Mark C. Butcher
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View article: The butterfly effect: collateral damage and impacts of antimicrobial strategies on the oral microbiome
The butterfly effect: collateral damage and impacts of antimicrobial strategies on the oral microbiome Open
View article: Dry Surface Biofilm Formation by <i>Candida auris</i> Facilitates Persistence and Tolerance to Sodium Hypochlorite
Dry Surface Biofilm Formation by <i>Candida auris</i> Facilitates Persistence and Tolerance to Sodium Hypochlorite Open
Candida auris is an enigmatic fungal pathogen, recently elevated as a critical priority group pathogen by the World Health Organisation, linked with its ability to cause outbreaks within nosocomial care units, facilitated through environme…
View article: Lactams Exhibit Potent Antifungal Activity Against Monospecies and Multispecies Interkingdom Biofilms on a Novel Hydrogel Skin Model
Lactams Exhibit Potent Antifungal Activity Against Monospecies and Multispecies Interkingdom Biofilms on a Novel Hydrogel Skin Model Open
Infections of intact and damaged skin barriers and keratin are frequently associated with complex biofilm communities containing bacteria and fungi, yet there are limited options for successful management. This study intended to focus on t…
View article: The Effect of Chitosan Incorporation on Physico-Mechanical and Biological Characteristics of a Calcium Silicate Filling Material
The Effect of Chitosan Incorporation on Physico-Mechanical and Biological Characteristics of a Calcium Silicate Filling Material Open
Objectives: A tricalcium silicate-based cement, Biodentine™, has displayed antibiofilm activity when mixed with chitosan powder. This study aimed to assess the effect of chitosan incorporation on the physico-mechanical and biological prope…
View article: Dry surface biofilm formation by<i>Candida auris</i>facilitates persistence and tolerance to sodium hypochlorite
Dry surface biofilm formation by<i>Candida auris</i>facilitates persistence and tolerance to sodium hypochlorite Open
Candida auris is an enigmatic fungal pathogen, recently elevated to the critical priority group of pathogens by the World Health Organization. Of key concern is its ability to cause outbreaks within intensive and chronic care units, facili…
View article: Staphylococcus aureus strains exhibit heterogenous tolerance to direct cold atmospheric plasma therapy
Staphylococcus aureus strains exhibit heterogenous tolerance to direct cold atmospheric plasma therapy Open
The global clinical and socioeconomic impact of chronic wounds is substantial. The main difficulty that clinicians face during the treatment of chronic wounds is the risk of infection at the wound site. Infected wounds arise from an accumu…
View article: Limitations of using <scp>16S rRNA</scp> microbiome sequencing to predict oral squamous cell carcinoma
Limitations of using <span>16S rRNA</span> microbiome sequencing to predict oral squamous cell carcinoma Open
A new era of next‐generation sequencing has changed our perception of the oral microbiome in health and disease, and with this there is a growing understanding that the oral microbiome is a contributing factor to oral squamous cell carcino…
View article: Generation of Multispecies Oral Bacteria Biofilm Models
Generation of Multispecies Oral Bacteria Biofilm Models Open
View article: Meta‐analysis of caries microbiome studies can improve upon disease prediction outcomes
Meta‐analysis of caries microbiome studies can improve upon disease prediction outcomes Open
As one of the most prevalent infective diseases worldwide, it is crucial that we not only know the constituents of the oral microbiome in dental caries but also understand its functionality. Herein, we present a reproducible meta‐analysis …
View article: Investigating Dual-Species Candida auris and Staphylococcal Biofilm Antiseptic Challenge
Investigating Dual-Species Candida auris and Staphylococcal Biofilm Antiseptic Challenge Open
Candida auris can persistently colonize human skin, alongside a diverse bacterial microbiome. In this study we aimed to investigate the efficacy of antiseptic activities on dual-species interkingdom biofilms containing staphylococci to det…
View article: The denture microbiome in health and disease: an exploration of a unique community
The denture microbiome in health and disease: an exploration of a unique community Open
The United Nations suggests the global population of denture wearers (an artificial device that acts as a replacement for teeth) is likely to rise significantly by the year 2050. Dentures become colonized by microbial biofilms, the composi…
View article: An In Vitro Evaluation of Denture Cleansing Regimens against a Polymicrobial Denture Biofilm Model
An In Vitro Evaluation of Denture Cleansing Regimens against a Polymicrobial Denture Biofilm Model Open
Denture stomatitis (DS) is an inflammatory disease resulting from a polymicrobial biofilm perturbation at the denture surface–palatal mucosa interface. Recommendations made by dental health care professionals often lack clarity for appropr…
View article: Chitosan Enhances the Anti-Biofilm Activity of Biodentine against an Interkingdom Biofilm Model
Chitosan Enhances the Anti-Biofilm Activity of Biodentine against an Interkingdom Biofilm Model Open
Endodontic infection is a biofilm disease that is difficult to irradicate with current treatment protocols, and as such, persistent micro-organisms may lead to ongoing or recurrent disease. The potential for the use of enhanced filling mat…
View article: Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris
Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris Open
Candida auris provides a substantial global nosocomial threat clinically. With the recent emergence that the organism can readily colonize skin niches, it will likely continue to pose a risk in health care units, particularly to patients u…
View article: Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicans
Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicans Open
The highly conserved, ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. In human pathogenic fungi, which kill more than 1.6 million patients each year worldwide, Hsp90 gove…
View article: Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms
Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms Open
Calcium sulfate (CS) has been used clinically as a bone- or void-filling biomaterial, and its resorptive properties have provided the prospect for its use as a release mechanism for local antibiotics to control biofilms. Here, we aimed to …
View article: Correction for Arias et al., “Chitosan Ameliorates Candida auris Virulence in a Galleria mellonella Infection Model”
Correction for Arias et al., “Chitosan Ameliorates Candida auris Virulence in a Galleria mellonella Infection Model” Open
View article: Filling the Void: An Optimized Polymicrobial Interkingdom Biofilm Model for Assessing Novel Antimicrobial Agents in Endodontic Infection
Filling the Void: An Optimized Polymicrobial Interkingdom Biofilm Model for Assessing Novel Antimicrobial Agents in Endodontic Infection Open
There is a growing realization that endodontic infections are often polymicrobial, and may contain Candida spp. Despite this understanding, the development of new endodontic irrigants and models of pathogenesis remains limited to mono-spec…
View article: A novel Hsp90 phospho-switch modulates virulence in the major human fungal pathogen<i>Candida albicans</i>
A novel Hsp90 phospho-switch modulates virulence in the major human fungal pathogen<i>Candida albicans</i> Open
The ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. Hsp90 also regulates cellular morphogenesis, drug resistance, and virulence in human pathogenic fungi, which kill more…
View article: Candida auris Phenotypic Heterogeneity Determines Pathogenicity <i>In Vitro</i>
Candida auris Phenotypic Heterogeneity Determines Pathogenicity <i>In Vitro</i> Open
Candida auris has recently emerged as an important cause of concern within health care environments due to its ability to persist and tolerate commonly used antiseptics and disinfectants, particularly when attached to a surface (biofilms).…
View article: Chitosan Ameliorates Candida auris Virulence in a Galleria mellonella Infection Model
Chitosan Ameliorates Candida auris Virulence in a Galleria mellonella Infection Model Open
Candida auris has emerged as a multidrug-resistant nosocomial pathogen over the last decade. Outbreaks of the organism in health care facilities have resulted in life-threatening invasive candidiasis in over 40 countries worldwide. Resista…
View article: <i>Candida auris</i>phenotypic heterogeneity determines pathogenicity<i>in vitro</i>
<i>Candida auris</i>phenotypic heterogeneity determines pathogenicity<i>in vitro</i> Open
Candida auris is an enigmatic yeast that provides substantial global risk in healthcare facilities and intensive care units. A unique phenotype exhibited by certain isolates of C. auris is their ability to form small clusters of cells know…
View article: A nanocarrier system that potentiates the effect of miconazole within different interkingdom biofilms
A nanocarrier system that potentiates the effect of miconazole within different interkingdom biofilms Open
In conclusion, the IONPs-CS-MCZ nanocarrier was efficient against three in vitro models of pathogenic oral biofilms, showing potential to possibly interfere in the synergistic interactions among fungal and bacterial cells within pol…
View article: Assessing the bioactive profile of anti-fungal loaded Calcium sulphate
Assessing the bioactive profile of anti-fungal loaded Calcium sulphate Open
Biomaterials, natural or synthetic materials that have been adapted for clinical use, have been a historically important tool in the development of care regimen for many years. In order to be considered successful, the material must be str…
View article: Polymicrobial oral biofilm models: simplifying the complex
Polymicrobial oral biofilm models: simplifying the complex Open
Over the past century, numerous studies have used oral biofilm models to investigate growth kinetics, biofilm formation, structure and composition, antimicrobial susceptibility and host-pathogen interactions. In vivo animal models p…