Chellan Kumarasamy
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View article: Factors associated with hospitalization of people with influenza in a Malaysian tertiary hospital from 2015 to 2019
Factors associated with hospitalization of people with influenza in a Malaysian tertiary hospital from 2015 to 2019 Open
Influenza contributes substantially to global morbidity and mortality. While most individuals recover from influenza without complications, certain groups are at higher risk of developing severe illness requiring hospitalization. This retr…
View article: Artificial intelligence in prenatal ultrasound: A systematic review of diagnostic tools for detecting congenital anomalies
Artificial intelligence in prenatal ultrasound: A systematic review of diagnostic tools for detecting congenital anomalies Open
Background Artificial intelligence (AI) has potentially shown promise in interpreting ultrasound imaging through flexible pattern recognition and algorithmic learning, but implementation in clinical practice remains limited. This study aim…
View article: Future risk projection to engage �near-miss� individuals in lung cancer screening eligibility: an analysis of ILST data
Future risk projection to engage �near-miss� individuals in lung cancer screening eligibility: an analysis of ILST data Open
Introduction Lung cancer risk increases with time, and participants who are initially ineligible for lung cancer screening (LCS) could become eligible later. The aim of this study was to determine the proportion of people (initially inelig…
View article: The Western Australian Mesothelioma Registry: Analysis of 60 years of cases
The Western Australian Mesothelioma Registry: Analysis of 60 years of cases Open
Background and Objective Australia introduced a partial ban on asbestos consumption in 1984. There is continuing concern about exposure to asbestos in the built environment and non‐occupational exposures. The aim of this study was to descr…
View article: P1.14-02 Validation of Lung Cancer Risk Prediction Models in an Asbestos Exposed Population
P1.14-02 Validation of Lung Cancer Risk Prediction Models in an Asbestos Exposed Population Open
View article: Lung cancer screening an asbestos exposed population: Existing lung cancer risk criteria are not sufficient
Lung cancer screening an asbestos exposed population: Existing lung cancer risk criteria are not sufficient Open
Background and Objective Asbestos is a major risk factor for lung cancer, with or without tobacco smoke exposure. Low dose computed tomography (LDCT) screening for early lung cancer is effective but only when targeting high risk population…
View article: Correlation of lung function with ultra-low-dose CT-detected lung parenchymal abnormalities: a cohort study of 1344 asbestos exposed individuals
Correlation of lung function with ultra-low-dose CT-detected lung parenchymal abnormalities: a cohort study of 1344 asbestos exposed individuals Open
Introduction Deliberate exposure to medical ionising radiation should be as low as reasonably practicable but the reduction of radiation from CT should be balanced against diagnostic image quality. The ability of ultra-low-dose CT (uLDCT: …
View article: Rapid Assessment of Oxidative Damage Potential: A Comparative Study of Engineered Stone Dusts Using a Deoxyguanosine Assay
Rapid Assessment of Oxidative Damage Potential: A Comparative Study of Engineered Stone Dusts Using a Deoxyguanosine Assay Open
The popularity of engineered stone (ES) has been associated with a global increase in occupational lung disease in workers exposed to respirable dust during the fabrication of benchtops and other ES products. In this study, the reactivity …
View article: Assessing the oxidative damage potential of engineered stone dust using a deoxyguanosine assay
Assessing the oxidative damage potential of engineered stone dust using a deoxyguanosine assay Open
<p>The popularity of engineered stone (ES), alternatively known as artificial stone, as a building material for kitchen and bathroom benchtops in residential houses has expanded rapidly over the last decade. This has been associated …
View article: What Do Safety Data Sheets for Artificial Stone Products Tell Us About Composition? A Comparative Analysis with Physicochemical Data
What Do Safety Data Sheets for Artificial Stone Products Tell Us About Composition? A Comparative Analysis with Physicochemical Data Open
Artificial stone (AS) is a composite material that has seen widespread use in construction, particularly for kitchen benchtops. However, fabrication processes with AS have been associated with serious lung disease. Safety data sheets (SDSs…
View article: Mapping Research on miRNAs in Cancer: A Global Data Analysis and Bibliometric Profiling Analysis
Mapping Research on miRNAs in Cancer: A Global Data Analysis and Bibliometric Profiling Analysis Open
miRNAs biomarkers are emerging as an essential part of clinical oncology. Their oncogenic and tumour suppressor properties playing a role in malignancy has generated interest in their potential for use in disease prognosis. While several s…
View article: Hospital-based multidisciplinary lung cancer care in Australia: a survey of the landscape in 2021
Hospital-based multidisciplinary lung cancer care in Australia: a survey of the landscape in 2021 Open
Introduction Lung cancer is the leading cause of cancer death in Australia and has the highest cancer burden. Numerous reports describe variations in lung cancer care and outcomes across Australia. There are no data assessing compliance wi…
View article: Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol
Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol Open
Background: The microRNAs (miRNAs) are small noncoding single-stranded RNAs typically 19–25 nucleotides long and regulated by cellular and epigenetic factors. These miRNAs plays important part in several pathways necessary for cancer devel…
View article: Clinical comments on “Mental disorder prevalence among populations impacted by coronavirus pandemics: A multilevel meta-analytic study of COVID-19, MERS & SARS”
Clinical comments on “Mental disorder prevalence among populations impacted by coronavirus pandemics: A multilevel meta-analytic study of COVID-19, MERS & SARS” Open
View article: Prognostic Utility of Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Monocyte–Lymphocyte Ratio in Head and Neck Cancers: A Detailed PRISMA Compliant Systematic Review and Meta-Analysis
Prognostic Utility of Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Monocyte–Lymphocyte Ratio in Head and Neck Cancers: A Detailed PRISMA Compliant Systematic Review and Meta-Analysis Open
Inflammation plays a major role in cancer development and progression and has the potential to be used as a prognostic marker in cancer. Previous studies have attempted to evaluate Platelet-to-lymphocyte ratio (PLR), neutrophil–lymphocyte …
View article: Clinical and conceptual comments on “Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis”
Clinical and conceptual comments on “Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis” Open
View article: Prognostic Value of MicroRNAs in Stage II Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
Prognostic Value of MicroRNAs in Stage II Colorectal Cancer Patients: A Systematic Review and Meta-Analysis Open
View article: <p>The Significance of miRNAs as a Prognostic Biomarker for Survival Outcome in T Cell – Acute Lymphoblastic Leukemia Patients: A Systematic Review and Meta-Analysis</p>
The Significance of miRNAs as a Prognostic Biomarker for Survival Outcome in T Cell – Acute Lymphoblastic Leukemia Patients: A Systematic Review and Meta-Analysis Open
Our systematic review and meta-analysis findings suggest that the overall miRNA expression is potentially associated with a decreased likelihood of death in T-ALL patients. Although our findings are inconclusive, the results point toward m…
View article: Preparing for a COVID-19 pandemic: a review of outbreak response measures from Australia perspective
Preparing for a COVID-19 pandemic: a review of outbreak response measures from Australia perspective Open
View article: Clinical Theragnostic Relationship between Drug-Resistance Specific miRNA Expressions, Chemotherapeutic Resistance, and Sensitivity in Breast Cancer: A Systematic Review and Meta-Analysis
Clinical Theragnostic Relationship between Drug-Resistance Specific miRNA Expressions, Chemotherapeutic Resistance, and Sensitivity in Breast Cancer: A Systematic Review and Meta-Analysis Open
Awareness of breast cancer has been increasing due to early detection, but the advanced disease has limited treatment options. There has been growing evidence on the role of miRNAs involved in regulating the resistance in several cancers. …
View article: Key approaches to interpret the findings of a meta-analysis on role of chemotherapy in 5000 patients with head and neck cancer treated by curative surgery
Key approaches to interpret the findings of a meta-analysis on role of chemotherapy in 5000 patients with head and neck cancer treated by curative surgery Open
View article: Prognostic Value of miRNAs in Head and Neck Cancers: A Comprehensive Systematic and Meta-Analysis
Prognostic Value of miRNAs in Head and Neck Cancers: A Comprehensive Systematic and Meta-Analysis Open
Head and Neck Cancer (HNC) is the sixth most common type of cancer across the globe, with more than 300,000 deaths each year, globally. However, there are currently no standardised molecular markers that assist in determining HNC prognosis…
View article: Diagnostic and prognostic role of HE4 expression in multiple carcinomas
Diagnostic and prognostic role of HE4 expression in multiple carcinomas Open
Background: Human epididymis protein 4 (HE4) protein has garnered a great degree of interest as a complementary biomarker to carbohydrate antigen 125 (CA125), or even as an independent biomarker for monitoring, diagnosis, and prognosticati…
View article: miRNA Predictors of Pancreatic Cancer Chemotherapeutic Response: A Systematic Review and Meta-Analysis
miRNA Predictors of Pancreatic Cancer Chemotherapeutic Response: A Systematic Review and Meta-Analysis Open
Background: pancreatic cancer (PC) has increasing incidence and mortality in developing countries, and drug resistance is a significant hindrance to the efficacy of successful treatment. The objective of this systematic review and meta-ana…
View article: Conceptual Interpretation and Clinical Validity of Meta-analysis on Vegetarian-Based Dietary Patterns and Their Relation with Inflammatory and Immune Biomarkers
Conceptual Interpretation and Clinical Validity of Meta-analysis on Vegetarian-Based Dietary Patterns and Their Relation with Inflammatory and Immune Biomarkers Open
View article: Prognostic significance of blood inflammatory biomarkers NLR, PLR, and LMR in cancer—A protocol for systematic review and meta-analysis
Prognostic significance of blood inflammatory biomarkers NLR, PLR, and LMR in cancer—A protocol for systematic review and meta-analysis Open
Background: The neutrophil-lymphocyte-ratio, platelet-lymphocyte-ratio, and monocyte-lymphocyte-ratio have been explored as a simple, inexpensive, and effective method for cancer prognosis. However, there are no studies that have investiga…
View article: <p>Approaches to interpret the outcomes of a network meta-analysis on comparative efficacy of different targeted therapies plus fulvestrant for advanced breast cancer following progression on prior endocrine therapy</p>
Approaches to interpret the outcomes of a network meta-analysis on comparative efficacy of different targeted therapies plus fulvestrant for advanced breast cancer following progression on prior endocrine therapy Open
View article: Comment on “Increased risk of second cancers at sites associated with HPV after a prior HPV-associated malignancy, a systematic review and meta-analysis”
Comment on “Increased risk of second cancers at sites associated with HPV after a prior HPV-associated malignancy, a systematic review and meta-analysis” Open
View article: Validation of miRNA prognostic significance in stage II colorectal cancer
Validation of miRNA prognostic significance in stage II colorectal cancer Open
Background: Advances in early detection and treatment of colorectal cancer (CRC) has seen marked improvements in recent years. However, it is still the third leading cause of cancer-related deaths worldwide. Although there are studies repo…
View article: Prognostic miRNA classifiers in t cell acute lymphoblastic leukemia
Prognostic miRNA classifiers in t cell acute lymphoblastic leukemia Open
Background: The prognostic value of microRNA (miRNA) expression in T-cell acute lymphoblastic leukemia (T-ALL) has generated significant research interest in recent years. However, most diagnostic and prognostic studies with regards to miR…