Catherine Helmer
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View article: Retinal Microvascular Correlates of Cerebral Small Vessel Disease in Older Age
Retinal Microvascular Correlates of Cerebral Small Vessel Disease in Older Age Open
We provide multimodal evidence that geometric characteristics of the retinal microvasculature are associated with increased burden of MRI-cSVD and possibly worse executive function.
View article: Associations of plasma persistent organic pollutants with brain atrophy, cognitive decline and risk of dementia in older adults
Associations of plasma persistent organic pollutants with brain atrophy, cognitive decline and risk of dementia in older adults Open
Overall, this prospective study does not provide robust evidence to support an adverse association between exposure to POPs in the general population and the risk of all-cause dementia, cognitive decline, or brain atrophy in older adults.
View article: <scp>SCORE2</scp> ‐Older Persons ( <scp>SCORE2</scp> ‐ <scp>OP</scp> ): Validation and Added Value of Excessive Daytime Sleepiness in a French Cohort
<span>SCORE2</span> ‐Older Persons ( <span>SCORE2</span> ‐ <span>OP</span> ): Validation and Added Value of Excessive Daytime Sleepiness in a French Cohort Open
Background Cardiovascular diseases are the leading cause of death worldwide, particularly in older adults. While the Systematic Coronary Risk Evaluation 2‐Older Persons (SCORE2‐OP) model estimates 10‐year cardiovascular risk in this popula…
View article: Long-Term Blood Pressure Variability and Risk of Age-Related Macular Degeneration in Older Adults: The ALIENOR Study
Long-Term Blood Pressure Variability and Risk of Age-Related Macular Degeneration in Older Adults: The ALIENOR Study Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: “Open book facial dissection” : an ideal pedagogical approach for learning safe and effective fillers and botulinum toxin injection techniques
“Open book facial dissection” : an ideal pedagogical approach for learning safe and effective fillers and botulinum toxin injection techniques Open
Knowledge of facial anatomy and ageing is essential for safe fillers and botulinum toxin injection procedures with effective aesthetic results. Open book dissection is a reliable and reproducible method of teaching anatomy. It is a visual …
View article: Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro
Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro Open
In Alzheimer’s disease, microglial phagocytosis is engaged in the pathogenesis as it clears abnormal protein accumulations, debris, and apoptotic cells in the early stages of Alzheimer’s disease, but fuels neuroinflammation and accelerates…
View article: Development and indirect validation of a model predicting frailty in the French healthcare claims database
Development and indirect validation of a model predicting frailty in the French healthcare claims database Open
This study aimed to build a predictive model to identify frailty in the French national health data system (SNDS) so as to create a new tool to monitor and anticipate the disability burden associated with population ageing. We developed th…
View article: Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium
Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium Open
INTRODUCTION To investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers. METHODS Data from six community‐based samples from the Cross‐Cohort Collaboration Consortium w…
View article: Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification
Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification Open
INTRODUCTION An integrative polygenic risk score (iPRS) capturing the neurodegenerative and vascular contribution to dementia could identify high‐risk individuals and improve risk prediction. METHODS We developed an iPRS for dementia (iPRS…
View article: Including an infrequently measured time-dependent error-prone covariate in survival analyses: a simulation-based comparison of methods
Including an infrequently measured time-dependent error-prone covariate in survival analyses: a simulation-based comparison of methods Open
Epidemiologic studies often evaluate the association between an exposure and an event risk. When time-varying, exposure updates usually occur at discrete visits although changes are in continuous time and survival models require values to …
View article: Development and validation of the Montreal Cognitive Assessment for People with Vision Impairment (MOCA-VI).
Development and validation of the Montreal Cognitive Assessment for People with Vision Impairment (MOCA-VI). Open
Vision impairment is common among older adults and affects dementia screening assessments, which include visually presented items. We developed and validated a version of the Montreal Cognitive Assessment (MoCA) for people with vision impa…
View article: Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial
Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial Open
In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. Here, we studied the association between HSV-1 and Alzheimer’s…
View article: A Two-stage Joint Modeling Approach for Multiple Longitudinal Markers and Time-to-event Data
A Two-stage Joint Modeling Approach for Multiple Longitudinal Markers and Time-to-event Data Open
Collecting multiple longitudinal measurements and time-to-event outcomes is a common practice in clinical and epidemiological studies, often focusing on exploring associations between them. Joint modeling is the standard analytical tool fo…
View article: A Two-Stage Bayesian Approach for Variable Selection in Joint Modeling of Multiple Longitudinal Markers with Competing Risks
A Two-Stage Bayesian Approach for Variable Selection in Joint Modeling of Multiple Longitudinal Markers with Competing Risks Open
In many clinical and epidemiological studies, collecting longitudinal measurements together with time-to-event outcomes is essential. Accurately estimating the association between longitudinal markers and event risks, as well as identifyin…
View article: Are there trends towards compression of morbidity for dementia? Evidences from four international population‐based cohorts
Are there trends towards compression of morbidity for dementia? Evidences from four international population‐based cohorts Open
Background Dementia is a major contributor to loss of autonomy in the elderly. Every year spent with dementia results in significant medical and societal costs. Understanding secular trends of life expectancy with and without dementia woul…
View article: Dietary exposure to chemical contaminants and risk of dementia in older persons
Dietary exposure to chemical contaminants and risk of dementia in older persons Open
Background Diet is a primary source of exposure to chemicals in the general population. Dietary contaminants originate from food production (e.g.pesticides) or from environmental contamination by industrial (polychlorinated biphenyls [PCB]…
View article: Associations of the LIBRA risk score with cognitive resistance to susceptibility genes for dementia
Associations of the LIBRA risk score with cognitive resistance to susceptibility genes for dementia Open
Background Some older adults succeed in maintaining excellent cognition despite high genetic risk for Alzheimer’s disease (AD), reflecting cognitive resistance (CR) to potential neuropathologies. Although the etiological factors for CR are…
View article: Mortality in Newly Admitted Nursing Home Older Adults with Dementia in France: A Post Hoc Analysis from an Observational Study in the Bordeaux Region
Mortality in Newly Admitted Nursing Home Older Adults with Dementia in France: A Post Hoc Analysis from an Observational Study in the Bordeaux Region Open
Background/Objectives: A significant proportion of older adults with Alzheimer’s disease or related disorders live in a long-term care facility. This study aimed to determine the time delay between admission and death for older adults with…
View article: Ambient air pollution exposure and incidence of cataract surgery: The prospective 3City‐Alienor study
Ambient air pollution exposure and incidence of cataract surgery: The prospective 3City‐Alienor study Open
Purpose Cataract, the leading cause of blindness worldwide, is a multifactorial disease involving oxidative stress mechanisms. The aim of our study was to investigate the relationship between air pollution exposure and the incidence of cat…
View article: Association between dietary exposure to chemical contaminants and risk of dementia in older persons
Association between dietary exposure to chemical contaminants and risk of dementia in older persons Open
In this large population-based study, dietary exposure to several chemicals was associated with higher dementia risk among older persons consuming > 35 % energy from fat in diet.
View article: Functional Principal Component Analysis as an Alternative to Mixed‐Effect Models for Describing Sparse Repeated Measures in Presence of Missing Data
Functional Principal Component Analysis as an Alternative to Mixed‐Effect Models for Describing Sparse Repeated Measures in Presence of Missing Data Open
Analyzing longitudinal data in health studies is challenging due to sparse and error‐prone measurements, strong within‐individual correlation, missing data and various trajectory shapes. While mixed‐effect models (MM) effectively address t…
View article: Joint model for interval-censored semi-competing events and longitudinal data with subject-specific within and between visits variabilities
Joint model for interval-censored semi-competing events and longitudinal data with subject-specific within and between visits variabilities Open
Dementia currently affects about 50 million people worldwide, and this number is rising. Since there is still no cure, the primary focus remains on preventing modifiable risk factors such as cardiovascular factors. It is now recognized tha…
View article: Urea Level and Depression in Patients with Chronic Kidney Disease
Urea Level and Depression in Patients with Chronic Kidney Disease Open
Depression is common in patients with chronic kidney disease (CKD). Experimental studies suggest the role of urea toxicity in depression. We assessed both the incidence of antidepressant prescriptions and depressive symptoms (measured by C…
View article: A <scp>cross‐cultural</scp> study of the Montreal Cognitive Assessment for people with hearing impairment
A <span>cross‐cultural</span> study of the Montreal Cognitive Assessment for people with hearing impairment Open
Background Cognitive screening tools enable the detection of cognitive impairment, facilitate timely intervention, inform clinical care, and allow long‐term planning. The Montreal Cognitive Assessment for people with hearing impairment (Mo…
View article: Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline
Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline Open
INTRODUCTION Evaluating whether genetic susceptibility modifies the impact of lifestyle‐related factors on dementia is critical for prevention. METHODS We studied 5170 participants from a French cohort of older persons free of dementia at …
View article: Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing
Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing Open
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, and late-life depression, such that altered HN could rep…