Explanipedia

TIGER: A tdTomato in vivo genome-editing reporter mouse for investigating precision-editor delivery approaches Open

Samuel W. Du, Grażyna Palczewska, Zhiqian Dong, Julie C. Lauterborn, Balasankara Reddy Kaipa , et al. · 2025

In vivo genome editing has the potential to address many inherited and environmental disorders. However, a major hurdle for the clinical translation of genome editing is safe, efficient delivery to disease-relevant tissues. A modality-agno…

A depression–like phenotype is associated with discrete defects in the primary hippocampal circuit. Open

Benjamin G. Gunn, Chenyi Yang, Julie C. Lauterborn, Benedict Pruess, Julian Quintanilla , et al. · 2025

Major depressive disorder is known to disturb the hippocampus, but how this impacts signal processing performed by the structure remains poorly understood. Here, we report that single housing (7–10 days) promotes a depression-like phenotyp…

Unexpected mechanisms of sex-specific memory vulnerabilities to acute traumatic stress Open

Rachael E. Hokenson, Kiara L. Rodríguez-Acevedo, Yuncai Chen, Annabel K. Short, Sara A Samrari , et al. · 2025

It is increasingly recognized that severe acute traumatic events (e.g., mass shooting, natural disasters) can provoke enduring memory disturbances, and these problems are more common in women. We probed the fundamental sex differences unde…

Peripartum and Perinatal Outcomes in Pregnant Women with Elevated Preconceptional Body Mass Index in a Maternity Hospital (Care Level IV) Open

Ulf Dammer, Christine M. Gall, Jutta Pretscher, Michael Schneider, Florian Faschingbauer , et al. · 2025

Preconception obesity is a risk factor for pregnancy and delivery, which is why giving birth in a perinatal center (care levels I and II) is recommended. There are currently no studies which have investigated the birth outcomes of obese pa…

Early-life Oxytocin Rescues Hippocampal Synaptic Plasticity and Episodic Memory in a Mouse Model of Fragile X Syndrome Open

Jasmine Chavez, Aliza A. Le, Julie C. Lauterborn, Brittney M. Cox, Yousheng Jia , et al. · 2024

Cognitive disabilities including impairments to episodic memory are debilitating features of autism spectrum disorder (ASD). Here we report that early-life treatment with oxytocin (OXT) fully restores episodic memory and associated synapti…

De-intensification of postoperative radiotherapy in head and neck cancer irrespective of human papillomavirus status—results of a prospective multicenter phase II trial (DIREKHT Trial) Open

Marlen Haderlein, Jens von der Grün, Panagiotis Balermpas, Claus Rödel, Matthias Hautmann , et al. · 2024

Background Current standard treatment concepts in head and neck squamous cell carcinoma (HNSCC) are based on former studies using 2D and 3D treatment plans. However, modern radiation techniques allow for a more precise and individual dose …

Long-Term Experience of Arterio-Venous Fistula Surgery in Children on Hemodialysis Open

Veronika Almási‐Sperling, Christine M. Gall, Briain Haney, Nina Latzel, Ferdinand Knieling , et al. · 2024

Background: Arterio-venous fistulas (AVF) are used as first-line access for hemodialysis (HD) in the pediatric population. The aim of this investigation was to describe a single-center experience in the creation of AVF, together with its p…

Contributions of site- and sex-specific LTPs to everyday memory Open

Christine M. Gall, Aliza A. Le, Gary Lynch · 2024

Commentaries about long-term potentiation (LTP) generally proceed with an implicit assumption that largely the same physiological effect is sampled across different experiments. However, this is clearly not the case. We illustrate the poin…

Correction: Variation in cartilage T2 and T2* mapping of the wrist: a comparison between 3- and 7-T MRI Open

R. Heiß, Marc‐André Weber, Eva L. Balbach, Maximilian Hinsen, Frederik Geissler , et al. · 2024

Sex differences in the context dependency of episodic memory Open

Aliza A. Le, Linda Palmer, Jasmine Chavez, Christine M. Gall, Gary Lynch · 2024

Context contributes to multiple aspects of human episodic memory including segmentation and retrieval. The present studies tested if, in adult male and female mice, context influences the encoding of odors encountered in a single unsupervi…

Pre- versus Post-synaptic Forms of LTP in Two Branches of the Same Hippocampal Afferent Open

J. Quintanilla, Yongheng Jia, Benedict Pruess, Juan C. Chávez, Christine M. Gall , et al. · 2024

There has been considerable controversy about pre- versus postsynaptic expression of memory-related long-term potentiation (LTP), with corresponding disputes about underlying mechanisms. We report here an instance in male mice, in which bo…

Metabotropic NMDA Receptor Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory Open

Aliza A. Le, Julie C. Lauterborn, Conor D. Cox, Yousheng Jia, Gary Lynch , et al. · 2024

Summary Men generally outperform women on encoding spatial components of episodic memory whereas the reverse holds for semantic elements. Here we show that female mice outperform males on tests for non-spatial aspects of episodic memory (“…

Variation in cartilage T2 and T2* mapping of the wrist: a comparison between 3- and 7-T MRI Open

R. Heiß, Marc‐André Weber, Eva L. Balbach, Maximilian Hinsen, Frederik Geissler , et al. · 2023

Background To analyze regional variations in T2 and T2* relaxation times in wrist joint cartilage and the triangular fibrocartilage complex (TFCC) at 3 and 7 T and to compare values between field strengths. Methods Twenty-five healthy cont…

Contrasting synaptic roles of MDGA1 and MDGA2 Open

Michael A. Bemben, Matthew A. Sandoval, Aliza A. Le, Sehoon Won, Vivian N. Chau , et al. · 2023

Neurodevelopmental disorders are frequently linked to mutations in synaptic organizing molecules. MAM domain containing glycosylphosphatidylinositol anchor 1 and 2 (MDGA1 and MDGA2) are a family of synaptic organizers suggested to play an …

Microglia Depletion Selectively Eliminates a Singular Form of Hippocampal Long-Term Potentiation Open

Jasmine Chavez, Aliza A. Le, Julian Quintanilla, Alex Mabou Tagne, Daniele Piomelli , et al. · 2022

There has been considerable recent interest in the possibility that microglia contribute to synaptic plasticity and some forms of learning. We report here that elimination of the cells in young adult male mice with a 7-12 day treatment wit…

Novel types of frequency filtering in the lateral perforant path projections to dentate gyrus Open

Julian Quintanilla, Yousheng Jia, Julie C. Lauterborn, Benedict S. Pruess, Aliza A. Le , et al. · 2022

Despite its evident importance to learning theory and models, the manner in which the lateral perforant path (LPP) transforms signals from entorhinal cortex to hippocampus is not well understood. The present studies measured synaptic respo…

Reactogenicity after heterologous and homologous COVID-19 prime-boost vaccination regimens: descriptive interim results of a comparative observational cohort study Open

Lisette Warkentin, Nikoletta Zeschick, Thomas Kühlein, Philipp Steininger, Klaus Überla , et al. · 2022

Prepubescent female rodents have enhanced hippocampal LTP and learning relative to males, reversing in adulthood as inhibition increases Open

Aliza A. Le, Julie C. Lauterborn, Yousheng Jia, Weisheng Wang, Conor D. Cox , et al. · 2022

General anesthesia in the first 36 months of life Open

Christina Schüttler, Tino Münster, Christine M. Gall, Regina Trollmann, J. Schüttler · 2021

The fact that both groups achieved a higher IQ score than the expected 100 points may be attributable, at least in part, to the restriction of the study to children born at term. The results indicate that general anesthesia in early childh…

Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents Open

Aliza A. Le, Julian Quintanilla, Mohammad Amani, Daniele Piomelli, Gary Lynch , et al. · 2021

There is evidence that cannabis use during adolescence leads to memory and cognitive problems in young adulthood but little is known about effects of early life cannabis exposure on synaptic operations that are critical for encoding and or…

Review for "Hippocampal CA1 theta‐burst induced LTP from weaning to adulthood: cellular and molecular mechanisms in young male rats revisited" Open

Christine M. Gall · 2021

Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease Open

Julie C. Lauterborn, Pietro Scaduto, Conor D. Cox, Anton Schulmann, Gary Lynch , et al. · 2021

Sex differences in synaptic plasticity underlying learning Open

Christine M. Gall, Aliza A. Le, Gary Lynch · 2021

Although sex differences in learning behaviors are well documented, sexual dimorphism in the synaptic processes of encoding is only recently appreciated. Studies in male rodents have built upon the discovery of long‐term potentiation (LTP)…

Retrograde enhancement of episodic learning by a postlearning stimulus Open

Julian Quintanilla, Brittney M. Cox, Christine M. Gall, Stephen V. Mahler, Gary Lynch · 2021

Evidence suggests encoding of recent episodic experiences may be enhanced by a subsequent salient event. We tested this hypothesis by giving rats a 3-min unsupervised experience with four odors and measuring retention after different delay…

Review for "Hippocampal CA1 theta‐burst induced LTP from weaning to adulthood: cellular and molecular mechanisms in young male rats revisited" Open

Christine M. Gall · 2021

Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus Open

Mohammad Amani, Julie C. Lauterborn, Aliza A. Le, Brittney M. Cox, Weisheng Wang , et al. · 2021

Why layers II/III of entorhinal cortex (EC) deteriorate in advance of other regions during the earliest stages of Alzheimer's disease is poorly understood. Failure of retrograde trophic support from synapses to cell bodies is a common caus…

Reactogenicity After Heterologous and Homologous COVID-19 Prime-Boost Vaccination Regimens: Descriptive Interim Results of a Comparative Observational Cohort Study Open

Lisette Warkentin, Nikoletta Lippert, Thomas Kühlein, Philipp Steiniger, Klaus Überla , et al. · 2021

Quality of life in rectal cancer patients with or without oxaliplatin in the randomised CAO/ARO/AIO-04 phase 3 trial Open

Rebekka Kosmala, Emmanouil Fokas, Michael Flentje, Rolf Sauer, Torsten Liersch , et al. · 2020

NCT00349076.

Unexpected Role of Physiological Estrogen in Acute Stress-Induced Memory Deficits Open

Rachael E. Hokenson, Annabel K. Short, Yuncai Chen, Aidan L. Pham, Emily T. Adams , et al. · 2020

Stress may promote emotional and cognitive disturbances, which differ by sex. Adverse outcomes, including memory disturbances, are typically observed following chronic stress, but are now being recognized also after short events, including…

Review for "Chronic stress differentially alters mRNA expression of opioid peptides and receptors in the dorsal hippocampus of female and male rats" Open

Christine M. Gall · 2020

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