Juan C. Gómez‐Fernández
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View article: Subspace-based identification integrated to recursive PLS modeling: A preliminary result
Subspace-based identification integrated to recursive PLS modeling: A preliminary result Open
In this work a new multivariable dynamic recursive estimation approach is presented. The overall methodology is based on the classical subspace state-space identification (4SID) theory and integrated with the recursive partial least square…
View article: Deciphering the Role and Signaling Pathways of PKCα in Luminal A Breast Cancer Cells
Deciphering the Role and Signaling Pathways of PKCα in Luminal A Breast Cancer Cells Open
Protein kinase C (PKC) comprises a family of highly related serine/threonine protein kinases involved in multiple signaling pathways, which control cell proliferation, survival, and differentiation. The role of PKCα in cancer has been stud…
View article: The Myth of The Annular Lipids
The Myth of The Annular Lipids Open
In the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the bulk lipid in the …
View article: Clotrimazole Fluidizes Phospholipid Membranes and Localizes at the Hydrophobic Part near the Polar Part of the Membrane
Clotrimazole Fluidizes Phospholipid Membranes and Localizes at the Hydrophobic Part near the Polar Part of the Membrane Open
Clotrimazole (1-[(2-chlorophenyl)-diphenylmethyl]-imidazole) is an azole antifungal drug belonging to the imidazole subclass that is widely used in pharmacology and that can be incorporated in membranes. We studied its interaction with 1,2…
View article: Diethylstilbestrol Modifies the Structure of Model Membranes and Is Localized Close to the First Carbons of the Fatty Acyl Chains
Diethylstilbestrol Modifies the Structure of Model Membranes and Is Localized Close to the First Carbons of the Fatty Acyl Chains Open
The synthetic estrogen diethylstilbestrol (DES) is used to treat metastatic carcinomas and prostate cancer. We studied its interaction with membranes and its localization to understand its mechanism of action and side-effects. We used diff…
View article: Greetings from IUPAB Secretary General
Greetings from IUPAB Secretary General Open
View article: A comparison of the location in membranes of curcumin and curcumin-derived bivalent compounds with potential neuroprotective capacity for Alzheimer’s disease
A comparison of the location in membranes of curcumin and curcumin-derived bivalent compounds with potential neuroprotective capacity for Alzheimer’s disease Open
View article: The Interaction with Different Membranes of the C2 Domain of PKC-Epsilon
The Interaction with Different Membranes of the C2 Domain of PKC-Epsilon Open
View article: Plan S for publishing science in an open access way: not everyone is likely to be happy
Plan S for publishing science in an open access way: not everyone is likely to be happy Open
View article: Liposome-Encapsulated Morphine Affords a Prolonged Analgesia While Facilitating Extinction of Reward and Aversive Memories
Liposome-Encapsulated Morphine Affords a Prolonged Analgesia While Facilitating Extinction of Reward and Aversive Memories Open
Morphine is thoroughly used for pain control; however, it has a high addictive potential. Opioid liposome formulations produce controlled drug release and have been thoroughly tested for pain treatment although their role in addiction is s…
View article: ¿Quiénes son los grandes escritores africanos y por qué no los conocemos?
¿Quiénes son los grandes escritores africanos y por qué no los conocemos? Open
View article: Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topical Candidiasis
Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topical Candidiasis Open
New three-dimensionally-structured hybrid phospholipid vesicles, able to load clotrimazole in a high amount (10 mg/mL), were obtained for the first time in this work by significantly reducing the amount of water (≤10%), which was replaced …
View article: Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin
Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin Open
View article: Structural characterization of the Rabphilin-3A–SNAP25 interaction
Structural characterization of the Rabphilin-3A–SNAP25 interaction Open
Significance Membrane fusion is essential in multiple cell processes, including neuronal communication. Numerous proteins are recruited to the presynaptic space to execute a highly controlled process, resulting in the liberation of neurotr…
View article: X-ray diffraction and NMR data for the study of the location of idebenone and idebenol in model membranes
X-ray diffraction and NMR data for the study of the location of idebenone and idebenol in model membranes Open
View article: Capsaicin Fluidifies the Membrane and Localizes Itself near the Lipid–Water Interface
Capsaicin Fluidifies the Membrane and Localizes Itself near the Lipid–Water Interface Open
Capsaicin is the chemical responsible for making some peppers spicy hot, but additionally it is used as a pharmaceutical to alleviate different pain conditions. Capsaicin binds to the vanilloid receptor TRPV1, which plays a role in coordin…
View article: Attenuated total reflectance infrared spectroscopy: A powerful method for the simultaneous study of structure and spatial orientation of lipids and membrane proteins
Attenuated total reflectance infrared spectroscopy: A powerful method for the simultaneous study of structure and spatial orientation of lipids and membrane proteins Open
One of the most powerful techniques used to gain structural information of membrane proteins is the Attenuated Total Reflectance Fourier Transformed Infrared spectroscopy (ATR-FTIR). Secondary structure, conformational changes, interaction…