Ho Cheung Shum
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View article: Self-organized flows and droplet swimming drive rapid fibril formation from ATP condensates
Self-organized flows and droplet swimming drive rapid fibril formation from ATP condensates Open
Biomolecular condensates are central to cellular physiology, yet their pathological aging into fibrillar aggregates underlies neurodegenerative diseases such as ALS and other disorders of protein aggregation. Yet, this process remains poor…
View article: All‐Aqueous Phase Segregation Integrated Electrochemical Aptamer Biosensor Enables Picomolar Detection of SARS‐CoV‐2 Spike Protein
All‐Aqueous Phase Segregation Integrated Electrochemical Aptamer Biosensor Enables Picomolar Detection of SARS‐CoV‐2 Spike Protein Open
Electrochemical aptamer biosensors (E‐ABs) are promising tools for rapid point‐of‐care (POC) diagnosis which utilize aptamers for the molecular recognition of specific disease biomarkers. However, E‐AB sensitivity is typically limited by t…
View article: Solvent-responsive solid/liquid phase transitions of condensates depend on trade-off molecular interactions
Solvent-responsive solid/liquid phase transitions of condensates depend on trade-off molecular interactions Open
Nature effectively leverages multivalent interactions among fundamental building blocks in solvents to build structures of remarkable complexity and functionality. For example, biomolecular condensates, formed through phase separation of b…
View article: Endogenous flow and dialytaxis govern aging of Adenosine 5’-triphosphate (ATP) condensates
Endogenous flow and dialytaxis govern aging of Adenosine 5’-triphosphate (ATP) condensates Open
Biomolecular condensates are increasingly recognized as pivotal regulators of cellular physiology, yet their pathological aging underlies numerous diseases. However, the mechanisms governing this condensate aging remain largely elusive. Li…
View article: Vortex‐Generated Microdroplets Enable Simple, Rapid, and Low‐Volume Measurement of Condensate Volume and Concentration
Vortex‐Generated Microdroplets Enable Simple, Rapid, and Low‐Volume Measurement of Condensate Volume and Concentration Open
Biomolecular condensates are increasingly recognized for their crucial roles in intracellular organization and the origin of life. Despite their growing importance, efficiently and accurately quantifying condensate volume and concentration…
View article: An Automated Micro‐Immunobeads‐Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease
An Automated Micro‐Immunobeads‐Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease Open
The anticipated rise in the prevalence of Alzheimer's disease (AD) under global demographic shifts necessitates the development of universally accessible screening and diagnostic tools, of which blood tests hold the promise. However, the w…
View article: CeyeHao: AI-driven microfluidic flow programming with hierarchically assembled obstacles and receptive field–augmented neural network
CeyeHao: AI-driven microfluidic flow programming with hierarchically assembled obstacles and receptive field–augmented neural network Open
Microfluidic fabrication technologies are increasingly used to produce functional anisotropic microstructures for broad applications. However, the limited flow manipulation methods hinder the production of intricate microstructure morpholo…
View article: A Phase Separation‐Assisted Pre‐Enrichment Method for Ultrasensitive Respiratory Virus Detection
A Phase Separation‐Assisted Pre‐Enrichment Method for Ultrasensitive Respiratory Virus Detection Open
Enriching trace biomarkers (e.g., proteins, nucleic acids) is critical for biomedical applications; yet conventional methods often lack versatility, limiting their effectiveness to specific biomarker types. To address this, the phase separ…
View article: Pentose Sugars Encode Sequence-Dependent DNA-RNA Segregation for Biomimetic Multiphase Condensates
Pentose Sugars Encode Sequence-Dependent DNA-RNA Segregation for Biomimetic Multiphase Condensates Open
DNA and RNA are compartmentalized into distinct, heterogeneous structures within cells. However, the separation between RNA and DNA, especially in the absence of modern transcription machinery, is inherently hindered by thermodynamic const…
View article: Fluidic-manipulation-enabled multiplexed dose delivery of RONS by a CAP chip for dose optimization enhancement
Fluidic-manipulation-enabled multiplexed dose delivery of RONS by a CAP chip for dose optimization enhancement Open
The plasma-derived reactive oxygen and nitrogen species (RONS) enable cold atmospheric plasma (CAP) to combat cancer and infectious wounds. Achieving therapeutic outcomes with CAP necessitates precise treatment doses. Current CAP devices a…
View article: Rapid antimicrobial susceptibility tests performed by self-diluting microfluidic chips for drug resistance studies and point-of-care diagnostics
Rapid antimicrobial susceptibility tests performed by self-diluting microfluidic chips for drug resistance studies and point-of-care diagnostics Open
View article: Engineered 3D-Printable Nanohydroxyapatite Biocomposites with Cold Plasma-Tailored Surface Features to Boost Osseointegration
Engineered 3D-Printable Nanohydroxyapatite Biocomposites with Cold Plasma-Tailored Surface Features to Boost Osseointegration Open
Medical implants, being biomaterials with increasing global use, continue to attract researchers focused on enhancing clinical performance. In situations requiring bone substitutes, there is a search for advancements in synthetic graft bio…
View article: Evolution Driven Microscale Combinatorial Chemistry in Intracellular Mimicking Droplets to Engineer Thermostable RNA for Cellular Imaging
Evolution Driven Microscale Combinatorial Chemistry in Intracellular Mimicking Droplets to Engineer Thermostable RNA for Cellular Imaging Open
Fluorescent light‐up aptamer/fluorogen pairs are powerful tools for tracking RNA in the cell, however limitations in thermostability and fluorescence intensity exist. Current in vitro selection techniques struggle to mimic complex intracel…
View article: Gum-on-a-Chip Exploring Host-Microbe Interactions: Periodontal Disease Modeling and Drug Discovery
Gum-on-a-Chip Exploring Host-Microbe Interactions: Periodontal Disease Modeling and Drug Discovery Open
Periodontal disease is a pervasive and serious health issue, affecting millions globally and leading to severe oral and systemic health complications. This underscores the urgent need to thoroughly understand the complex host-microbe inter…
View article: Affinity‐Controlled Partitioning of Biomolecules at Aqueous Interfaces and Their Bioanalytic Applications
Affinity‐Controlled Partitioning of Biomolecules at Aqueous Interfaces and Their Bioanalytic Applications Open
All‐aqueous phase separation systems play essential roles in bioanalytical and biochemical applications. Compared to conventional oil and organic solvent‐based systems, these systems are characterized by their rich bulk and interfacial pro…
View article: Thermo-responsive aqueous two-phase system for two-level compartmentalization
Thermo-responsive aqueous two-phase system for two-level compartmentalization Open
Hierarchical compartmentalization responding to changes in intracellular and extracellular environments is ubiquitous in living eukaryotic cells but remains a formidable task in synthetic systems. Here we report a two-level compartmentaliz…
View article: Responsive‐Hydrogel Aquabots
Responsive‐Hydrogel Aquabots Open
It remains a challenge to produce soft robots that can mimic the responsive adaptability of living organisms. Rather than fabricating soft robots from bulk hydrogels,hydrogels are integrated into the interfacial assembly of aqueous two‐pha…
View article: A droplet robotic system enabled by electret-induced polarization on droplet
A droplet robotic system enabled by electret-induced polarization on droplet Open
View article: Point-of-care testing: a critical analysis of the market and future trends
Point-of-care testing: a critical analysis of the market and future trends Open
Point-of-care testing (POCT) involves conducting diagnostic tests outside the laboratory. These tests are utilized for their quick and reliable results in detecting chronic diseases and acute infections. We examined the historical market v…
View article: High-throughput measurement of elastic moduli of microfibers by rope coiling
High-throughput measurement of elastic moduli of microfibers by rope coiling Open
There are many fields where it is of interest to measure the elastic moduli of tiny fragile fibers, such as filamentous bacteria, actin filaments, DNA, carbon nanotubes, and functional microfibers. The elastic modulus is typically deduced …
View article: Genetically Encoded DNA-RNA Segregation Stimulates Biomimetic Multiphase Compartments
Genetically Encoded DNA-RNA Segregation Stimulates Biomimetic Multiphase Compartments Open
DNA and RNA are compartmentalized into distinct, heterogeneous structures within cells. However, the separation between RNA and DNA, especially in the absence of modern transcription machinery, is inherently hindered by thermodynamic const…
View article: Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls
Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls Open
In vascular networks, the transport across different vessel walls regulates chemical compositions in blood over space and time. Replicating such trans-wall transport with spatial heterogeneity can empower synthetic fluidic systems to progr…
View article: Author Correction: High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2
Author Correction: High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2 Open
View article: Simple and complex coacervation in systems involving plant proteins
Simple and complex coacervation in systems involving plant proteins Open
This review covers simple and complex coacervation in plant proteins: legume, oil seed, and cereal. We grouped the proteins by sources and properties and examined how processing affects phase behaviors.
View article: Development and future of droplet microfluidics
Development and future of droplet microfluidics Open
This review introduces the development of droplet microfluidics by explaining the physical mechanisms of droplet generation, discussing various approaches in manipulating droplets, and summarizing key applications in material science and b…
View article: High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2
High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2 Open
Mapping mutations and discovering cellular determinants that cause the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to induce infected cells to form syncytia would facilitate the development of strategies f…
View article: Entropic interfacial charge separation suppresses coarsening of nanoscale condensates
Entropic interfacial charge separation suppresses coarsening of nanoscale condensates Open
Droplet coarsening is a long-standing phenomenon widely observed in our daily life and industrial processes. This process is typically governed by classic theories, such as Brownian motion-induced coalescence and Ostwald ripening, predicti…
View article: Synthetic Membraneless Droplets for Synaptic‐Like Clustering of Lipid Vesicles
Synthetic Membraneless Droplets for Synaptic‐Like Clustering of Lipid Vesicles Open
In eukaryotic cells, the membraneless organelles (MLOs) formed via liquid‐liquid phase separation (LLPS) are found to interact intimately with membranous organelles (MOs). One major mode is the clustering of MOs by MLOs, such as the format…
View article: Synthetic Membraneless Droplets for Synaptic‐Like Clustering of Lipid Vesicles
Synthetic Membraneless Droplets for Synaptic‐Like Clustering of Lipid Vesicles Open
In eukaryotic cells, the membraneless organelles (MLOs) formed via liquid‐liquid phase separation (LLPS) are found to interact intimately with membranous organelles (MOs). One major mode is the clustering of MOs by MLOs, such as the format…
View article: Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel
Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel Open