outcomes of chronic kidney disease (CKD); however, the effects o…
View article: The potential role of myosin motor proteins in mediating the subcellular distribution of NHE3 in the renal proximal tubule
The potential role of myosin motor proteins in mediating the subcellular distribution of NHE3 in the renal proximal tubule Open
Isoform 3 of the Na + /H + exchanger (NHE3) is responsible for the majority of the reabsorption of NaCl, NaHCO 3 , and, consequently, water in the renal proximal tubule. As such, this transporter plays an essential role in acid-base balanc…