David J. Webb
YOU?
Author Swipe
View article: 3 Identifying Hospitalized Patients with Acute Decompensation Risk from Peripheral Blood Smears and Laboratory Results using Multimodal, Multiencoder, Multiple Instance Learning (M3MIL)
3 Identifying Hospitalized Patients with Acute Decompensation Risk from Peripheral Blood Smears and Laboratory Results using Multimodal, Multiencoder, Multiple Instance Learning (M3MIL) Open
For hospitalized patients in critical condition, anticipating clinical deterioration and identifying its cause is imperative for timely interventions, such as escalation of care, ventilatory support, or sepsis protocol; we therefore propos…
View article: Higher ultraviolet light exposure is associated with lower mortality: An analysis of data from the UK biobank cohort study
Higher ultraviolet light exposure is associated with lower mortality: An analysis of data from the UK biobank cohort study Open
We aimed to examine associations between ultraviolet (UV) exposure and mortality among older adults in the United Kingdom (UK). We used data from UK Biobank participants with two UV exposures, validated with measured vitamin D levels: sola…
View article: <i>UMOD</i> Genotype-Blinded Trial of Ambulatory Blood Pressure Response to Torasemide
<i>UMOD</i> Genotype-Blinded Trial of Ambulatory Blood Pressure Response to Torasemide Open
BACKGROUND: UMOD (uromodulin) has been linked to hypertension through potential activation of Na + -K + -2Cl − cotransporter (NKCC2), a target of loop diuretics. We posited that hypertensive patients carrying the rs13333226-AA UMOD genotyp…
View article: Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy)
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy) Open
Drug-induced liver injury (DILI) is a challenge in clinical medicine and drug development. Highly sensitive novel biomarkers have been identified for detecting DILI following a paracetamol overdose. The study objective was to evaluate biom…
View article: Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment
Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment Open
In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, and predict outcomes. Here, we investigate the potential of retinal optical coher…
View article: Higher ultraviolet light exposure is associated with lower mortality: an analysis of data from the UK Biobank cohort study
Higher ultraviolet light exposure is associated with lower mortality: an analysis of data from the UK Biobank cohort study Open
Objective To examine to what extent UV exposure is associated with all-cause and cause-specific mortality. Design Prospective population-based study. Setting UK Biobank. Participants 376,729 participants with white ancestry and no missing …
View article: Natural language processing on customer note data
Natural language processing on customer note data Open
Automatic analysis of customer data for businesses is an area that is of interest to companies. Business to business data is studied rarely in academia due to the sensitive nature of such information. Applying natural language processing c…
View article: Urotensin receptor in GtoPdb v.2023.1
Urotensin receptor in GtoPdb v.2023.1 Open
The urotensin-II (U-II) receptor (UT, nomenclature as agreed by the NC-IUPHAR Subcommittee on the Urotensin receptor [26, 36, 94]) is activated by the endogenous dodecapeptide urotensin-II, originally isolated from the urophysis, the endoc…
View article: Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice
Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice Open
Acute kidney injury (AKI) is common and associated with increased risks of cardiovascular and chronic kidney disease. Causative molecular/physiological pathways are poorly defined. There are no therapies to improve long-term outcomes. An a…
View article: Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans
Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans Open
Introduction South Asians (SAs) have an elevated risk of cardiovascular disease (CVD) compared with White Europeans (WEs). Postprandial endothelial function (flow-mediated dilatation (FMD%)) in SA women and SA men with central obesity has …
View article: Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review
Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review Open
Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interference technology, using synthetic structurally well‐defined short double‐stranded RNA (small interfering RNA …
View article: Small Interfering RNA Therapeutics in Hypertension: A Viewpoint on Vasopressor and Vasopressor‐Sparing Strategies for Counteracting Blood Pressure Lowering by Angiotensinogen–Targeting Small Interfering RNA
Small Interfering RNA Therapeutics in Hypertension: A Viewpoint on Vasopressor and Vasopressor‐Sparing Strategies for Counteracting Blood Pressure Lowering by Angiotensinogen–Targeting Small Interfering RNA Open
HomeJournal of the American Heart AssociationVol. 11, No. 20Small Interfering RNA Therapeutics in Hypertension: A Viewpoint on Vasopressor and Vasopressor‐Sparing Strategies for Counteracting Blood Pressure Lowering by Angiotensinogen–Targ…
View article: On New Notions of Algorithmic Dimension, Immunity, and Medvedev Degree
On New Notions of Algorithmic Dimension, Immunity, and Medvedev Degree Open
We prove various results connected together by the common thread of computability theory. First, we investigate a new notion of algorithmic dimension, the inescapable dimension, which lies between the effective Hausdorff and packing dimens…
View article: Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis
Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis Open
Cardiovascular disease is a complication of systemic inflammatory diseases including anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). The mechanisms of cardiovascular morbidity in AAV are poorly understood, and risk-reductio…
View article: Strong Medvedev reducibilities and the KL-randomness problem
Strong Medvedev reducibilities and the KL-randomness problem Open
While it is not known whether each real that is Kolmogorov-Loveland random is Martin-Löf random, i.e., whether $\mathrm{KLR}\subseteq\mathrm{MLR}$, Kjos-Hanssen and Webb (2021) showed that $\mathrm{MLR}$ is truth-table Medvedev reducible (…
View article: Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial
Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial Open
Background: Acetaminophen is widely used as first-line therapy for chronic pain because of its perceived safety and the assumption that, unlike nonsteroidal anti-inflammatory drugs, it has little or no effect on blood pressure (BP). Althou…
View article: Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast‐Induced Nephropathy: A Failure of Academic Clinical Science
Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast‐Induced Nephropathy: A Failure of Academic Clinical Science Open
Contrast‐induced nephropathy (CIN) is a major complication of imaging in patients with chronic kidney disease (CKD). The publication of an academic randomized controlled trial (RCT; n = 83) reporting oral (N)‐acetylcysteine (NAC) to reduce…
View article: De‐risking Clinical Trials: The BIAL Phase I Trial in Foresight
De‐risking Clinical Trials: The BIAL Phase I Trial in Foresight Open
Disasters in early drug development are rare but, because they generally harm healthy young people, remembered for a long time. Few will forget the death of a volunteer after a new anti-arrhythmic drug (eproxindine) in 1985, the TGN1412 ev…
View article: Urotensin receptor in GtoPdb v.2021.3
Urotensin receptor in GtoPdb v.2021.3 Open
The urotensin-II (U-II) receptor (UT, nomenclature as agreed by the NC-IUPHAR Subcommittee on the Urotensin receptor [26, 36, 93]) is activated by the endogenous dodecapeptide urotensin-II, originally isolated from the urophysis, the endoc…
View article: Effects of Spironolactone and Chlorthalidone on Cardiovascular Structure and Function in Chronic Kidney Disease
Effects of Spironolactone and Chlorthalidone on Cardiovascular Structure and Function in Chronic Kidney Disease Open
Background and objectives In a randomized double-blind, placebo-controlled trial, treatment with spironolactone in early-stage CKD reduced left ventricular mass and arterial stiffness compared with placebo. It is not known if these effects…
View article: Endothelin receptor antagonists for the treatment of diabetic and nondiabetic chronic kidney disease
Endothelin receptor antagonists for the treatment of diabetic and nondiabetic chronic kidney disease Open
Purpose of review To summarize new clinical findings of endothelin receptor antagonists (ERA) in various etiologies of kidney disease targeted in clinical trials. Recent findings Endothelin-1 is a multifunctional peptide with potential rel…
View article: Response to Reviewer #2
Response to Reviewer #2 Open
Abstract. Research, based on both observations and ocean models, has indicated that strong East Pacific El Niños are preceded by the development of unusually low sea levels at the western end of the North Equatorial Trough early in the y…
View article: Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease
Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease Open
Vascular and kidney dysfunction commonly co-exist. There is a need for biomarkers of vascular health. Circulating microRNAs are biomarkers; miR-126 is endothelial cell-enriched. We measured circulating miR-126 in rats with nephrotoxic neph…