Menaka C. Thounaojam
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View article: CYP46A1 Activation Improves Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity
CYP46A1 Activation Improves Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity Open
Previous studies have shown the metabolic and regulatory significance of CYP46A1 in the adult retina; however, its role in the developing retina is unknown. Here, we evaluate CYP46A1 expression and the impact of its activation in the devel…
View article: CD8+ T–NK cell crosstalk establishes preemptive immunosurveillance to eliminate antigen–escape tumors
CD8+ T–NK cell crosstalk establishes preemptive immunosurveillance to eliminate antigen–escape tumors Open
Background and objective Tumor antigen–escape variants undermine immunotherapy by subverting lymphocyte effector functions and reshaping tumor–immune dynamics. It is essential to delineate functional interplay within immune networks during…
View article: Editorial: Women in science: ophthalmology 2023
Editorial: Women in science: ophthalmology 2023 Open
Keywords: ophthalmology, women in science, gender disparities in STEM, vision research, academic publishing
View article: Protective Effects of Butyrate on Retinal Neovascularization in Preclinical Retinopathy of Prematurity Models
Protective Effects of Butyrate on Retinal Neovascularization in Preclinical Retinopathy of Prematurity Models Open
Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness worldwide, necessitating new therapeutic strategies. Current interventions targeting advanced disease stages often fail to prevent long-term visual impairment.…
View article: Unveiling the gut-eye axis: how microbial metabolites influence ocular health and disease
Unveiling the gut-eye axis: how microbial metabolites influence ocular health and disease Open
The intricate interplay between the gut microbiota and ocular health has surpassed conventional medical beliefs, fundamentally reshaping our understanding of organ interconnectivity. This review investigates into the intricate relationship…
View article: miR34a-5p impedes CLOCK expression in chronodisruptive C57BL/6J mice and potentiates pro-atherogenic manifestations
miR34a-5p impedes CLOCK expression in chronodisruptive C57BL/6J mice and potentiates pro-atherogenic manifestations Open
Introduction Altered circadian rhythms underlie manifestation of several cardiovascular disorders, however a little is known about the mediating biomolecules. Multiple transcriptional-translational feedback loops control circadian-clockwor…
View article: Editorial: Lymphocyte functional crosstalk and regulation, volume II
Editorial: Lymphocyte functional crosstalk and regulation, volume II Open
EDITORIAL article Front. Immunol., 17 May 2023Sec. Molecular Innate Immunity Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1214843
View article: CORM-A1 Alleviates Pro-Atherogenic Manifestations via miR-34a-5p Downregulation and an Improved Mitochondrial Function
CORM-A1 Alleviates Pro-Atherogenic Manifestations via miR-34a-5p Downregulation and an Improved Mitochondrial Function Open
Atherogenesis involves multiple cell types undergoing robust metabolic processes resulting in mitochondrial dysfunction, elevated reactive oxygen species (ROS), and consequent oxidative stress. Carbon monoxide (CO) has been recently explor…
View article: Supplementary Figure S3 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Supplementary Figure S3 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity Open
Calreticulin expression on bortezomib-treated tumor cells.
View article: Supplementary Figure Legends from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Supplementary Figure Legends from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity Open
Legends for Supplementary Figures S1-S3.
View article: Supplementary Figure S2 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Supplementary Figure S2 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity Open
Lasting immunosuppressive effect on lung metastases following the suppressive regimen of bortezomib.
View article: Supplementary Figure S3 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Supplementary Figure S3 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity Open
Calreticulin expression on bortezomib-treated tumor cells.
View article: Data from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Data from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity Open
Cancer immunotherapy shows great promise but many patients fail to show objective responses, including in cancers that can respond well, such as melanoma and renal adenocarcinoma. The proteasome inhibitor bortezomib sensitizes solid tumors…
View article: Data from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Data from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity Open
Cancer immunotherapy shows great promise but many patients fail to show objective responses, including in cancers that can respond well, such as melanoma and renal adenocarcinoma. The proteasome inhibitor bortezomib sensitizes solid tumors…
View article: Supplementary Figure S2 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Supplementary Figure S2 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity Open
Lasting immunosuppressive effect on lung metastases following the suppressive regimen of bortezomib.
View article: Supplementary Figure Legends from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Supplementary Figure Legends from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity Open
Legends for Supplementary Figures S1-S3.
View article: Supplementary Figure S1 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Supplementary Figure S1 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity Open
Increase in the number of lung metastases following the suppressive regimen of bortezomib.
View article: Supplementary Figure S1 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Supplementary Figure S1 from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity Open
Increase in the number of lung metastases following the suppressive regimen of bortezomib.
View article: Editorial: Women in Science - Ophthalmology 2021
Editorial: Women in Science - Ophthalmology 2021 Open
EDITORIAL article Front. Med., 30 June 2022Sec. Ophthalmology https://doi.org/10.3389/fmed.2022.966392
View article: Expression and Activation of the Ketone Body Receptor HCAR2/GPR109A Promotes Preservation of Retinal Endothelial Cell Barrier Function
Expression and Activation of the Ketone Body Receptor HCAR2/GPR109A Promotes Preservation of Retinal Endothelial Cell Barrier Function Open
View article: Differential bile acids biosynthetic pathways in the developing retina and in the oxygen-induced model of retinopathy of prematurity
Differential bile acids biosynthetic pathways in the developing retina and in the oxygen-induced model of retinopathy of prematurity Open
View article: Diabetes-induced HDAC6-miR-34a pathway downregulates SIRT-1-miR-146a axis to promote stress-induced premature senescence and diabetic retinal microangiopathy
Diabetes-induced HDAC6-miR-34a pathway downregulates SIRT-1-miR-146a axis to promote stress-induced premature senescence and diabetic retinal microangiopathy Open
View article: Bortezomib Sustains T Cell Function by Inducing miR-155-Mediated Downregulation of SOCS1 and SHIP1
Bortezomib Sustains T Cell Function by Inducing miR-155-Mediated Downregulation of SOCS1 and SHIP1 Open
Suppressive mechanisms operating within T cells are linked to immune dysfunction in the tumor microenvironment. We have previously reported using adoptive T cell immunotherapy models that tumor–bearing mice treated with a regimen of protea…
View article: Pharmacological and Metabolic Significance of Bile Acids in Retinal Diseases
Pharmacological and Metabolic Significance of Bile Acids in Retinal Diseases Open
Bile acids (BAs) are amphipathic sterols primarily synthesized from cholesterol in the liver and released in the intestinal lumen upon food intake. BAs play important roles in micellination of dietary lipids, stimulating bile flow, promoti…
View article: Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neuronal and Vascular Damage
Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neuronal and Vascular Damage Open
Retinal ischemia contributes to visual impairment in ischemic retinopathies. A disintegrin and metalloproteinase ADAM17 is implicated in multiple vascular pathologies through its ability to regulate inflammatory signaling via ectodomain sh…
View article: Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy
Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy Open
We investigated the contributing role of the histone deacetylase 6 (HDAC6) to the early stages of diabetic retinopathy (DR). Furthermore, we examined the mechanism of action of HDAC6 in human retinal endothelial cells (HuREC) exposed to gl…
View article: Ursodeoxycholic Acid Halts Pathological Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy
Ursodeoxycholic Acid Halts Pathological Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy Open
Retinopathy of prematurity (ROP) is the leading cause of blindness in infants. We have investigated the efficacy of the secondary bile acid ursodeoxycholic acid (UDCA) and its taurine and glycine conjugated derivatives tauroursodeoxycholic…
View article: Altered balance of miR-144-3p and miR-124-5p regulates amyloid-beta autocrine production in retinal pigment epithelial cells
Altered balance of miR-144-3p and miR-124-5p regulates amyloid-beta autocrine production in retinal pigment epithelial cells Open
View article: Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neurovascular Abnormalities
Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neurovascular Abnormalities Open
View article: Oxidative stress-induced ADAM10 and BACE1 imbalance leads to amyloid beta (Abeta) production in retinal pigment epithelial cells (RPE)
Oxidative stress-induced ADAM10 and BACE1 imbalance leads to amyloid beta (Abeta) production in retinal pigment epithelial cells (RPE) Open