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View article: Correlates of Protection Against Symptomatic COVID-19: The CORSER 5 Case–Control Study
Correlates of Protection Against Symptomatic COVID-19: The CORSER 5 Case–Control Study Open
Background Establishing correlates of protection often requires large cohorts. A rapid and adaptable case–control study design can be used to identify antibody correlates of protection against severe acute respiratory syndrome coronavirus …
View article: Immunogenicity of a Plasmodium vivax vaccine based on the duffy binding protein formulated using adjuvants compatible for use in humans
Immunogenicity of a Plasmodium vivax vaccine based on the duffy binding protein formulated using adjuvants compatible for use in humans Open
The invasion of reticulocytes by Plasmodium vivax merozoites is dependent on the interaction of the Plasmodium vivax Duffy Binding Protein (PvDBP) with the Duffy antigen receptor for chemokines (DARC). The N-terminal cysteine-rich region I…
View article: T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations Open
Familial adenomatous polyposis (FAP) is an inherited disease characterized by the development of large number of colorectal adenomas with high risk of evolving into colorectal tumors. Mutations of the Adenomatous polyposis coli (APC) gene …
View article: Complement-dependent mpox-virus-neutralizing antibodies in infected and vaccinated individuals
Complement-dependent mpox-virus-neutralizing antibodies in infected and vaccinated individuals Open
View article: Complement-dependent mpox virus-neutralizing antibodies in infected and vaccinated individuals
Complement-dependent mpox virus-neutralizing antibodies in infected and vaccinated individuals Open
Mpox virus (MPXV) caused a multi-country outbreak in non-endemic areas in 2022. The Modified Vaccinia Ankara (MVA)-based vaccine was used as prophylaxis, but its effectiveness remains poorly characterized. Here, we developed two assays for…
View article: The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration
The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration Open
Adenomatous polyposis coli (APC) is a tumor suppressor whose mutations underlie familial adenomatous polyposis (FAP) and colorectal cancer. Although its role in intestinal epithelial cells is well characterized, APC importance in T cell bi…
View article: The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration. Insights from familial polyposis patients
The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration. Insights from familial polyposis patients Open
Adenomatous polyposis coli (APC) is a tumor suppressor whose mutations underlie familial adenomatous polyposis (FAP) and colorectal cancer. Although its role in intestinal epithelial cells is well characterized, APC importance for anti-tum…
View article: Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus
Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus Open
View article: Clinical and pathological data and <i>Human papillomavirus</i> (HPV) status of all oral squamous cell carcinoma (OSCC) cases.
Clinical and pathological data and <i>Human papillomavirus</i> (HPV) status of all oral squamous cell carcinoma (OSCC) cases. Open
View article: Clinical and pathological data and <i>Human papillomavirus</i> (HPV) status of all potentially malignant disorder (PMD) cases.
Clinical and pathological data and <i>Human papillomavirus</i> (HPV) status of all potentially malignant disorder (PMD) cases. Open
View article: Investigation of viral etiology in potentially malignant disorders and oral squamous cell carcinomas in non-smoking, non-drinking patients
Investigation of viral etiology in potentially malignant disorders and oral squamous cell carcinomas in non-smoking, non-drinking patients Open
Head and neck squamous cell carcinomas (HNSCC) are the seventh most frequent cancers. Among HNSCCs, oral squamous cell carcinomas (OSCCs) include several anatomical locations of the oral cavity, but exclude the oropharynx. The known risk f…
View article: The ICAReB Platform: A Human Biobank for the Institut Pasteur and Beyond
The ICAReB Platform: A Human Biobank for the Institut Pasteur and Beyond Open
The ICAReB platform of Institut Pasteur provides access to human bio-resources for academic and private research teams worldwide, essentially in the fields of infection, immunity and neurosciences. More than 134,000 human quality controlle…
View article: Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France
Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France Open
Background Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). Methods We analyzed incidence and clearance of HPV-1…
View article: The rabbit as an orthologous small animal model for APOBEC3A oncogenesis
The rabbit as an orthologous small animal model for APOBEC3A oncogenesis Open
APOBEC3 are cytidine deaminases that convert cytidine to uridine residues. APOBEC3A and APOBEC3B enzymes able to target genomic DNA are involved in oncogenesis of a sizeable proportion of human cancers. While the APOBEC3 locus is co…
View article: Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage
Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage Open
Foreign and self-cytoplasmic DNA are recognized by numerous DNA sensor molecules leading to the production of type I interferons. Such DNA agonists should be degraded otherwise cells would be chronically stressed. Most human APOBEC3 cytidi…
View article: Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme
Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme Open
The human APOBEC3A and APOBEC3B genes (A3A and A3B) encode DNA mutator enzymes that deaminate cytidine and 5-methylcytidine residues in single-stranded DNA (ssDNA). They are important sources of mutations in many cancer genomes which show …