Gcf Chan
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View article: Landscape of paediatric oncology clinical trials in Asia
Landscape of paediatric oncology clinical trials in Asia Open
In this second paper of a Series on childhood cancer in Asia, we provide an overview on the Paediatric Oncology Clinical Trials in Asia. Asia with a population of 4.7 billion constitutes about 60% of the world's population. The continent a…
View article: Clinical Utility of Amino Acid PET-MRI in Children with CNS Neoplasms: A Territory-Wide Study from Hong Kong
Clinical Utility of Amino Acid PET-MRI in Children with CNS Neoplasms: A Territory-Wide Study from Hong Kong Open
Background: Amino acid tracer positron emission tomography–magnetic resonance imaging (PET-MRI) was shown to be superior to MRI alone for evaluating central nervous system (CNS) tumours in adults. This study aimed to investigate the utilit…
View article: Qualitative Interview with Older Adults and Caregivers on their Perspectives with Self-Management and Remote Vital Sign Monitoring
Qualitative Interview with Older Adults and Caregivers on their Perspectives with Self-Management and Remote Vital Sign Monitoring Open
Background Research underscores the role of self-management capabilities as a strategy for enhancing the well-being of older adults by mitigating potential health risks and functional decline. Self-management tools like remote vital sign m…
View article: Iron overload and morbidities in Chinese with non‐transfusion‐dependent thalassaemia
Iron overload and morbidities in Chinese with non‐transfusion‐dependent thalassaemia Open
Summary Non‐transfusion‐dependent thalassaemia (NTDT) is associated with chronic health problems. A cross‐sectional study was conducted in Hong Kong Chinese patients to evaluate the presentation and complications of NTDT. One hundred and n…
View article: Designs of NKG2D-based immunotherapeutics for cancer
Designs of NKG2D-based immunotherapeutics for cancer Open
Natural killer group 2 D (NKG2D) receptor, one of the activation receptors on NK cells, has gained increasing attention in recent years because its ligands are widely expressed in most cancers. Naturally, NKG2D reacts to 8 different stress…
View article: The anti-GD2 monoclonal antibody naxitamab plus GM-CSF for relapsed or refractory high-risk neuroblastoma: a phase 2 clinical trial
The anti-GD2 monoclonal antibody naxitamab plus GM-CSF for relapsed or refractory high-risk neuroblastoma: a phase 2 clinical trial Open
In this single-arm, non-randomized, phase 2 trial (NCT03363373), 74 patients with relapsed/refractory high-risk neuroblastoma and residual disease in bone/bone marrow (BM) received naxitamab on Days 1, 3, and 5 (3 mg/kg/day) with granulocy…
View article: An innovative virtual fellowship leveraging global and regional mentorship to foster pediatric neuro-oncologists in low/middle-income countries
An innovative virtual fellowship leveraging global and regional mentorship to foster pediatric neuro-oncologists in low/middle-income countries Open
Abstract BackgroundMost children with central nervous system (CNS) tumors reside in low- and middle-income countries (LMICs), with limited availability of trained pediatric neuro-oncologists. Methods Using a series of structured interviews…
View article: Lenvatinib Plus Ifosfamide and Etoposide in Children and Young Adults With Relapsed Osteosarcoma
Lenvatinib Plus Ifosfamide and Etoposide in Children and Young Adults With Relapsed Osteosarcoma Open
Importance The combination of ifosfamide and etoposide (IE) is commonly used to treat relapsed or refractory osteosarcoma; however, second-line treatment recommendations vary across guidelines. Objective To evaluate whether the addition of…
View article: Germline mismatch repair gene mutations in children with tumors: a case series from two centers
Germline mismatch repair gene mutations in children with tumors: a case series from two centers Open
More than half of CMMRD syndrome and LS patients have no family history of cancer; thus, the absence of a positive family history does not rule out CMMRD syndrome and LS. A better diagnostic approach is to perform genetic testing to rule o…
View article: GCT-07. CONTRIBUTORS TO DELAYED TREATMENT OF NON-GERMINOMATOUS GERM CELL TUMORS IN CHINA: A TERTIARY-CENTER REVIEW
GCT-07. CONTRIBUTORS TO DELAYED TREATMENT OF NON-GERMINOMATOUS GERM CELL TUMORS IN CHINA: A TERTIARY-CENTER REVIEW Open
BACKGROUND Non-Germinomatous Germ Cell Tumors (NGGCT) are rare malignancies with potential for treatment delays. This study aims to identify risk factors and systemic challenges contributing to delayed management of NGGCT in China. METHODS…
View article: LMIC-26. DEVELOPMENT OF THE ST. JUDE GLOBAL VIRTUAL PEDIATRIC NEURO-ONCOLOGY FELLOWSHIP (VPNOF): INCREASING PEDIATRIC NEURO-ONCOLOGY CAPACITY IN LOW- AND MIDDLE- INCOME COUNTRIES (LMIC)
LMIC-26. DEVELOPMENT OF THE ST. JUDE GLOBAL VIRTUAL PEDIATRIC NEURO-ONCOLOGY FELLOWSHIP (VPNOF): INCREASING PEDIATRIC NEURO-ONCOLOGY CAPACITY IN LOW- AND MIDDLE- INCOME COUNTRIES (LMIC) Open
BACKGROUND Most children with central nervous system (CNS) tumors reside in LMICs, yet their complex management is limited by the availability of trained pediatric neuro-oncologists (PNO). The St. Jude Global VPNOF was designed to train pe…
View article: IMG-19. CLINICAL UTILITY OF NON-FDG PET-MRI IN CHILDREN WITH CNS NEOPLASMS: A TERRITORY-WIDE STUDY FROM HONG KONG
IMG-19. CLINICAL UTILITY OF NON-FDG PET-MRI IN CHILDREN WITH CNS NEOPLASMS: A TERRITORY-WIDE STUDY FROM HONG KONG Open
INTRODUCTION Magnetic resonance imaging (MRI) is the gold-standard for neuroimaging, yet details from anatomical scans might be inconclusive in certain scenarios. This study aimed to investigate the utility of amino-acid tracer positron em…
View article: A systematic review on the applicability of cell‐free DNA level as an obesity biomarker
A systematic review on the applicability of cell‐free DNA level as an obesity biomarker Open
Summary Obesity has become a global health concern in recent decades. Utilizing biomarkers presents a promising approach to comprehensively monitor the progress of obesity and its associated health conditions. This review aims to synthesiz…
View article: ExomiRHub: a database to explore human extracellular and intracellular microRNA transcriptomics data
ExomiRHub: a database to explore human extracellular and intracellular microRNA transcriptomics data Open
Extracellular microRNA (miRNA) expression data, generated by different laboratories, exhibit heterogeneity, posing challenges for researchers lacking bioinformatics expertise to explore these valuable data. To expedite the discovery of cli…
View article: Association of vitamin D‐binding protein polymorphisms and serum 25(OH)D concentration varies among Chinese healthy infants of different <scp>VDR‐FokI</scp> genotypes: A multi‐centre cross‐sectional study
Association of vitamin D‐binding protein polymorphisms and serum 25(OH)D concentration varies among Chinese healthy infants of different <span>VDR‐FokI</span> genotypes: A multi‐centre cross‐sectional study Open
Hypovitaminosis D during infancy is associated with the development of chronic diseases and poor health later in life. While the effect of environmental factors on vitamin D concentration has been extensively explored, this study aimed to …
View article: 129P Naxitamab efficacy in patients with refractory/relapsed high-risk neuroblastoma and bone metastases as assessed by Curie score
129P Naxitamab efficacy in patients with refractory/relapsed high-risk neuroblastoma and bone metastases as assessed by Curie score Open
High-risk neuroblastoma (HR-NB) commonly metastasizes to the bone, a frequent site of resistant disease. Naxitamab, a humanized GD2-binding monoclonal antibody, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF),…
View article: Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group
Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group Open
In Asia, a few countries have a long and established history of collaborative clinical trials successfully formed national children's cancer study groups, but many still do not have such groups. The process of forming national children's c…
View article: Tumor vaccine based on extracellular vesicles derived from γδ‐T cells exerts dual antitumor activities
Tumor vaccine based on extracellular vesicles derived from γδ‐T cells exerts dual antitumor activities Open
γδ‐T cells are innate‐like T cells with dual antitumor activities. They can directly eradicate tumor cells and function as immunostimulatory cells to promote antitumor immunity. Previous studies have demonstrated that small extracellular v…
View article: Data from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Data from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Purpose: Tumor relapse is the most frequent cause of death in stage 4 neuroblastomas. Since genomic information on the relapse precursor cells could guide targeted therapy, our aim was to find the most appropriate tissue for identifying re…
View article: Supplementary Table S1 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S1 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S1. Tumor cell content of samples of the single neuroblastoma patient
View article: Supplementary Table S5 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S5 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S5. Presence of 1q, 19q, and ATRX deletions in samples of patients with these aberrations
View article: Supplementary Table S7 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S7 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S7. Effect of low expression of some genes located at 1q or 19q on survival of neuroblastoma patients according to different datasets in R2 database
View article: Supplementary Table S7 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S7 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S7. Effect of low expression of some genes located at 1q or 19q on survival of neuroblastoma patients according to different datasets in R2 database
View article: Supplementary Table S2 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S2 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S2. Samples' information and clinical information of stage 4 neuroblastoma patients included in the cohort
View article: Supplementary Table S6 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S6 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S6. Genes in the SROs of 1q and 19 deletions