C.E.M. Griffiths
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Impact of weight‐loss interventions on psoriasis severity: A systematic review and meta‐analysis Open
Background Psoriasis affects at least 60 million people worldwide, and 80% also live with overweight or obesity. Excess weight increases susceptibility to psoriasis and is associated with more severe disease. Objective To evaluate the impa…
View article: 101 Community-based testing of migrants for infectious diseases (COMBAT-ID): the effectiveness of routine testing for infectious diseases among migrants attending primary care
101 Community-based testing of migrants for infectious diseases (COMBAT-ID): the effectiveness of routine testing for infectious diseases among migrants attending primary care Open
OP 34: Diseases and Interventions 2, B304 (FCSH), September 5, 2025, 10:15 - 11:15 Background Migrants are at increased risk of chronic infections and have poorer outcomes. Early diagnosis and management can reduce morbidity, mortality and…
Breaking the cycle of psoriasis: the role for early intervention Open
Psoriasis is typically managed via a ‘Staircase’ approach, slowly escalating treatment from topical treatments to biologics, often delaying effective intervention for several years. Recent evidence supports an ‘Elevator’ approach, advocati…
View article: Glucocorticoids Unleash Immune-dependent Melanoma Control through Inhibition of the GARP/TGFβ Axis
Glucocorticoids Unleash Immune-dependent Melanoma Control through Inhibition of the GARP/TGFβ Axis Open
Half of patients with advanced melanoma fail to benefit from immune checkpoint blockade, and novel treatments are urgently required. Testing topical medications for anticancer activity in an immunotherapy-resistant murine melanoma model, w…
Efficacy and safety of tildrakizumab for the treatment of moderate-to-severe plaque psoriasis over 5 years in patients living with obesity Open
People with plaque psoriasis are more likely to live with obesity relative to individuals without psoriasis, which can affect response to biologic treatment. This pooled analysis of the phase III reSURFACE 1 and reSURFACE 2 trials explored…
View article: Psoriasis and risk of 26 cancers: pooled population-based cohort studies from Denmark, England, Israel and Taiwan
Psoriasis and risk of 26 cancers: pooled population-based cohort studies from Denmark, England, Israel and Taiwan Open
Background Psoriasis is a chronic inflammatory skin disease, and the risk of developing cancer has been postulated due to the presence of several plausible underlying mechanisms. Understanding the association between psoriasis and cancer i…
Skin disease in the Eastern Cape (SKINSCAPE): a Global Psoriasis Atlas point prevalence study in rural South Africa Open
Background The Eastern Cape is an under-resourced province and the poorest in South Africa, where little is known about the epidemiology of skin diseases. Objectives To examine the nature and prevalence of skin diseases in two neighbouring…
Grand challenges for skin health revisited: the International League of Dermatological Societies skin disease atlases Open
On 24 May 2025, the Seventy-Eighth World Health Assembly (WHA78) adopted a resolution recognizing skin diseases as a global public health priority. This reflects a collective commitment from WHO member states to strengthen policies, secure…
View article: Mesenchymal stromal cells as rescue therapy in biologic-refractory psoriasis: insights from a case series
Mesenchymal stromal cells as rescue therapy in biologic-refractory psoriasis: insights from a case series Open
Cytokine-targeted biologics have revolutionized the management of moderate-to-severe psoriasis; however, all available therapies have failed a growing number of patients. Mesenchymal stromal cells (MSCs), with their immunomodulatory proper…
Associations between food intake and psoriasis severity and comorbidity: a cross-sectional analysis using UK Biobank data Open
Psoriasis is a chronic, inflammatory skin condition characterized by red, scaly patches that can cause substantial discomfort and social stigma (1) . Psoriasis significantly impairs the quality of life of those affected, particularly when …
View article: Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity
Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity Open
Background Despite increased understanding of psoriasis pathogenesis, molecular classification of clinical phenotypes and disease severity is poorly defined. Knowledge gaps include whether molecular endotypes of psoriasis underlie distinct…
View article: Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis
Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis Open
Half of advanced melanoma patients fail to benefit from immune checkpoint blockade and novel treatments are urgently required. Testing topical medications used in other skin diseases for anti-cancer activity in an immunotherapy-resistant m…
Mendelian randomization identifies OX40 as a potential mediator of the effects of cigarette smoking on palmoplantar pustulosis Open
We used two-step Mendelian randomization to investigate the inflammatory mediators underlying the effects of cigarette smoking on palmoplantar pustulosis (PPP). We first examined the causal effects of smoking on plasma cytokine levels and …
Optimising long-term management in acute asthma presentations to the emergency department: an interview study on patient beliefs Open
Background Emergency department (ED) attendances with acute asthma are an opportunity for simple medication changes to improve long-term self-management, but patients’ beliefs and behaviours need to be considered for interventions to be su…
Sex Differences in 1600-m Running Performance and Participation for Children Aged 6–12 yr Open
Introduction In children, females participate in sport and physical activity less than males and have lower peak oxygen intake values. How this sexual dimorphism in the aerobic capacity of children affects the aerobic performances of child…
Adalimumab Monotherapy vs Adalimumab With Methotrexate for Psoriasis Open
Importance It is unclear whether concomitant methotrexate enhances the effectiveness and persistence of adalimumab for psoriasis. The recent OPTIMAP randomized clinical trial that tested adalimumab against adalimumab with methotrexate coul…
Drug survival of IL‐23 and IL‐17 inhibitors versus other biologics for psoriasis: A British Association of Dermatologists Biologics and Immunomodulators Register cohort study Open
Background Interleukin (IL)‐23p19 and IL‐17 inhibitors have demonstrated high efficacy for psoriasis in randomized controlled trials, though real‐world data, particularly for risankizumab (IL‐23p19 inhibitor) and brodalumab (IL‐17 receptor…
View article: Outcomes of Psoriasis Area and Severity Index (PASI) and PASI components in two phase III trials of deucravacitinib in patients with moderate to severe plaque psoriasis
Outcomes of Psoriasis Area and Severity Index (PASI) and PASI components in two phase III trials of deucravacitinib in patients with moderate to severe plaque psoriasis Open
Deucravacitinib was significantly more effective than placebo in the 52-week, phase III POETYK PSO-1 and PSO-2 trials. This study further evaluated deucravacitinib efficacy compared with placebo in these trials based on Psoriasis Area and …
View article: Evaluating changes in baseline characteristics and drug-utilization pattern in patients with moderate-to-severe psoriasis: findings from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR) cohort
Evaluating changes in baseline characteristics and drug-utilization pattern in patients with moderate-to-severe psoriasis: findings from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR) cohort Open
Background Since the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR) was established in 2007, numerous biologic therapies have been introduced for the better management of psoriasis. Objectives To des…
Are psoriasis severity and comorbidities associated with diet quality? A cross-sectional analysis using UK Biobank Open
Participants with psoriasis showed slightly better adherence to a Mediterranean-style diet but also consumed more processed meat, sodium, free sugars, and alcohol. Those with the most severe psoriasis or comorbidities had poorer diet quali…
View article: Epidemiology of Psoriasis in Poland: Prevalence, Incidence, and Mortality Rates
Epidemiology of Psoriasis in Poland: Prevalence, Incidence, and Mortality Rates Open
Background Although the data on psoriasis epidemiology included in the Global Psoriasis Atlas (GPA) provide valuable information on psoriasis prevalence worldwide, the GPA database is still incomplete. Therefore, the aim of the study was t…
Introducing dietary advice as a therapeutic tool to manage psoriasis Open
Psoriasis is a chronic debilitating skin disease affecting 2 % of the UK population. The aetiopathogenesis of psoriasis arises from a combination of genetic susceptibly and lifestyle patterns including stress, infections, alcohol misuse, l…
View article: Efficacy and safety of tildrakizumab in patients with early- vs. late-onset psoriasis
Efficacy and safety of tildrakizumab in patients with early- vs. late-onset psoriasis Open
Background The age of psoriasis onset is bimodally distributed with distinct peaks at 0.05). Efficacy findings were supported in a subset of patients matched by disease duration. TEAEs and serious TEAEs occurred in 65.8% vs. 66.2% and 3.6%…
Circulating CD8 T cells from patients with mild-to-moderate psoriasis are functionally impaired Open
Background Psoriasis is a systemic, immune-mediated, inflammatory skin disease in which T cells have been found to play a significant role. The phenotypic and functional properties of circulating CD8 T cells in the pathogenesis of the dise…
Are acute asthma presentations to the emergency department an opportunity for optimising long-term management? A qualitative study on beliefs and behaviours of healthcare professionals Open
Background Guidelines recommend Emergency Department (ED) healthcare professionals (HCPs) ensure patients have a supply of inhaled corticosteroid on discharge after an acute asthma presentation. By optimising medication, acute asthma prese…