Explanipedia

Risk of Late-Onset Depression in Long-Term Survivors of Breast, Prostate, and Colorectal Cancer Open

Melissa Taylor, Sarah J. Westvold, Jessica B. Long, Terry Hyslop, Andrea Silber , et al. · 2025

Importance: The prevalence of depression is higher in cancer survivors than in the general population. As the long-term cancer survivor population increases, it is increasingly important to understand risk factors for late-onset depression…

Risk of Late-Onset Depression in Long-Term Survivors of Breast, Prostate, and Colorectal Cancer Open

Melissa Taylor, Sarah Westvold, Jessica B. Long, Terry Hyslop, Rebecca Forman , et al. · 2025

Importance The prevalence of depression is higher in cancer survivors than in the general population. As the long-term cancer survivor population increases, it is increasingly important to understand risk factors for late-onset depression.…

Physician-level variability in adopting opportunistic salpingectomy for ovarian cancer prevention at the time of hysterectomy Open

Xiao Xu, Vrunda Desai, Cary P. Gross, Erica S. Spatz, Craig Evan Pollack , et al. · 2025

Opportunistic salpingectomy reduces ovarian cancer risk. To examine heterogeneity among physicians in their adoption of opportunistic salpingectomy in hysterectomy practice, we identified 33,401 non-pregnant patients aged 18 to 49 years in…

Cost-Effectiveness and Evidence Gaps Surrounding PSMA-PET for Recurrent Prostate Cancer Evaluation Open

Natalia Kunst, Jessica B. Long, Preston C. Sprenkle, Isaac Yi Kim, Lawrence Saperstein , et al. · 2025

Importance Prostate-specific membrane antigen positron emission tomography (PSMA-PET), a form of molecular imaging, increases detection of advanced and metastatic prostate cancer, but its potential to increase treatment costs due to increa…

Changes in Colorectal Cancer Screening Modalities Among Insured Individuals Open

Sunny Siddique, Rong Wang, Folasade P. May, Laura Van Metre Baum, Cary P. Gross , et al. · 2025

Importance Several colorectal cancer (CRC) screening modalities (eg, colonoscopy, stool-based tests) are currently available. Yet, recent national patterns in screening using these modalities and potential differences across sociodemograph…

Incarceration and Quality of Cancer Care Open

Oluwadamilola T. Oladeru, Ilana B. Richman, Jenerius A. Aminawung, Jason Weinstein, Lisa B. Puglisi , et al. · 2025

Importance Although incarceration is associated with worse cancer outcomes, little is known about quality of cancer care among people with a history of incarceration. Objective To describe quality of cancer care among those diagnosed with …

Federal Housing Assistance and Stage at Cancer Diagnosis Among Older Adults in the US Open

Craig Evan Pollack, Amanda L. Blackford, Taylor K. Craig, Qinjin Fan, S. M. Qasim Hussaini , et al. · 2025

Importance A growing number of older adults live in unaffordable and unstable housing; however, whether programs designed to counter housing insecurity contribute to earlier-stage cancer diagnosis remains largely unknown. Objective To exam…

Opioid prescribing trends and pain scores among adult patients with cancer in a large health system Open

Laura Van Metre Baum, Pamela R. Soulos, Madhav KC, Molly M. Jeffery, Kathryn J. Ruddy , et al. · 2025

Background Opioid stewardship policies could adversely affect pain management for patients with cancer. Yet patients with cancer are also at risk for opioid‐related harms. This study sought to determine trends in opioid prescribing by clin…

Physician Peer Influence on Salpingectomy Uptake for Tubal Sterilization and Ovarian Cancer Prevention Open

Xiao Xu, Jessica B. Long, Craig Evan Pollack, Vrunda Desai, Cary P. Gross , et al. · 2025

Importance Prophylactic removal of the fallopian tubes (opportunistic salpingectomy) in lieu of conventional methods of tubal sterilization helps reduce ovarian cancer risk. Objective To examine how peer influence among physicians is assoc…

The Comparative Toxicity of Focal Ablation Versus Intensity Modulated Radiation Therapy for Prostate Cancer Open

James B. Yu, David DeStephano, Brian Jeffers, Alexander Tward, Catherine S. Spina , et al. · 2025

Outcomes with trastuzumab deruxtecan by biomarker status, line of treatment and prior receipt of sacituzumab govitecan in a large real-world database of patients with metastatic breast cancer Open

Paolo Tarantino, David Lee, Julia Foldi, Pamela R. Soulos, Cary P. Gross , et al. · 2025

Patterns of adjuvant bone modifying agent use in patients with early-stage breast cancer in the United States Open

Nicole Odzer, Rachel Jaber Chehayeb, Sarah Schellhorn, Maryam B. Lustberg, Cary P. Gross , et al. · 2025

Even after release of the ACGD guidelines, adjuvant BMA prescribing was low, and the majority of patients who received BMA did not receive bisphosphonates.

Representation of Women, Older Adults, and Racial and Ethnic Minoritized Patients in Pivotal Trials for US Food and Drug Administration Novel Oncology Therapeutic Approvals, 2012-2021: Bright Spot Trials and Trends Over Time Open

Jennifer Miller, William Pelletiers, Cary P. Gross, Michelle M. Mello, Reshma Ramachandran , et al. · 2025

PURPOSE To examine trends over time in clinical trial diversity for oncology therapeutics, identify bright spot trials adequately representing Black or Latino patients, and examine their associations with trial characteristics. METHODS Thi…

Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer Open

Juanyi Tan, Szu‐Chun Yang, Michaela A. Dinan, Anne C. Chiang, Cary P. Gross , et al. · 2025

Importance Targeted therapies and immunotherapies prolong survival but are associated with high costs for patients with advanced non–small cell lung cancer (aNSCLC). To date, little is known about survival and medication cost by biomarker …

Salary Differences by Gender, Race, and Ethnicity Among Assistant Professors at US Medical Schools Open

Dalia Owda, Michael O. Mensah, David Y. Yang, Maureen Canavan, Cary P. Gross , et al. · 2025

Importance Salary inequities by gender are well documented in medicine, but there is limited understanding of racial and ethnic disparities or how these intersect with gender across clinical specialties. Objective To determine whether sala…

314P Outcomes with trastuzumab deruxtecan (T-DXd) for metastatic breast cancer (MBC) according to BRCA and PD-L1 status Open

P. Tarantino, D. Lee, Julia Foldi, Pamela R. Soulos, Cary P. Gross , et al. · 2025

Prostate-Specific Membrane Antigen Imaging Findings and Subsequent Clinical Management Among Patients With Biochemically Recurrent Prostate Cancer Open

Maximilian Rabil, Umar Ghaffar, Jessica B. Long, Sarah Westvold, Preston C. Sprenkle , et al. · 2025

Purpose: Prostate-specific membrane antigen positron emission tomography (PSMA-PET) improves prostate cancer (PCa) localization, particularly in biochemical recurrence (BCR). The primary objective was to assess management patterns after PS…

“Cancer Will Make You Bankrupt!”– Stakeholders perspectives on managing health–related social needs in ovarian cancer Open

Anand Habib, Sarah Pitafi, Elena Ratner, Stacy Tessler Lindau, Cary P. Gross , et al. · 2025

Developing a digital video to support lung cancer screening in diverse populations Open

Meghan Lindsay, Iyanuoluwa Odole, Olivia Belliveau, Fuad Abujarad, Cary P. Gross , et al. · 2025

Mediators of Racial Inequities in Non‐Small Cell Lung Cancer Care Open

Safraz A. Hamid, D. Lee, Jeph Herrin, James B. Yu, Craig Evan Pollack , et al. · 2025

Background Black patients with non‐small cell lung cancer (NSCLC) are more often diagnosed at a later stage and receive inadequate evaluation and treatment compared to White patients. We aimed to identify factors representing exposure to s…

Racial and ethnic disparities in conversion to mastectomy following lumpectomy Open

Jasmine A. Khubchandani, Madhav KC, Pranam Dey, Ellie M. Proussaloglou, Monica G. Valero , et al. · 2025

Physicians in Private Equity Practices—Canaries in a Coal Mine? Open

Cary P. Gross, Giselle Corbie‐Smith · 2025

In the rapidly changing health care environment, financing of clinical practices through private equity (PE) can offer the prospect of fiscal stabilization.

Physician Variation in Adopting Opportunistic Salpingectomy at the Time of Postpartum and Interval Sterilization for Ovarian Cancer Risk Reduction Open

Katherine Yoh, Vrunda Desai, Cary P. Gross, Erica S. Spatz, Craig Evan Pollack , et al. · 2025

Concordance between clinical trial data use request proposals and corresponding publications: A cross-sectional study Open

Enrique Vázquez, Joseph S. Ross, Cary P. Gross, Karla Childers, S. P. Bamford , et al. · 2024

Background/Aims The reuse of clinical trial data available through data-sharing platforms has grown over the past decade. Several prominent clinical data-sharing platforms require researchers to submit formal research proposals before gran…

Active Surveillance or Watchful Waiting for Intermediate-Risk Prostate Cancer, 2010-2020 Open

Ismail Ajjawi, Stacy Loeb, Matthew R. Cooperberg, William J. Catàlona, Cary P. Gross , et al. · 2024

This cross-sectional study evaluates trends and factors associated with selecting active surveillance or watchful waiting among individuals with intermediate-risk prostate cancer.

Construction and performance of a clinical prediction rule for ureteral stone without the use of race or ethnicity: A new STONE score Open

Christopher Moore, Cary P. Gross, Louis Hart, Annette M. Molinaro, Deborah J. Rhodes , et al. · 2024

Long-Term Outcomes of Prostate-Specific Membrane Antigen–PET Imaging of Recurrent Prostate Cancer Open

Natalia Kunst, Jessica B. Long, Sarah Westvold, Preston C. Sprenkle, Isaac Yi Kim , et al. · 2024

Importance Although prostate-specific membrane antigen positron emission tomography (PSMA-PET) has shown improved sensitivity and specificity compared with conventional imaging for the detection of biochemical recurrent (BCR) prostate canc…

USPSTF Colorectal Cancer Screening Recommendation and Uptake for Individuals Aged 45 to 49 Years Open

Sunny Siddique, Rong Wang, Faiza Yasin, Jacquelyne Gaddy, Lan Zhang , et al. · 2024

Importance In May 2021, the US Preventive Services Task Force (USPSTF) issued a grade B recommendation encouraging colorectal cancer (CRC) screening among average-risk individuals aged 45 to 49 years. The patterns of screening uptake and p…

Cost trends of metastatic renal cell carcinoma therapy: the impact of oral anticancer agents and immunotherapy Open

Rebecca Forman, Jessica B. Long, Sarah Westvold, Khushi Agnish, Hannah D. McManus , et al. · 2024

Background Immunotherapy (IO) and oral anticancer agents (OAA) have improved outcomes for metastatic renal cell carcinoma (mRCC), but there is a need to understand real-world costs from the perspective of payers and patients. Methods We us…

Trends in use of intensive care during hospitalizations at the end‐of‐life among older adults with advanced cancer Open

Snigdha Jain, Jessica B. Long, Vinay Rao, Anica C. Law, Allan J. Walkey , et al. · 2024

Background High‐intensity end‐of‐life (EOL) care, marked by admission to intensive care units (ICUs) or in‐hospital death, can be costly and burdensome. Recent trends in use of ICUs, life‐sustaining treatments (LSTs), and noninvasive venti…

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