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View article: Fibroblast-derived interleukin-11 as a potential biomarker for intestinal fibrostenosis in Crohn’s disease
Fibroblast-derived interleukin-11 as a potential biomarker for intestinal fibrostenosis in Crohn’s disease Open
Background: Intestinal fibrosis-associated stricture can lead to bowel complications and subsequent surgeries in patients with Crohn’s disease (CD), but there are no widely accepted biomarkers for intestinal fibrostenosis. Objectives: This…
View article: Study on the flow field characteristics of the air-suction jujube harvester pipeline based on magnetohydrodynamic airflow control
Study on the flow field characteristics of the air-suction jujube harvester pipeline based on magnetohydrodynamic airflow control Open
View article: Bifurcation Dynamics Govern Sharp Wave Ripple Generation and Rhythmic Transitions in Hippocampal-Cortical Memory Networks
Bifurcation Dynamics Govern Sharp Wave Ripple Generation and Rhythmic Transitions in Hippocampal-Cortical Memory Networks Open
This study investigates the bifurcation dynamics underlying rhythmic transitions in a biophysical hippocampal-cortical neural network model. We specifically focus on the membrane potential dynamics of excitatory neurons in the hippocampal …
View article: Efficacy of injection therapies in reducing hemiplegic shoulder pain: a systematic review and meta-analysis
Efficacy of injection therapies in reducing hemiplegic shoulder pain: a systematic review and meta-analysis Open
Objective This systematic review of randomized controlled trials (RCTs) with meta-analysis aimed to investigate the efficacy of injection therapies in reducing hemiplegic shoulder pain (HSP) in stroke survivors. Methods PubMed, Embase and …
View article: Associations between aerobic and muscle-strengthening physical activity, joint pain severity, and risk of depressive disorder among adults with arthritis: a large population-based study (Preprint)
Associations between aerobic and muscle-strengthening physical activity, joint pain severity, and risk of depressive disorder among adults with arthritis: a large population-based study (Preprint) Open
BACKGROUND Depressive disorder is a common comorbidity among adults with arthritis, significantly affecting treatment adherence and quality of life, while physical inactivity is considered a major risk factor for depressive disorder. Alth…
View article: Internet addiction and anxiety-depressive comorbidity among chinese adolescents: the mitigating effects of physical activity in a large-scale cross-sectional study
Internet addiction and anxiety-depressive comorbidity among chinese adolescents: the mitigating effects of physical activity in a large-scale cross-sectional study Open
View article: Cost-effectiveness evaluation of benmelstobart, anlotinib and chemotherapy in patients with extensive-stage small-cell lung cancer
Cost-effectiveness evaluation of benmelstobart, anlotinib and chemotherapy in patients with extensive-stage small-cell lung cancer Open
Introduction Programmed death-ligand 1 (PD-L1) blockade is a growing treatment for extensive-stage small cell lung cancer (ES-SCLC). This study evaluates the cost-effectiveness of benmelstobart and anlotinib plus etoposide/carboplatin (EC)…
View article: Platelet‐to‐Neutrophil Ratio: A Novel Prognostic Indicator for Anti‐PD‐1‐Based Therapy in Relapsed/Refractory Hodgkin Lymphoma and Solid Tumors
Platelet‐to‐Neutrophil Ratio: A Novel Prognostic Indicator for Anti‐PD‐1‐Based Therapy in Relapsed/Refractory Hodgkin Lymphoma and Solid Tumors Open
Program cell death‐1 (PD‐1) blockade treatment has been shown effective in cases with relapsed/refractory classical Hodgkin Lymphoma (R/R cHL), while prognostic biomarkers remain unclear. Seventy‐seven cases with R/R cHL who received immun…
View article: Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease
Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease Open
Intestinal stricture remains one of the most challenging complications in Crohn's disease, and its underlying mechanisms are poorly understood. Accumulating evidence suggests that gut microbiota is significantly altered in stenotic intesti…
View article: Epidemiological Characteristics and Influencing Factors of Flatfoot among Primary and Middle School Students in Inner Mongolia
Epidemiological Characteristics and Influencing Factors of Flatfoot among Primary and Middle School Students in Inner Mongolia Open
Objective: To analyze the epidemiological characteristics and influencing factors of flatfoot among primary and middle school students in Inner Mongolia. Methods: A survey was conducted among 2,800 primary and middle school students in Inn…
View article: A new perspective: Acyl-CoA synthetase long-chain family member 4 inhibits ubiquitin-specific protease 7-induced epithelial ovarian cancer progression by inducing ferroptosis and M1 macrophage polarization
A new perspective: Acyl-CoA synthetase long-chain family member 4 inhibits ubiquitin-specific protease 7-induced epithelial ovarian cancer progression by inducing ferroptosis and M1 macrophage polarization Open
Objective Epithelial ovarian cancer (EOC) is the most common and lethal type of ovarian cancer, and the cross-talk between tumor cell ferroptosis and macrophages is essential to cancer progression. This study aims to investigate the roles …
View article: Irradiation-responsive PRDM10-DT modulates the angiogenic response in human NSCLC cells in an SP1-dependent manner via the miR-663a/TGF-β1 axis
Irradiation-responsive PRDM10-DT modulates the angiogenic response in human NSCLC cells in an SP1-dependent manner via the miR-663a/TGF-β1 axis Open
These results illustrate the proangiogenic function of the PRDM10-DT/miR-663a/TGF-β1 axis and reveal the regulatory role of ROS and SP1 in the upstream response to radiation, with differential ROS production mediating the differential angi…
View article: Impact and Mechanisms of Action of <scp>BDNF</scp> on Neurological Disorders, Cancer, and Cardiovascular Diseases
Impact and Mechanisms of Action of <span>BDNF</span> on Neurological Disorders, Cancer, and Cardiovascular Diseases Open
Brain‐derived neurotrophic factor (BDNF), which is primarily expressed in the brain and nervous tissues, is the most abundant neurotrophic factor in the adult brain. BDNF serves not only as a major neurotrophic signaling agent in the human…
View article: A case of primary mediastinal mixed neuroendocrine carcinoma (large-cell and small-cell neuroendocrine carcinoma) and the effect of chemotherapy: A case report
A case of primary mediastinal mixed neuroendocrine carcinoma (large-cell and small-cell neuroendocrine carcinoma) and the effect of chemotherapy: A case report Open
View article: Possible Mediation of the Association Between Education Attainment and Breast Cancer in a Hispanic Female Population Experiencing Historical Changes in Social Determinants of Health
Possible Mediation of the Association Between Education Attainment and Breast Cancer in a Hispanic Female Population Experiencing Historical Changes in Social Determinants of Health Open
PURPOSE While higher educational level (HEL) is associated with generally better health status, and educational attainment is a well-known social determinant of health, HEL has been associated with an increased breast cancer risk (BCR). Li…
View article: Serum total bilirubin levels and the risk of new-onset diabetes in hypertensive adults
Serum total bilirubin levels and the risk of new-onset diabetes in hypertensive adults Open
Background: The association between bilirubin and risk of diabetes was still uncertain. We aimed to examine the prospective relationship of serum total bilirubin (TBiL) with incident diabetes and explore possible effect modifiers among hyp…
View article: Intestinal strictures in Crohn's disease: An update from 2023
Intestinal strictures in Crohn's disease: An update from 2023 Open
Crohn's disease (CD) is a chronic inflammatory disease that leads to intestinal stricture in nearly 35% of cases within 10 years of initial diagnosis. The unknown pathogenesis, lack of universally accepted criteria, and absence of an effec…
View article: Cost-effectiveness of pembrolizumab versus chemotherapy in patients with platinum-pretreated, recurrent or metastatic nasopharyngeal cancer
Cost-effectiveness of pembrolizumab versus chemotherapy in patients with platinum-pretreated, recurrent or metastatic nasopharyngeal cancer Open
Background Programmed cell death protein 1 (PD-1) monoclonal antibody, pembrolizumab, is a promising drug for platinum-pretreated, recurrent or metastatic nasopharyngeal cancer (NPC). We aimed to assess the cost-effectiveness of pembrolizu…
View article: Additional file 1 of Cost-effectiveness of pembrolizumab versus chemotherapy in patients with platinum-pretreated, recurrent or metastatic nasopharyngeal cancer
Additional file 1 of Cost-effectiveness of pembrolizumab versus chemotherapy in patients with platinum-pretreated, recurrent or metastatic nasopharyngeal cancer Open
Supplementary Material 1
View article: The association of the Affordable Care Act with nutrient consumption in adults in the United States
The association of the Affordable Care Act with nutrient consumption in adults in the United States Open
The Patient Protection and Affordable Care Act, more commonly known as the ACA, was legislation passed in the United States in 2010 to expand access to health insurance coverage for millions of Americans with a key emphasis on preventive c…
View article: Long‐term complete remission and peripheral biomarkers in Hodgkin lymphoma patients after decitabine‐plus‐camrelizumab epi‐immunotherapy and treatment cessation
Long‐term complete remission and peripheral biomarkers in Hodgkin lymphoma patients after decitabine‐plus‐camrelizumab epi‐immunotherapy and treatment cessation Open
Patients with relapsed/refractory classical Hodgkin lymphoma (cHL) achieve complete response (CR) after decitabine‐plus‐camrelizumab therapy, while long‐term outcome especially after treatment discontinuation remains unclear. We present a …
View article: Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T cell expansion in tumor models
Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T cell expansion in tumor models Open
CD8+ exhausted T cells (Tex) are heterogeneous. PD-1 inhibitors reinvigorate progenitor Tex, which subsequently differentiate into irresponsive terminal Tex. The ability to maintain a capacity for durable proliferation of progenitor Tex is…
View article: Correction: Numb Promotes Cell Proliferation and Correlates with Poor Prognosis in Hepatocellular Carcinoma
Correction: Numb Promotes Cell Proliferation and Correlates with Poor Prognosis in Hepatocellular Carcinoma Open
[This corrects the article DOI: 10.1371/journal.pone.0095849.].
View article: Perinatal factors, female breast cancer, and associated risk factors in Puerto Rico: evidence from the Atabey epidemiology of breast cancer study
Perinatal factors, female breast cancer, and associated risk factors in Puerto Rico: evidence from the Atabey epidemiology of breast cancer study Open
View article: Cost-Effectiveness of Nutrient Supplementation in Cancer Survivors
Cost-Effectiveness of Nutrient Supplementation in Cancer Survivors Open
Cancer patients are at risk for malnutrition; the aim of this study was to provide a cost-effectiveness analysis of dietary supplementation in cancer survivors. We estimated prevalence of supplementation, hospitalization rates, quality of …
View article: Anthropometric Measures and Breast Cancer Risk among Hispanic Women in Puerto Rico
Anthropometric Measures and Breast Cancer Risk among Hispanic Women in Puerto Rico Open
While there is consistent evidence of increased risk of postmenopausal breast cancer associated with higher body mass index (BMI), higher adult weight gain and higher waist circumference in North American and European populations, there is…
View article: Long Non-Coding RNA SNHG6 Supports Glioma Progression Through Upregulation of Notch1, Sox2, and EMT
Long Non-Coding RNA SNHG6 Supports Glioma Progression Through Upregulation of Notch1, Sox2, and EMT Open
Gliomas, particularly the advanced grade glioblastomas, have poor 5-year survival rates and worse outcomes. lncRNAs and EMT have been extensively studied in gliomas but the disease progression remains poorly understood. SNHG6 has been show…
View article: Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors
Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors Open
Programmed cell death protein-1 (PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T (CAR-T) cells in solid tumors. We generated PD-1 and T cell receptor (TCR) de…
View article: Anti-PD-1 antibodies as a salvage therapy for patients with diffuse large B cell lymphoma who progressed/relapsed after CART19/20 therapy
Anti-PD-1 antibodies as a salvage therapy for patients with diffuse large B cell lymphoma who progressed/relapsed after CART19/20 therapy Open
View article: Regulation of MRP4 Expression by circHIPK3 via Sponging miR-124-3p/miR-4524-5p in Hepatocellular Carcinoma
Regulation of MRP4 Expression by circHIPK3 via Sponging miR-124-3p/miR-4524-5p in Hepatocellular Carcinoma Open
Multidrug resistance-associated protein 4 (MRP4), a member of the adenosine triphosphate (ATP) binding cassette transporter family, pumps various molecules out of the cell and is involved in cell communication and drug distribution. Severa…