Christie M. Ballantyne
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View article: Proteomic analysis identifies lipoprotein(a)-associated proteins linked to incident atherosclerotic cardiovascular disease events
Proteomic analysis identifies lipoprotein(a)-associated proteins linked to incident atherosclerotic cardiovascular disease events Open
Background The pathways linking lipoprotein(a) (Lp[a]) to atherosclerotic cardiovascular disease (ASCVD) are unclear. This study aimed to discover Lp(a)-associated plasma proteins and estimate their associations with incident ASCVD. Method…
View article: Understanding the mechanisms linking GDF15 to dementia risk: A translational approach
Understanding the mechanisms linking GDF15 to dementia risk: A translational approach Open
Background Our group previously identified higher growth/differentiation factor‐15 (GDF15) abundance in plasma among individuals who developed dementia (Figure 1a), which was accompanied by altered expression of immune proteins in plasma a…
View article: Proteomics Analysis of Plasma for Risk of Sepsis: Findings from the Atherosclerosis Risk in Communities Study
Proteomics Analysis of Plasma for Risk of Sepsis: Findings from the Atherosclerosis Risk in Communities Study Open
Background Sepsis is a life-threatening complication of infection with high mortality. A high-throughput analysis of circulating blood proteins may provide mechanistic insight and potent therapeutic targets for the prevention of sepsis. Me…
View article: Real-World Adherence and Effectiveness of Inclisiran in Lowering LDL-C: Results from 1 Year of Follow-Up
Real-World Adherence and Effectiveness of Inclisiran in Lowering LDL-C: Results from 1 Year of Follow-Up Open
Inclisiran significantly reduced LDL-C. The dosing schedule promoted high adherence in a real-world setting, particularly among older adults with ASCVD. These findings indicate inclisiran may be a particularly valuable addition to lipid-lo…
View article: cpiVAE: Robust and Interpretable Cross-Platform Proteomics Imputation
cpiVAE: Robust and Interpretable Cross-Platform Proteomics Imputation Open
Large-scale plasma proteomic studies often use different high-throughput affinity platforms, and measurements of the same protein across platforms are often discordant. Discordance hinders cross-study integration. Improving proteomics data…
View article: Association of infection frequency and incident clonal hematopoiesis
Association of infection frequency and incident clonal hematopoiesis Open
Background: Clonal hematopoiesis (CH) is an age-related phenomenon in which hematopoietic stem cells acquire somatic mutations that confer relative fitness advantage, resulting in clonal expansion. CH is a malignancy precursor state: peopl…
View article: ApoB, small-dense LDL-C, Lp(a), LpPLA2 activity, and cognitive change.
ApoB, small-dense LDL-C, Lp(a), LpPLA2 activity, and cognitive change. Open
OBJECTIVE: To examine the association of specific lipoproteins/inflammatory enzyme with cognitive change. METHODS: We examined the association of apolipoprotein B (ApoB), small-dense low-density lipoprotein cholesterol (sdLDL-C), lipoprote…
View article: High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC Study
High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC Study Open
BACKGROUND: We assessed whether plasma troponin I measured by a high-sensitivity assay (hs-TnI) is associated with incident cardiovascular disease (CVD) and mortality in a community-based sample without prior CVD. METHODS: ARIC study (Athe…
View article: High-sensitivity cardiac troponin and natriuretic peptide with risk of lower-extremity peripheral artery disease: the Atherosclerosis Risk in Communities (ARIC) Study
High-sensitivity cardiac troponin and natriuretic peptide with risk of lower-extremity peripheral artery disease: the Atherosclerosis Risk in Communities (ARIC) Study Open
Aims: Cardiac troponin T (cTnT) is suggested as a predictor of amputation in patients with peripheral artery disease (PAD). However, cTnT-PAD association has not been systematically studied in a large study. This study evaluated the associ…
View article: Postprandial lipemia and the risk of coronary heart disease and stroke: the Atherosclerosis Risk in Communities (ARIC) Study
Postprandial lipemia and the risk of coronary heart disease and stroke: the Atherosclerosis Risk in Communities (ARIC) Study Open
OBJECTIVE: Excessive levels of triglyceride-rich lipoproteins during postprandial lipemia (PPL) have been reported to be atherogenic. However, it is unclear whether the degree of PPL independently predicts cardiovascular disease (CVD) give…
View article: Response by Jia et al to Letter Regarding Article, “High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC Study”
Response by Jia et al to Letter Regarding Article, “High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC Study” Open
Li and colleagues noted in their letter that there were significant differences in cardiac risk factors across high-sensitivity troponin I (hs-TnI) quantiles in our study. Specifically, higher quantiles were associated with more risk facto…
View article: Conventional and Novel Lipid Measures and Risk of Peripheral Artery Disease
Conventional and Novel Lipid Measures and Risk of Peripheral Artery Disease Open
OBJECTIVE: The aim of this study was to comprehensively assess the association of multiple lipid measures with incident peripheral artery disease (PAD). Approach and Results: We used Cox proportional hazards models to characterize the asso…
View article: Association between circulating Galectin-3 and arterial stiffness in older adults.
Association between circulating Galectin-3 and arterial stiffness in older adults. Open
Background: Galectin-3 (gal-3) is a β-galactoside-binding lectin associated tissue fibrosis and inflammation. There is limited understanding of the relationship between gal-3 and vascular health. Our aim was to assess the association betwe…
View article: Reproducibility and Variability of Protein Analytes Measured Using a Multiplexed Modified Aptamer Assay
Reproducibility and Variability of Protein Analytes Measured Using a Multiplexed Modified Aptamer Assay Open
BACKGROUND: There is growing interest in the use of multiplexed aptamer-based assays for large-scale proteomic studies. However, the analytic, short- and long-term variation of the measured proteins is largely uncharacterized. METHODS: We …
View article: High‐Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change
High‐Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change Open
OBJECTIVES: Cardiac troponin T, measured using a high-sensitive assay (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are associated with increased stroke risk and perhaps with cognitive decline. However, few well-desi…
View article: Benefit of icosapent ethyl across types and sizes of myocardial infarction in REDUCE-IT
Benefit of icosapent ethyl across types and sizes of myocardial infarction in REDUCE-IT Open
Aims We studied the efficacy and safety of icosapent ethyl (IPE) 4 g daily in reducing the risk of myocardial infarction (MI) across different MI subtypes and sizes among REDUCE-IT high-risk patients with hypertriglyceridaemia. Methods and…
View article: Natriuretic Peptide Cut Points for Heart Failure Classification in Individuals With and Without Obesity
Natriuretic Peptide Cut Points for Heart Failure Classification in Individuals With and Without Obesity Open
BACKGROUND: The 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America guidelines introduced elevated natriuretic peptide (NP) levels as a criterion for defining stage B heart failure (HF), or pre-H…