John C. Marshall
YOU?
Author Swipe
View article: Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients
Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients Open
Importance Pantoprazole reduces clinically important upper gastrointestinal bleeding in critically ill patients. However, the cost-effectiveness of this strategy is unclear. Objective To assess the cost-effectiveness of daily intravenous p…
View article: Frailty and the risk of ICU-acquired infections in a randomised trial: a protocol and statistical analysis plan
Frailty and the risk of ICU-acquired infections in a randomised trial: a protocol and statistical analysis plan Open
Introduction Dysregulated immunity may account for an increased risk of infection and other adverse outcomes among frail hospitalised persons. The primary objective of this study is to examine whether baseline frailty is associated with th…
View article: Evidence for Functional Ovarian Hyperandrogenism in Early Pubertal, but Not Late Pubertal, Girls With Excess Weight
Evidence for Functional Ovarian Hyperandrogenism in Early Pubertal, but Not Late Pubertal, Girls With Excess Weight Open
Context Sources of androgen overproduction in peripubertal girls with overweight/obesity (excess weight [EW]) remain unclear. Objective To assess 17-hydroxyprogesterone (17-OHP) responses to recombinant human chorionic gonadotropin (r-hCG)…
View article: Primary Varicella in an Adult Patient With Diabetes
Primary Varicella in an Adult Patient With Diabetes Open
Although the introduction of the varicella vaccine has significantly reduced the incidence of primary varicella in adults, individuals with compromised immune systems, such as those with diabetes mellitus, remain at heightened risk for sev…
View article: Coenrollment of critically ill patients in PROSPECT: characteristics and association with treatment efficacy and safety
Coenrollment of critically ill patients in PROSPECT: characteristics and association with treatment efficacy and safety Open
View article: Lipid Nanoparticle Delivery of Mesenchymal Stromal Cell-Derived microRNA 187-3p as a First-in-Class Therapy for Myocardial Dysfunction in Sepsis
Lipid Nanoparticle Delivery of Mesenchymal Stromal Cell-Derived microRNA 187-3p as a First-in-Class Therapy for Myocardial Dysfunction in Sepsis Open
Background Sepsis-induced myocardial dysfunction is a common and critical complication of sepsis. Extracellular vesicles (EVs) from clonally expanded immortalized mesenchymal stromal cells (ciMSCs) contain microRNAs that may be exploited a…
View article: Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings
Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings Open
Introduction SARS-CoV-2 is now endemic and expected to remain a health threat, with new variants continuing to emerge and the potential for vaccines to become less effective. While effective vaccines and natural immunity have significantly…
View article: Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report
Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report Open
Background Almost all large-scale trials of disease-modifying therapeutic agents in critical care have failed to show benefit for patients, which may be explained in part by the clinical and biological heterogeneity inherent in virtually a…
View article: Clinical evaluation of adults undergoing elective surgery utilizing intraoperative incisional wound irrigation (CLEAN Wound): protocol for a randomised controlled trial
Clinical evaluation of adults undergoing elective surgery utilizing intraoperative incisional wound irrigation (CLEAN Wound): protocol for a randomised controlled trial Open
Introduction In moderate to high-risk surgical procedures, 15–25% of patients develop a postoperative surgical site infection. Intraoperative incisional wound irrigation has the potential to reduce surgical site infections, and additional …
View article: Publisher Correction: A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis
Publisher Correction: A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis Open
View article: Publisher Correction: Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia
Publisher Correction: Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia Open
View article: A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis
A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis Open
Sepsis is a life-threatening organ dysfunction due to a dysfunctional response to infection. Delays in diagnosis have substantial impact on survival. Herein, blood samples from 586 in-house patients with suspected sepsis are used in conjun…
View article: Therapeutic-dose heparin combined with antiplatelets in noncritically ill patients with COVID-19: a secondary analysis of a multiplatform randomized controlled trial
Therapeutic-dose heparin combined with antiplatelets in noncritically ill patients with COVID-19: a secondary analysis of a multiplatform randomized controlled trial Open
View article: Co-designing and pilot-testing an infographic to support the consent process in an adaptive platform trial for adults in ICU with community-acquired pneumonia or COVID-19: a mixed methods study within a trial (SWAT)
Co-designing and pilot-testing an infographic to support the consent process in an adaptive platform trial for adults in ICU with community-acquired pneumonia or COVID-19: a mixed methods study within a trial (SWAT) Open
The Northern Ireland Hub for Trials Methodology Research SWAT Repository (SWAT #176).
View article: Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trial
Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trial Open
View article: Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial
Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial Open
Background Maintaining a diverse gut microbiome and minimizing antimicrobial resistance gene (ARG) carriage through reduced antibiotic utilization may decrease antimicrobial resistance. We compared gut microbiome disruption and ARG carriag…
View article: High-level, high-resolution ocean modeling at all scales with Oceananigans
High-level, high-resolution ocean modeling at all scales with Oceananigans Open
We describe the user interface, governing equations, and numerical methods underpinning the community ocean modeling software called "Oceananigans". Oceananigans development has been lead by the Climate Modeling Alliance to build a trainab…
View article: Caspase-8: Arbitrating Life and Death in the Innate Immune System
Caspase-8: Arbitrating Life and Death in the Innate Immune System Open
The canonical function of caspase-8 is to control timely cellular apoptosis to maintain tissue homeostasis and clear dysfunctional cells; however, emerging findings reveal novel, non-canonical roles of caspase in addition to regulating cel…
View article: A91 OUTCOMES OF PATIENTS WITH PRIOR BIOLOGIC INTOLERANCE ARE BETTER THAN THOSE WITH BIOLOGIC FAILURE IN CLINICAL TRIALS OF INFLAMMATORY BOWEL DISEASE
A91 OUTCOMES OF PATIENTS WITH PRIOR BIOLOGIC INTOLERANCE ARE BETTER THAN THOSE WITH BIOLOGIC FAILURE IN CLINICAL TRIALS OF INFLAMMATORY BOWEL DISEASE Open
Background Inflammatory bowel disease (IBD) trials often stratify patients by prior biologic exposure, including prior biologic failure or intolerance. Aims This study aimed to assess clinical outcomes in IBD patients with prior biologic f…
View article: Enrolment patterns in a randomized controlled trial of probiotics in critically ill patients: a retrospective analysis of the PROSPECT trial
Enrolment patterns in a randomized controlled trial of probiotics in critically ill patients: a retrospective analysis of the PROSPECT trial Open
View article: Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials
Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials Open
Dr Sabri Soussi was awarded the Canadian Institutes of Health Research (CIHR) Doctoral Foreign Study Award (DFSA) and the Merit Awards Program (Department of Anesthesiology and Pain Medicine, University of Toronto, Canada) for the current …
View article: Complex Thrombo-Inflammatory Responses versus Outcomes of Non-COVID-19 Community-Acquired Pneumonia and COVID-19
Complex Thrombo-Inflammatory Responses versus Outcomes of Non-COVID-19 Community-Acquired Pneumonia and COVID-19 Open
Introduction: The thrombo-inflammatory response and outcomes of community-acquired pneumonia (CAP) due to various organisms (non-COVID-19 CAP) versus CAP due to a single virus, SARS-CoV-2 (i.e., COVID-19) may differ. Methods: Adults hospit…
View article: Community versus academic hospital community-acquired pneumonia patients: a nested cohort study
Community versus academic hospital community-acquired pneumonia patients: a nested cohort study Open
Background Most Canadians receive their care in community hospitals, yet most clinical research is conducted in academic hospitals. This study aims to compare patients with community acquired pneumonia (CAP) treated in academic and communi…
View article: Strengthening acute care in low and middle income countries: The role of clinical research
Strengthening acute care in low and middle income countries: The role of clinical research Open
Not available
View article: The association of antiplatelet agents with mortality among patients with non–COVID-19 community-acquired pneumonia: a systematic review and meta-analysis
The association of antiplatelet agents with mortality among patients with non–COVID-19 community-acquired pneumonia: a systematic review and meta-analysis Open
In hospitalized patients with non-COVID-19 CAP, antiplatelet agents may be associated with reduced mortality compared with usual care or placebo, but the certainty of evidence is low.
View article: Critical illness and the gut microbiome
Critical illness and the gut microbiome Open
View article: The response of Canada’s clinical health research ecosystem to the COVID-19 pandemic
The response of Canada’s clinical health research ecosystem to the COVID-19 pandemic Open
A minority of Canadian hospitals enrolled the majority of participants in CIHR-funded studies on COVID-19. This analysis sheds light on the Canadian health research ecosystem and provides information for multiple key partners to consider w…
View article: Protocol implementation during the COVID-19 pandemic: experiences from a randomized trial of stress ulcer prophylaxis
Protocol implementation during the COVID-19 pandemic: experiences from a randomized trial of stress ulcer prophylaxis Open
Background During the COVID-19 pandemic, many intensive care units (ICUs) halted research to focus on COVID-19-specific studies. Objective To describe the conduct of an international randomized trial of stress ulcer prophylaxis ( R e- Ev a…
View article: From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU
From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU Open
Critical care uses syndromic definitions to describe patient groups for clinical practice and research. There is growing recognition that a "precision medicine" approach is required and that integrated biologic and physiologic data identif…
View article: The effect of anti-platelet agents on end organ dysfunction and mortality in community acquired pneumonia: A protocol for a systematic review and meta-analysis
The effect of anti-platelet agents on end organ dysfunction and mortality in community acquired pneumonia: A protocol for a systematic review and meta-analysis Open
Background Community acquired pneumonia (CAP) is a common cause of morbidity and mortality globally. Poor outcomes are driven by maladaptive inflammatory and thrombotic host responses. Effective therapies that modulate host responses are l…