David Gillespie
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View article: Are you afraid of <scp>COVID</scp> ‐19? Motivation and engagement in infection–prevention behaviour in a <scp>UK</scp> community cohort during the first 2 years of the <scp>COVID</scp> ‐19 pandemic
Are you afraid of <span>COVID</span> ‐19? Motivation and engagement in infection–prevention behaviour in a <span>UK</span> community cohort during the first 2 years of the <span>COVID</span> ‐19 pandemic Open
Objectives To investigate the relationship between motivation and COVID‐19 infection–prevention behaviour during the first 2 years of the COVID‐19 pandemic. Design Prospective longitudinal online survey in a UK community‐based cohort. Meth…
View article: Assessing the content validity of a Patient Reported Outcome Measure item pool for Rheumatoid Arthritis Disease Activity using cognitive interviews
Assessing the content validity of a Patient Reported Outcome Measure item pool for Rheumatoid Arthritis Disease Activity using cognitive interviews Open
Objectives Using Rasch measurement theory, an item pool of 12 questions has been identified, covering tenderness and swelling, disease activity, pain, physical functioning and stiffness for assessing the construct of RA disease activity. T…
View article: Risk of myocardial infarction and stroke following microbiologically confirmed urinary tract infection: a self-controlled case series study using linked electronic health data
Risk of myocardial infarction and stroke following microbiologically confirmed urinary tract infection: a self-controlled case series study using linked electronic health data Open
Objectives The inflammatory response from acute infection may trigger cardiovascular events. We aimed to estimate associations between microbiologically confirmed urinary tract infections (UTIs) and first acute myocardial infarction (MI) a…
View article: Patient Reported Outcome Measures for Rheumatoid Arthritis Disease Activity: Rasch measurement theory to identify items and domains
Patient Reported Outcome Measures for Rheumatoid Arthritis Disease Activity: Rasch measurement theory to identify items and domains Open
Objectives Disease activity (DA) monitoring is a standard of care in RA. There is demand for achieving this through patient-reported outcome measures (PROMs). The aim of this study was to determine which items could be used to measure the …
View article: Influencing Factors for the Acceptability of Accessing HIV Pre‐exposure Prophylaxis via Community Pharmacies in Wales
Influencing Factors for the Acceptability of Accessing HIV Pre‐exposure Prophylaxis via Community Pharmacies in Wales Open
Introduction HIV prevention methods, such as pre‐exposure prophylaxis (PrEP), have been a significant contributing factor to a global decline in HIV transmission. PrEP has been available through the NHS in Wales since 2017. However, access…
View article: Teaching Early Reading Skills to Adults With Intellectual Disabilities Using a Support Worker/Family Carer Mediated Online Reading Programme: A Feasibility Randomised Controlled Trial
Teaching Early Reading Skills to Adults With Intellectual Disabilities Using a Support Worker/Family Carer Mediated Online Reading Programme: A Feasibility Randomised Controlled Trial Open
Background There is a paucity of research into interventions that help people with intellectual disabilities learn to read. This feasibility study examines whether an online reading programme, Headsprout, with additional support strategies…
View article: Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT
Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT Open
Background Children with a learning disability experience a range of inequalities and adverse life events that put them at greater risk of mental health problems. The construct of emotional literacy has been shown to be a moderating factor…
View article: Cost-effectiveness of C-reactive protein point of care testing for safely reducing antibiotic consumption for acute exacerbations of chronic obstructive pulmonary disease as part of the multicentre, parallel-arm, open, individually randomised, controlled PACE trial
Cost-effectiveness of C-reactive protein point of care testing for safely reducing antibiotic consumption for acute exacerbations of chronic obstructive pulmonary disease as part of the multicentre, parallel-arm, open, individually randomised, controlled PACE trial Open
Objectives Many patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care do not benefit from antibiotics. Excessive use wastes resources, promotes antimicrobial resistance and can harm …
View article: Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: the BEAMS-ID feasibility study
Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: the BEAMS-ID feasibility study Open
Background Interventions for anxiety need to be adapted to meet the needs of autistic people with moderate to severe learning disabilities and successfully modelled before evidence about efficacy can be generated from clinical trials. Obje…
View article: HIV Pre‐Exposure Prophylaxis (PrEP) Users' Experiences of PrEP Access, Sexual Behaviour, and Well‐Being During the COVID‐19 Pandemic: A Welsh Qualitative Study
HIV Pre‐Exposure Prophylaxis (PrEP) Users' Experiences of PrEP Access, Sexual Behaviour, and Well‐Being During the COVID‐19 Pandemic: A Welsh Qualitative Study Open
Background HIV Pre‐Exposure Prophylaxis (PrEP) has been available in Wales since 2017. The coronavirus disease (COVID‐19) pandemic impacted UK sexual health services, leading to a reduction in service provision. There is a lack of research…
View article: The optimal antibiotic treatment duration for community-acquired pneumonia in adults diagnosed in general practice in Denmark (CAP-D): an open-label, pragmatic, randomised controlled trial
The optimal antibiotic treatment duration for community-acquired pneumonia in adults diagnosed in general practice in Denmark (CAP-D): an open-label, pragmatic, randomised controlled trial Open
This study will provide evidence for the optimal antibiotic treatment duration of CAP in general practice and inform future guidelines on CAP in all countries using phenoxymethylpenicillin for the treatment of acute respiratory tract infec…
View article: Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: The <scp>BEAMS</scp>‐<scp>ID</scp> feasibility study
Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: The <span>BEAMS</span>‐<span>ID</span> feasibility study Open
Background The aim of this feasibility study was to adapt and model a behavioural intervention for anxiety with autistic adults with moderate to severe intellectual disabilities. Method Twenty‐eight autistic adults with moderate or severe …
View article: All-cause and Infection-attributable Mortality Amongst Adults With Bloodstream Infection—a Population-based Study
All-cause and Infection-attributable Mortality Amongst Adults With Bloodstream Infection—a Population-based Study Open
Background Bloodstream infections (BSIs) are common, life-threatening infections. However, it remains unclear whether deaths following BSIs are primarily from uncontrolled infection or underlying comorbidities. We aimed to determine the ov…
View article: Behavioural activation for depressive symptoms in adults with severe to profound intellectual disabilities: Modelling and initial feasibility study
Behavioural activation for depressive symptoms in adults with severe to profound intellectual disabilities: Modelling and initial feasibility study Open
Background Almost no research has been published reporting on evaluations of the effectiveness of psychological interventions for people with severe to profound intellectual disabilities and depression. This paper describes the development…
View article: Digital adaptation of the Standing up for Myself intervention in young people and adults with intellectual disabilities: the STORM feasibility study
Digital adaptation of the Standing up for Myself intervention in young people and adults with intellectual disabilities: the STORM feasibility study Open
Background Stigma contributes to the negative social conditions persons with intellectual disabilities are exposed to, and it needs tackling at multiple levels. Standing Up for Myself is a psychosocial group intervention designed to enable…
View article: Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis
Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis Open
Background Resistance to antibiotics is rising and threatens future antibiotic effectiveness. ‘Antibiotic targeting’ ensures patients who may benefit from antibiotics receive them, while being safely withheld from those who may not. Point-…
View article: Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis
Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis Open
Background Resistance to antibiotics is rising and threatens future antibiotic effectiveness. ‘Antibiotic targeting’ ensures patients who may benefit from antibiotics receive them, while being safely withheld from those who may not. Point-…
View article: All-cause and infection-attributable mortality amongst adults with bloodstream infection – a population-based study
All-cause and infection-attributable mortality amongst adults with bloodstream infection – a population-based study Open
Background Bloodstream infections (BSI), are common, life threatening infections. However, it remains unclear whether deaths following BSI are primarily due to uncontrolled infection or underlying comorbidities. We aimed to determine the o…
View article: Patterns of GP and nurse independent prescriber prescriptions for antibiotics dispensed in the community in England: a retrospective analysis
Patterns of GP and nurse independent prescriber prescriptions for antibiotics dispensed in the community in England: a retrospective analysis Open
Background Physician–nurse task shifting, a process of delegation whereby tasks are moved to other specialized healthcare workers, is used in primary care in many countries to improve access, efficiency and quality of care. One such task i…
View article: Gut microbiology of UK care home residents: a cross-sectional analysis from a randomised controlled trial
Gut microbiology of UK care home residents: a cross-sectional analysis from a randomised controlled trial Open
We demonstrated that care home residents harbour significant levels of antimicrobial-resistant organisms in their stool. This work emphasises the importance of both enhanced infection control practices and antimicrobial stewardship program…
View article: O02 Patterns of GP and nurse-independent prescriber prescriptions for antibiotics dispensed in the community in England: a retrospective analysis
O02 Patterns of GP and nurse-independent prescriber prescriptions for antibiotics dispensed in the community in England: a retrospective analysis Open
Background The substitution of nurses for doctors is a strategy used in primary care to improve access to, and efficiency and quality of, care. Many of these nurses prescribe medicines including antibiotics. Objectives To identify nurse-in…
View article: DS27 Establishing clinician and patient perspectives on a proposed trial investigating antibiotics in skin surgery
DS27 Establishing clinician and patient perspectives on a proposed trial investigating antibiotics in skin surgery Open
Surgical site infection (SSI) following excision of ulcerated skin cancers is a well-recognized complication; however, the exact risk is unknown and there is no consensus on antibiotic prescribing in this setting. The EXCISE trial (EXamini…
View article: Perspectives of Statistician, Microbiologist, and Clinician Stakeholders on the Use of Microbiological Outcomes in Randomised Trials of Antimicrobial Stewardship Interventions
Perspectives of Statistician, Microbiologist, and Clinician Stakeholders on the Use of Microbiological Outcomes in Randomised Trials of Antimicrobial Stewardship Interventions Open
Microbiological data are used as indicators of infection, for diagnosis, and the identification of antimicrobial resistance in trials of antimicrobial stewardship interventions. However, several problems have been identified in a recently …
View article: P035 Patient-reported outcome measures for rheumatoid arthritis disease activity: using Rasch measurement theory to achieve more meaningful measurement
P035 Patient-reported outcome measures for rheumatoid arthritis disease activity: using Rasch measurement theory to achieve more meaningful measurement Open
Background/Aims Disease activity (DA) monitoring is a standard of care in rheumatoid arthritis (RA), and there is demand for achieving this through patient-reported outcome measures (PROMs). A systematic review of PROMs for RA DA following…
View article: Effects of implementation support on children's reading outcomes following an online early reading programme: A cluster‐randomised controlled trial
Effects of implementation support on children's reading outcomes following an online early reading programme: A cluster‐randomised controlled trial Open
Well‐designed computer or app‐based instruction has a number of potential benefits (eg increasing accessibility and feasibility of high‐quality instruction, reducing time and resources required for training expert delivery, saving instruct…