Wenjun Zhang
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View article: Development of human mycoplasma vaccines: navigating the IL-17A paradox
Development of human mycoplasma vaccines: navigating the IL-17A paradox Open
Despite decades of effort, effective vaccines against pathogenic human mycoplasmas remain elusive, largely due to vaccine-enhanced disease (VED). Recent discoveries highlight the paradoxical role of interleukin-17A (IL-17A) as both protect…
View article: Survival strategies of mycoplasmas: the critical role of post-translational modifications
Survival strategies of mycoplasmas: the critical role of post-translational modifications Open
Mycoplasmas are unique prokaryotic pathogens distinguished by their lack of a cell wall. These microorganisms are widespread in nature and can cause severe infections, leading to substantial tissue damage. Recent advances in mycoplasmology…
View article: CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses
CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses Open
View article: Complications Associated With Filler Injection for Breast Augmentation: A Case Report and Literature Review
Complications Associated With Filler Injection for Breast Augmentation: A Case Report and Literature Review Open
View article: Real‐world prediction of early‐onset dementia by health record data: A multi‐center machine learning study
Real‐world prediction of early‐onset dementia by health record data: A multi‐center machine learning study Open
INTRODUCTION We aimed to develop risk and prognostic prediction tools for early‐onset dementia (EOD) using health record data shared across five major international cohorts. METHODS More than 400,000 dementia‐free individuals younger than …
View article: The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8+CD103+ cDC1 and tissue-resident memory T cell responses
The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8+CD103+ cDC1 and tissue-resident memory T cell responses Open
Irreversible electroporation (IRE) is a relatively new, non-thermal ablation technology for cancer treatment that requires further investigation to optimize its therapeutic efficacy. To improve IRE-ablation, we developed an IRE+Combo-treat…
View article: Ultrathin Graphene Strain Sensor Arrays for High‐Sensitivity Multifunctional Sensing with Millimeter‐Scale Resolution
Ultrathin Graphene Strain Sensor Arrays for High‐Sensitivity Multifunctional Sensing with Millimeter‐Scale Resolution Open
The deployment of graphene flexible sensor arrays is hindered by two major limitations—difficulty in achieving high spatial resolution with existing fabrication methods and the lack of system‐level integration for practical applications. T…
View article: Centrifugal microfluidic systems for cancer cell separation: Advances, challenges, and applications
Centrifugal microfluidic systems for cancer cell separation: Advances, challenges, and applications Open
View article: A collaborative large language model for drug analysis
A collaborative large language model for drug analysis Open
Large language models (LLMs), such as ChatGPT, have substantially helped in understanding human inquiries and generating textual content with human-level fluency. However, directly using LLMs in healthcare applications faces several proble…
View article: Stem-breaking strength affects stem lodging and BnaC04.NST1–BnaA10.COMT enhances its resistance in Brassica napus
Stem-breaking strength affects stem lodging and BnaC04.NST1–BnaA10.COMT enhances its resistance in Brassica napus Open
View article: Modeling of morphologically realistic large-scale multicellular electroporation for population-level analysis
Modeling of morphologically realistic large-scale multicellular electroporation for population-level analysis Open
This study explores the dynamics of multicellular electroporation within a monolayer cluster of HCMEC/D3 cells subjected to pulsed electric fields. By proposing an automated approach capable of reconstructing realistic multicellular morpho…
View article: Micro-spring force sensors using conductive photosensitive resin fabricated via two-photon polymerization
Micro-spring force sensors using conductive photosensitive resin fabricated via two-photon polymerization Open
View article: Tumor‐Associated Neutrophils Regulate Breast Cancer Progression Through the <scp>AQP9</scp>/<scp>STAT3</scp> Signaling Pathway
Tumor‐Associated Neutrophils Regulate Breast Cancer Progression Through the <span>AQP9</span>/<span>STAT3</span> Signaling Pathway Open
Tumor‐associated neutrophils (TANs) contribute to breast cancer (BC) progression, and aquaporin 9 (AQP9) plays a critical role in tumor development. However, the interactions between TANs and AQP9 in BC are poorly understood. Bioinformatic…
View article: Intramedullary spinal cord abscess caused by Janibacter melonis
Intramedullary spinal cord abscess caused by Janibacter melonis Open
View article: Structure-based molecular screening and dynamic simulation of phytocompounds targeting VEGFR-2: a novel therapeutic approach for papillary thyroid carcinoma
Structure-based molecular screening and dynamic simulation of phytocompounds targeting VEGFR-2: a novel therapeutic approach for papillary thyroid carcinoma Open
Papillary thyroid carcinoma (PTC) is the most prevalent type of thyroid cancer, with aggressive variants presenting major therapeutic challenges. Vascular endothelial growth factor receptor-2 (VEGFR-2) is a key regulator of tumor angiogene…
View article: The influence rule of near-field wake vortex of tanker and the evaluation of dangerous area
The influence rule of near-field wake vortex of tanker and the evaluation of dangerous area Open
The development of wake vortex of refuelling aircraft includes two stages: near-field and far-field. In the near-field stage, wake vortex is in the phase of rolling up and maturity. The evolution mechanism of wake vortex is complex and the…
View article: Oscillating microbubble array–based metamaterials (OMAMs) for rapid isolation of high-purity exosomes
Oscillating microbubble array–based metamaterials (OMAMs) for rapid isolation of high-purity exosomes Open
Exosomes secreted by cells hold substantial potential for disease diagnosis and treatment. However, the rapid isolation of high-purity exosomes and their subpopulations from biofluids (e.g., undiluted whole blood) remains challenging. This…
View article: Numerical study on the longitudinal seismic performance of novel prefabricated Concrete-Filled Steel Tubular (CFST) bridge piers
Numerical study on the longitudinal seismic performance of novel prefabricated Concrete-Filled Steel Tubular (CFST) bridge piers Open
This study investigates the longitudinal (namely along the bridge length direction) seismic performance of a novel prefabricated concrete-filled steel tube (CFST) bridge pier. The novel CFST pier, constructed using prefabricated components…
View article: Vibration analysis and control of 2SPS+SR suspension seat for improving vehicle ride comfort
Vibration analysis and control of 2SPS+SR suspension seat for improving vehicle ride comfort Open
View article: Design of Reward Functions for Autonomous Driving Based on Reinforcement Learning: Balancing Safety and Efficiency
Design of Reward Functions for Autonomous Driving Based on Reinforcement Learning: Balancing Safety and Efficiency Open
Autonomous driving, leveraging artificial intelligence and reinforcement learning (RL), has made significant strides in improving traffic efficiency and safety. However, current RL-based approaches often focus on single-objective optimizat…
View article: Bayesian FDOA Positioning with Correlated Measurement Noise
Bayesian FDOA Positioning with Correlated Measurement Noise Open
In this paper, the problem of source localization using only frequency difference of arrival (FDOA) measurements is considered. A new FDOA-only localization technique is developed to determine the position of a narrow-band source. In this …
View article: BEATING PHENOMENON IN STANDING WAVES
BEATING PHENOMENON IN STANDING WAVES Open
View article: A translocation between chromosome 6 and 8 influences <i>lncRNA_MYB114</i> and <i>PpRPP13</i> expression and underpins red leaf trait and powdery mildew resistance in peach
A translocation between chromosome 6 and 8 influences <i>lncRNA_MYB114</i> and <i>PpRPP13</i> expression and underpins red leaf trait and powdery mildew resistance in peach Open
Summary Red leaf peach has important ornamental value owing to its characteristic leaf coloration. However, this species is highly susceptible to powdery mildew, and the mechanisms of red leaf formation, resistance to powdery mildew, and t…
View article: Chronic Periodontal Disease and Its Correlation with Carotid Intima-Media Thickness
Chronic Periodontal Disease and Its Correlation with Carotid Intima-Media Thickness Open
Chronic periodontal disease (periodontal disease, PD) is considered the sixth most prevalent disease affecting human health, with approximately 740 million people impacted globally. Over the past few decades, numerous studies have focused …
View article: Advanced image-identified extranodal extension of retropharyngeal lymph nodes in the refinement of N classification for nasopharyngeal carcinoma
Advanced image-identified extranodal extension of retropharyngeal lymph nodes in the refinement of N classification for nasopharyngeal carcinoma Open
Advanced extranodal extension (ENE) in cervical lymph nodes (CLNs) increases the risk of distant metastasis in nasopharyngeal carcinoma (NPC). The 9th NPC staging system classifies N1/N2 patients with advanced CLN ENE as N3 due to similar …
View article: Three-dimensional nozzle design method without drag surface under full geometric constraints
Three-dimensional nozzle design method without drag surface under full geometric constraints Open
View article: Blind Super-Resolution Network for Thyroid Ultrasound Image Based on Multiple Degradation Model
Blind Super-Resolution Network for Thyroid Ultrasound Image Based on Multiple Degradation Model Open
View article: Influence of electrospinning parameters on the development of high-quality electrospun nanofibers: A brief critical assessment
Influence of electrospinning parameters on the development of high-quality electrospun nanofibers: A brief critical assessment Open
View article: Kalman and Savitzky-Golay Filter Augmented Cnn-Lstm Framework for Predictive Maintenance in Space Manufacturing
Kalman and Savitzky-Golay Filter Augmented Cnn-Lstm Framework for Predictive Maintenance in Space Manufacturing Open
View article: Modifying Role of Serum Sodium on the Association Between Serum Total Homocysteine and All-Cause Mortality Among Chinese Centenarians
Modifying Role of Serum Sodium on the Association Between Serum Total Homocysteine and All-Cause Mortality Among Chinese Centenarians Open