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View article: Study Models for Non-Syndromic Hearing Loss
Study Models for Non-Syndromic Hearing Loss Open
Hearing loss is the most common sensory disorder; It is estimated that nearly 2.5 billion people will have some degree of hearing loss by 2050. Although the causes are diverse, a significant proportion of cases have a genetic origin, which…
View article: A Multimodal and Multi-centric Head and Neck Cancer Dataset for Segmentation, Diagnosis and Outcome Prediction
A Multimodal and Multi-centric Head and Neck Cancer Dataset for Segmentation, Diagnosis and Outcome Prediction Open
We present a publicly available multimodal dataset for head and neck cancer research, comprising 1123 annotated Positron Emission Tomography/Computed Tomography (PET/CT) studies from patients with histologically confirmed disease, acquired…
View article: Comprendre et traiter les surdités génétiques : étude de l'otoferline, et stratégies thérapeutiques utilisant des vecteurs synthétiques
Comprendre et traiter les surdités génétiques : étude de l'otoferline, et stratégies thérapeutiques utilisant des vecteurs synthétiques Open
The aims of this work were to improve our understanding of the pathophysiology of a form of genetic deafness caused by the protein otoferlin, and to explore non-viral vectors for the development of a gene therapy-based treatment. The first…
View article: Robot-Assisted and Manual Cochlear Implantation: An Intra-Individual Study of Speech Recognition
Robot-Assisted and Manual Cochlear Implantation: An Intra-Individual Study of Speech Recognition Open
Cochlear implantation (CI) allows rehabilitation for patients with severe to profound hearing impairment. Although the use of a robotic assistant provides technical assistance to the surgeon, the assessment of the impact of its use on audi…
View article: Robot-Assisted and Manual Cochlear Implantation: An Intra-Individual Study of Speech Recognition
Robot-Assisted and Manual Cochlear Implantation: An Intra-Individual Study of Speech Recognition Open
Cochlear implantation (CI) allows rehabilitation for patients with severe to profound hearing impairment. Although the use of a robotic assistant provides technical assistance to the surgeon, the assessment of the impact of its use on audi…
View article: An Intensive <sup>18</sup>F-Fludeoxyglucose–Positron Emission Tomography With Computed Tomography–Based Strategy of Follow-Up in Patients Treated for Head and Neck Squamous Cell Carcinoma Who Are Clinically Asymptomatic
An Intensive <sup>18</sup>F-Fludeoxyglucose–Positron Emission Tomography With Computed Tomography–Based Strategy of Follow-Up in Patients Treated for Head and Neck Squamous Cell Carcinoma Who Are Clinically Asymptomatic Open
Importance Patients with head and neck squamous cell carcinoma (HNSCC) have a significant risk of locoregional recurrence within the first 2 years, with approximately two-thirds of patients experiencing such recurrence. While early recurre…
View article: Otoferlin as a multirole Ca2+ signaling protein: from inner ear synapses to cancer pathways
Otoferlin as a multirole Ca2+ signaling protein: from inner ear synapses to cancer pathways Open
Humans have six members of the ferlin protein family: dysferlin, myoferlin, otoferlin, fer1L4, fer1L5, and fer1L6. These proteins share common features such as multiple Ca 2+ -binding C2 domains, FerA domains, and membrane anchoring throug…
View article: Ultrasound‐guided hookwire localization of non palpable cervical lymphadenopathy: A case–control study of operative time
Ultrasound‐guided hookwire localization of non palpable cervical lymphadenopathy: A case–control study of operative time Open
Objective We aimed at evaluating the impact of ultrasound‐guided (US) hookwire localization of nonpalpable cervical lymphadenopathy on operating time. Design and Methods Retrospective case control study (January 2017 and May 2021) of 26 pa…
View article: Abscopal Response in Metastatic Melanoma: Real-World Data of a Retrospective, Multicenter Study
Abscopal Response in Metastatic Melanoma: Real-World Data of a Retrospective, Multicenter Study Open
Objective: To evaluate the incidence of the abscopal response (AR) in patients with metastatic melanoma requiring palliative radiotherapy (RT). Patients and methods: Patients treated for metastatic melanoma between January 1998 and Februar…
View article: Comparison of Volumetric Quantitative PET Parameters Before and After a CT-Based Elastic Deformation on Dual-Time 18FDG-PET/CT Images: A Feasibility Study in a Perspective of Radiotherapy Planning in Head and Neck Cancer
Comparison of Volumetric Quantitative PET Parameters Before and After a CT-Based Elastic Deformation on Dual-Time 18FDG-PET/CT Images: A Feasibility Study in a Perspective of Radiotherapy Planning in Head and Neck Cancer Open
Background The use of 18FDG-PET/CT for delineating a gross tumor volume (GTV, also called MTV metabolic tumor volume) in radiotherapy (RT) planning of head neck squamous cell carcinomas (HNSCC) is not included in current recommendations, a…
View article: Case Report: Nasal Cavity Epithelial-Myoepithelial Carcinoma With High Fluoro-D-Glucose Uptake on Positron Emission Tomography/Computed Tomography
Case Report: Nasal Cavity Epithelial-Myoepithelial Carcinoma With High Fluoro-D-Glucose Uptake on Positron Emission Tomography/Computed Tomography Open
Epithelial-myoepithelial carcinoma (EMC) is a rare malignant neoplasm arising most frequently in the salivary glands and exceptionally in the nasal cavity. EMC accounts for ~1–2% of salivary gland tumors. Even if the nodal and distant meta…
View article: <sup>18</sup>F-FDG PET/CT–Based Prognostic Survival Model After Surgery for Head and Neck Cancer
<sup>18</sup>F-FDG PET/CT–Based Prognostic Survival Model After Surgery for Head and Neck Cancer Open
The aims of this multicenter study were to identify clinical and preoperative PET/CT parameters predicting overall survival (OS) and distant metastasis-free survival (DMFS) in a cohort of head and neck squamous cell carcinoma patients trea…
View article: External ear canal exostectomy: influence of surgeon’s experience on 3-years recurrence and occurrence of complications
External ear canal exostectomy: influence of surgeon’s experience on 3-years recurrence and occurrence of complications Open
Background External ear canal exostoses are usually bilateral and broad-based, secondary to external ear canal chronic cold exposure, especially water. Objectives The objectives were to analyze the influence of the surgeon’s experience on …
View article: First Description of Alveolar Rhabdomyosarcoma of the Larynx in a Young Child
First Description of Alveolar Rhabdomyosarcoma of the Larynx in a Young Child Open
Rhabdomyosarcoma of the larynx has been very rarely described in pediatric population. There are 3 histological subtypes: embryonal, pleomorphic, and alveolar. With regard to the English literature, we present the first case of alveolar rh…
View article: Integration of 18-FDG PET/CT in the Initial Work-Up to Stage Head and Neck Cancer: Prognostic Significance and Impact on Therapeutic Decision Making
Integration of 18-FDG PET/CT in the Initial Work-Up to Stage Head and Neck Cancer: Prognostic Significance and Impact on Therapeutic Decision Making Open
Background: The objective of this study was to assess the therapeutic and prognostic impact of integrating18F-fluorodeoxyglucose (18-FDG) positron emission tomography (PET)/computed tomography (CT) into work-up (WU) at initial staging of p…
View article: Correlation Between FDG Hotspots on Pre-radiotherapy PET/CT and Areas of HNSCC Local Relapse: Impact of Treatment Position and Images Registration Method
Correlation Between FDG Hotspots on Pre-radiotherapy PET/CT and Areas of HNSCC Local Relapse: Impact of Treatment Position and Images Registration Method Open
Aim: Several series have already demonstrated that intratumoral subvolumes with high tracer avidity (hotspots) in 18F-flurodesoxyglucose positron-emission tomography (FDG-PET/CT) are preferential sites of local recurrence (LR) in various s…
View article: Management of neonatal retro-auricular embryonal rhabdomyosarcoma – Case report
Management of neonatal retro-auricular embryonal rhabdomyosarcoma – Case report Open
Introduction Rhabdomyosarcoma (RMS) arises from mesenchymal cells committed to skeletal muscle. It is the most frequent soft-tissue sarcoma in children and makes up 5% of all pediatric malignant tumors. In this population, there are two ma…