Ralf Moeller
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View article: The biofilm matrix protects<i>Bacillus subtilis</i>against hydrogen peroxide
The biofilm matrix protects<i>Bacillus subtilis</i>against hydrogen peroxide Open
Biofilms formed by Bacillus subtilis confer protection against environmental stressors through extracellular polysaccharides (EPS) and sporulation. This study investigates the roles of these biofilm components in resistance to hydrogen per…
View article: FLASH Bragg-Peak Irradiation With a Therapeutic Carbon Ion Beam: First In Vivo Results
FLASH Bragg-Peak Irradiation With a Therapeutic Carbon Ion Beam: First In Vivo Results Open
These results suggest that the UHDR irradiations can improve the safety and effectiveness of heavy ion therapy, and provide a crucial benchmark for current mechanistic FLASH models. However, additional experiments are needed to validate th…
View article: Earth’s most needed uncultivated aquatic prokaryotes
Earth’s most needed uncultivated aquatic prokaryotes Open
Aquatic ecosystems house a significant fraction of Earth’s biosphere, yet most prokaryotes inhabiting these environments remain uncultivated. While recently developed genome-resolved metagenomics and single-cell genomics techniques have un…
View article: An overview of the bacterial microbiome of public transportation systems—risks, detection, and countermeasures
An overview of the bacterial microbiome of public transportation systems—risks, detection, and countermeasures Open
When we humans travel, our microorganisms come along. These can be harmless but also pathogenic, and are spread by touching surfaces or breathing aerosols in the passenger cabins. As the pandemic with SARS-CoV-2 has shown, those environmen…
View article: Exploring Andean High-Altitude Lake Extremophiles through Advanced Proteotyping
Exploring Andean High-Altitude Lake Extremophiles through Advanced Proteotyping Open
Quickly identifying and characterizing isolates from extreme environments is currently challenging while very important to explore the Earth′s biodiversity. As these isolates may, in principle, be distantly related to known species, techni…
View article: Multifactorial resistance of <i>Bacillus subtilis</i> spores to low-pressure plasma sterilization
Multifactorial resistance of <i>Bacillus subtilis</i> spores to low-pressure plasma sterilization Open
Common sterilization techniques for labile and sensitive materials have far-reaching applications in medical, pharmaceutical, and industrial fields. Heat inactivation, chemical treatment, and radiation are established methods to inactivate…
View article: Fungi under Modified Atmosphere—The Effects of CO2 Stress on Cell Membranes and Description of New Yeast Stenotrophomyces fumitolerans gen. nov., sp. nov.
Fungi under Modified Atmosphere—The Effects of CO2 Stress on Cell Membranes and Description of New Yeast Stenotrophomyces fumitolerans gen. nov., sp. nov. Open
High levels of carbon dioxide are known to inhibit the growth of microorganisms. A total of twenty strains of filamentous fungi and yeasts were isolated from habitats with enriched carbon dioxide concentration. Most strains were derived fr…
View article: Identification of staphyloxanthin and derivates in yellow-pigmented Staphylococcus capitis subsp. capitis
Identification of staphyloxanthin and derivates in yellow-pigmented Staphylococcus capitis subsp. capitis Open
Introduction Staphylococcus capitis naturally colonizes the human skin but as an opportunistic pathogen, it can also cause biofilm-associated infections and bloodstream infections in newborns. Previously, we found that two strains from the…
View article: Human gut microbiome and metabolite dynamics under simulated microgravity
Human gut microbiome and metabolite dynamics under simulated microgravity Open
The Artificial Gravity Bed Rest - European Space Agency (AGBRESA) study was the first joint bed rest study by ESA, DLR, and NASA that examined the effect of simulated weightlessness on the human body and assessed the potential benefits of …
View article: Seasonality Is the Main Determinant of Microbial Diversity Associated to Snow/Ice around Concordia Station on the Antarctic Polar Plateau
Seasonality Is the Main Determinant of Microbial Diversity Associated to Snow/Ice around Concordia Station on the Antarctic Polar Plateau Open
The French–Italian Concordia Research Station, situated on the Antarctic Polar Plateau at an elevation of 3233 m above sea level, offers a unique opportunity to study the presence and variation of microbes introduced by abiotic or biotic v…
View article: Aspergillus niger as a cell factory for the production of pyomelanin, a molecule with UV-C radiation shielding activity
Aspergillus niger as a cell factory for the production of pyomelanin, a molecule with UV-C radiation shielding activity Open
Melanins are complex pigments with various biological functions and potential applications in space exploration and biomedicine due to their radioprotective properties. Aspergillus niger, a fungus known for its high radiation resistance, i…
View article: Biomining of Lunar regolith simulant EAC-1A with the fungus Penicillium simplicissimum
Biomining of Lunar regolith simulant EAC-1A with the fungus Penicillium simplicissimum Open
On a future lunar habitat, acquiring needed resources in situ will inevitably come from the Lunar regolith. Biomining-the use of microorganisms to extract metals from the regolith-is sustainable and energy-efficient, making it highly promi…
View article: Enabling deep-space experimentations on cyanobacteria by monitoring cell division resumption in dried Chroococcidiopsis sp. 029 with accumulated DNA damage
Enabling deep-space experimentations on cyanobacteria by monitoring cell division resumption in dried Chroococcidiopsis sp. 029 with accumulated DNA damage Open
Cyanobacteria are gaining considerable interest as a method of supporting the long-term presence of humans on the Moon and settlements on Mars due to their ability to produce oxygen and their potential as bio-factories for space biotechnol…
View article: Snow Surface Microbial Diversity at the Detection Limit within the Vicinity of the Concordia Station, Antarctica
Snow Surface Microbial Diversity at the Detection Limit within the Vicinity of the Concordia Station, Antarctica Open
The Concordia Research Station provides a unique location for preparatory activities for future human journey to Mars, to explore microbial diversity at subzero temperatures, and monitor the dissemination of human-associated microorganisms…
View article: Enhanced assembly of bacteriophage T7 produced in cell-free reactions under simulated microgravity
Enhanced assembly of bacteriophage T7 produced in cell-free reactions under simulated microgravity Open
On-demand biomanufacturing has the potential to improve healthcare and self-sufficiency during space missions. Cell-free transcription and translation reactions combined with DNA blueprints can produce promising therapeutics like bacteriop…
View article: Phenotypic and genomic assessment of the potential threat of human spaceflight-relevant Staphylococcus capitis isolates under stress conditions
Phenotypic and genomic assessment of the potential threat of human spaceflight-relevant Staphylococcus capitis isolates under stress conditions Open
Previous studies have reported that spaceflight specific conditions such as microgravity lead to changes in bacterial physiology and resistance behavior including increased expression of virulence factors, enhanced biofilm formation and de…
View article: Mars-like UV Flux and Ionizing Radiation Differently Affect Biomarker Detectability in the Desert Cyanobacterium <i>Chroococcidiopsis</i> as Revealed by the Life Detector Chip Antibody Microarray
Mars-like UV Flux and Ionizing Radiation Differently Affect Biomarker Detectability in the Desert Cyanobacterium <i>Chroococcidiopsis</i> as Revealed by the Life Detector Chip Antibody Microarray Open
The effect of a Mars-like UV flux and γ-radiation on the detectability of biomarkers in dried cells of Chroococcidiopsis sp. CCMEE 029 was investigated using a fluorescence sandwich microarray immunoassay. The production of anti-Chroococci…
View article: Colony growth and biofilm formation of Aspergillus niger under simulated microgravity
Colony growth and biofilm formation of Aspergillus niger under simulated microgravity Open
The biotechnology- and medicine-relevant fungus Aspergillus niger is a common colonizer of indoor habitats such as the International Space Station (ISS). Being able to colonize and biodegrade a wide range of surfaces, A. niger can ultimate…
View article: Nucleic acids and melanin pigments after exposure to high doses of gamma rays: a biosignature robustness test
Nucleic acids and melanin pigments after exposure to high doses of gamma rays: a biosignature robustness test Open
The question about the stability of certain biomolecules is directly connected to the life-detection missions aiming to search for past or present life beyond Earth. The extreme conditions experienced on extraterrestrial planet surface ( e…
View article: Experiment verification test of the Artemis I ‘Deep Space Radiation Genomics’ experiment
Experiment verification test of the Artemis I ‘Deep Space Radiation Genomics’ experiment Open
When the Artemis missions launch, NASA's Orion spacecraft (and crew as of the Artemis II mission) will be exposed to the deep space radiation environment beyond the protection of Earth's magnetosphere. Hence, it is essential to characteriz…
View article: Chemical, Thermal, and Radiation Resistance of an Iron Porphyrin: A Model Study of Biosignature Stability
Chemical, Thermal, and Radiation Resistance of an Iron Porphyrin: A Model Study of Biosignature Stability Open
Metal complexes of porphyrins and porphyrin-type compounds are ubiquitous in all three domains of life, with hemes and chlorophylls being the best-known examples. Their diagenetic transformation products are found as geoporphyrins, in whic…