Catherine J. Karr
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View article: Educational attainment and self-reported environmental exposures of pregnant women living in Nairobi, Kenya
Educational attainment and self-reported environmental exposures of pregnant women living in Nairobi, Kenya Open
Environmental exposures experienced by pregnant women living in cities of low- and middle-income countries are poorly described. We collected information on housing characteristics, household and ambient air pollution, and work-related exp…
View article: Wildfire-specific fine particulate matter and preterm birth: a US ECHO Cohort analysis
Wildfire-specific fine particulate matter and preterm birth: a US ECHO Cohort analysis Open
ECHO Program, US National Institutes of Health Office of the Director.
View article: Prenatal exposure to polycyclic aromatic hydrocarbons and birth outcomes in a pregnancy cohort in Nairobi, Kenya
Prenatal exposure to polycyclic aromatic hydrocarbons and birth outcomes in a pregnancy cohort in Nairobi, Kenya Open
Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to lower birth weight (BW) and shorter gestational age (GA) at delivery. Most research has focused on populations in high-income countries, leaving low- and middl…
View article: Prenatal Air Pollution Exposure and Autism Spectrum Disorder in the ECHO Consortium
Prenatal Air Pollution Exposure and Autism Spectrum Disorder in the ECHO Consortium Open
Associations with ASD outcomes were present even at low levels of air pollutants. https://doi.org/10.1289/EHP16675.
Pesticides and neurodevelopment of children in low and middle-income countries: A systematic review Open
Background Pesticides are increasingly common in low- and middle-income countries (LMICs), where weaker regulations and multiple risk factors for poor neurodevelopment exist. Due to biological and behavioral factors, children are vulnerabl…
View article: Disparities in the association of ambient air pollution with childhood asthma incidence in the ECHO consortium: A US-wide multi-cohort study
Disparities in the association of ambient air pollution with childhood asthma incidence in the ECHO consortium: A US-wide multi-cohort study Open
Background: Characterization of US sociodemographic disparities in air pollution respiratory effects has often been limited by lack of participant diversity, geography, exposure characterization, and small sample size. Methods: We included…
View article: Early-Life Ozone Exposure and Asthma and Wheeze in Children
Early-Life Ozone Exposure and Asthma and Wheeze in Children Open
Importance Ozone (O 3 ) is the most frequently exceeded air pollutant standard in the US. While short-term exposure is associated with acute respiratory health, the epidemiologic evidence linking postnatal O 3 exposure to childhood asthma …
View article: Wildfire Smoke Exposure is Associated with Decreased Sperm Concentration and Total Motile Sperm Count
Wildfire Smoke Exposure is Associated with Decreased Sperm Concentration and Total Motile Sperm Count Open
Structured Abstract Objective As wildfires become more prevalent, their impact on fertility warrants evaluation. We aimed to examine the impact of smoke exposure on semen analysis parameters of intrauterine insemination patients in the gre…
View article: Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study
Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study Open
Introduction Air pollution is linked with poor neurodevelopment in high-income countries. Comparable data are scant for low-income countries, where exposures are higher. Longitudinal pregnancy cohort studies are optimal for individual expo…
Associations of placental lncRNA expression with maternal pre-pregnancy BMI and infant birthweight in two birth cohorts Open
Pre-pregnancy obesity (ppOB) is linked to pregnancy complications and abnormal fetal growth through placental mechanisms, and long non-coding RNAs (lncRNAs) may play an epigenetic role in these processes. We investigated overall and sex-sp…
View article: A descriptive examination of rurality in the Environmental influences on Child Health Outcomes Cohort: Implications, illustrations, and future directions
A descriptive examination of rurality in the Environmental influences on Child Health Outcomes Cohort: Implications, illustrations, and future directions Open
Purpose The Environmental influences on Child Health Outcomes (ECHO) Cohort has enrolled over 60,000 children to examine how early environmental factors (broadly defined) are associated with key child health outcomes. The ECHO Cohort may b…
View article: Prenatal ozone exposure and child lung function: Exploring effect modification by oxidative balance score
Prenatal ozone exposure and child lung function: Exploring effect modification by oxidative balance score Open
In a large, well-characterized pregnancy cohort, we did not find robust evidence of an effect of prenatal O3 on lung function. There was suggestion of enhanced vulnerability for some subgroups in exploratory analyses.
View article: Prenatal exposure to ambient fine particulate matter and child lung function in the CANDLE cohort
Prenatal exposure to ambient fine particulate matter and child lung function in the CANDLE cohort Open
We did not find strong evidence of associations between prenatal ambient PM2.5 exposure and child lung function in a large, well-characterized study sample. However, there was a suggested adverse association between FEV1 and exposure durin…
View article: Longitudinal Changes in Youth Mental Health From Before to During the COVID-19 Pandemic
Longitudinal Changes in Youth Mental Health From Before to During the COVID-19 Pandemic Open
Importance Robust longitudinal studies of within-child changes in mental health associated with the COVID-19 pandemic are lacking, as are studies examining sources of heterogeneity in such changes. Objective To investigate within-child cha…
View article: Using ECHO program data to develop a brief measure of caregiver support and cognitive stimulation using the home observation for measurement of the environment-infant/toddler (HOME-IT)
Using ECHO program data to develop a brief measure of caregiver support and cognitive stimulation using the home observation for measurement of the environment-infant/toddler (HOME-IT) Open
Data from three NIH Environmental influences on Child Health Outcomes (ECHO) Program cohorts that collected the HOME-Infant-Toddler (HOME-IT age 0–3 years) version were used to examine the reliability of a brief scale of caregiver support …
View article: Urinary polycyclic aromatic hydrocarbon (PAH) metabolite concentrations in three pregnancy cohorts from 7 U.S. study sites
Urinary polycyclic aromatic hydrocarbon (PAH) metabolite concentrations in three pregnancy cohorts from 7 U.S. study sites Open
Objective Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with adverse birth and developmental outcomes in children. We aimed to describe prenatal PAH exposures in a large, multisite U.S. consortium. Methods We m…
View article: Association of maternal fish consumption and ω-3 supplement use during pregnancy with child autism-related outcomes: results from a cohort consortium analysis
Association of maternal fish consumption and ω-3 supplement use during pregnancy with child autism-related outcomes: results from a cohort consortium analysis Open
These results extend previous work by suggesting that prenatal fish intake, but not ω-3 supplement use, may be associated with lower likelihood of both autism diagnosis and related traits. Given the low-fish intake in the United States gen…
View article: Association of maternal education, neighborhood deprivation, and racial segregation with gestational age at birth by maternal race/ethnicity and United States Census region in the ECHO cohorts
Association of maternal education, neighborhood deprivation, and racial segregation with gestational age at birth by maternal race/ethnicity and United States Census region in the ECHO cohorts Open
Background: In the United States, disparities in gestational age at birth by maternal race, ethnicity, and geography are theorized to be related, in part, to differences in individual- and neighborhood-level socioeconomic status (SES). Yet…
View article: The Role of Childhood Asthma in Obesity Development
The Role of Childhood Asthma in Obesity Development Open
RATIONALE: Asthma and obesity often co-occur. It has been hypothesized that asthma may contribute to childhood obesity onset. OBJECTIVES: To determine if childhood asthma is associated with incident obesity and examine the role of asthma m…
View article: A genome scale transcriptional regulatory model of the human placenta
A genome scale transcriptional regulatory model of the human placenta Open
Gene regulation is essential to placental function and fetal development. We built a genome-scale transcriptional regulatory network (TRN) of the human placenta using digital genomic footprinting and transcriptomic data. We integrated 475 …