Explanipedia

P2X receptors in GtoPdb v.2025.3 Open

Francesco Di Virgilio, Annette Nicke, Jessica Meades, Brian F. King, Charles Kennedy , et al. · 2025

P2X receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2X Receptors [49, 150]) have a trimeric topology [121, 132, 148, 201] with two putative TM domains per P2X subunit, gating primarily Na+, K+ and Ca2+, exceptionally Cl…

Ligand-gated ion channels in GtoPdb v.2025.3 Open

Susan Wonnacott, Annette Nicke, Shigetada Nakanishi, Christophe Mulle, Masayoshi Mishina , et al. · 2025

Ligand-gated ion channels (LGICs) are integral membrane proteins that contain a pore which allows the regulated flow of selected ions across the plasma membrane. Ion flux is passive and driven by the electrochemical gradient for the permea…

681. ENDOCANNABINOIDS AND INTRUSIVE MEMORIES: EVIDENCE FOR A ROLE OF ANANDAMIDE FROM TWO EXPERIMENTAL HUMAN STUDIES Open

Luke J. Ney, Michael F. Jarvis, Khalisa Amir Hamzah, Karolynn Hsu, Daniel V. Zuj , et al. · 2025

Background Preclinical evidence strongly suggests that the endocannabinoid system (particularly the ligands anandamide and 2-AG) is involved in trauma responses and negative emotional memories, which are relevant to posttraumatic stress di…

Anastomosing hemangioma of adrenal gland: rare benign vascular tumor Open

Su Su Hlaing, Johannes W. Von den Hoff, Prasad Jayaratne, Kayla Tran, Michael F. Jarvis , et al. · 2025

Anastomosing hemangioma of the adrenal gland is a rare benign vascular neoplasm that often presents incidentally during imaging for unrelated conditions. This tumor may mimic more aggressive lesions, such as angiosarcoma, due to its vascul…

Dark Energy Survey Year 3 results: $w$CDM cosmology from simulation-based inference with persistent homology on the sphere Open

J. Prat, Marco Gatti, C. Doux, Pratyush Pranav, C. Chang , et al. · 2025

We present cosmological constraints from Dark Energy Survey Year 3 (DES Y3) weak lensing data using persistent homology, a topological data analysis technique that tracks how features like clusters and voids evolve across density threshold…

Weak Gravitational Lensing around Low Surface Brightness Galaxies in the DES Year 3 Data Open

Nathalie Chicoine, J. Prat, G Zacharegkas, C. L. Chang, Dimitrios Tanoglidis , et al. · 2024

We present galaxy-galaxy lensing measurements using a sample of low surface brightness galaxies (LSBGs) drawn from the Dark Energy Survey Year 3 (Y3) data as lenses. LSBGs are diffuse galaxies with a surface brightness dimmer than the ambi…

Scientific integrity in the era of predatory journals: Insights from an editors in chief symposium Open

Zoltán Benyó, Emilio Clementi, Serge Cremers, Beáta Dávid, Tomasz J Guzik , et al. · 2024

In recent years, the academic community has faced a growing threat from predatory journals. These are publications that prioritize profit over quality scholarship and compromise the integrity of scientific discourse. Predatory journals oft…

Experimental pharmacology in precision medicine Open

Alicja Urbaniak, Kenneth E. Thummel, Ayoade N. Alade, Allan E. Rettie, Bhagwat Prasad , et al. · 2023

Following the initial sequencing of the human genome, it was widely predicted that this knowledge would lead to transformational advances in the identification, prevention, and treatment of disease.1 The terms "Precision Medicine" and "Per…

Forces on and in the cell walls of living plants Open

Michael F. Jarvis · 2023

Environmental influences and differential growth subject plants to mechanical forces. Forces on the whole plant resolve into tensile forces on its primary cell walls and both tensile and compression forces on the secondary cell wall layers…

Metadetection Weak Lensing for the Vera C. Rubin Observatory Open

E. Sheldon, M. R. Becker, Michael F. Jarvis, Robert Armstrong · 2023

Forthcoming astronomical imaging surveys will use weak gravitational lensing shear as a primary probe to study dark energy, with accuracy requirements at the 0.1% level. We present an implementation of the Metadetection shear measurement a…

P2X receptors in GtoPdb v.2023.1 Open

Francesco Di Virgilio, Simonetta Falzoni, Anna Fortuny‐Gomez, Samuel J. Fountain, Michael F. Jarvis , et al. · 2023

P2X receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2X Receptors [49, 146]) have a trimeric topology [118, 128, 144, 197] with two putative TM domains per P2X subunit, gating primarily Na+, K+ and Ca2+, exceptionally Cl…

Issue Information Open

Michael F. Jarvis, Jennifer Martin · 2023

of several types of special articles.These are: 1. Target validation -publication of negative fi ndings• including preclinical papers that show a hypothesis is incorrect • or papers on drugs that have failed in early clinical development 2…

Metadetection Weak Lensing for the Vera C. Rubin Observatory Open

E. Sheldon, M. R. Becker, Michael F. Jarvis, Robert Armstrong, The LSST Dark Energy Science Collaboration · 2023

Forthcoming astronomical imaging surveys will use weak gravitational lensing shear as a primary probe to study dark energy, with accuracy requirements at the 0.1% level. We present an implementation of the Metadetection shear measurement a…

FastPoints: A State-of-the-Art Point Cloud Renderer for Unity Open

Elias Neuman-Donihue, Michael F. Jarvis, Yuhao Zhu · 2023

In this paper, we introduce FastPoints, a state-of-the-art point cloud renderer for the Unity game development platform. Our program supports standard unprocessed point cloud formats with non-programmatic, drag-and-drop support, and create…

Pharmacology Research & Perspectives: A Decade of Progress Open

Michael F. Jarvis, Emily Davies, Jennifer Martin · 2023

Pharmacology Research & Perspectives (PR&P) began publication in 2013 as a gold open-access journal collaboration between the American Society for Pharmacology and Experimental Therapeutics (ASPET), the British Pharmacology Society (BPS), …

Patient Centered Medical Home (PCMH) Patient Education Brochure Research Proposal Open

Michael F. Jarvis · 2022

INTRODUCTION: Clinics within the Grady Health System (GHS) have been recently recognized as Patient Centered Medical Homes (PCMH) by the National Committee for Quality Assurance (NCQA). This creates a new standard of care for GHS, its clin…

Pharmacology Research & Perspectives calls for pharmacology education papers Open

Jennifer Martin, Michael F. Jarvis · 2021

Since its inception, Pharmacology Research & Perspectives (PR&P) has championed the publication of state-of-the-art pharmacological science and practice. Key strategies for the journal have focused on advancing pharmacology research rigor …

Digital Reconstruction of Elmina Castle for Mobile Virtual Reality via Point-based Detail Transfer Open

Sifan Ye, Ting Wu, Michael F. Jarvis, Yuhao Zhu · 2020

Reconstructing 3D models from large, dense point clouds is critical to enable Virtual Reality (VR) as a platform for entertainment, education, and heritage preservation. Existing 3D reconstruction systems inevitably make trade-offs between…

Andrew Lawrence, Editor‐in‐Chief 2018–2020 Open

Michael F. Jarvis, Jennifer L. Martin · 2020

Prof. Andrew Lawrence completes his tenure as the Editor-in-Chief of Pharmacology Research & Perspectives (PR&P) on December 31, 2020. Under Andy's guidance, the journal has experienced remarkable growth over the last several years. Submis…

Adenosine kinase: A key regulator of purinergic physiology Open

Detlev Boison, Michael F. Jarvis · 2020

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30 Open

Péter Illés, Christa E. Müller, Kenneth A. Jacobson, Thomas Grütter, Annette Nicke , et al. · 2020

The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting of two transmembrane regions (TM1 and TM2), intracellular N‐ and …

Geoffery Burnstock’s influence on the evolution of P2X3 receptor pharmacology Open

Michael F. Jarvis · 2020

P2X receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database Open

Francesco Di Virgilio, Richard J. Evans, Simonetta Falzoni, Samuel J. Fountain, Michael F. Jarvis , et al. · 2020

P2X receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2X Receptors [48, 141]) have a trimeric topology [124, 139, 188] with two putative TM domains, gating primarily Na+, K+ and Ca2+, exceptionally Cl-. The Nomenclature S…

New author guidelines and launch of Short Reports Open

Andrew J. Lawrence, Michael F. Jarvis · 2020

Pharmacology Research & Perspectives (PR&P) has experienced remarkable growth over the last several years. As a Gold Open Access collaborative journal between the American Society for Pharmacology and Experimental Therapeutics (ASPET), the…

Chemical and Mechanical Differences between Historic and Modern Scots Pine Wood Open

Kate Hudson-McAulay, Craig Kennedy, Michael F. Jarvis · 2020

Timber is one of the most common historic building materials, but relatively little is known about how it ages in situ. Here we investigate historic and modern Scots pine to determine any chemical or mechanical differences between them. Fo…

P2X receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open

Francesco Di Virgilio, Richard J. Evans, Simonetta Falzoni, Michael F. Jarvis, Charles Kennedy , et al. · 2019

P2X receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2X Receptors [46, 134]) have a trimeric topology [118, 132, 177] with two putative TM domains, gating primarily Na+, K+ and Ca2+, exceptionally Cl-. The Nomenclature S…

Therapeutic potential of adenosine kinase inhibition—Revisited Open

Michael F. Jarvis · 2019

Adenosine (ADO) is an endogenous protective regulator that restores cellular energy balance in response to tissue trauma. Extracellular ADO has a half‐life of the order of seconds thus restricting its actions to tissues and cellular sites …

A Patient‐Centric Model for Discontinuation of a Single‐Sourced Approved Drug Open

Arthur L. Caplan, J. Russell Teagarden, Hans Peter Bacher, Michael F. Jarvis · 2019

When and how to discontinue an obsolete single-sourced approved drug? Transitioning patients to newer therapies in diseases such as epilepsy where therapeutic responses are often idiosyncratic presents a significant clinical challenge. Com…

Characterization and comparison of rat monosodium iodoacetate and medial meniscal tear models of osteoarthritic pain Open

Jill‐Desiree Brederson, Katharine L. Chu, Jun Xu, Arthur L. Nikkel, Stella Markosyan , et al. · 2018

Osteoarthritis (OA) is a degenerative form of arthritis that can result in loss of joint function and chronic pain. The pathological pain state that develops with OA disease involves plastic changes in the peripheral and central nervous sy…

Evaluation of Lipid Profile and Residual Cardiovascular Risk in Patients Prior to Initiation of Niaspan Therapy Open

Syed Aminul Islam, Raghava Danwada, Minoti Ganguli, Ramon Espaillat, Michael F. Jarvis , et al. · 2017

Background: Despite significant impact of statins, there are a number of patients with residual risk of cardio vascular disease who have optimally controlled low-density lipoprotein cholesterol (LDL-C). Niaspan (extended-release nicotinic …

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