C. Griffin McDaniel
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View article: Trametinib Normalizes Angiopoietin-2 Levels and Successfully Treats Kaposiform Lymphangiomatosis
Trametinib Normalizes Angiopoietin-2 Levels and Successfully Treats Kaposiform Lymphangiomatosis Open
Kaposiform lymphangiomatosis (KLA) is a complex lymphatic anomaly with high morbidity and mortality. Angiopoietin-2 (Ang-2) levels are elevated in the blood of patients with KLA and can be used to aid in diagnosis and monitor treatment res…
View article: Human Lymphatic Endothelial Cells Expressing NRAS<sup>Q61R</sup> Model Characteristics of Kaposiform Lymphangiomatosis
Human Lymphatic Endothelial Cells Expressing NRAS<sup>Q61R</sup> Model Characteristics of Kaposiform Lymphangiomatosis Open
Kaposiform lymphangiomatosis (KLA) is a complex lymphatic anomaly characterized by lymphatic overgrowth and dysfunction. The goal of this study was to determine how the NRAS Q61R variant found in the tissue of KLA patients impacts key char…
View article: NRAS<sup>Q61R</sup> mutation drives elevated angiopoietin‐2 expression in human endothelial cells and a genetic mouse model
NRAS<sup>Q61R</sup> mutation drives elevated angiopoietin‐2 expression in human endothelial cells and a genetic mouse model Open
Background Angiopoietin‐2 (Ang‐2) is increased in the blood of patients with kaposiform lymphangiomatosis (KLA) and kaposiform hemangioendothelioma (KHE). While the genetic causes of KHE are not clear, a somatic activating NRAS Q61R mutati…
View article: Meropenem extraction by <i>ex vivo</i> extracorporeal life support circuits
Meropenem extraction by <i>ex vivo</i> extracorporeal life support circuits Open
Background : Meropenem is a broad-spectrum carbapenem-type antibiotic commonly used to treat critically ill patients infected with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. As many of these patients require extraco…
View article: Kaposiform lymphangiomatosis: Diagnosis, pathogenesis, and treatment
Kaposiform lymphangiomatosis: Diagnosis, pathogenesis, and treatment Open
Kaposiform lymphangiomatosis (KLA) is a life‐threatening rare disease that can cause substantial morbidity, mortality, and social burdens for patients and their families. Diagnosis often occurs long after initial symptoms, and there are fe…
View article: Aptamer-based factor IXa inhibition preserves hemostasis and prevents thrombosis in a piglet model of ECMO
Aptamer-based factor IXa inhibition preserves hemostasis and prevents thrombosis in a piglet model of ECMO Open
View article: Amiodarone Extraction by the Extracorporeal Membrane Oxygenation Circuit.
Amiodarone Extraction by the Extracorporeal Membrane Oxygenation Circuit. Open
Amiodarone is an anti-arrhythmic agent that is frequently used to treat tachycardias in critically ill adults and children. Because of physicochemical properties of amiodarone, extracorporeal membrane oxygenation (ECMO) circuits are expect…
View article: Amiodarone Extraction by the Extracorporeal Membrane Oxygenation Circuit
Amiodarone Extraction by the Extracorporeal Membrane Oxygenation Circuit Open
Amiodarone is an anti-arrhythmic agent that is frequently used to treat tachycardias in critically ill adults and children. Because of physicochemical properties of amiodarone, extracorporeal membrane oxygenation (ECMO) circuits are expect…