Carlo Greco
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View article: Predicting lung cancer survival with attention-based CT slices combination
Predicting lung cancer survival with attention-based CT slices combination Open
Accurate prognosis of Non-Small Cell Lung Cancer (NSCLC) is crucial for enhancing patient care and treatment outcomes. Despite the advancements in deep learning, the task of overall survival prediction in NSCLC has not fully leveraged thes…
View article: Trastuzumab-deruxtecan and radiotherapy: a safety sub-analysis of COMBART prospective cohort study
Trastuzumab-deruxtecan and radiotherapy: a safety sub-analysis of COMBART prospective cohort study Open
Aim This observational analysis, derived from the prospective mono-institutional COMBART cohort (stage IV breast cancer patients undergoing radiation therapy during novel systemic treatments), evaluates the safety of combining radiotherapy…
View article: Clinical Value of Bone Radiotherapy in a Prospective Cohort of Metastatic Breast Cancer Treated with Anti-CDK4/6
Clinical Value of Bone Radiotherapy in a Prospective Cohort of Metastatic Breast Cancer Treated with Anti-CDK4/6 Open
Background: CDK4/6 inhibitor plus ET is a standard treatment for advanced HR+ BC. This study evaluates the efficacy and safety of CDK4/6 inhibitors with concurrent RT (SBRT and non-SBRT) in terms of pain, analgesic therapy changes, toxicit…
View article: Real-world outcomes of subsequent treatment strategies after durvalumab consolidation in stage III unresectable non-small cell lung cancer
Real-world outcomes of subsequent treatment strategies after durvalumab consolidation in stage III unresectable non-small cell lung cancer Open
Platinum-based chemotherapy was the predominant treatment after durvalumab consolidation. Immunotherapy rechallenge was associated with the best survival outcome in selected cases, warranting further investigation.
View article: Multimodal Doctor-in-the-Loop: A Clinically-Guided Explainable Framework for Predicting Pathological Response in Non-Small Cell Lung Cancer
Multimodal Doctor-in-the-Loop: A Clinically-Guided Explainable Framework for Predicting Pathological Response in Non-Small Cell Lung Cancer Open
This study proposes a novel approach combining Multimodal Deep Learning with intrinsic eXplainable Artificial Intelligence techniques to predict pathological response in non-small cell lung cancer patients undergoing neoadjuvant therapy. D…
View article: Front Matter
Front Matter Open
Assemblages of Cancer offers a comparative, in-depth analysis of breast cancer in the UK, France and Italy, linking patients’ experiences with the biomedical, political and cultural context of the disease. The book is based on ten years of…
View article: Doctor-in-the-Loop: An Explainable, Multi-View Deep Learning Framework for Predicting Pathological Response in Non-Small Cell Lung Cancer
Doctor-in-the-Loop: An Explainable, Multi-View Deep Learning Framework for Predicting Pathological Response in Non-Small Cell Lung Cancer Open
Non-small cell lung cancer (NSCLC) remains a major global health challenge, with high post-surgical recurrence rates underscoring the need for accurate pathological response predictions to guide personalized treatments. Although artificial…
View article: Accuracy-dependent dose-constraints and dose-based safety margins for organs-at-risk in radiotherapy
Accuracy-dependent dose-constraints and dose-based safety margins for organs-at-risk in radiotherapy Open
We introduced a first model relating dose constraints and complication probabilities with treatment uncertainties and safety margins for OARs. Among other things, it quantified how higher constraints can be applied with increasing radiothe…
View article: Predicting Lung Cancer Survival with Attention-based CT Slices Combination
Predicting Lung Cancer Survival with Attention-based CT Slices Combination Open
Accurate prognosis of Non-Small Cell Lung Cancer (NSCLC) is crucial for enhancing patient care and treatment outcomes. Despite the advancements in deep learning, the task of overall survival prediction in NSCLC has not fully leveraged thes…
View article: Exploring Negated Entites for Named Entity Recognition in Italian Lung Cancer Clinical Reports
Exploring Negated Entites for Named Entity Recognition in Italian Lung Cancer Clinical Reports Open
This paper explores the potential of leveraging electronic health records (EHRs) for personalized health research through the application of artificial intelligence (AI) techniques, specifically Named Entity Recognition (NER). By extractin…
View article: 142P AI-based approaches to predict early response in unresectable LA-NSCLC patients undergoing chemoradiation
142P AI-based approaches to predict early response in unresectable LA-NSCLC patients undergoing chemoradiation Open
We developed a multimodal dataset that combines features computed from radiomics, clinical data, medical and histopathology images routinely collected to predict clinical outcomes for NSCLC patients. Patients with unresectable LA-NSCLC wer…
View article: Breast Volume Is a Predictor of Higher Heart Dose in Whole-Breast Supine Free-Breathing Volumetric-Modulated Arc Therapy Planning
Breast Volume Is a Predictor of Higher Heart Dose in Whole-Breast Supine Free-Breathing Volumetric-Modulated Arc Therapy Planning Open
In breast cancer volumetric-modulated arc therapy (VMAT) planning, the rotation of the gantry around the target implies a greater dose spreading to the whole heart, compared to tangential-field standard treatment. A consecutive cohort of 1…
View article: Deep pathomics: A new image-based tool for predicting response to treatment in stage III non-small cell lung cancer
Deep pathomics: A new image-based tool for predicting response to treatment in stage III non-small cell lung cancer Open
Despite the advantages offered by personalized treatments, there is presently no way to predict response to chemoradiotherapy in patients with non-small cell lung cancer (NSCLC). In this exploratory study, we investigated the application o…
View article: Field output correction factors of small static field for IBA razor nanochamber
Field output correction factors of small static field for IBA razor nanochamber Open
Purpose. The goal of this work is present results of field output factors (OF) using an IBA CC003 (Razor NanoChamber) and compare these results with PTW 60019 (MicroDiamond) and IBA Razor Diode. The experimental results for IBA CC003 were …
View article: Preventing Cardiotoxicity in Personalized Breast Irradiation
Preventing Cardiotoxicity in Personalized Breast Irradiation Open
Background: This study aims to assess the benefit of a deep inspiration breath hold (DIBH) over the standard irradiation technique, and eventually to identify anatomical and/or treatment preplanning characteristics correlated with the LAD …
View article: An approach to generate synthetic 4DCT datasets to benchmark Mid-Position implementations
An approach to generate synthetic 4DCT datasets to benchmark Mid-Position implementations Open
The described approach and the proposed experiments provide an independent method that can be used in the validation of any Mid-P implementation being developed.
View article: Preventing Cardiotoxicity in Personalized Breast Irradiation
Preventing Cardiotoxicity in Personalized Breast Irradiation Open
Background: to assess the benefit of a deep inspiration breath hold (DIBH) over standard irradiation technique, and eventually to identify anatomical and/or treatment preplanning characteristics correlated with LAD dose. Methods: We retros…
View article: The impact of intensified staging and combined therapies in locally advanced pancreatic cancer: a secondary analysis of prospective studies
The impact of intensified staging and combined therapies in locally advanced pancreatic cancer: a secondary analysis of prospective studies Open
Aim: The aim was to investigate the use of comprehensive pretreatment staging with multiple diagnostic modalities, including functional imaging and minimally invasive surgical procedures, in locally advanced pancreatic cancer (LAPC) patien…
View article: Non-Oncological Radiotherapy: A Review of Modern Approaches
Non-Oncological Radiotherapy: A Review of Modern Approaches Open
Despite being usually delivered in oncological patients, radiotherapy can be used as a successful treatment for several non-malignant disorders. Even though this use of radiotherapy has been scarcely investigated since the 1950s, more rece…
View article: Health-related quality of life of salvage prostate reirradiation using stereotactic ablative radiotherapy with urethral-sparing
Health-related quality of life of salvage prostate reirradiation using stereotactic ablative radiotherapy with urethral-sparing Open
Purpose To explore whether prostate motion mitigation using the rectal distension-mediated technique is safe and effective in stereotactic ablative radiation therapy (SABR) salvage treatment of intraprostatic cancer recurrences following i…