Christel Herold‐Mende
YOU?
Author Swipe
View article: A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma
A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma Open
Background DNA methylation profiling can be used to robustly predict postsurgical outcomes and response to radiotherapy (RT) for meningioma patients. To allow for seamless integration of these complementary models into clinical practice, a…
View article: IMMU-27. Identification of prognostically relevant immune ecotypes in lung adenocarcinoma brain metastases
IMMU-27. Identification of prognostically relevant immune ecotypes in lung adenocarcinoma brain metastases Open
Brain metastases are a severe complication for lung adenocarcinoma patients. Immunotherapies build a promising treatment option, but there is still a limited understanding of the patient-individual immune cell composition within these brai…
View article: TMIC-86. Meningioma brain-invasion is linked to inflammatory induced tumor-neuronal connectivity
TMIC-86. Meningioma brain-invasion is linked to inflammatory induced tumor-neuronal connectivity Open
Brain-invasion of meningioma is a hallmark of malignant behavior and linked to higher risk of surgical resection and poor clinical outcome. Here, we hypothesized that meningioma tumor ecosystems with invasive behavior enhance cellular comm…
View article: EXTH-146. The Pharmacological Atlas of Meningiomas
EXTH-146. The Pharmacological Atlas of Meningiomas Open
There are currently no systemic treatment options available for patients with recurrent or refractory meningiomas. This study aims to address this gap by developing a comprehensive pharmacological atlas of FDA-approved oncology drugs using…
View article: PATH-19. Distinct epigenetic and transcriptional profiles of Epstein-Barr virus (EBV) positive and negative primary CNS lymphomas
PATH-19. Distinct epigenetic and transcriptional profiles of Epstein-Barr virus (EBV) positive and negative primary CNS lymphomas Open
BACKGROUND Epstein-Barr virus (EBV)+ and EBV- primary CNS lymphomas (PCNSL) carry distinct mutational landscapes, but their transcriptional and epigenetic profiles have not been integrated and compared. This precludes further insights into…
View article: Delivering precision oncology in metastatic breast cancer: Clinical impact of comprehensive genomic profiling—The <scp>CATCH</scp> experience
Delivering precision oncology in metastatic breast cancer: Clinical impact of comprehensive genomic profiling—The <span>CATCH</span> experience Open
CATCH is a prospective precision oncology registry trial that exploits whole‐genome/exome‐ and RNA‐sequencing to enable actionable biomarker detection in metastatic breast cancer (mBC) patients of any subtype. We herein report long‐term fo…
View article: P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy
P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy Open
Extracellular ATP (eATP) accumulates substantially in the tumor microenvironment (TME) and rises further during immunotherapy. While canonically an immune-activating danger signal, eATP also promotes immunosuppression in tumors, thus far l…
View article: Tumor-associated macrophages in meningiomas: a novel biomarker for poor survival outperforming the benefits of T cells
Tumor-associated macrophages in meningiomas: a novel biomarker for poor survival outperforming the benefits of T cells Open
Tumor-associated macrophages (TAMs) represent the main immune cell population in various brain malignancies, but there is rare knowledge on the functional and, in particular, the prognostic role of TAMs in the meningioma (MGM) microenviron…
View article: Spatial Transcriptomics Characterisation of Radionecrotic Changes in Glioblastoma Patients
Spatial Transcriptomics Characterisation of Radionecrotic Changes in Glioblastoma Patients Open
Background: IDH-wildtype Glioblastoma (GB) is the most prevalent primary CNS tumour in adults. The standard treatment involves radiotherapy, which can cause radionecrotic changes. Progressive GB and radionecrotic changes can be challenging…
View article: P11.37.B NOVEL PATIENT-DERIVED BREAST CANCER BRAIN METASTASES MODELS CHARACTERIZED BY LARGE-SCALE DRUG SCREENING AND INTEGRATIVE MULTI-OMICS PROFILING
P11.37.B NOVEL PATIENT-DERIVED BREAST CANCER BRAIN METASTASES MODELS CHARACTERIZED BY LARGE-SCALE DRUG SCREENING AND INTEGRATIVE MULTI-OMICS PROFILING Open
BACKGROUND The development brain metastases is among the most critical predictive factors for breast cancer patient survival. At the same time, personalized selection of effective drugs against BCBM is particularly challenging due to vario…
View article: KS03.5.A DISSECTING THE CELLULAR ARCHITECTURE OF BREAST CANCER BRAIN METASTASES REVEALS PROGNOSTICALLY DISTINCT IMMUNE LANDSCAPES
KS03.5.A DISSECTING THE CELLULAR ARCHITECTURE OF BREAST CANCER BRAIN METASTASES REVEALS PROGNOSTICALLY DISTINCT IMMUNE LANDSCAPES Open
BACKGROUND Breast cancer brain metastases are associated with a poor prognosis, and there is a high demand for improved personalized treatment strategies. It is still poorly understood which breast cancer brain metastases patients benefit …
View article: OS13.5.A INTEGRATIVE MULTIOMICS ANALYSIS IDENTIFIES TUMOR-ASSOCIATED MACROPHAGES AS NOVEL INDEPENDENT BIOMARKER FOR POOR SURVIVAL IN MENINGIOMAS
OS13.5.A INTEGRATIVE MULTIOMICS ANALYSIS IDENTIFIES TUMOR-ASSOCIATED MACROPHAGES AS NOVEL INDEPENDENT BIOMARKER FOR POOR SURVIVAL IN MENINGIOMAS Open
BACKGROUND Tumor-associated macrophages (TAMs) represent the main immune cell population in various brain malignancies, but their role in the meningioma (MGM) microenvironment remains to be elucidated. MATERIAL AND METHODS Here, we investi…
View article: P11.32.A IDENTIFICATION OF PROGNOSTICALLY RELEVANT IMMUNE ECOTYPES IN LUNG ADENOCARCINOMA BRAIN METASTASES
P11.32.A IDENTIFICATION OF PROGNOSTICALLY RELEVANT IMMUNE ECOTYPES IN LUNG ADENOCARCINOMA BRAIN METASTASES Open
BACKGROUND Brain metastases are a severe complication for lung adenocarcinoma patients. Immunotherapies build a promising treatment option, but there is still a limited understanding of the patient-individual immune cell composition within…
View article: P11.15.B TUMOUR-SECRETED PHOSPHOPROTEIN 1 (SPP1) VIA ACTIVATION OF MICROGLIA CONTRIBUTES TO THE FORMATION OF THE BREAST AND LUNG CANCER BRAIN METASTASES
P11.15.B TUMOUR-SECRETED PHOSPHOPROTEIN 1 (SPP1) VIA ACTIVATION OF MICROGLIA CONTRIBUTES TO THE FORMATION OF THE BREAST AND LUNG CANCER BRAIN METASTASES Open
BACKGROUND Brain metastases (BrMets) occur in 20%-40% of patients with breast and lung cancers and contribute significantly to morbidity and/or mortality. The molecular mechanisms that drive and permit the progression of metastasis in the …
View article: P14.25.B DECODING MORPHO-MOLECULAR DIVERSITY IN GLIOSARCOMA AND INSIGHTS INTO RESISTANCE USING SPATIAL TRANSCRIPTOMICS
P14.25.B DECODING MORPHO-MOLECULAR DIVERSITY IN GLIOSARCOMA AND INSIGHTS INTO RESISTANCE USING SPATIAL TRANSCRIPTOMICS Open
BACKGROUND Gliosarcoma, a rare and aggressive variant of IDH-wildtype glioblastoma, is characterized by striking intra-tumoral heterogeneity with alternating glial and mesenchymal differentiation. The mesenchymal component is often enriche…
View article: KS03.6.A THE RECURRENT TISSUE STATES ACROSS ADULT GLIOMAS AS REVEALED BY SPATIAL TRANSCRIPTOMICS
KS03.6.A THE RECURRENT TISSUE STATES ACROSS ADULT GLIOMAS AS REVEALED BY SPATIAL TRANSCRIPTOMICS Open
BACKGROUND Adult gliomas are a diverse class of tumors with substantial molecular and pathological variation. While prior single-cell omics studies have characterized intratumoral heterogeneity, they often examined tumors in isolation, thu…
View article: P14.10.A DISTINCT EPIGENETIC AND TRANSCRIPTIONAL PROFILES OF EPSTEIN-BARR VIRUS (EBV) POSITIVE AND NEGATIVE PRIMARY CNS LYMPHOMAS
P14.10.A DISTINCT EPIGENETIC AND TRANSCRIPTIONAL PROFILES OF EPSTEIN-BARR VIRUS (EBV) POSITIVE AND NEGATIVE PRIMARY CNS LYMPHOMAS Open
BACKGROUND Epstein-Barr virus (EBV)+ and EBV- primary CNS lymphomas (PCNSL) carry distinct mutational landscapes, but their transcriptional and epigenetic profiles have not been integrated and compared. This precludes further insights into…
View article: Cisplatin resistance in head and neck squamous cell carcinoma is linked to DNA damage response and cell cycle arrest transcriptomics rather than poor drug uptake
Cisplatin resistance in head and neck squamous cell carcinoma is linked to DNA damage response and cell cycle arrest transcriptomics rather than poor drug uptake Open
Aim: Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC) is thought to involve both reduced drug uptake and altered molecular responses. However, the relative contribution of these mechanisms remains unclear. Methods: Two…
View article: Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas
Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas Open
Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profiling in patient-derived organoids offers…
View article: Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial
Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial Open
Advances in molecular understanding and diagnostic precision of glioblastoma enable the identification of key genetic alterations in a timely manner and, in principle, allow treatments with targeted compounds based on molecular markers. He…
View article: Kynurenine enhances aryl hydrocarbon receptor signaling and expression levels of multidrug resistance genes in head and neck squamous cell carcinoma cell lines but does not change the potency of antineoplastic drugs
Kynurenine enhances aryl hydrocarbon receptor signaling and expression levels of multidrug resistance genes in head and neck squamous cell carcinoma cell lines but does not change the potency of antineoplastic drugs Open
Efficacy of the standard cytotoxic drugs against head and neck squamous cell carcinoma (HNSCC) is limited, underlining the potential relevance of multidrug resistance (MDR), mediated by drug transporters and drug-metabolising enzymes. Whil…
View article: Distinct molecular profile and outcome of oligodendroglioma, <i>IDH</i>-mutant, 1p/19q-codeleted, and <i>TERT</i>p-wildtype: A grade 1 oligodendroglioma of young patients?
Distinct molecular profile and outcome of oligodendroglioma, <i>IDH</i>-mutant, 1p/19q-codeleted, and <i>TERT</i>p-wildtype: A grade 1 oligodendroglioma of young patients? Open
Background Oligodendrogliomas, characterized by isocitrate dehydrogenase (IDH) mutations and 1p/19q codeletion, often exhibit telomerase reverse transcriptase promoter (TERTp) mutations, which have been linked to telomere maintenance (TM) …
View article: Spatial Distribution and Prognostic Value of T Cell Subtypes and Immune Biomarkers in p16-Negative HNSCC
Spatial Distribution and Prognostic Value of T Cell Subtypes and Immune Biomarkers in p16-Negative HNSCC Open
Patients with head and neck squamous cell carcinoma (HNSCC) suffer from severe morbidity and mortality. Immunotherapy represents a novel promising treatment option. Therefore, a better understanding of the immune niche is needed. This stud…
View article: Use of Tissue Specimens from Stereotactic Biopsies for Patient-Derived GBM Organoid-Based Drug Testing
Use of Tissue Specimens from Stereotactic Biopsies for Patient-Derived GBM Organoid-Based Drug Testing Open
IDH-wildtype glioblastoma (GBM) represents the most common malignant form of brain tumor and is still incurable despite comprehensive therapeutic efforts. Due to tumor location and patient condition, open surgical resection of recurrent GB…
View article: Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors
Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors Open
Molecular data integration plays a central role in central nervous system (CNS) tumor diagnostics but currently used assays pose limitations due to technical complexity, equipment and reagent costs, as well as lengthy turnaround times. We …
View article: Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy
Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy Open
Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications for predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individual…