Shirley Vasconcelos Komninakis
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View article: Investigating STLV-1 infection in African green monkeys: a model for understanding HTLV-1 pathogenesis
Investigating STLV-1 infection in African green monkeys: a model for understanding HTLV-1 pathogenesis Open
Introduction Simian T-cell leukemia virus type 1 (STLV-1) and human T-lymphotropic virus type 1 (HTLV-1) are homologous viruses with high genetic identity. STLV-1 infections in non-human primates serve as valuable models to study HTLV-1 pa…
View article: The application of metagenomics in the detection of arboviruses in mosquitoes (Diptera: Culicidade). A systematic review
The application of metagenomics in the detection of arboviruses in mosquitoes (Diptera: Culicidade). A systematic review Open
Advances in deforestation and climate change directly imply changes in habits and the distribution of Culicidae across the globe, especially mosquitoes of medical importance and the main vectors of arboviruses. The viral metagenomics techn…
View article: The application of metagenomics in the detection of arboviruses in mosquitoes (Diptera: Culicidade): a systematic review.
The application of metagenomics in the detection of arboviruses in mosquitoes (Diptera: Culicidade): a systematic review. Open
Advances in deforestation and climate change directly cause changes in habits and the distribution of Culicidae across the globe, especially mosquitoes of medical importance and the main vectors of arboviruses. The viral metagenomics techn…
View article: Detection of Plasmodium in Anopheles spp (Diptera: Nematocera: Culicidae) using molecular biology techniques: a systematic review
Detection of Plasmodium in Anopheles spp (Diptera: Nematocera: Culicidae) using molecular biology techniques: a systematic review Open
This study aims to find evidence of the effectiveness of molecular biology techniques in detecting Plasmodium in Anopheles spp mosquitoes. This systematic review was based on the PRISMA 2020 protocol. It was carried out in five electronic …
View article: Unraveling clinical outcomes of long-term cART treatment in HIV-1 patients with or without the Brazilian GWGR motif in the V3 loop
Unraveling clinical outcomes of long-term cART treatment in HIV-1 patients with or without the Brazilian GWGR motif in the V3 loop Open
The presence of genetic mutations in HIV poses a significant challenge, potentially leading to antiretroviral resistance and hampering therapeutic development. The Brazilian population has presented variations in the HIV envelope V3 loop g…
View article: Environmental Changes and the Impact on the Human Infections by Dengue, Chikungunya and Zika Viruses in Northern Brazil, 2010–2019
Environmental Changes and the Impact on the Human Infections by Dengue, Chikungunya and Zika Viruses in Northern Brazil, 2010–2019 Open
Environmental changes are among the main factors that contribute to the emergence or re-emergence of viruses of public health importance. Here, we show the impact of environmental modifications on cases of infections by the dengue, chikung…
View article: Detection of human feces pecovirus in newly diagnosed HIV patients in Brazil
Detection of human feces pecovirus in newly diagnosed HIV patients in Brazil Open
Circular single stranded DNA viruses (CRESS DNA) encoding a homologous replication-associated protein (REP) have been identified in most of eukaryotic groups. It is not clear yet the role in human diseases or details of the life cycle of t…
View article: Re-emergence of mayaro virus and coinfection with chikungunya during an outbreak in the state of Tocantins/Brazil
Re-emergence of mayaro virus and coinfection with chikungunya during an outbreak in the state of Tocantins/Brazil Open
Objective To perform a molecular screening to detect infections by the mayaro virus and possible coinfections with Chikungunya during an outbreak in the state of Tocantins/Brazil in 2017. Results Of a total 102 samples analyzed in this stu…
View article: Serological and molecular epidemiology of the Dengue, Zika and Chikungunya viruses in a risk area in Brazil
Serological and molecular epidemiology of the Dengue, Zika and Chikungunya viruses in a risk area in Brazil Open
Background The co-circulation of types of arbovirus in areas where they are endemic increased the risk of outbreaks and limited the diagnostic methods available. Here, we analyze the epidemiological profile of DENV, CHIKV and ZIKV at the s…
View article: Detection of coinfection with Chikungunya virus and Dengue virus serotype 2 in serum samples of patients in State of Tocantins, Brazil
Detection of coinfection with Chikungunya virus and Dengue virus serotype 2 in serum samples of patients in State of Tocantins, Brazil Open
The presence of co-circulating arboviruses increases the chance of coinfection and demonstrates the importance of differential diagnosis and vector control.
View article: First identification of mammalian orthoreovirus type 3 by gut virome analysis in diarrheic child in Brazil
First identification of mammalian orthoreovirus type 3 by gut virome analysis in diarrheic child in Brazil Open
Diarrhea remains one of the most common causes of deaths in children. Although many studies have investigated the prevalence of enteric pathogens around the globe some diarrheal episodes remain unexplained. It is possible that some yet-uni…
View article: Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum
Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum Open
The resurgence of cases of Zika virus (ZIKV) infection, accompanied by epidemic of microcephaly in Brazil, has aroused worldwide interest in understanding the biological mechanisms of the virus that allow patient management and the viral d…
View article: Recombinant Strains of Human Parechovirus in Rural Areas in the North of Brazil
Recombinant Strains of Human Parechovirus in Rural Areas in the North of Brazil Open
We characterized the 24 nearly full-length genomes of human parechoviruses (PeV) from children in the north of Brazil. The initial phylogenetic analysis indicated that 17 strains belonged to genotype 1, 5 to genotype 4, and 1 to genotype 1…
View article: Detection of RNA-Dependent RNA Polymerase of Hubei Reo-Like Virus 7 by Next-Generation Sequencing in Aedes aegypti and Culex quinquefasciatus Mosquitoes from Brazil
Detection of RNA-Dependent RNA Polymerase of Hubei Reo-Like Virus 7 by Next-Generation Sequencing in Aedes aegypti and Culex quinquefasciatus Mosquitoes from Brazil Open
Advancements in next-generation sequencing and bioinformatics have expanded our knowledge of the diversity of viruses (pathogens and non-pathogens) harbored by mosquitoes. Hubei reo-like virus 7 (HRLV 7) was recently detected by the virome…
View article: The rare enterovirus c99 and echovirus 29 strains in Brazil: potential risks associated to silent circulation
The rare enterovirus c99 and echovirus 29 strains in Brazil: potential risks associated to silent circulation Open
Human enteroviruses (EVs) are associated with a wide spectrum of human diseases. Here we report the complete genome sequences of one EV-C99 strain and one E29 strain obtained from children suffering from acute gastroenteritis, without symp…
View article: Human sapovirus GI.2 and GI.3 from children with acute gastroenteritis in northern Brazil
Human sapovirus GI.2 and GI.3 from children with acute gastroenteritis in northern Brazil Open
Human sapoviruses (HSaV) are considered important causative agents of acute gastroenteritis in humans worldwide. However, knowledge of the genetic characteristics of the whole genome of HSaV in Brazil is limited. Here we report the complet…
View article: Human sapovirus GI.2 and GI.3 from children with acute gastroenteritis in northern Brazil
Human sapovirus GI.2 and GI.3 from children with acute gastroenteritis in northern Brazil Open
Human sapoviruses (HSaV) are considered important causative agents of acute gastroenteritis in humans worldwide. However, knowledge of the genetic characteristics of the whole genome of HSaV in Brazil is limited. Here we report the complet…
View article: Detection and Characterization of Enterovirus B73 from a Child in Brazil
Detection and Characterization of Enterovirus B73 from a Child in Brazil Open
Enterovirus B73 is a new member of the Enterovirus B species. First detected in the USA, it has been subsequently identified in China, India, Oman, and the Netherlands. In this study, we characterize the first B73 strain (named TO-127) to …
View article: A Novel Highly Divergent Strain of Cell Fusing Agent Virus (CFAV) in Mosquitoes from the Brazilian Amazon Region
A Novel Highly Divergent Strain of Cell Fusing Agent Virus (CFAV) in Mosquitoes from the Brazilian Amazon Region Open
Classical insect-specific flaviviruses (cISFs) have been widely detected in different countries in the last decades. Here, we characterize the near full-length genomes of two cISFs detected in mosquitoes collected in the city of Macapá, st…
View article: Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus
Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus Open
Here we report the nearly full-length genome of a recombinant Saffold virus strain (SAFV-BR-193) isolated from a child with acute gastroenteritis. Evolutionary analysis performed using all available near-full length Saffold picornavirus ge…
View article: Genomic and epidemiological monitoring of yellow fever virus transmission potential
Genomic and epidemiological monitoring of yellow fever virus transmission potential Open
Arbovirus risk in Brazil Despite the existence of an effective vaccine for yellow fever, there are still almost 80,000 fatalities from this infection each year. Since 2016, there has been a resurgence of cases in Africa and South America—a…
View article: Complete Genome Sequences of Six Human Bocavirus Strains from Patients with Acute Gastroenteritis in the North Region of Brazil
Complete Genome Sequences of Six Human Bocavirus Strains from Patients with Acute Gastroenteritis in the North Region of Brazil Open
Human bocavirus (HBoV) is commonly associated with acute respiratory tract illness and gastroenteritis. We report six complete genomic sequences of HBoV strains from patients with gastroenteritis in Belém do Pará and Tocantins in the North…
View article: Genomic and epidemiological monitoring of yellow fever virus transmission potential
Genomic and epidemiological monitoring of yellow fever virus transmission potential Open
The yellow fever virus (YFV) epidemic that began in Dec 2016 in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes sp. vectors highlights the urgent need to monitor the risk of re-establishment of domestic YFV…
View article: External Quality Assessment for Zika Virus Molecular Diagnostic Testing, Brazil
External Quality Assessment for Zika Virus Molecular Diagnostic Testing, Brazil Open
We conducted an external quality assessment of Zika virus molecular diagnostic tests in Brazil using a new Zika virus standard. Of 15 laboratories, 73% showed limited sensitivity and specificity. Viral load estimates varied significantly. …