Christian Melle
YOU?
Author Swipe
View article: <scp>FLIM‐FRET</scp> ‐based analysis of <scp>S100A11</scp> /annexin interactions in living cells
<span>FLIM‐FRET</span> ‐based analysis of <span>S100A11</span> /annexin interactions in living cells Open
Proteins achieve their biological functions in cells by cooperation in protein complexes. In this study, we employed fluorescence lifetime imaging microscopy (FLIM)‐based Förster resonance energy transfer (FRET) measurements to investigate…
View article: cGMP Analogues with Opposing Actions on CNG Channels Selectively Modulate Rod or Cone Photoreceptor Function
cGMP Analogues with Opposing Actions on CNG Channels Selectively Modulate Rod or Cone Photoreceptor Function Open
The vertebrate retina harbors rod and cone photoreceptors. Human vision critically depends on cone photoreceptor function. In the phototransduction cascade, cGMP activates distinct rod and cone isoforms of the cyclic nucleotide-gated (CNG)…
View article: Using cGMP analogues to modulate photoreceptor light sensitivity: Perspectives for the treatment of retinal degeneration
Using cGMP analogues to modulate photoreceptor light sensitivity: Perspectives for the treatment of retinal degeneration Open
Cyclic nucleotide-gated (CNG) channels play an essential role within the phototransduction cascade in vertebrates. Although rod and cone light responses are mediated through similar pathways, each photoreceptor type relies on a specific CN…
View article: Determination of the number of RAD51 molecules in different human cell lines
Determination of the number of RAD51 molecules in different human cell lines Open
Knowledge about precise numbers of specific molecules is necessary for understanding and verification of biological pathways. The RAD51 protein is central in the repair of DNA double-strand breaks (DSBs) by homologous recombination repair …
View article: S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci
S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci Open
The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is an essential process in maintenance of chromosomal stability. A key player of HR is the strand exchange factor RAD51 whose assembly at sites of DNA damage is…