Cristina Grosu
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View article: Integrated Biomarker–Volumetric Profiling Defines Neurodegenerative Subtypes and Predicts Neuroaxonal Injury in Multiple Sclerosis Based on Bayesian and Machine Learning Analyses
Integrated Biomarker–Volumetric Profiling Defines Neurodegenerative Subtypes and Predicts Neuroaxonal Injury in Multiple Sclerosis Based on Bayesian and Machine Learning Analyses Open
Background: The clinical–radiological paradox in multiple sclerosis (MS) underscores the need for biomarkers that better reflect neurodegenerative pathology. Serum neurofilament light chain (sNfL) is a dynamic marker of neuroaxonal injury,…
View article: Hereditary Transthyretin Amyloidosis (ATTRv) with Symmetric Paresthesia in All Limbs: A Case Report and Literature Review
Hereditary Transthyretin Amyloidosis (ATTRv) with Symmetric Paresthesia in All Limbs: A Case Report and Literature Review Open
We present the case of a 57-year-old male with a four-year history of progressive, symmetric paresthesia and numbness in all four limbs, associated with bilateral carpal tunnel syndrome. Past medical history included mild mitral regurgitat…
View article: Integrative Perspectives on Myocardial Infarction Risk and Ischemic stroke: The Interplay Between Microbiota, Metabolism, and Epigenetics
Integrative Perspectives on Myocardial Infarction Risk and Ischemic stroke: The Interplay Between Microbiota, Metabolism, and Epigenetics Open
Cardiovascular disease remains the leading cause of morbidity and mortality worldwide, with an increasing incidence despite advances in diagnosis and treatment. Coronary heart disease, particularly acute myocardial infarction, accounts for…
View article: Validation of the Romanian Version of the Modified Fatigue Impact Scale (MFIS) in Multiple Sclerosis Patients
Validation of the Romanian Version of the Modified Fatigue Impact Scale (MFIS) in Multiple Sclerosis Patients Open
Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS), with major impact on quality of life. Reliable, culturally adapted instruments are essential for accurate assessment. To validate the Romanian version o…
View article: Fingolimod as a Neuroprotective Agent in Ischemic Stroke: A Review of Preclinical and Clinical Evidence
Fingolimod as a Neuroprotective Agent in Ischemic Stroke: A Review of Preclinical and Clinical Evidence Open
Ischemic stroke remains a leading cause of mortality and disability worldwide, with current therapies such as intravenous thrombolysis and mechanical thrombectomy benefiting only a limited proportion of patients. Neuroinflammation is a key…
View article: The Role of Nutrition and Physical Activity in Modulating Disease Progression and Quality of Life in Multiple Sclerosis
The Role of Nutrition and Physical Activity in Modulating Disease Progression and Quality of Life in Multiple Sclerosis Open
Multiple sclerosis (MS) is a chronic, immune-mediated neurological disorder with increasing global prevalence. Emerging evidence underscores the role of lifestyle interventions (particularly diet and physical activity) in modulating diseas…
View article: Social and Demographic Determinants of Consanguineous Marriage: Insights from a Literature Review
Social and Demographic Determinants of Consanguineous Marriage: Insights from a Literature Review Open
Consanguinity is the marriage of two related persons. This type of marriage is one of the main pillars when it comes to recessive hereditary diseases, birth defects, infertility, miscarriages, abortion, and infant deaths. Intermarriage con…
View article: The Role of MRI Lesions in Identifying Secondary Progressive Multiple Sclerosis: A Comprehensive Review
The Role of MRI Lesions in Identifying Secondary Progressive Multiple Sclerosis: A Comprehensive Review Open
Secondary Progressive Multiple Sclerosis (SPMS) represents a challenging phase of multiple sclerosis, marked by gradual neurological decline and reduced inflammatory activity. In recent years, magnetic resonance imaging (MRI) has become es…
View article: Common Peroneal Nerve Paralysis Following Rapid Weight Loss—A Case Report and Literature Review
Common Peroneal Nerve Paralysis Following Rapid Weight Loss—A Case Report and Literature Review Open
Common peroneal nerve neuropathy at the fibular head secondary to weight loss is known as slimmer’s paralysis. Although this pathology has long been documented in medical literature, it has gained more clinical significance in recent years…
View article: Neurodegenerative Biomarkers in Multiple Sclerosis: At the Interface Between Research and Clinical Practice
Neurodegenerative Biomarkers in Multiple Sclerosis: At the Interface Between Research and Clinical Practice Open
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While the inflammatory components of MS have been extensively studied, th…
View article: Evaluating Fundoscopy as a Screening Tool for Optic Nerve Atrophy in Multiple Sclerosis: An Optical Coherence Tomography (OCT) Comparative Study
Evaluating Fundoscopy as a Screening Tool for Optic Nerve Atrophy in Multiple Sclerosis: An Optical Coherence Tomography (OCT) Comparative Study Open
Background: Multiple sclerosis (MS) is a chronic, immune-mediated disorder of the central nervous system (CNS), characterized by inflammation, demyelination, and neurodegeneration, resulting in the disruption of axonal signal conduction. O…
View article: Knitted linings for protective equipment against vibrations
Knitted linings for protective equipment against vibrations Open
Vibrations can affect the human body during everyday activities or in the workplace through various tools. It can occur at any point that comes into contact with a vibrating surface, including the hands (hand-arm vibration, HAV), the feet …
View article: Behaviour of Knitted Materials in a Vibrating Environment
Behaviour of Knitted Materials in a Vibrating Environment Open
The energy generated by the impact of vibrations from industrial tools or ongoing activities can be transmitted to humans and cause various injuries. Knitted materials can be considered as parts of anti-vibration equipment as they have pro…
View article: Neurogenic Orthostatic Hypotension in Parkinson Disease—A Narrative Review of Diagnosis and Management
Neurogenic Orthostatic Hypotension in Parkinson Disease—A Narrative Review of Diagnosis and Management Open
Background: Neurogenic orthostatic hypotension (NOH) is a significant non-motor manifestation of Parkinson’s disease (PD), that substantially affects patient disability and has a powerful impact on the quality of life of PD patients, while…
View article: Validation of a Set of Clinical Criteria for the Diagnosis of Secondary Progressive Multiple Sclerosis
Validation of a Set of Clinical Criteria for the Diagnosis of Secondary Progressive Multiple Sclerosis Open
Background/Objectives: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by progressive impairment of neuronal transmission due to focal demyelination. The most common form is RRMS (relap…
View article: The long-term impact of rehabilitation in upper limb plexopathies
The long-term impact of rehabilitation in upper limb plexopathies Open
The main objective of the research consists in providing evidence that a long-term rehabilitation protocol is favorable for the patient. In adult brachial plexus (BP) palsies, after several surgical attempts, the lack of results in the upp…
View article: The Faces of “Too Late”—A Surprisingly Progressive Cohort of “Stable” Relapsing Remitting Multiple Sclerosis Patients
The Faces of “Too Late”—A Surprisingly Progressive Cohort of “Stable” Relapsing Remitting Multiple Sclerosis Patients Open
Background and Objectives: Although available therapies have changed the natural evolution of multiple sclerosis (MS), in time some patients assume a progressive course and no longer respond to treatment. There is no definitive clinical or…
View article: Psychomotric Perspectives of Rehabilitation in Chronic Brachial Plexus Palsies
Psychomotric Perspectives of Rehabilitation in Chronic Brachial Plexus Palsies Open
Background. The perspective of ongoing electric signals within the motor cortex, conditioned by continuous rehabilitation strategies (doubled by adherence to the treatment protocol), is of interest related to understanding how cerebral pla…
View article: Association between Serum Lipids and Asthma in Adults—A Systematic Review
Association between Serum Lipids and Asthma in Adults—A Systematic Review Open
(1) Background: Asthma is a syndrome found in both adults and children, characterized by airflow obstruction caused by the inflammation of the airways. In recent years, an increasing number of studies have found that lipid metabolism influ…
View article: Medical–Surgical Implications of Branching Variation of Human Aortic Arch Known as Bovine Aortic Arch (BAA)
Medical–Surgical Implications of Branching Variation of Human Aortic Arch Known as Bovine Aortic Arch (BAA) Open
(1) Background: The aortic arch (AA) branching model is challenging, considering the multiple anatomical variations documented in existing research. The bovine aortic arch (BAA) is the most prevalent anatomical variation among these. This …
View article: Poststroke Spasticity: Pathophysiology and Management An Accurate Evaluation of Spasticity
Poststroke Spasticity: Pathophysiology and Management An Accurate Evaluation of Spasticity Open
Stroke is a major contributor to long-term impairment and disability, affecting up to one-third of survivors and almost half of patients showing neurological deficit at six months. Spasticity affects approximately 25% of individuals within…
View article: Brain Mapping – Neuromuscular correlations in long-term Postsurgical rehabilitation of Adult Brachial Plexus Palsies
Brain Mapping – Neuromuscular correlations in long-term Postsurgical rehabilitation of Adult Brachial Plexus Palsies Open
Background: Correlations of Transcranial magnetic stimulation (TMS) mapping of the cortical area and electromyography (EMG) + dynamometric testing may demonstrate active neuroplas-ticity events that are reliant on rehabilitation therapy (R…
View article: Lipid-Derived Biomarkers as Therapeutic Targets for Chronic Coronary Syndrome and Ischemic Stroke: An Updated Narrative Review
Lipid-Derived Biomarkers as Therapeutic Targets for Chronic Coronary Syndrome and Ischemic Stroke: An Updated Narrative Review Open
The incidence and prevalence of cardiac and cerebrovascular diseases are constantly increasing, with chronic coronary syndrome and ischemic stroke as the leading causes of morbidity and mortality worldwide. According to current knowledge, …
View article: Influence of Education, Cognition, and Physical Disability on Quality of Life of Romanian Patients with Multiple Sclerosis—A Cohort Study
Influence of Education, Cognition, and Physical Disability on Quality of Life of Romanian Patients with Multiple Sclerosis—A Cohort Study Open
Background and Objectives: objective measures of disability and neurological impairmentare used to search for disease activity and monitor disease evolution in multiple sclerosis (MS). These are sometimes in disagreement with subjective qu…
View article: Lidocaine–Liposomes—A Promising Frontier for Transdermal Pain Management
Lidocaine–Liposomes—A Promising Frontier for Transdermal Pain Management Open
(1) Background: We aim to develop novel gel formulations for transdermal drug delivery systems in acute and inflammatory pain therapy. (2) Methods: We induced inflammation by the injection of λ-carrageenan on the hind paw of 80 Wistar male…