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View article: The Effect of Mucuna pruriens on Depression-like Behavior Induced by a Mild Traumatic Brain Injury in Rats Is Associated with a Decrease in Brain Nitrite and Nitrate Levels
The Effect of Mucuna pruriens on Depression-like Behavior Induced by a Mild Traumatic Brain Injury in Rats Is Associated with a Decrease in Brain Nitrite and Nitrate Levels Open
Traumatic brain injury (TBI), even when mild, has been associated with the presence of depression. Depression is a mood disorder characterized by persistent negative thoughts and sadness and is challenging to treat due to the multiple mech…
View article: Biological Plausibility of Using Plasma Amino Acid Profile Determination as a Potential Biomarker for Pediatric Patients with Mild Traumatic Brain Injuries
Biological Plausibility of Using Plasma Amino Acid Profile Determination as a Potential Biomarker for Pediatric Patients with Mild Traumatic Brain Injuries Open
Background: Amino acid biomarkers have a crucial influence on our understanding of brain injury mechanisms, and their plasma concentrations may indicate neurological damage and recovery patterns. Pediatric mild traumatic brain injury (mTBI…
View article: Plasma Glutathione Concentrations Are Associated with Leukocyte and Neutrophils’ Counts in Clozapine-Treated Patients
Plasma Glutathione Concentrations Are Associated with Leukocyte and Neutrophils’ Counts in Clozapine-Treated Patients Open
Clozapine’s potential hematological toxicity, particularly its effect on white blood cell counts, is well documented and routinely monitored in clinical practice. In this study, a significant association was identified between reduced glut…
View article: Mucuna pruriens, a Possible Treatment for Depressive Disorders
Mucuna pruriens, a Possible Treatment for Depressive Disorders Open
Depression is a mental disorder that depicts a wide variety of symptoms, including mood and cognitive alterations, as well as recurrent thoughts of death or suicide. It could become the second leading cause of premature death or disability…
View article: Dietary Risk Assessment of Cadmium Exposure Through Commonly Consumed Foodstuffs in Mexico
Dietary Risk Assessment of Cadmium Exposure Through Commonly Consumed Foodstuffs in Mexico Open
Cadmium (Cd) is a toxic heavy metal widely distributed in foodstuffs. In Mexico, few studies have evaluated Cd content in foods. This study aimed to determine Cd concentrations in foodstuffs that are highly consumed and bought in Mexico Ci…
View article: Effect of Mucuna pruriens seed extract on depression-like behavior derived from mild traumatic brain injury in rats
Effect of Mucuna pruriens seed extract on depression-like behavior derived from mild traumatic brain injury in rats Open
M. pruriens extract did not decrease neurobehavioral impairment caused by mTBI. Nevertheless, it prevented depression-like behaviors starting three days after mTBI, reduced LP, and increased GSH in some brain areas. Conclusions: M. prurien…
View article: TiO2-ZnPc nanoparticles functionalized with folic acid as a target photosensitizer for photodynamic therapy against glioblastoma cells
TiO2-ZnPc nanoparticles functionalized with folic acid as a target photosensitizer for photodynamic therapy against glioblastoma cells Open
The use of TiO2 as a photosensitizer in photodynamic therapy is limited due to TiO2 generates reactive oxygen species only under UV irradiation. The TiO2 surface has been modified with different functional groups to achieve activation at l…
View article: Dysregulation of the dopaminergic system secondary to traumatic brain injury: implications for mood and anxiety disorders
Dysregulation of the dopaminergic system secondary to traumatic brain injury: implications for mood and anxiety disorders Open
Traumatic brain injury (TBI) represents a public health issue with a high mortality rate and severe neurological and psychiatric consequences. Mood and anxiety disorders are some of the most frequently reported. Primary and secondary damag…
View article: Isobolographic Analysis of the Cytoprotective Effect of Dapsone and Cannabidiol Alone or Combination upon Oxygen–Glucose Deprivation/Reoxygenation Model in SH-SY5Y Cells
Isobolographic Analysis of the Cytoprotective Effect of Dapsone and Cannabidiol Alone or Combination upon Oxygen–Glucose Deprivation/Reoxygenation Model in SH-SY5Y Cells Open
Oxidative stress and apoptosis cell death are critical secondary damage mechanisms that lead to losing neighboring healthy tissue after cerebral ischemia. This study aims to characterize the type of interaction between dapsone (DDS) and ca…
View article: Lead Levels in the Most Consumed Mexican Foods: First Monitoring Effort
Lead Levels in the Most Consumed Mexican Foods: First Monitoring Effort Open
Globally, there is growing concern over the presence of lead (Pb) in foods because it is a heavy metal with several toxic effects on human health. However, monitoring studies have not been conducted in Mexico. In this study, we estimated t…
View article: Armodafinil as a Potential Pharmacological Treatment for AttentionDeficit Hyperactivity Disorder in Adults: A Review
Armodafinil as a Potential Pharmacological Treatment for AttentionDeficit Hyperactivity Disorder in Adults: A Review Open
Introduction: Armodafinil is a psychostimulant that promotes alertness, and it has been shown to improve attention, memory, and fatigue in healthy adults and adults with neurodevelopmental conditions that share symptoms with Attention Defi…
View article: Development and Characterization of Electrodes Coated with Plasma-Synthesized Polypyrrole Doped with Iodine, Implanted in the Rat Brain Subthalamic Nucleus
Development and Characterization of Electrodes Coated with Plasma-Synthesized Polypyrrole Doped with Iodine, Implanted in the Rat Brain Subthalamic Nucleus Open
Biological treatments involve the application of metallic material coatings to enhance biocompatibility and properties. In invasive therapies, metallic electrodes are utilized, which are implanted in patients. One of these invasive therape…
View article: [Translated article] Postsurgical analgesic efficacy by the intra-articular administration of ropivacaine with dexmedetomidine versus simple ropivacaine in patients undergoing knee arthroscopy
[Translated article] Postsurgical analgesic efficacy by the intra-articular administration of ropivacaine with dexmedetomidine versus simple ropivacaine in patients undergoing knee arthroscopy Open
Dexmedetomidine as an adjuvant to intra-articular ropivacaine improves the quality and duration of postoperative analgesia in patients undergoing knee arthroscopy.
View article: The role of poly(3‐hydroxybutyrate)‐based derivatives in skin, nerve, cartilage, and bone tissue engineering applications—An updated review
The role of poly(3‐hydroxybutyrate)‐based derivatives in skin, nerve, cartilage, and bone tissue engineering applications—An updated review Open
Poly(3‐hydroxybutyrate) (PHB) has gained significant attention in the realm of medical applications in recent years. This acceptability is rooted in its bioactive properties and remarkable biocompatibility, as the degradation products exhi…
View article: Copper release by MOF-74(Cu): a novel pharmacological alternative to diseases with deficiency of a vital oligoelement
Copper release by MOF-74(Cu): a novel pharmacological alternative to diseases with deficiency of a vital oligoelement Open
Copper deficiency can trigger various diseases such as Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease (PD) and even compromise the development of living beings, as manifested in Menkes disease (MS).
View article: Human Health Risk Assessment of Arsenic and Other Metals in Herbal Products Containing St. John’s Wort in the Metropolitan Area of Mexico City
Human Health Risk Assessment of Arsenic and Other Metals in Herbal Products Containing St. John’s Wort in the Metropolitan Area of Mexico City Open
Consumption of St. John’s wort plant is high worldwide due to its various medicinal properties. However, herbal products containing St. John’s wort may be contaminated with toxic metals. This is often related to contamination of both water…
View article: Repurposing Simvastatin in Parkinson’s Disease Model: Protection Is throughout Modulation of the Neuro-Inflammatory Response in the Substantia nigra
Repurposing Simvastatin in Parkinson’s Disease Model: Protection Is throughout Modulation of the Neuro-Inflammatory Response in the Substantia nigra Open
Parkinson’s disease is a neurodegenerative disorder characterized by oxidative stress and immune activation in the nigro-striatal pathway. Simvastatin regulates cholesterol metabolism and protects from atherosclerosis disease. Simvastatin-…
View article: Melatonin in Combination with Albendazole or Albendazole Sulfoxide Produces a Synergistic Cytotoxicity against Malignant Glioma Cells through Autophagy and Apoptosis
Melatonin in Combination with Albendazole or Albendazole Sulfoxide Produces a Synergistic Cytotoxicity against Malignant Glioma Cells through Autophagy and Apoptosis Open
Glioblastoma is the most aggressive and lethal brain tumor in adults, presenting diffuse brain infiltration, necrosis, and drug resistance. Although new drugs have been approved for recurrent patients, the median survival rate is two years…
View article: Early treatment with dapsone after spinal cord injury in rats decreases the inflammatory response and promotes long-term functional recovery
Early treatment with dapsone after spinal cord injury in rats decreases the inflammatory response and promotes long-term functional recovery Open
Failure of therapeutic strategies for the management and recovery from traumatic spinal cord injury (SCI) is a serious concern. Dapsone (DDS) has been reported as a neuroprotective drug after SCI, although the phase after SC damage (acute …
View article: Repurposing Simvastatin in Parkinson's Disease Model: Protection is throughout Modulation of the Neuro-inflammatory Response in the Substantia Nigra
Repurposing Simvastatin in Parkinson's Disease Model: Protection is throughout Modulation of the Neuro-inflammatory Response in the Substantia Nigra Open
Parkinson’s disease is a neurodegenerative disorder characterized by oxidative stress and immune activation in the nigro-striatal pathway. Simvastatin regulates cholesterol metabolism and protects from atherosclerosis disease. Simvas…
View article: Predictors of intrahospital mortality in patients with coronavirus disease 2019 and cerebrovascular diseases: rapid systematic review and meta-analysis protocol
Predictors of intrahospital mortality in patients with coronavirus disease 2019 and cerebrovascular diseases: rapid systematic review and meta-analysis protocol Open
Background: Coronavirus disease 2019 (COVID19) is a novel pandemic disease caused by the β-coronavirus SARS-CoV-2. This disease affects primarily the respiratory organs, but the vascular system may also be compromised. COVID19 may lead to …
View article: Predictors of intrahospital mortality in patients with coronavirus disease 2019 and cerebrovascular diseases: rapid systematic review and meta-analysis protocol
Predictors of intrahospital mortality in patients with coronavirus disease 2019 and cerebrovascular diseases: rapid systematic review and meta-analysis protocol Open
Background: Coronavirus disease 2019 (COVID19) is a novel pandemic disease caused by the β-coronavirus SARS-CoV-2. This disease affects primarily the respiratory organs, but the vascular system may also be compromised. COVID19 may lead to …
View article: Central and peripheral mechanisms of pain in fibromyalgia: scoping review protocol
Central and peripheral mechanisms of pain in fibromyalgia: scoping review protocol Open
Fibromyalgia is characterised by widespread musculoskeletal pain, which may present with fatigue, depression, anxiety, sleep and cognitive disturbances. It is the second most prevalent rheumatic disease. An accurate diagnosis is challengin…
View article: Influence of glutathione-related genetic variants on the oxidative stress profile of Mexican patients with psychotic disorders
Influence of glutathione-related genetic variants on the oxidative stress profile of Mexican patients with psychotic disorders Open
GCLC variants were associated with the oxidative stress profile of PD patients raising opportunities for intervention to improve their antioxidant defenses. Further studies with larger samples should explore this proposal.
View article: Alpha<sub>2</sub>-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injury
Alpha<sub>2</sub>-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injury Open
Norepinephrine plays an important role in motor functional recovery after a brain injury caused by ferrous chloride. Inhibition of norepinephrine release by clonidine is correlated with motor deficits after motor cortex injury. The aim of …
View article: Mechanisms of nerve regeneration for drug-resistant epilepsy: scoping review protocol
Mechanisms of nerve regeneration for drug-resistant epilepsy: scoping review protocol Open
Drug-resistant epilepsy is defined as “the failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules”, 30-40% of the patients with epilepsy present this condition decreasing their quality-of-li…
View article: Heavy Metals in Unprocessed or Minimally Processed Foods Consumed by Humans Worldwide: A Scoping Review
Heavy Metals in Unprocessed or Minimally Processed Foods Consumed by Humans Worldwide: A Scoping Review Open
Heavy metals (HM) can be accumulated along the food chain; their presence in food is a global concern for human health because some of them are toxic even at low concentrations. Unprocessed or minimally processed foods are good sources of …