Ke Liu
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View article: Targeted therapy in advanced <i>BRAF</i> -mutated colorectal cancer: systematic review and network meta-analysis
Targeted therapy in advanced <i>BRAF</i> -mutated colorectal cancer: systematic review and network meta-analysis Open
Objective To investigate the individual and comparative efficacy and safety of targeted therapy based strategies in advanced BRAF -mutated colorectal cancer. Design Systematic review and network meta-analysis. Data sources PubMed, Embase, …
View article: Correction: Post-translational modifications in sepsis-induced acute kidney injury: mechanisms and perspectives
Correction: Post-translational modifications in sepsis-induced acute kidney injury: mechanisms and perspectives Open
[This corrects the article DOI: 10.3389/fphar.2025.1625139.].
View article: Post-translational modifications in sepsis-induced acute kidney injury: mechanisms and perspectives
Post-translational modifications in sepsis-induced acute kidney injury: mechanisms and perspectives Open
Sepsis-induced acute kidney injury (SA-AKI), a grave clinical issue with a high mortality rate, has impacted millions of individuals worldwide. Sepsis is a syndrome characterized by life-threatening organ dysfunction resulting from a dysre…
View article: Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates
Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates Open
Targeted degradation of membrane-associated proteins, which constitute a crucial class of drug targets implicated in diverse disease pathologies, has garnered considerable attention in chemical biology and drug discovery recently. Taking a…
View article: Pneumatosis cystoides intestinalis and ketoacidosis in a diabetic patient: A case report and literature review
Pneumatosis cystoides intestinalis and ketoacidosis in a diabetic patient: A case report and literature review Open
Rationale: Pneumatosis cystoides intestinalis (PCI) is a rare disease characterized by gas accumulation in the intestinal wall, and is usually treated conservatively. Patients with diabetic ketoacidosis (DKA) sometimes present with severe …
View article: Targeted Degradation Technologies Utilizing Autophagy
Targeted Degradation Technologies Utilizing Autophagy Open
Targeted degradation technologies, primarily referring to targeted protein degradation, have emerged as promising drug discovery strategies. In contrast to traditional “occupancy-driven” inhibition approaches, these technologies ingeniousl…
View article: Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis
Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis Open
Pathological process of CID can be partially explained by compositional alterations in the gut microbiota. Supplementation with hk-B. f reduces 5-FU-stimulated epithelial injury through mitochondrial apoptotic pathway in CID murine models.…
View article: Single‑cell analysis reveals distinct immune characteristics of hepatocellular carcinoma in HBV‑positive vs. HBV‑negative cases
Single‑cell analysis reveals distinct immune characteristics of hepatocellular carcinoma in HBV‑positive vs. HBV‑negative cases Open
Infection with the hepatitis B virus (HBV) is a key risk factor for hepatocellular carcinoma (HCC) development and progression. It is widely recognized that immunopathological mechanisms are pivotal in the development of HBV-associated HCC…
View article: Association between inflammatory diet and cognitive function with the moderating role of workforce participation in older adults: findings from NHANES 2011-2014
Association between inflammatory diet and cognitive function with the moderating role of workforce participation in older adults: findings from NHANES 2011-2014 Open
Background This study aimed to investigate the association between inflammatory diets and cognitive function in older adults and examine whether workforce participation moderates this relationship. Methods Using data from the National Heal…
View article: Correction: Evidence of WNV infection in migratory birds passing through Xinjiang, china, using viral genome amplicon approach
Correction: Evidence of WNV infection in migratory birds passing through Xinjiang, china, using viral genome amplicon approach Open
[This corrects the article DOI: 10.3389/fmicb.2025.1468530.].
View article: Polyol-solid surface/interface transesterification strategy to construct precise anatase/rutile TiO<sub>2</sub> hetero-phase junctions towards enhanced photocatalytic performance
Polyol-solid surface/interface transesterification strategy to construct precise anatase/rutile TiO<sub>2</sub> hetero-phase junctions towards enhanced photocatalytic performance Open
Heterophase anatase/rutile junctions (A/R-HPJs) in TiO2 hold significant promise for photocatalysis, yet precise control over phase composition remains elusive. Here, we develop a novel polyol-solid surface/interface transesterification st…
View article: Evidence of WNV infection in migratory birds passing through Xinjiang, China, using viral genome amplicon approach
Evidence of WNV infection in migratory birds passing through Xinjiang, China, using viral genome amplicon approach Open
The West Nile virus (WNV) is a mosquito-borne virus of the Flaviviridae family that is transmitted through the mosquito-migratory bird-mosquito cycle. Currently, WNV infection is widespread in the Americas, Europe, and Africa, and is one o…
View article: Plant-Based Diet Indices with Greenhouse Gas Emissions and Risk of Cardiometabolic Diseases and All-Cause Mortality: Longitudinal China Cohort Study
Plant-Based Diet Indices with Greenhouse Gas Emissions and Risk of Cardiometabolic Diseases and All-Cause Mortality: Longitudinal China Cohort Study Open
Background: Environmental and cardiometabolic impacts of adherence to plant-based dietary patterns with different quality are unclear. Objectives: To investigate the associations between adherence to the overall, healthy, and unhealthy pla…
View article: Federated learning for nurse stress prediction using wearable sensors: Integrating biomechanical data
Federated learning for nurse stress prediction using wearable sensors: Integrating biomechanical data Open
In today’s fast-paced work environments, accurately predicting stress levels is essential for effective healthcare workforce management, particularly among nurses in high-pressure settings. Despite the availability of various mental health…
View article: L-Arabinose Alleviates Functional Constipation in Mice by Regulating Gut Microbiota and Metabolites
L-Arabinose Alleviates Functional Constipation in Mice by Regulating Gut Microbiota and Metabolites Open
Functional constipation ranks among the most common disorders impacting human health, which is manifested by difficulty in defecation and a complex etiology. L-Arabinose, a pentose found naturally in fruit rinds and cereal husks, has been …
View article: High-Density Lipoprotein in Patients with Diabetic Kidney Disease: Friend or Foe?
High-Density Lipoprotein in Patients with Diabetic Kidney Disease: Friend or Foe? Open
High-density lipoprotein (HDL) exhibits multiple metabolic protective functions, such as facilitating cellular cholesterol efflux, antioxidant, anti-inflammatory, anti-apoptotic and anti-thrombotic properties, showing antidiabetic and reno…
View article: eIF3a function in immunity and protection against severe sepsis by regulating B cell quantity and function through m6A modification
eIF3a function in immunity and protection against severe sepsis by regulating B cell quantity and function through m6A modification Open
eIF3a is a N 6-methyladenosine (m6A) reader that regulates mRNA translation by recognizing m6A modifications of these mRNAs. It has been suggested that eIF3a may play an important role in regulating …
View article: Optimizing the NGS-based discrimination of multiple lung cancers from the perspective of evolution
Optimizing the NGS-based discrimination of multiple lung cancers from the perspective of evolution Open
Next-generation sequencing (NGS) offers a promising approach for differentiating multiple primary lung cancers (MPLC) from intrapulmonary metastasis (IPM), though panel selection and clonal interpretation remain challenging. Whole-exome se…
View article: Dynamic Car-Following Model With Jerk Suppression for Highway Autonomous Driving
Dynamic Car-Following Model With Jerk Suppression for Highway Autonomous Driving Open
This study proposes a dynamic safe car-following strategy that is based on dynamic adjustment of headway time with jerk suppression. Reinforcement learning models trained with this strategy result in enhanced safety and driving comfort, va…
View article: Effectiveness of Sodium-Glucose Transporter 2 Inhibitors and Semaglutide on Body Composition in Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Real-World Cohort Study with Bioelectrical Impedance Analysis.
Effectiveness of Sodium-Glucose Transporter 2 Inhibitors and Semaglutide on Body Composition in Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Real-World Cohort Study with Bioelectrical Impedance Analysis. Open
SGLT-2Is with/without Semaglutide reduced body composition parameters of fat, muscle, water, and BMC in T2DM-CKD. Combination therapy exacerbated absolute muscle loss but increased the muscle mass-to-body weight percentage, without signifi…
View article: FAT1 knockdown enhances the CSC properties of HNSCC through p-CaMKII-mediated inactivation of the IFN pathway
FAT1 knockdown enhances the CSC properties of HNSCC through p-CaMKII-mediated inactivation of the IFN pathway Open
FAT atypical cadherin 1 (FAT1), which encodes an atypical cadherin-coding protein, has a high mutation rate and is commonly regarded as a tumor suppressor gene in head and neck squamous cell carcinoma (HNSCC). Nonetheless, the poten…
View article: The potential mechanisms and material basis of Fuzheng Jiedu decoction broad-spectrum inhibiting coronaviruses
The potential mechanisms and material basis of Fuzheng Jiedu decoction broad-spectrum inhibiting coronaviruses Open
View article: Co‐Translational Deposition of <i>N</i><sup>6</sup>‐Acetyl‐<i>L</i>‐Lysine in Nascent Proteins Contributes to the Acetylome in Mammalian Cells
Co‐Translational Deposition of <i>N</i><sup>6</sup>‐Acetyl‐<i>L</i>‐Lysine in Nascent Proteins Contributes to the Acetylome in Mammalian Cells Open
N 6 ‐acetyl‐ L ‐ lysine residue is abundant in dietary protein but little is known about its potential influences on the diet‐consumers. Herein, it is reported that Lysyl‐tRNA synthetase (KARS) mediates co‐translational deposition of diet‐…
View article: Construction of Co-Modified MXene/PES Catalytic Membrane for Effective Separation and Degradation of Tetracycline Antibiotics in Aqueous Solutions
Construction of Co-Modified MXene/PES Catalytic Membrane for Effective Separation and Degradation of Tetracycline Antibiotics in Aqueous Solutions Open
The application of antibiotics has advanced modern medicine significantly. However, the abuse and discharge of antibiotics have led to substantial antibiotic residues in water, posing great harm to natural organisms and humans. To address …
View article: Spatial position changes in the semicircular canals may be the anatomical basis of Meniere’s disease: a preliminary study based on ultra-high-resolution computed tomography (CT) and intelligent segmentation
Spatial position changes in the semicircular canals may be the anatomical basis of Meniere’s disease: a preliminary study based on ultra-high-resolution computed tomography (CT) and intelligent segmentation Open
Spatial position changes in the semicircular canals may be the anatomical basis of MD.
View article: Precision prognosis of colorectal cancer: a multi-tiered model integrating microsatellite instability genes and clinical parameters
Precision prognosis of colorectal cancer: a multi-tiered model integrating microsatellite instability genes and clinical parameters Open
Background Prognostic assessment for colorectal cancer (CRC) displays substantial heterogeneity, as reliance solely on traditional TNM staging falls short of achieving precise individualized predictions. The integration of diverse biologic…
View article: Dynamic Sickling Assay: A Novel Approach for Assessing RBC Sickling Kinetics in SCD
Dynamic Sickling Assay: A Novel Approach for Assessing RBC Sickling Kinetics in SCD Open
Presentation Date: 6/9/2024 Presentation Start Time: 4:00:00 PM Background Sickle cell anemia has been considered a rare disease for a long time. Recently it has been estimated that the number of cases is constantly increasing and the numb…
View article: Neem Leaf Extract Exhibits Anti-Aging and Antioxidant Effects from Yeast to Human Cells
Neem Leaf Extract Exhibits Anti-Aging and Antioxidant Effects from Yeast to Human Cells Open
Neem leaves have long been used in traditional medicine for promoting longevity. However, the precise mechanisms underlying their anti-aging effects remain elusive. In this study, we investigated the impact of neem leaf extract (NLE) extra…
View article: Engineering non-conventional yeast Rhodotorula toruloides for ergothioneine production
Engineering non-conventional yeast Rhodotorula toruloides for ergothioneine production Open
Background Ergothioneine (EGT) is a distinctive sulfur-containing histidine derivative, which has been recognized as a high-value antioxidant and cytoprotectant, and has a wide range of applications in food, medical, and cosmetic fields. C…
View article: Development and biological characterization of an infectious cDNA clone of NADC34-like PRRSV
Development and biological characterization of an infectious cDNA clone of NADC34-like PRRSV Open
Introduction Porcine Reproductive and Respiratory Syndrome virus (PRRSV) causes high abortion rates in gestating sows and stillbirths, as well as high piglet mortality, seriously jeopardizing the pig industry in China and worldwide. Method…