Explanipedia

Metal fluoride nanoregulators reverse therapeutic resistance via stemness remodeling to trigger pyroptosis for chemoimmunotherapy Open

Shumin Sun, Nailin Yang, Jihu Nie, Linzhu Zhang, Di Wang , et al. · 2025

Chemoresistance and immunosuppression serve as major obstacles that compromise the therapeutic efficacy of chemoimmunotherapy. Herein, we reported a novel chemoimmunotherapy strategy employing metal fluoride to modulate Wnt/β-catenin signa…

RGD-grafted dextran methacrylate hydrogel incorporating osteogenic peptide and Mn3O4 nanozymes for enhanced bone defect healing Open

Yuxuan Pang, Xin Wang, Huan Zhang, Xin Li, Min Lin , et al. · 2025

Biomimetic membrane-coating zinc sulfide nanoparticles for anti-inflammatory combined neuroprotective therapy for spinal cord injury Open

Qin Qin, Bingrong Jin, Chaowen Bai, Zijie Zhou, Bingchen Shan , et al. · 2025

Spinal cord regeneration remains challenging due to complex inflammatory microenvironments, imbalances in metal ions, and obstacles to neuronal regeneration following spinal cord injury (SCI). Herein, microglial cell membranes coated with …

Metal-doping engineering-driven STING-PANoptosis cascade for enhanced cancer sono-immunotherapy Open

Huali Lei, X. Li, Lin Liu, Youdong Chen, Shumin Sun , et al. · 2025

Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice Open

Shunyi Lu, Jie Cao, Zhuorun Song, Fei Gong, Peng Yang , et al. · 2025

Sonodynamic therapy augmented by glycolysis inhibition: a novel metabolic reprogramming strategy for enhanced osteosarcoma treatment Open

Zhuorun Song, Shunyi Lu, Yuqi Yang, Zijun Chen, Youdong Chen , et al. · 2025

A metabolic reprogramming strategy, considered an efficient way to enhance current therapies, has provided renewed hope for treating osteosarcoma (OS), which has reached a bottleneck in clinical practice. In this study, SHK@Mn-TiO2 were de…

Lactate‐Modulating Nanoreactors Facilitate Self‐Amplifying Pyroptosis and the cGAS‐STING Cascade for Potentiated Catalytic‐Immunotherapy Open

Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang , et al. · 2025

The strategic induction of pyroptosis, coupled with the targeted potentiation of cGAS‐STING activation, represents a promising immunostimulatory approach. Herein, an intelligent lactate‐depleting LOCoF 2 nanoreactor system is developed tha…

An experimental investigation of local scour at squat, shallowly embedded subsea structures Open

Lili Qu, Hongwei An, Scott Draper, P. Watson, Liang Cheng · 2025

Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy Open

Linzhu Zhang, Di Wang, Yiming Liu, Nailin Yang, Shumin Sun , et al. · 2025

Advancing antiferromagnetic nitrides via metal alloy nitridation Open

Qianying Wang, Lele Zhang, Zhi He, Qian Li, Haitao Hong , et al. · 2025

Nitride materials, valued for their structural stability and exceptional physical properties, have garnered significant interest in both fundamental research and technological applications. The fabrication of high-quality nitride thin film…

Efficacy and safety of Fe-curcumin coordination polymer nanodots to prevent corneal neovascularization in alkali burn models Open

Yan Huo, Lele Song, Zhihui Han, Yihan Yang, Tianyao Wang , et al. · 2025

Alkali burns pose a significant risk of corneal injury, leading to potential blindness. During the progression of alkali burns, heightened oxidation levels can induce corneal damage, resulting in diminished clarity and vision loss. In this…

Magnesium microspheres for enhanced transarterial chemoembolization therapy of hepatocellular carcinoma: From animal models to a pilot clinical study Open

Fei Gong, Liyun Zheng, Jiachen Xu, Yumin Wu, Qiaoling Jin , et al. · 2025

Transarterial chemoembolization (TACE) has been extensively used in clinic to treat unresectable hepatocellular carcinoma (HCC). Herein, magnesium microspheres (Mg MSs) were used as embolic devices to enhance lipiodol-mediated TACE. After …

Mechanisms of the regulation of tumor cell death by metal ion-based nanomaterials Open

Yali Yang, Shumin Sun, Nailin Yang, Jihu Nie, Liang Cheng · 2025

High-Yield Production of MXene Nanosheets by Graphite-Assisted Ball-Milling Open

Liang Cheng, Feng Tai, Zishuo Wang, Zejun Zhang, Z. Huang , et al. · 2025

Neuroblastoma‐Targeting π‐Conjugated COP Nanostructure with Multiple Enzyme‐Mimetic Actions for Sonochemodynamic Immunotherapies Open

Qian Li, Tian Tian, Wei Geng, Xiaotong Huang, Xiaohui Xu , et al. · 2025

Sonodynamic therapy (SDT) has emerged as a promising strategy for neuroblastoma treatment, leveraging ultrasound to induce the production of reactive oxygen species (ROS) at tumor sites, thereby enhancing the efficacy of immunotherapy. How…

Advancing Antiferromagnetic Nitrides via Metal Alloy Nitridation Open

Qianying Wang, Zexu He, Lele Zhang, Qian Li, Haitao Hong , et al. · 2025

Nitride materials, valued for their structural stability and exceptional physical properties, have garnered significant interest in both fundamental research and technological applications. The fabrication of high-quality nitride thin film…

Preparation and properties of chitosan quaternary ammonium salt/α-calcium sulfate hemihydrate/β-tricalcium phosphate composite bone cement Open

Shaobing Zhang, Ziyu Lian, Xingtao Chen, Ke Duan, Liang Cheng , et al. · 2025

HACC/α-CSH/β-TCP composite bone cements demonstrate promising clinical potential owing to their improved setting time, mechanical properties, injectability, and cytocompatibility. This material is a strong candidate as a substitute for art…

Multi‐Core Functional Microspheres for Osteoporotic Bone Defects Therapy: From Local Treatment to Systematic Relief Open

Jie Cao, Zhihui Han, Shumin Sun, Changhao Li, X. Pan , et al. · 2025

Bone repair in patients with osteoporosis is a major challenge. In this study, multi‐enhanced bioactive microsphere scaffolds (abbr. GMA MSs) composed of a gelatin framework with alendronate (ALN) and magnesium (Mg) spheres encapsulants ar…

Corrigendum to “Mutual dissolution and exsolution enables superior coking resistance of cermet fuel electrode” [Chem. Eng. J. 505 (2025) 159587] Open

Liang Cheng, Yucun Zhou, Linghong Luo, Leying Wang, Xu Xu , et al. · 2025

Synergistic effects of oleic acid modified TiO <sub>2</sub> and alkyl polysulfide in forming extreme pressure tribo-films: A mechanistic study Open

Kaiyang Zeng, Hongfei Shi, Liang Cheng, Li Zhang, Feng Liang , et al. · 2025

Synthesis, Stability, and Tribological Performance of TiO2 Nanomaterials for Advanced Applications Open

Kai Zeng, Liang Cheng, Wen‐Jing Hu, Jiusheng Li · 2025

The enhancement of tribological properties represents a pivotal strategy for achieving energy efficiency and environmental protection. Titanium dioxide (TiO2) nanomaterials have been garnering significant attention due to their exemplary t…

Mutual dissolution and exsolution enables superior coking resistance of cermet fuel electrode Open

Liang Cheng, Yucun Zhou, Linghong Luo, Leying Wang, Xu Xu , et al. · 2025

Dual functional nanoplatforms potentiate osteosarcoma immunotherapy via microenvironment modulation Open

Shunyi Lu, Yuqi Yang, Zhuorun Song, Jie Cao, Zhihui Han , et al. · 2025

Osteosarcoma (OS), a highly aggressive bone tumor, presents significant challenges in terms of effective treatment. We identified that cellular autophagy was impaired within OS by comparing clinical OS samples through bioinformatic analyse…

Amplification of scour onset due to external geometric features on seabed pipelines Open

Terry Griffiths, Feifei Tong, Liang Cheng, David White, Antonino Fogliani · 2025

Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy Open

Guanghui Hou, Youdong Chen, Huali Lei, Shunyi Lu, Liang Cheng · 2024

Malignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become a critical strategy for cancer treatment. PANoptosis, a newly discovered form of regulated cell death, integrate…

Bimetallic peroxide nanoparticles induce PANoptosis by disrupting ion homeostasis for enhanced immunotherapy Open

Guanghui Hou, Youdong Chen, Huali Lei, Yu‐Ling Lu, Lin Liu , et al. · 2024

PANoptosis has recently emerged as a potential approach to improve the immune microenvironment. However, current methods for inducing PANoptosis are limited. Herein, through biological screening, the rational use of the nutrient metal ions…

Oncogenic <i>SLC2A11–MIF</i> fusion protein interacts with polypyrimidine tract binding protein 1 to facilitate bladder cancer proliferation and metastasis by regulating mRNA stability Open

Liang Cheng, Chenwei Yang, Junlin Lu, Ming Huang, Ruihui Xie , et al. · 2024

Chimeric RNAs, distinct from DNA gene fusions, have emerged as promising therapeutic targets with diverse functions in cancer treatment. However, the functional significance and therapeutic potential of most chimeric RNAs remain unclear. H…

Associations of dietary pattern, insulin resistance and risk of developing metabolic syndrome among Chinese population Open

Liyong Kou, Jing Ping Sun, Ping Wu, Cheng Zhou, Ping Zhou , et al. · 2024

Evidence regarding the role of dietary patterns in metabolic syndrome (MetS) is limited. The mechanistic links between dietary patterns, insulin resistance, and MetS are not fully understood. This study aimed to evaluate the associations b…

Magnesium implants with alternating magnetic field-enhanced hydrogen release and proton depletion for anti-infection treatment and tissue repair Open

Nailin Yang, Xiaoyuan Yang, Shuning Cheng, Xiang Gao, Shumin Sun , et al. · 2024

Implant-related osteomyelitis is a formidable hurdle in the clinical setting and is characterized by inflammation, infection, and consequential bone destruction. Therefore, effective reactive oxygen species (ROS) scavenging, bacterial kill…

Application of nanotechnology in the treatment of glomerulonephritis: current status and future perspectives Open

He-Qin Zhan, Xiaoxun Zhang, Xu‐Lin Chen, Liang Cheng, Xianwen Wang · 2024

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