Chandra Mohan
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View article: ConStruct: Structural Distillation of Foundation Models for Prototype-Based Weakly Supervised Histopathology Segmentation
ConStruct: Structural Distillation of Foundation Models for Prototype-Based Weakly Supervised Histopathology Segmentation Open
Weakly supervised semantic segmentation (WSSS) in histopathology relies heavily on classification backbones, yet these models often localize only the most discriminative regions and struggle to capture the full spatial extent of tissue str…
View article: DualProtoSeg: Simple and Efficient Design with Text- and Image-Guided Prototype Learning for Weakly Supervised Histopathology Image Segmentation
DualProtoSeg: Simple and Efficient Design with Text- and Image-Guided Prototype Learning for Weakly Supervised Histopathology Image Segmentation Open
Weakly supervised semantic segmentation (WSSS) in histopathology seeks to reduce annotation cost by learning from image-level labels, yet it remains limited by inter-class homogeneity, intra-class heterogeneity, and the region-shrinkage ef…
View article: LPD: Learnable Prototypes with Diversity Regularization for Weakly Supervised Histopathology Segmentation
LPD: Learnable Prototypes with Diversity Regularization for Weakly Supervised Histopathology Segmentation Open
Weakly supervised semantic segmentation (WSSS) in histopathology reduces pixel-level labeling by learning from image-level labels, but it is hindered by inter-class homogeneity, intra-class heterogeneity, and CAM-induced region shrinkage (…
View article: Correction: A novel technology for home monitoring of lupus nephritis that tracks the pathogenic urine biomarker ALCAM
Correction: A novel technology for home monitoring of lupus nephritis that tracks the pathogenic urine biomarker ALCAM Open
View article: Contrastive Integrated Gradients: A Feature Attribution-Based Method for Explaining Whole Slide Image Classification
Contrastive Integrated Gradients: A Feature Attribution-Based Method for Explaining Whole Slide Image Classification Open
Interpretability is essential in Whole Slide Image (WSI) analysis for computational pathology, where understanding model predictions helps build trust in AI-assisted diagnostics. While Integrated Gradients (IG) and related attribution meth…
View article: Immunomodulation of behavior impairment via spleen-specific targeting lipid nanoparticles in a MeCP2 transgenic mouse model
Immunomodulation of behavior impairment via spleen-specific targeting lipid nanoparticles in a MeCP2 transgenic mouse model Open
This study investigates a novel approach using spleen-targeting lipid nanoparticles (LNPs) to immunomodulate behavioral impairment in a Methyl-CpG-binding protein 2 (Mecp2) transgenic mouse model. In a human Mecp2 transgenic mouse model (B…
View article: New proteomic biomarkers identified in plasma extracellular vesicles in sarcoidosis: a case-control matched study
New proteomic biomarkers identified in plasma extracellular vesicles in sarcoidosis: a case-control matched study Open
Summary BACKGROUND Sarcoidosis is a heterogeneous disease with unknown mechanisms, nonspecific therapies, and multiple etiologies. The role of blood extracellular vesicles (EVs) in the diagnosis and pathogenesis of sarcoidosis remains obsc…
View article: Urine proteins reveal distinct coagulation and complement cascades underlying acute versus chronic lupus nephritis
Urine proteins reveal distinct coagulation and complement cascades underlying acute versus chronic lupus nephritis Open
The current gold standard for assessing renal pathology in lupus nephritis (LN) is invasive and cannot be serially repeated. To assess if urine can serve as a liquid biopsy for underlying renal pathology, urine obtained from patients with …
View article: Double Vessel Disease Diagnosed by Spandan Smartphone-Based ECG and Confirmed by Coronary Angiography: A Case Report
Double Vessel Disease Diagnosed by Spandan Smartphone-Based ECG and Confirmed by Coronary Angiography: A Case Report Open
Introduction: Early diagnosis of obstructive coronary artery disease (CAD), particularly double vessel disease (DVD), is critical for preventing adverse cardiovascular outcomes. Patient Information: A 67-year-old male with known CAD presen…
View article: A CASE REPORT ON SINGLE-VESSEL CORONARY ARTERY DISEASE DETECTED WITH A SMARTPHONE-BASED ECG DEVICE.
A CASE REPORT ON SINGLE-VESSEL CORONARY ARTERY DISEASE DETECTED WITH A SMARTPHONE-BASED ECG DEVICE. Open
View article: Dysregulation of innate and adaptive lymphoid immunity may have implications for symptom attribution and predict responses to targeted therapies in neuropsychiatric systemic lupus erythematosus
Dysregulation of innate and adaptive lymphoid immunity may have implications for symptom attribution and predict responses to targeted therapies in neuropsychiatric systemic lupus erythematosus Open
View article: Corrigendum to “Integrated genomic, proteomic and cognitive assessment in Duchenne Muscular Dystrophy suggest astrocyte centric pathology” [Heliyon Volume 9, Issue 8, August 2023, Article e18530]
Corrigendum to “Integrated genomic, proteomic and cognitive assessment in Duchenne Muscular Dystrophy suggest astrocyte centric pathology” [Heliyon Volume 9, Issue 8, August 2023, Article e18530] Open
[This corrects the article DOI: 10.1016/j.heliyon.2023.e18530.].
View article: Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography
Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography Open
Our results indicate that OCT and its extensions effectively analyze dermal fibrosis. OCE revealed increased stiffness in fibrotic skin, OCTA showed vessel dilation, and OCT noted morphological changes in fibrosis tissue.
View article: Molecular and Cellular Mediators of Renal Fibrosis in Lupus Nephritis
Molecular and Cellular Mediators of Renal Fibrosis in Lupus Nephritis Open
Lupus nephritis (LN), a significant complication of systemic lupus erythematosus (SLE), represents a challenging manifestation of the disease. One of the prominent pathophysiologic mechanisms targeting the renal parenchyma is fibrosis, a t…
View article: Permutation-Invariant Cascaded Attentional Set Operator for Computational Nephropathology
Permutation-Invariant Cascaded Attentional Set Operator for Computational Nephropathology Open
Key Points Permutation-invariant cascaded attentional set operator (PICASO) is a versatile set operator that uses Transformers to dynamically aggregate histopathologic features from a set of glomerular crops. For detecting active crescent …
View article: Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets
Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets Open
Introduction To further advance our understanding of Muscular Dystrophies (MDs) and Spinocerebellar Ataxias (SCAs), it is necessary to identify the biological patterns associated with disease pathology. Although progress has been made in t…
View article: Addressing statistical challenges in the analysis of proteomics data with extremely small sample size: a simulation study
Addressing statistical challenges in the analysis of proteomics data with extremely small sample size: a simulation study Open
When the aim of the study is to identify a statistical model that best distinguishes between cohort groups using proteomics data and to uncover the biological pathways and disorders common among the selected proteins, the majority of widel…
View article: KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes
KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes Open
View article: Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis
Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis Open
Objectives To evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of LN progression or disease resolution across a 1-year study. Methods Serum and urine samples from biopsy proven LN subjects (n = 122)…
View article: iTRAQ-based mass spectrometry screen to identify serum biomarkers in systemic lupus erythematosus
iTRAQ-based mass spectrometry screen to identify serum biomarkers in systemic lupus erythematosus Open
Objective Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disorder with no reliable serum biomarkers currently available other than autoantibodies. Methods In the present study, isobaric tags for relative and absolute q…
View article: Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus
Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus Open
Background Neuropsychiatric lupus (NPSLE) describes the cognitive, memory, and affective emotional burdens faced by many lupus patients. While NPSLE’s pathogenesis has not been fully elucidated, clinical imaging studies and cerebrospinal f…
View article: Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis
Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis Open
View article: Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL/6 background
Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL/6 background Open
Introduction Systemic Lupus Erythematosus (SLE) impacts the central nervous system (CNS), leading to severe neurological and psychiatric manifestations known as neuropsychiatric lupus (NPSLE). The complexity and heterogeneity of clinical p…
View article: O23 Interferon upregulation and B and plasma cell gene dysregulation patterns reveal three distinct lupus nephritis subgroups with differential anticipated response to targeted therapies
O23 Interferon upregulation and B and plasma cell gene dysregulation patterns reveal three distinct lupus nephritis subgroups with differential anticipated response to targeted therapies Open
Objective Current therapeutic management of lupus nephritis (LN) fails to induce long-term remission in over 50% of patients, highlighting the urgent need for more effective drugs. The aim of this study was to investigate the LN transcript…
View article: O15 B cell, T cell, cytotoxic/NK cell, and mitochondrial gene dysregulation patterns separate neuropsychiatric systemic lupus erythematosus patients into two distinct subgroups with differential anticipated response to targeted therapies
O15 B cell, T cell, cytotoxic/NK cell, and mitochondrial gene dysregulation patterns separate neuropsychiatric systemic lupus erythematosus patients into two distinct subgroups with differential anticipated response to targeted therapies Open
Objective The management of neuropsychiatric (NP) systemic lupus erythematosus (SLE) is poorly optimised and specific treatment is lacking. The aim of this study was to perform an in-depth investigation of the transcriptome of SLE patients…
View article: Duplex Vertical-Flow Rapid Tests for Point-of-Care Detection of Anti-dsDNA and Anti-Nuclear Autoantibodies
Duplex Vertical-Flow Rapid Tests for Point-of-Care Detection of Anti-dsDNA and Anti-Nuclear Autoantibodies Open
The goal of this study is to develop a rapid diagnostic test for rheumatic disease and systemic lupus erythematosus (SLE) screening. A novel rapid vertical flow assay (VFA) was engineered and used to assay anti-nuclear (ANA) and anti-dsDNA…
View article: Diagnostic outcome of pro bono neurogenetic diagnostic service in Sri Lanka: A wealth creation
Diagnostic outcome of pro bono neurogenetic diagnostic service in Sri Lanka: A wealth creation Open
View article: Duplex vertical flow rapid tests for point-of-care detection of anti-dsDNA and anti-nuclear autoantibodies
Duplex vertical flow rapid tests for point-of-care detection of anti-dsDNA and anti-nuclear autoantibodies Open
The goal of this study was to develop a rapid diagnostic kit for rheumatic disease and systemic lupus erythematosus (SLE) screening. A novel rapid vertical flow assay (VFA) was engineered and used to assay anti-nuclear (ANA) and anti-dsDNA…
View article: IoT-Enhanced Healthcare: A Patient Care Evaluation Using the IoT Healthcare Test
IoT-Enhanced Healthcare: A Patient Care Evaluation Using the IoT Healthcare Test Open
Empirical insights into the significant effects of IoT-Enhanced Healthcare on patient care and health outcomes are provided by this study. The transformational potential of IoT technology is shown by data generated from a varied patient gr…
View article: Fas gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus
Fas gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus Open
Sle1 and Faslpr are two lupus susceptibility loci that lead to manifestations of systemic lupus erythematosus. To evaluate the dosage effects of Faslpr in determining cellular and serological phenotypes associated wit…