Rajesh C. Miranda
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View article: Perinatal and prenatal alcohol exposure impairs striatal cholinergic function and cognitive flexibility in adult offspring
Perinatal and prenatal alcohol exposure impairs striatal cholinergic function and cognitive flexibility in adult offspring Open
Fetal Alcohol Spectrum Disorder (FASD), caused by perinatal alcohol exposure (PeAE) and prenatal alcohol exposure (PAE), is characterized by significant cognitive impairments, including reduced cognitive flexibility. Despite the critical r…
View article: Early life outcomes of prenatal exposure to alcohol and synthetic cannabinoids in mice
Early life outcomes of prenatal exposure to alcohol and synthetic cannabinoids in mice Open
View article: Prenatal alcohol exposure worsens acute but not long‐term cognitive outcomes due to stroke in middle‐aged Sprague–Dawley rat offspring
Prenatal alcohol exposure worsens acute but not long‐term cognitive outcomes due to stroke in middle‐aged Sprague–Dawley rat offspring Open
Background Prenatal alcohol exposure (PAE) is the major cause of developmental disability, ultimately resulting in a wide range of long‐term health consequences across the lifespan. PAE adults are at increased risk for metabolic, immune, a…
View article: Prenatal Alcohol Exposure Impairs Striatal Cholinergic Function and Cognitive Flexibility in Adult Offspring
Prenatal Alcohol Exposure Impairs Striatal Cholinergic Function and Cognitive Flexibility in Adult Offspring Open
Fetal Alcohol Spectrum Disorder (FASD), caused by prenatal alcohol exposure (PAE), is characterized by significant cognitive impairments, including reduced cognitive flexibility. Despite the critical role of cholinergic interneurons (CINs)…
View article: Early Life Outcomes of Prenatal Exposure to Alcohol and Synthetic Cannabinoids in Mice
Early Life Outcomes of Prenatal Exposure to Alcohol and Synthetic Cannabinoids in Mice Open
This study explores the effects of prenatal co-exposure to alcohol and synthetic cannabinoids on offspring viability, physical development, and neurobehavioral outcomes in young adulthood. The aim is to identify distinct outcomes of co-exp…
View article: Noncoding RNA and Alcohol Use Disorder: A Scoping Review of Current Research and Knowledge Gaps
Noncoding RNA and Alcohol Use Disorder: A Scoping Review of Current Research and Knowledge Gaps Open
The field of ncRNA research in pathologies associated with alcohol use is still emerging. Given the enormous sizes and species variations of mammalian ncRNA genomes, a significant amount of research is needed to identify relevant ncRNAs in…
View article: Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders
Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders Open
View article: Reduced fetal cerebral blood flow predicts perinatal mortality in a mouse model of prenatal alcohol and cannabinoid exposure
Reduced fetal cerebral blood flow predicts perinatal mortality in a mouse model of prenatal alcohol and cannabinoid exposure Open
Background Children exposed prenatally to alcohol or cannabinoids individually can exhibit growth deficits and increased risk for adverse birth outcomes. However, these drugs are often co-consumed and their combined effects on early brain …
View article: Reduced fetal cerebral blood flow following prenatal drug exposure predicts perinatal mortality
Reduced fetal cerebral blood flow following prenatal drug exposure predicts perinatal mortality Open
Background Children exposed prenatally to alcohol or cannabinoids individually can exhibit growth deficits and increased risk for adverse birth outcomes. However, these drugs are often co-consumed and their combined effects on early brain …
View article: Maternal circulating miRNAs contribute to negative pregnancy outcomes by altering placental transcriptome and fetal vascular dynamics
Maternal circulating miRNAs contribute to negative pregnancy outcomes by altering placental transcriptome and fetal vascular dynamics Open
Circulating miRNAs the in blood are promising biomarkers for predicting pregnancy complications and adverse birth outcomes. Previous work identified 11 gestationally elevated maternal circulating miRNAs ( HEa miRNAs) that predicted infant …
View article: The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan Open
View article: Prenatal alcohol alters inflammatory signatures in enteric portal tissues following adult-onset cerebrovascular ischemic stroke
Prenatal alcohol alters inflammatory signatures in enteric portal tissues following adult-onset cerebrovascular ischemic stroke Open
View article: Assessing the effects of prenatal poly-drug exposure on fetal brain vasculature using optical coherence angiography
Assessing the effects of prenatal poly-drug exposure on fetal brain vasculature using optical coherence angiography Open
Results suggested antagonistic effects of ethanol and nicotine on fetal brain vasculature.
View article: Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure
Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure Open
Alcohol exposure in adulthood can result in inflammation, malnutrition, and altered gastroenteric microbiota, which may disrupt efficient nutrient extraction. Clinical and preclinical studies have documented convincingly that prenatal alco…
View article: Alterations in the proteome of extracellular vesicles secreted by neural stem cells as a means for intercellular transfer of stress signals following developmental ethanol exposure
Alterations in the proteome of extracellular vesicles secreted by neural stem cells as a means for intercellular transfer of stress signals following developmental ethanol exposure Open
View article: Prenatal alcohol and/or cannabinoid exposure in mice leads to sex-specific motor impairments and ethanol self-administration in adult offspring
Prenatal alcohol and/or cannabinoid exposure in mice leads to sex-specific motor impairments and ethanol self-administration in adult offspring Open
View article: Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure
Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure Open
Background Prenatal alcohol (ethanol) exposure (PAE) results in brain growth restriction, in part, by reprogramming self-renewal and maturation of fetal neural stem cells (NSCs) during neurogenesis. We recently showed that ethanol resulted…
View article: Vascular contributions to the neurobiological effects of prenatal alcohol exposure
Vascular contributions to the neurobiological effects of prenatal alcohol exposure Open
Background: Fetal alcohol spectrum disorders (FASD) are often characterized as a cluster of brain-based disabilities. Though cardiovascular effects of prenatal alcohol exposure (PAE) have been documented, the vascular deficits due to PAE a…
View article: Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression
Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression Open
Alcohol use disorder (AUD) is one of the most common preventable mental health disorders and can result in pathology within the CNS, including the cerebellum. Cerebellar alcohol exposure during adulthood has been associated with disruption…
View article: Alcohol & cannabinoid co-use: Implications for impaired fetal brain development following gestational exposure
Alcohol & cannabinoid co-use: Implications for impaired fetal brain development following gestational exposure Open
Alcohol and marijuana are two of the most consumed psychoactive substances by pregnant people, and independently, both substances have been associated with lifelong impacts on fetal neurodevelopment. Importantly, individuals of child-beari…
View article: Dose-related shifts in proteome and function of extracellular vesicles secreted by fetal neural stem cells following chronic alcohol exposure
Dose-related shifts in proteome and function of extracellular vesicles secreted by fetal neural stem cells following chronic alcohol exposure Open
Accumulating evidence indicates that extracellular vesicles (EVs) mediate endocrine functions and also pathogenic effects of neurodevelopmental perturbagens like ethanol. We performed mass-spectrometry on EVs secreted by fetal murine cereb…
View article: Prenatal alcohol exposure exacerbates acute sensorimotor deficits and impedes long‐term behavioral recovery from the effects of an adult‐onset cerebrovascular ischemic stroke
Prenatal alcohol exposure exacerbates acute sensorimotor deficits and impedes long‐term behavioral recovery from the effects of an adult‐onset cerebrovascular ischemic stroke Open
Background Prenatal alcohol exposure (PAE) is a significant risk factor for developmental disability, although its health consequences across the lifespan are poorly understood. Here, we hypothesized that latent brain and systemic conseque…
View article: Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome
Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome Open
Background Prenatal alcohol exposure (PAE) has been shown to alter fetal blood flow in utero and is also associated with placental insufficiency and intrauterine growth restriction (IUGR), suggesting an underlying connection between pertur…
View article: Prenatal opioid-exposed infant extracellular miRNA signature obtained at birth predicts severity of neonatal opioid withdrawal syndrome
Prenatal opioid-exposed infant extracellular miRNA signature obtained at birth predicts severity of neonatal opioid withdrawal syndrome Open
View article: Gag‐like proteins: Novel mediators of prenatal alcohol exposure in neural development
Gag‐like proteins: Novel mediators of prenatal alcohol exposure in neural development Open
Background We previously showed that ethanol did not kill fetal neural stem cells (NSCs), but that their numbers nevertheless are decreased due to aberrant maturation and loss of self‐renewal. To identify mechanisms that mediate this loss …
View article: Hemorrhage and Locomotor Deficits Induced by Pain Input after Spinal Cord Injury Are Partially Mediated by Changes in Hemodynamics
Hemorrhage and Locomotor Deficits Induced by Pain Input after Spinal Cord Injury Are Partially Mediated by Changes in Hemodynamics Open
Nociceptive input diminishes recovery and increases lesion area after a spinal cord injury (SCI). Recent work has linked these effects to the expansion of hemorrhage at the site of injury. The current article examines whether these adverse…
View article: Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood
Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood Open
Prenatal alcohol exposure (PAE) can have immediate and long-lasting toxic and teratogenic effects on an individual’s development and health. As a toxicant, alcohol can lead to a variety of physical and neurological anomalies in the fetus t…
View article: Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats
Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats Open
Prenatal alcohol exposure (PAE) can result in neurobehavioral anomalies, that may be exacerbated by co-occurring metabolic and immune system deficits. To test the hypothesis that the peripheral inflammation in adult PAE offspring is linked…
View article: Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period Open
Background The developing hippocampus and cerebellum, unique among brain regions, exhibit a secondary surge in neurogenesis during the third trimester of pregnancy. Ethanol (EtOH) exposure during this period is results in a loss of tissue …
View article: Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex
Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex Open