Pan‐Chyr Yang
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View article: Local M1 Macrophage Reprogramming with Gluconic Acid-Coated Selenium Nanoparticles
Local M1 Macrophage Reprogramming with Gluconic Acid-Coated Selenium Nanoparticles Open
Their dual localization within both TAMs and cancer cells further highlights their therapeutic potential, presenting a promising strategy to advance TAM-based cancer therapies and improve clinical outcomes.
View article: LCRMP-1 induces tumor angiogenesis by transcriptionally upregulating SERPINE1 in lung adenocarcinoma
LCRMP-1 induces tumor angiogenesis by transcriptionally upregulating SERPINE1 in lung adenocarcinoma Open
Angiogenesis is a crucial process in cancer progression, particularly in malignant tumors, as it facilitates tumor growth and metastasis by generating new blood vessels that supply vital nutrients and oxygen. However, the regulatory mechan…
View article: Decoding the enigma of multiple primary lung cancers: from mechanism to bedside—a narrative review
Decoding the enigma of multiple primary lung cancers: from mechanism to bedside—a narrative review Open
MPLC is a distinct entity arising from genetic, epigenetic, and microenvironmental interplay. Advancing its management requires multi-omics integration to decipher pathology and identify biomarkers. Future work should develop AI-enhanced d…
View article: Alcohol consumption patterns and risk of HIV transmission among men who have sex with men living with HIV in Chongqing, southwestern China
Alcohol consumption patterns and risk of HIV transmission among men who have sex with men living with HIV in Chongqing, southwestern China Open
Introduction There has been limited research on alcohol consumption patterns and their specific risks for the transmission of human immunodeficiency virus (HIV) and sexually transmitted infections (STIs) among men who have sex with men (MS…
View article: Lessons Learned From International Lung Cancer Screening Trials; People at Risk Deserve Screening for Early Detection
Lessons Learned From International Lung Cancer Screening Trials; People at Risk Deserve Screening for Early Detection Open
In the modern era, the role of lung cancer screening by low dose computed tomography (CT) is now broadly accepted, with many jurisdictions offering or intending to offer population‐based screening based on high quality randomised controlle…
View article: Phage and enzyme therapies in wound infections: From lab to bedside
Phage and enzyme therapies in wound infections: From lab to bedside Open
Antibiotic-resistant (AR) bacterial wound infections (WIs) impose major burdens on healthcare systems, exacerbated by ineffective therapies and stalled antibiotic development. Phage therapy and phage-derived enzymes have gained traction as…
View article: LIO-GC: LiDAR Inertial Odometry with Adaptive Ground Constraints
LIO-GC: LiDAR Inertial Odometry with Adaptive Ground Constraints Open
LiDAR-based simultaneous localization and mapping (SLAM) techniques are commonly applied in high-precision mapping and positioning for mobile platforms. However, the vertical resolution limitations of multi-beam spinning LiDAR sensors can …
View article: Association between vitamin B2 intake and female infertility: a cross-sectional study
Association between vitamin B2 intake and female infertility: a cross-sectional study Open
The high rate of unexplained female infertility significantly affects public health and women's mental well-being. Research on dietary nutrients' impact on infertility often overlooks vitamin B2. Exploring this vitamin's role could be cruc…
View article: Brain miR-137 governs growth and development via GH/IGF-1 signaling
Brain miR-137 governs growth and development via GH/IGF-1 signaling Open
Background Brain-enriched miR-137 is highly associated with neuropsychiatric disorders and neural development. Although complete loss of miR-137 that leads to postnatal lethality had been addressed in mice, the underlying mechanism particu…
View article: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation
The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation Open
Background The COVID-19 pandemic continues to affect the world in 2025. The rapid mutation of SARS-CoV-2 results in breakthrough infections and diminishes the efficacy of vaccines and anti-viral drugs. The severity of the disease varies ac…
View article: The HBV seroprevalence and immune responses to hepatitis B vaccination among college students from four universities in China
The HBV seroprevalence and immune responses to hepatitis B vaccination among college students from four universities in China Open
The HBsAg prevalence among college students has been significantly reduced after the integration of hepatitis B vaccine into Expanded Program on Immunization, but the rate of seroprotective anti-HBs among these students remains low. Hepati…
View article: Progression of drug resistance or multiple primary lung cancer: a case report and literature review of a patient with mesenchymal–epithelial transition factor exon 14 skipping alterations lung adenocarcinoma
Progression of drug resistance or multiple primary lung cancer: a case report and literature review of a patient with mesenchymal–epithelial transition factor exon 14 skipping alterations lung adenocarcinoma Open
Mesenchymal–epithelial transition factor (MET) exon 14 skipping alterations are rare mutations in non-small-cell lung cancer, associated with high malignancy and poor prognosis. This article presents a case of a patient diagnosed with adva…
View article: Benefit of switching to firmonertinib following almonertinib-induced interstitial pneumonitis in a patient with advanced non-small-cell lung cancer: a case report
Benefit of switching to firmonertinib following almonertinib-induced interstitial pneumonitis in a patient with advanced non-small-cell lung cancer: a case report Open
Almonertinib, a representative epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is the first-line standard treatment for EGFR-mutant advanced non-small-cell lung cancer; however, it may induce drug-related interstitia…
View article: From Cas proteins to cutting-edge biosensors: A new era in clinical pathogen diagnostics
From Cas proteins to cutting-edge biosensors: A new era in clinical pathogen diagnostics Open
Infectious pathogens exert a profound impact on global health and socio-economic stability, positioning them as a critical focus of scientific inquiry. To safeguard public health, propel advancements in medical diagnostics, and ensure food…
View article: Pharmacokinetics and Safety Profile of <scp>SNS812</scp>, a First in Human Fully Modified <scp>siRNA</scp> Targeting Wide‐Spectrum <scp>SARS</scp>‐<scp>CoV</scp>‐2, in Healthy Subjects
Pharmacokinetics and Safety Profile of <span>SNS812</span>, a First in Human Fully Modified <span>siRNA</span> Targeting Wide‐Spectrum <span>SARS</span>‐<span>CoV</span>‐2, in Healthy Subjects Open
Severe acute respiratory syndrome caused by the coronavirus (SARS‐CoV‐2) in the COVID‐19 pandemic has highlighted the need for effective treatments, as rapid viral mutations complicate therapeutic development. SNS812, a fully modified inha…
View article: Table S1 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers
Table S1 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers Open
Table S1. Cell-type annotations for the scRNA data
View article: Table S7 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers
Table S7 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers Open
Table S7. The complete list of copy number alterations.
View article: Table S3 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers
Table S3 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers Open
Table S3. Clinical phenotypes of 167 patients.
View article: Table S5 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers
Table S5 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers Open
Table S5. Mutational profiles of 159 patients.
View article: Supplementary Figures from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers
Supplementary Figures from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers Open
Supplementary Figures
View article: Table S2 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers
Table S2 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers Open
Table S2. scRNA cell-type markers.
View article: Supplementary Data from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers
Supplementary Data from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers Open
Supplementary Information
View article: Table S6 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers
Table S6 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers Open
Table S6. The complete list of somatic mutations.
View article: Table S4 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers
Table S4 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers Open
Table S4. Molecular subtypes of 406 RNA-seq samples.
View article: Table S4 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers
Table S4 from Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers Open
Table S4. Molecular subtypes of 406 RNA-seq samples.