Chwee Teck Lim
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View article: Advances in machine learning–enhanced microfluidic cell sorting
Advances in machine learning–enhanced microfluidic cell sorting Open
Cell sorting, essential for diagnostics and early intervention, has evolved from conventional methods to sophisticated microfluidic approaches. These miniaturized systems leverage precise hydrodynamic control, facilitating major advances i…
View article: A plasmonic and intelligent sweat sensing patch for large‐scale health monitoring
A plasmonic and intelligent sweat sensing patch for large‐scale health monitoring Open
The need for rapid and comprehensive health monitoring is especially critical during health crises involving chronic diseases of epidemic proportions or infectious disease outbreaks. Sweat testing offers a rapid, in situ, and noninvasive a…
View article: Urgent needs, opportunities and challenges of virtual reality in healthcare and medicine in the era of large language models
Urgent needs, opportunities and challenges of virtual reality in healthcare and medicine in the era of large language models Open
The convergence of large language models (LLMs) and virtual reality (VR) technologies has led to significant breakthroughs across multiple domains, particularly in healthcare and medicine. Owing to its immersive and interactive capabilitie…
View article: Advancements and challenges in culturing patient-derived cancer cells for personalized therapeutics
Advancements and challenges in culturing patient-derived cancer cells for personalized therapeutics Open
Patient-derived cancer cells (PDCCs) have emerged as a key strategy for advancing personalized cancer treatment. Unlike traditional cancer cell lines, PDCCs retain the genetic and phenotypic characteristics of the patient’s original tumor …
View article: TRPM7–Annexin A1 Mechanosensitive Pathway Drives Capillary Infiltration by Circulating Tumor Cells
TRPM7–Annexin A1 Mechanosensitive Pathway Drives Capillary Infiltration by Circulating Tumor Cells Open
Successful metastatic dissemination requires tumor cells to overcome significant physical barriers. When circulating tumor cells (CTCs) become lodged in capillary beds, studies reveal that only a small subset can adapt to fluid shear stres…
View article: Strain‐Sensitive Thermochromic Smart Electronic Skin for Joint and Spine Healthcare Applications
Strain‐Sensitive Thermochromic Smart Electronic Skin for Joint and Spine Healthcare Applications Open
Electronic skins (E‐skins) that enable interactive and quantitative joint and spine healthcare hold transformative potential for personalized musculoskeletal rehabilitation. However, existing systems face three critical limitations: conven…
View article: An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial
An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial Open
Adolescents with obesity face numerous health risks and encounter barriers that lead to physical inactivity. We developed a virtual reality sports system, named REVERIE (Real-World Exercise and VR-Based Exercise Research in Education), whi…
View article: A Computationally Efficient Viscoelastic Eukaryotic Cell Model
A Computationally Efficient Viscoelastic Eukaryotic Cell Model Open
Purpose Modeling eukaryotic cell flow in microfluidic devices and capillary networks can be instrumental in assessing how cell mechanics influence its behavior. Due to the viscoelastic characteristics of cells and their capacity for substa…
View article: Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells
Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells Open
Chromatin architecture is critical in determining nuclear mechanics. Most studies focus on the mechanical rigidity conferred by chromatin condensation from densely packed heterochromatin, but less is known on how transient chromatin decomp…
View article: Dynamics of Spatial Organization of Bacterial Communities in a Tunable Flow Gut Microbiome‐on‐a‐Chip
Dynamics of Spatial Organization of Bacterial Communities in a Tunable Flow Gut Microbiome‐on‐a‐Chip Open
The human intestine, a biomechanically active organ, generates cyclic mechanical forces crucial for maintaining its health and functions. Yet, the physiological impact of these forces on gut microbiota dynamics remains largely unexplored. …
View article: Transforming Healthcare: Intelligent Wearable Sensors Empowered by Smart Materials and Artificial Intelligence
Transforming Healthcare: Intelligent Wearable Sensors Empowered by Smart Materials and Artificial Intelligence Open
Intelligent wearable sensors, empowered by machine learning and innovative smart materials, enable rapid, accurate disease diagnosis, personalized therapy, and continuous health monitoring without disrupting daily life. This integration fa…
View article: Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells
Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells Open
Chromatin architecture is critical in determining nuclear mechanics. Most studies focus on the mechanical rigidity conferred by chromatin compaction from densely packed heterochromatin, but less is known on how transient changes in chromat…
View article: Microfluidics for morpholomics and spatial omics applications
Microfluidics for morpholomics and spatial omics applications Open
Created in BioRender. Menon, N. (2025). https://www.BioRender.com/l48m487.
View article: Laser-induced graphene for biomedical applications: innovations in health monitoring and diagnostics
Laser-induced graphene for biomedical applications: innovations in health monitoring and diagnostics Open
This review explores laser-induced graphene as a versatile sensing material for multifunctional biomedical sensors, emphasizing its synthesis, properties, and advances in health monitoring and diagnostics.
View article: Topographic cues regulate collective cell dynamics in curved nano/microgrooved tubular microchannels
Topographic cues regulate collective cell dynamics in curved nano/microgrooved tubular microchannels Open
This study introduces tubular microchannels with micro/nanoscale grooves, fabricated by two-photon polymerization, to investigate how curvature with defined topography influences collective epithelial migration using live imaging and deep …
View article: Atomic force microscopy in the characterization and clinical evaluation of neurological disorders: current and emerging technologies
Atomic force microscopy in the characterization and clinical evaluation of neurological disorders: current and emerging technologies Open
This review examines the significant role of Atomic Force Microscopy (AFM) in neurobiological research and its emerging clinical applications in diagnosing neurological disorders and central nervous system (CNS) tumours. AFM, known for its…
View article: Insights into the mechanobiology of cancer metastasis via microfluidic technologies
Insights into the mechanobiology of cancer metastasis via microfluidic technologies Open
During cancer metastasis, cancer cells will encounter various microenvironments with diverse physical characteristics. Changes in these physical characteristics such as tension, stiffness, viscosity, compression, and fluid shear can genera…
View article: Correction to “Encapsulation of Human Spinal Cord Progenitor Cells in Hyaluronan-Gelatin Hydrogel for Spinal Cord Injury Treatment”
Correction to “Encapsulation of Human Spinal Cord Progenitor Cells in Hyaluronan-Gelatin Hydrogel for Spinal Cord Injury Treatment” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Encapsulation of Human Spinal Cord Progenitor Cells in Hyaluronan-Gelatin Hydrogel for Spinal Cord Injury Treatment"C…
View article: Interstitial fluid-based wearable biosensors for minimally invasive healthcare and biomedical applications
Interstitial fluid-based wearable biosensors for minimally invasive healthcare and biomedical applications Open
Interstitial fluid (ISF), a biological fluid rich in diverse biomarkers and analytes and similar to blood composition, has garnered significant attention as a valuable source of clinically relevant information. Consequently, ISF-based wear…
View article: Dissecting Gut‐Microbial Community Interactions using a Gut Microbiome‐on‐a‐Chip
Dissecting Gut‐Microbial Community Interactions using a Gut Microbiome‐on‐a‐Chip Open
While the human gut microbiota has a significant impact on gut health and disease, understanding of the roles of gut microbes, interactions, and collective impact of gut microbes on various aspects of human gut health is limited by the lac…
View article: Multiplex Profiling of Biomarker and Drug Uptake in Single Cells Using Microfluidic Flow Cytometry and Mass Spectrometry
Multiplex Profiling of Biomarker and Drug Uptake in Single Cells Using Microfluidic Flow Cytometry and Mass Spectrometry Open
To perform multiplex profiling of single cells and eliminate the risk of potential sample loss caused by centrifugation, we developed a microfluidic flow cytometry and mass spectrometry system (μCytoMS) to evaluate the drug uptake and indu…
View article: Potential of bioprinted intestine-on-chip models in advancing understanding of human coronavirus infections and drug screening
Potential of bioprinted intestine-on-chip models in advancing understanding of human coronavirus infections and drug screening Open
Human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contribute to both respiratory and gastrointestinal symptoms, necessitating a comprehensive approach to studying viral pathogenesis. In this conte…
View article: Author Response: Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion
Author Response: Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion Open
Epithelial cell extrusion is employed in maintaining a healthy epithelium. It remains unclear how environmental conditions specific to various epithelial tissues, such as geometry and fluid osmolarity, affect cell extrusions. We found that…