Clement Wilfred Devadass
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View article: Programmed Death-Ligand 1 Immunoexpression in Triple Negative Breast Carcinoma in South Indian Women: A Cross-sectional Study at a Tertiary Care Centre
Programmed Death-Ligand 1 Immunoexpression in Triple Negative Breast Carcinoma in South Indian Women: A Cross-sectional Study at a Tertiary Care Centre Open
Introduction: Triple Negative Breast Cancer (TNBC) comprises 10-20% of all breast cancer cases and is characterised by a lack of differentiation, subpar response to therapy and a low survival rate. Programmed Death-Ligand 1 (PD-L1) is a ty…
View article: Agreement between Ki-67 Proliferative Index in Breast Cancer by Conventional Hotspot Method and International Ki-67 in Breast Cancer Working Group Global Scoring Method: A Cross-sectional Study
Agreement between Ki-67 Proliferative Index in Breast Cancer by Conventional Hotspot Method and International Ki-67 in Breast Cancer Working Group Global Scoring Method: A Cross-sectional Study Open
Introduction: The role of the Ki-67 Proliferative Index (PI) in the molecular classification and as a predictive and prognostic biomarker in breast cancer is definitive. To address the inconsistency in Ki-67 interpretation and scoring, the…
View article: CD10 Expression in Colorectal Adenoma and Carcinoma and Its Association with the Pathological Prognostic Factors
CD10 Expression in Colorectal Adenoma and Carcinoma and Its Association with the Pathological Prognostic Factors Open
The results indicate a potential role of CD10 in the adenoma-carcinoma sequence. The significant increase in proliferating and high-grade CRCs suggests that CD10 could prove to be a potential biomarker for aggressiveness and also a therape…
View article: Breast Carcinoma: Correlation of Molecular Subtypes with Histopathologic Characteristics
Breast Carcinoma: Correlation of Molecular Subtypes with Histopathologic Characteristics Open
Context: Breast carcinoma is a heterogenous disease and similar histological subtypes may exhibit different behavior and treatment response. The molecular classification may provide better prognostic, predictive and therapeutic information…
View article: Histopathological Evaluation and Analysis of Immunohistochemical Markers p53 and CD44S in Renal Cell Carcinoma: A Cross-sectional Study
Histopathological Evaluation and Analysis of Immunohistochemical Markers p53 and CD44S in Renal Cell Carcinoma: A Cross-sectional Study Open
Introduction: Renal Cell Carcinoma (RCC) is the 9th and 14th most common cancer in men and women, respectively, and among the most lethal urological cancers. Upto 30% of patients experience recurrence within five years postnephrectomy. The…
View article: Histopathological Evaluation of Cardiac Lesions in Autopsy Specimens
Histopathological Evaluation of Cardiac Lesions in Autopsy Specimens Open
context: Evaluation of cardiac autopsy specimens is crucial for identifying concealed cardiovascular pathology and providing insights into the pathogenesis and progression of disease. Hence, this study was undertaken to evaluate the histop…
View article: Innovative Application of Ziplock Tags for External Tissue Expansion
Innovative Application of Ziplock Tags for External Tissue Expansion Open
Tissue expansion is a technique, which uses the biomechanical properties of skin and thereby aiding in wound closure. Commercially available devices for external expansion are not cost-effective. Hence, in this article, we would like to sh…
View article: Evaluation of Histopathological Spectrum of Hepatic Lesions in Liver Biopsies: A Two Years Prospective Study
Evaluation of Histopathological Spectrum of Hepatic Lesions in Liver Biopsies: A Two Years Prospective Study Open
Introduction: Liver biopsy is an important diagnostic tool that assists determination of specific diagnoses and directs therapeutic decisions in patients with acute and chronic liver diseases. It can also be used to estimate the degree of …
View article: Histopathologic patterns of nonrejection injury in renal allograft biopsies and their clinical characteristics; a single centre south Indian study
Histopathologic patterns of nonrejection injury in renal allograft biopsies and their clinical characteristics; a single centre south Indian study Open
Introduction: Graft dysfunction (GD) is the major complication of renal transplantation, and may result in graft loss. The major causes of GD are immunological rejection and non-rejection injury (NRI), which have different prognostic and t…
View article: Comparison of Clinicopathological Profile of Oral Squamous Cell Carcinoma between Younger and Older Indian Adults
Comparison of Clinicopathological Profile of Oral Squamous Cell Carcinoma between Younger and Older Indian Adults Open
Introduction: The relative incidence of Oral Squamous Cell Carcinoma (OSCC) seems to be increasing in young subjects and there is still no consensus regarding its pathogenesis, clinicopathological characteristics and prognosis in this popu…
View article: Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma
Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma Open
Introduction: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-…
View article: Renal Dysplasia: A 6 Year Retrospective Study with Clinicopathological Correlation
Renal Dysplasia: A 6 Year Retrospective Study with Clinicopathological Correlation Open
Bakground: Renal dysplasia (RD) is rare congenital disease resulting from anomalous development of metanephric elements. The objective of the study was to evaluate the clinicopathologic features of RD with emphasis on the morphological cha…
View article: Adenosquamous Variant of Metaplastic Carcinoma of Breast
Adenosquamous Variant of Metaplastic Carcinoma of Breast Open
View article: Histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics; a single center study from South India
Histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics; a single center study from South India Open
Background: The histologic pattern causing nephrotic syndrome (NS) and their clinical outcome varies depending on age, sex, race, socioeconomic status and geographic location. There has been a changing trend in the histologic spectrum of N…
View article: Fetal Autopsies and its Significance: A Tertiary Care Center Study
Fetal Autopsies and its Significance: A Tertiary Care Center Study Open
View article: Primary Amyloidosis - In a Case with Normal Plasma Cell Counts
Primary Amyloidosis - In a Case with Normal Plasma Cell Counts Open
Amyloidosis is a group of disease that is characterized by the deposition of extracellular abnormal proteinaceous material (amyloid), in various organs. Amyloidosis involving the liver is common and the radiological findings are often nons…
View article: Clinicopathological evaluation of Prostatic Adenocarcinoma: A unicenter study
Clinicopathological evaluation of Prostatic Adenocarcinoma: A unicenter study Open
Background: Prostate cancer is a significant cause of morbidity and mortality. It ranks fifth in cancer incidence and fourth in cancer mortality in India. As the literature on the issue in India is limited, we undertook the study with the…
View article: Histomorphologic Pattern of Renal Disease in Patients with Acute Nephritic syndrome: A Single Centre South Indian Study
Histomorphologic Pattern of Renal Disease in Patients with Acute Nephritic syndrome: A Single Centre South Indian Study Open
Background: The frequency and distribution of primary and secondary glomerular disorders presenting as acute nephritic syndrome (ANS) varies according to the geographic and racial characteristics, renal biopsy practices and patient selec…
View article: Clinical features and histological patterns of lupus nephritis in a single center of South India
Clinical features and histological patterns of lupus nephritis in a single center of South India Open
Renal involvement occurs in up to 60% of patients with systemic lupus erythematosus (SLE) and signifies a poor prognosis. The class of lupus nephritis (LN), determined on renal biopsy evaluation, guides the therapeutic management and has p…
View article: Histopatholgical Spectrum of Changes in Post Neoadjuvant Chemotherapy Treated Rectal Carcinoma: Single Center Study
Histopatholgical Spectrum of Changes in Post Neoadjuvant Chemotherapy Treated Rectal Carcinoma: Single Center Study Open
View article: Clinicopathological Evaluation of Colorectal Carcinoma: A Unicenter Study
Clinicopathological Evaluation of Colorectal Carcinoma: A Unicenter Study Open
View article: Evaluation of Renal Allograft Biopsies for Graft Dysfunction and Relevance of C4d Staining in Antibody Mediated Rejection
Evaluation of Renal Allograft Biopsies for Graft Dysfunction and Relevance of C4d Staining in Antibody Mediated Rejection Open
AMR and CNI Toxicity account for majority of graft dysfunction. C4d is not as sensitive a marker of AMR, as was initially thought. Higher proportion of moderate microvascular inflammation is found in diffuse C4d positive cases compared to …
View article: Clinical features and histological patterns of lupus nephritis in a single center of South India
Clinical features and histological patterns of lupus nephritis in a single center of South India Open
Renal involvement occurs in up to 60% of patients with systemic lupus erythematosus (SLE) and signifies a poor prognosis. The class of lupus nephritis (LN), determined on renal biopsy evaluation, guides the therapeutic management and has p…
View article: Malignant phyllodes tumor with heterologous differentiation
Malignant phyllodes tumor with heterologous differentiation Open
Sarcomas of the breast are rare neoplasms accounting for less than 1% of breast malignancy. A 40-year-old-female with left breast mass underwent wide-excision and on histopathological examination a diagnosis of malignant phyllodes tumor wi…