Kari C. Nadeau
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View article: A phase 2 randomized controlled trial using biologics to improve multi OIT outcomes (COMBINE): design, rationale, and methods
A phase 2 randomized controlled trial using biologics to improve multi OIT outcomes (COMBINE): design, rationale, and methods Open
Background Food allergy remains a serious public health concern associated with significantly lowered quality of life and the risk of potentially life-threatening allergic reactions. While oral immunotherapy (OIT) has consistently demonstr…
View article: Evaluating COVID-19 severity prediction and immune dynamics with NULISAseq: Insights from the IMPACC study.
Evaluating COVID-19 severity prediction and immune dynamics with NULISAseq: Insights from the IMPACC study. Open
The National Institutes of Health-funded IMPACC (IMmunoPhenotyping Assessment in a COVID-19 Cohort) evaluated longitudinal clinical and immunological features of human patients hospitalized for COVID-19. This study focuses on comparing the…
View article: Interferon-mediated NK cell activation increases cytolytic activity against T follicular helper cells and limits antibody response to SARS-CoV-2
Interferon-mediated NK cell activation increases cytolytic activity against T follicular helper cells and limits antibody response to SARS-CoV-2 Open
Natural killer (NK) cells are innate lymphocytes known for their ability to kill infected or malignant cells, but they have an overlooked role in regulating antibody responses. In mice, NK cells can kill T follicular helper (T FH ) cells, …
View article: Sex-associated and disease state-dependent monocyte polarization and CNS-trafficking phenotypes in pediatric acute-onset neuropsychiatric syndrome (PANS)
Sex-associated and disease state-dependent monocyte polarization and CNS-trafficking phenotypes in pediatric acute-onset neuropsychiatric syndrome (PANS) Open
Pediatric acute-onset neuropsychiatric syndrome (PANS) is characterized by the sudden onset of obsessive-compulsive symptoms alongside a constellation of neuropsychiatric and somatic features. Disease progression typically includes flare a…
View article: Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness
Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness Open
Oral immunotherapy (OIT) is the only U.S. Food and Drud Administration-approved treatment for peanut allergy. Peanut-reactive (pr) CD4+ T cells are pivotal in peanut allergy pathogenesis and OIT-induced desensitization. However, the underl…
View article: Trends in allergen-reactive CRTH2+ T cells and TARC associated with successful outcomes in a phase 2 cashew oral immunotherapy study
Trends in allergen-reactive CRTH2+ T cells and TARC associated with successful outcomes in a phase 2 cashew oral immunotherapy study Open
Background We designed an oral immunotherapy (OIT) clinical trial for cashew allergy to further our understanding of immunological responses with treatment, including changes in allergen-specific T cells. This information can further assis…
View article: Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS
Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS Open
Background Elevated circulating endothelial cells (CECs), released from monolayers after insult, have been implicated in worse outcomes in ARDS and COVID-19, however there is no consensus proteomic phenotype that define CECs. We queried wh…
View article: California Wildfire Inventory (CAWFI): An Extensive Dataset for Predictive Techniques based on Artificial Intelligence
California Wildfire Inventory (CAWFI): An Extensive Dataset for Predictive Techniques based on Artificial Intelligence Open
Due to climate change and the disruption of ecosystems worldwide, wildfires are increasingly impacting environment, infrastructure, and human lives globally. Additionally, an exacerbating climate crisis means that these losses would contin…
View article: Pilot proteomics study suggests elevated tumorigenesis-promoting biomarkers in healthy adults after air pollution exposure
Pilot proteomics study suggests elevated tumorigenesis-promoting biomarkers in healthy adults after air pollution exposure Open
Objectives Recent studies have shown that immune and cardiometabolic biomarker levels increased in individuals exposed to ambient air pollution. We sought to explore the feasibility of identifying a pollution exposure signature using the O…
View article: A multiomics recovery factor predicts long COVID in the IMPACC study
A multiomics recovery factor predicts long COVID in the IMPACC study Open
BACKGROUNDFollowing SARS-CoV-2 infection, approximately 10%-35% of patients with COVID-19 experience long COVID (LC), in which debilitating symptoms persist for at least 3 months. Elucidating the biologic underpinnings of LC could identify…
View article: Guidelines for Intersectional Analysis in Science and Technology: Implementation and Checklist Development
Guidelines for Intersectional Analysis in Science and Technology: Implementation and Checklist Development Open
Intersectional analysis goes beyond consideration of single variables to examine the compounded impact at the intersections of, for example, gender and race, or geographical location and caste. The Guidelines for Intersectional Analysis in…
View article: Call to action: recognize and prevent the effects of extreme heat on early childhood development and health
Call to action: recognize and prevent the effects of extreme heat on early childhood development and health Open
The frequency and severity of heat waves are expected to worsen with climate change. Exposure to extreme heat, or prolonged unusually high temperatures, are associated with increased morbidity and mortality. The fetus, infant, and young ch…
View article: Shrimp oral immunotherapy outcomes in the phase 2 clinical trial: MOTIF
Shrimp oral immunotherapy outcomes in the phase 2 clinical trial: MOTIF Open
Introduction Shrimp is a common but understudied food allergen with relatively high rates of emergency department visits. Here we report the shrimp OIT outcomes in the MOTIF (NCT03504774) clinical trial and discuss some of the challenges w…
View article: The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases
The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases Open
The epithelial barrier theory proposes that modern environmental exposures compromise skin and mucosal surfaces, initiating local inflammation that propagates systemically. The theory integrates epidemiological trends, molecular mechanisti…
View article: Impact of Residential Greeness Exposure on the Development of Allergic Diseases and Asthma and on Asthma Control—A Systematic Review for the <scp>EAACI</scp> Guidelines of Environmental Science for Allergic Diseases and Asthma
Impact of Residential Greeness Exposure on the Development of Allergic Diseases and Asthma and on Asthma Control—A Systematic Review for the <span>EAACI</span> Guidelines of Environmental Science for Allergic Diseases and Asthma Open
The role of residential greenness exposure (RGE) in prevention and control of allergic diseases remains controversial. This systematic review evaluated the association between RGE and the risk of developing asthma, allergic rhinitis (AR), …
View article: Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study
Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study Open
Introduction The coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study collected clinical, demograph…
View article: MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury
MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury Open
MHC class I polypeptide-related sequence B (MICB) is a ligand for NKG2D. We have shown NK cells are central to lung transplant acute lung injury (ALI) via NKG2D activation, and increased MICB in bronchoalveolar lavage predicts ALI severity…
View article: Characterizing everyday exposure to volatile organic compounds and upper respiratory health effects
Characterizing everyday exposure to volatile organic compounds and upper respiratory health effects Open
Volatile organic compounds (VOCs) are relatively understudied pollutants compared to particulate matter but are ubiquitous in outdoor and indoor environments. Prior studies on VOCs on sinonasal health have been difficult to generalize due …
View article: The Evolution, Immunopathogenesis and Biomarkers of Type 2 Inflammation in Common Allergic Disorders
The Evolution, Immunopathogenesis and Biomarkers of Type 2 Inflammation in Common Allergic Disorders Open
The prevalence of allergic diseases, including allergic rhinitis, chronic rhinosinusitis, asthma, eosinophilic esophagitis, food and drug allergies, and atopic dermatitis, has been increasing globally over the past few decades. Allergic di…
View article: Empiric Azithromycin in COVID-19 Impacts the Respiratory Microbiome and Antimicrobial Resistome without Anti-inflammatory Benefit
Empiric Azithromycin in COVID-19 Impacts the Respiratory Microbiome and Antimicrobial Resistome without Anti-inflammatory Benefit Open
Azithromycin is often prescribed unnecessarily for respiratory infections, many of which are viral. During the COVID-19 pandemic, its use was widespread, in part due to alleged therapeutic benefits, which have since been disproven. Here, w…
View article: Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort
Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort Open
T2 immune responses were associated with lower virus loads and more favorable clinical outcomes, suggesting that T2 inflammation related to asthma and allergic diseases may have a direct protective effect against SARS-CoV-2.
View article: High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19
High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19 Open
CD16A is an activating Fc receptor on NK cells that mediates antibody-dependent cellular cytotoxicity (ADCC), a key mechanism in antiviral immunity. However, the role of NK cell-mediated ADCC in SARS-CoV-2 infection remains unclear, partic…
View article: Extreme heat and hospital admissions in older adults: A small-area analysis in the Greater Boston metropolitan area
Extreme heat and hospital admissions in older adults: A small-area analysis in the Greater Boston metropolitan area Open
Extreme heat (EH) is a leading cause of weather-related fatalities in the United States. In Massachusetts, average temperatures have increased by 1.9 °C since the 20th century, higher than the global average increase of 1.1 °C. EH dispropo…