C. M. Rush
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View article: Small Interfering RNA Mediated Messenger RNA Knockdown in the Amphibian Pathogen <i>Batrachochytrium dendrobatidis</i>
Small Interfering RNA Mediated Messenger RNA Knockdown in the Amphibian Pathogen <i>Batrachochytrium dendrobatidis</i> Open
RNA interference (RNAi) has not been tested in the pandemic amphibian pathogen, Batrachochytrium dendrobatidis , but developing this technology could be useful to elucidate virulence mechanisms, identify therapeutic targets, and may presen…
Acute effects of exercise-induced muscle damage on sprint andchange of direction performance: A systematic review and metaanalysis Open
The aim of this study is to determine the acute effects of resistance and plyometric training on sprint and change of direction (COD) performance in healthy adults and adolescents. A systematic literature search was conducted via Medline, …
View article: Glutathione is required for growth and cadmium tolerance in the amphibian chytrid fungus, Batrachochytrium dendrobatidis
Glutathione is required for growth and cadmium tolerance in the amphibian chytrid fungus, Batrachochytrium dendrobatidis Open
Batrachochytrium dendrobatidis (Bd) is a lethal amphibian pathogen, partly due to its ability to evade the immune system of susceptible frog species. In many pathogenic fungi, the antioxidant glutathione is a virulence factor that helps ne…
Antibodies as clinical tools for tuberculosis Open
Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide. Global research efforts to improve TB control are hindered by insufficient understanding of the role that antibodies play in protective immunity and pathogenesis. T…
Effect of Savirin or Ticagrelor Treatment on the Expression of Commonly Used Reference Genes in Staphylococcus aureus Open
Reference genes are frequently used for the normalization of quantitative reverse transcriptase PCR (qRTPCR) data in gene expression studies. Staphylococcus aureus is one of the most common causes of biofilm-related infections. Savirin and…
Seroepidemiology of Strongyloides spp. Infection in Balimo, Western Province, Papua New Guinea Open
Strongyloidiasis in Papua New Guinea (PNG) is poorly understood. There have been limited surveys describing the levels of endemicity in some regions of PNG, but in the Western Province, its occurrence and level of burden are unknown. This …
Effect of savirin in the prevention of biofilm-related Staphylococcus aureus prosthetic joint infection Open
Background: Most of the arthroplasty surgery failure due to prosthetic joint infections (PJI) is caused by biofilm-associated Staphylococcus aureus . In a recent experimental study, savirin has been used to prevent and treat S. aureus skin…
View article: The Effect of Tropical Temperatures on the Quality of RNA Extracted from Stabilized Whole-Blood Samples
The Effect of Tropical Temperatures on the Quality of RNA Extracted from Stabilized Whole-Blood Samples Open
Whole-blood-derived transcriptional profiling is widely used in biomarker discovery, immunological research, and therapeutic development. Traditional molecular and high-throughput transcriptomic platforms, including molecular assays with q…
Non-Antimicrobial Adjuvant Therapy Using Ticagrelor Reduced Biofilm-Related Staphylococcus aureus Prosthetic Joint Infection Open
Background: Prosthetic joint infection (PJI), frequently caused by Staphylococcus aureus , leads to a significant arthroplasty failure rate. Biofilm is a crucial virulence factor of S. aureus that is intrinsic to the pathogenesis of PJI. B…
View article: The effect of tropical temperatures on the quality of RNA extracted from stabilized whole blood samples
The effect of tropical temperatures on the quality of RNA extracted from stabilized whole blood samples Open
Background Whole-blood derived transcriptional profiling is widely used in biomarker discovery, immunological research and therapeutic development. Traditional molecular and high-throughput transcriptomic platforms, including molecular ass…
Tropical fever in remote tropics: tuberculosis or melioidosis, it depends on the lab Open
Diagnostics tests used to identify the cause of infection using proteomics and genomics have revolutionised microbiology laboratories in recent times. However, approaches to build the capacity of clinical microbiology services in the rural…
Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice Open
Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis . In contr…
Mucosal delivery of ESX-1–expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes Open
Significance Tuberculosis (TB) susceptibility and disease are significantly exacerbated in people with type 2 diabetes. The underlying mechanisms are incompletely understood, and it is not known if new TB vaccine candidates will be safe an…
Disparate effects of metformin on <i>Mycobacterium tuberculosis</i> infection in diabetic and non-diabetic mice Open
Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here we assessed the efficacy of metformin (MET); an anti-diabetic drug, in mice infected with a very-low dose of Mycobacterium tuberculosis . In contr…
A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies Open
We provide an empirical model to evaluate and rank data obtained from preclinical tuberculosis vaccine studies.
Spatial distribution of tuberculosis in a rural region of Western Province, Papua New Guinea Open
Introduction: There is a high burden of tuberculosis (TB) in the Western Province, Papua New Guinea. This study aims to describe the spatial distribution of TB in the Balimo District Hospital (BDH) catchment area to identify TB patient clu…
Diversity of Mycobacterium tuberculosis in the Middle Fly District of Western Province, Papua New Guinea: microbead-based spoligotyping using DNA from Ziehl-Neelsen-stained microscopy preparations Open
Tuberculosis remains the world’s leading cause of death from an infectious agent, and is a serious health problem in Papua New Guinea (PNG) with an estimated 36,000 new cases each year. This study describes the genetic diversity of Mycobac…
View article: Molecular Evidence of Drug-Resistant Tuberculosis in the Balimo Region of Papua New Guinea
Molecular Evidence of Drug-Resistant Tuberculosis in the Balimo Region of Papua New Guinea Open
Papua New Guinea (PNG) has a high burden of tuberculosis (TB), including drug-resistant TB (DR-TB). DR-TB has been identified in patients in Western Province, although there has been limited study outside the provincial capital of Daru. Th…
Group A streptococcal M-protein specific antibodies and T-cells drive the pathology observed in the rat autoimmune valvulitis model Open
Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are autoimmune mediated diseases triggered by group A streptococcal (GAS) infections. Molecular mimicry between GAS M-proteins and host tissue proteins has been proposed as the …
Exacerbation status is linked to dysfunctional phagocytosis in stable in Chronic Obstructive Pulmonary Disease (COPD) patients but not to pulmonary function Open
Introduction/Aim: Chronic obstructive pulmonary disease (COPD) is a significant and increasing public health challenge. Much of the disease burden and economic cost of COPD is associated with acute exacerbations and resulting bacterial col…
9- and 13-HODE regulate fatty acid binding protein-4 in human macrophages, but does not involve HODE/GPR132 axis in PPAR-γ regulation of FABP4 Open
Background: Both activation of monocytes and increased serum fatty acid binding protein-4 (FABP4) occur in diabetes and are associated with increased atherosclerosis. The oxidized lipid, 9-hydroxyoctadecadienoic acid (9-HODE) increases FAB…
View article: Group G Streptococcus Induces an Autoimmune Carditis Mediated by Interleukin 17A and Interferon γ in the Lewis Rat Model of Rheumatic Heart Disease
Group G Streptococcus Induces an Autoimmune Carditis Mediated by Interleukin 17A and Interferon γ in the Lewis Rat Model of Rheumatic Heart Disease Open
Acute rheumatic fever and rheumatic heart disease (ARF/RHD) have long been described as autoimmune sequelae of Streptococcus pyogenes or group A streptococcal (GAS) infection. Both antibody and T-cell responses against immunodominant GAS v…
Increased Neurotropic Threat from <i>Burkholderia pseudomallei</i> Strains with a <i>B. mallei</i>–like Variation in the <i>bimA</i> Motility Gene, Australia Open
Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for diss…
View article: Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II–Induced Aortic Aneurysm and Atherosclerosis
Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II–Induced Aortic Aneurysm and Atherosclerosis Open
Objective— Sclerostin (SOST) has been identified as an important regulator of bone formation; however, it has not been previously implicated in arterial disease. The aim of this study was to assess the role of SOST in aortic aneurysm (AA) …
Repeat exposure to group A streptococcal M protein exacerbates cardiac damage in a rat model of rheumatic heart disease Open
Rheumatic fever and rheumatic heart disease (RF/RHD) develop following repeated infection with group A streptococci (GAS). We used the Rat Autoimmune Valvulitis (RAV) model of RF/RHD to demonstrate that repetitive booster immunization with…
Preclinical immunogenicity and safety of a Group A streptococcal M protein-based vaccine candidate Open
Streptococcus pyogenes (group A streptococcus, GAS) causes a wide range of clinical manifestations ranging from mild self-limiting pyoderma to invasive diseases such as sepsis. Also of concern are the post-infectious immune-mediated diseas…
Development of a diet-induced murine model of diabetes featuring cardinal metabolic and pathophysiological abnormalities of type 2 diabetes Open
The persistent rise in global incidence of type 2 diabetes (T2D) continues to have significant public health and economic implications. The availability of relevant animal models of T2D is critical to elucidating the complexity of the path…
Predicted Coverage and Immuno-Safety of a Recombinant C-Repeat Region Based Streptococcus pyogenes Vaccine Candidate Open
The C-terminal region of the M-protein of Streptococcus pyogenes is a major target for vaccine development. The major feature is the C-repeat region, consisting of 35-42 amino acid repeat units that display high but not perfect identity. S…