Christophe Legendre
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View article: Genetic screening in kidney transplant candidates
Genetic screening in kidney transplant candidates Open
Introduction The origin of chronic kidney disease (CKD) remains unknown in around 16% of patients at the time of renal replacement therapy. The aim of this study was to assess the proportion of monogenic kidney diseases in kidney transplan…
View article: Impact of Muscle Mass on the Performance of Creatinine‐Based eGFR Equations and Mortality Risk Assessment After Kidney Transplantation
Impact of Muscle Mass on the Performance of Creatinine‐Based eGFR Equations and Mortality Risk Assessment After Kidney Transplantation Open
Background Estimating glomerular filtration rate (eGFR) in kidney transplant recipients (KTR) typically relies on plasma creatinine, which is influenced by muscle mass. Reduced muscle mass is suspected to reduce eGFR performance in this po…
View article: Shiga Toxin–Producing Escherichia coli–Associated Hemolytic Uremic Syndrome in Adult Kidney Transplant Recipients
Shiga Toxin–Producing Escherichia coli–Associated Hemolytic Uremic Syndrome in Adult Kidney Transplant Recipients Open
This study highlights that STEC-HUS represents a serious complication in KTRs, significantly impairing renal and overall survival. It should be systematically considered in cases of de novo posttransplant TMA, whether in the absence…
View article: Somatic PIK3R1 mutations in the iSH2 domain are accessible to PI3Kα inhibition
Somatic PIK3R1 mutations in the iSH2 domain are accessible to PI3Kα inhibition Open
View article: Rapid On-Site Histopathological Analysis of Kidney Biopsy With Dynamic Full-Field Optical Coherence Tomography
Rapid On-Site Histopathological Analysis of Kidney Biopsy With Dynamic Full-Field Optical Coherence Tomography Open
This study demonstrates the potential of D-FF-OCT imaging for on-site analysis of kidney biopsies, providing rapid and high-resolution images without extensive sample preparation.
View article: Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR
Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR Open
View article: Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus
Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus Open
Highly sensitized (HS) patients in need of kidney transplantation (KTx) typically spend a longer time waiting for compatible kidneys, are unlikely to receive an organ offer, and are at increased risk of antibody-mediated rejection (AMR). D…
View article: Long-term outcomes at 5 years posttransplant in imlifidase-desensitized kidney transplant patients
Long-term outcomes at 5 years posttransplant in imlifidase-desensitized kidney transplant patients Open
View article: Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate
Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate Open
View article: Transforming kidney transplant monitoring with urine CXCL9 and CXCL10: practical clinical implementation
Transforming kidney transplant monitoring with urine CXCL9 and CXCL10: practical clinical implementation Open
View article: Estimating glomerular filtration in young people
Estimating glomerular filtration in young people Open
Background Creatinine-based equations are the most used to estimate glomerular filtration rate (eGFR). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), the re-expressed Lund-Malmö Revised (r-LMR) and the European Kidney Fun…
View article: A Randomized Trial Comparing Imlifidase to Plasmapheresis in Kidney Transplant Recipients With Antibody‐Mediated Rejection
A Randomized Trial Comparing Imlifidase to Plasmapheresis in Kidney Transplant Recipients With Antibody‐Mediated Rejection Open
Background Antibody‐mediated rejection (ABMR) poses a barrier to long‐term graft survival and is one of the most challenging events after kidney transplantation. Removing donor specific antibodies (DSA) through therapeutic plasma exchange …
View article: Targeted therapy for capillary-venous malformations
Targeted therapy for capillary-venous malformations Open
Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK , an endothelial transmembrane receptor signaling through PIK3CA. Venous malformations are associated with pain, bl…
View article: PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis
PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis Open
Proliferative glomerulonephritis is a severe condition that often leads to kidney failure. There is a significant lack of effective treatment for these disorders. Here, following the identification of a somatic PIK3CA gain-of-function muta…
View article: Prophylactic treatment of FSGS recurrence in patients who relapsed on a previous kidney graft
Prophylactic treatment of FSGS recurrence in patients who relapsed on a previous kidney graft Open
Background Recurrence of focal segmental glomerulosclerosis (FSGS) is common after kidney transplantation and is classically associated with a significant decrease in graft survival. A major risk factor is a prior history of FSGS recurrenc…
View article: The impact of competing risks in kidney allograft failure prediction
The impact of competing risks in kidney allograft failure prediction Open
Background Prognostic models are becoming increasingly relevant in clinical trials as potential surrogate endpoints, and for patient management as clinical decision support tools. However, the impact of competing risks on model performance…
View article: Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection
Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection Open
There is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov study (ClinicalTrials.gov, NCT03582436), an unselected deeply phenotyped cohort of kidney transplant recipie…
View article: De novo thrombotic microangiopathy after kidney transplantation in adults: Interplay between complement genetics and multiple endothelial injury
De novo thrombotic microangiopathy after kidney transplantation in adults: Interplay between complement genetics and multiple endothelial injury Open
De novo thrombotic microangiopathy (dnTMA), after renal transplantation may significantly alter graft outcomes. However, its pathogenesis and the role of complement alternative pathway dysregulation remain elusive. We studied all consecuti…
View article: Long-Term Outcomes after Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant Recipients
Long-Term Outcomes after Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant Recipients Open
Background Conversion to a belatacept-based immunosuppression is currently used as a calcineurin inhibitor (CNI) avoidance strategy when the CNI-based standard-of-care immunosuppression is not tolerated after kidney transplantation. Howeve…
View article: A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients
A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients Open
View article: Kidney Transplantation in Patients With AA Amyloidosis: Outcomes in a French Multicenter Cohort
Kidney Transplantation in Patients With AA Amyloidosis: Outcomes in a French Multicenter Cohort Open
View article: Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition Open
Hemifacial myohyperplasia (HFMH) is a rare cause of facial asymmetry exclusively involving facial muscles. The underlying cause and the mechanism of disease progression are unknown. Here, we identified a somatic gain-of-function mutation o…
View article: Routine surveillance of kidney allograft rejection using a fully automated urinary CXCL9 and CXCL10 immunoassay
Routine surveillance of kidney allograft rejection using a fully automated urinary CXCL9 and CXCL10 immunoassay Open
Background For kidney transplant recipients, assessing non-invasively the individualized risk of acute rejection is one of the most unmet need. Urinary chemokines are one of the short-term most promising biomarkers, because of their simple…
View article: Conversion From Intravenous In-Hospital Belatacept Injection to Subcutaneous Abatacept Injection in Kidney Transplant Recipients During the First COVID-19 Stay-at-Home Order in France
Conversion From Intravenous In-Hospital Belatacept Injection to Subcutaneous Abatacept Injection in Kidney Transplant Recipients During the First COVID-19 Stay-at-Home Order in France Open
The first COVID-19 stay-at-home order came into effect in France on 17 March 2020. Immunocompromised patients were asked to isolate themselves, and outpatient clinic visits were dramatically reduced. In order to avoid visits to the hospita…
View article: #5465 RACE-FREE EGFR EQUATION IN KIDNEY RECIPIENTS: A DEVELOPMENT AND VALIDATION STUDY
#5465 RACE-FREE EGFR EQUATION IN KIDNEY RECIPIENTS: A DEVELOPMENT AND VALIDATION STUDY Open
Background and Aims To assess the performances of the current eGFR equations, including the race-free CKD-EPI-2021, in the kidney transplant population, and compare these performances to a race-free kidney-recipient-specific (KRS) GFR equa…
View article: #6894 KIDNEY TRANSPLANTATION IN PATIENTS WITH AA AMYLOIDOSIS: A FRENCH MULTI-CENTER MATCHED COHORT STUDY IN THE ERA OF BIOTHERAPIES
#6894 KIDNEY TRANSPLANTATION IN PATIENTS WITH AA AMYLOIDOSIS: A FRENCH MULTI-CENTER MATCHED COHORT STUDY IN THE ERA OF BIOTHERAPIES Open
Background and Aims Outcomes of kidney transplantation for patients with renal AA amyloidosis are uncertain, with reports of poor survival and high allograft recurrence. However, recent advances in biotherapies, especially anti-IL-1 treatm…
View article: #3743 MULTIDIMENSIONAL RISK ASSESSMENT OF KIDNEY ALLOGRAFT REJECTION USING DONOR DERIVED CELL-FREE DNA
#3743 MULTIDIMENSIONAL RISK ASSESSMENT OF KIDNEY ALLOGRAFT REJECTION USING DONOR DERIVED CELL-FREE DNA Open
Background and Aims Post-transplantation patient care requires development and validation of non-invasive biomarkers to improve allograft monitoring and prevention from unnecessary and costly biopsies. Reports have suggested the associatio…
View article: Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study
Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study Open
Objective To compare the performance of a newly developed race-free kidney recipient specific glomerular filtration rate (GFR) equation with the three current main equations for measuring GFR in kidney transplant recipients. Design Develop…
View article: Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference Open
View article: Immunogenicity of Anti-SARS-CoV-2 Vaccination After Kidney Transplantation in Kidney Transplant Recipients Vaccinated Before Transplantation
Immunogenicity of Anti-SARS-CoV-2 Vaccination After Kidney Transplantation in Kidney Transplant Recipients Vaccinated Before Transplantation Open
Solid-organ transplant patients, including kidney transplant recipients (KTRs) are at high risk of severe forms of coronavirus disease 2019 (COVID-19) infection1 and fail to mount a robust and sustained humoral response to COVID-19 vaccine…