Christodoulos Papadopoulos
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View article: Machine-Learning-Driven Phenotyping in Heart Failure with Preserved Ejection Fraction: Current Approaches and Future Directions
Machine-Learning-Driven Phenotyping in Heart Failure with Preserved Ejection Fraction: Current Approaches and Future Directions Open
Heart failure with preserved ejection fraction (HFpEF) remains a major clinical challenge due to its heterogeneous presentation and limited therapeutic options. Accurate patient phenotyping is essential to improve diagnosis, prognosticatio…
View article: Iron Deficiency in Heart Failure: Cellular Mechanisms and Therapeutic Implications
Iron Deficiency in Heart Failure: Cellular Mechanisms and Therapeutic Implications Open
Iron deficiency (ID) is a prevalent comorbidity in heart failure (HF), affecting 37–75% of patients and contributing significantly to symptom burden and adverse outcomes independent of anemia status. Current diagnostic criteria for ID in H…
View article: Exploring the Role of Presepsin in the Prediction of Atrial Fibrillation Recurrence: Results from the PLACEBO Study
Exploring the Role of Presepsin in the Prediction of Atrial Fibrillation Recurrence: Results from the PLACEBO Study Open
Background: Presepsin, a soluble CD14 subtype released during immune activation, has emerged as a marker of inflammation in cardiometabolic disorders. Given the links between inflammation, metabolic dysregulation, and atrial fibrillation (…
View article: Mitral Annular Disjunction: Epidemiology, Diagnostic Methods, Prognosis, and Novel Implications
Mitral Annular Disjunction: Epidemiology, Diagnostic Methods, Prognosis, and Novel Implications Open
Mitral annular disjunction (MAD) is an increasingly recognized structural abnormality of the mitral valve apparatus, often associated with mitral valve prolapse and a heightened risk of ventricular arrhythmias and sudden cardiac death. It …
View article: Changes in Cardiac Function and Exercise Capacity Following Ferric Carboxymaltose Administration in HFrEF Patients with Iron Deficiency
Changes in Cardiac Function and Exercise Capacity Following Ferric Carboxymaltose Administration in HFrEF Patients with Iron Deficiency Open
Background/Objectives: Iron deficiency (ID) is a common and prognostically relevant comorbidity in heart failure with reduced ejection fraction (HFrEF). It contributes to reduced functional status, exercise capacity, and survival. Intraven…
View article: The “Mushroom Sign”
The “Mushroom Sign” Open
OCT is indispensable for detecting LSM and optimizing stent placement, improving outcomes in complex coronary interventions.
View article: Different left bundle branch block morphologies and response to CRT: a cohort study
Different left bundle branch block morphologies and response to CRT: a cohort study Open
Background Although left bundle branch block (LBBB) is a strong predictor of response to cardiac resynchronization therapy (CRT), a significant number of patients remain non-responders. Purpose The study sought to evaluate the impact of di…
View article: Integrated Diagnostics for Atrial Fibrillation Recurrence: Exploratory Results from the PLACEBO Trial
Integrated Diagnostics for Atrial Fibrillation Recurrence: Exploratory Results from the PLACEBO Trial Open
Background: Atrial fibrillation is a prevalent arrhythmia with significant morbidity and recurrence challenges. Paroxysmal atrial fibrillation (PAF) is characterized by episodic occurrences and unpredictable recurrences; therefore, it dema…
View article: Presepsin: An Emerging Biomarker in the Management of Cardiometabolic Disorders
Presepsin: An Emerging Biomarker in the Management of Cardiometabolic Disorders Open
Background/Objectives: Systemic and tissue inflammation play a crucial role in the pathophysiology of cardiometabolic disorders. Presepsin is a newly discovered marker of acute phase inflammation that is produced by monocytes or macrophage…
View article: The Uncommon Phenomenon of Short QT Syndrome: A Scoping Review of the Literature
The Uncommon Phenomenon of Short QT Syndrome: A Scoping Review of the Literature Open
Background: Short QT syndrome (SQTS) is a rare inheritable channelopathy characterized by a shortened corrected QT interval on an electrocardiogram and a significant risk of atrial and ventricular arrhythmias, potentially leading to sudden…
View article: Exploring the Feasibility of Integrating Cardiopulmonary Exercise Testing, Echocardiography, and Biomarkers for Predicting Atrial Fibrillation Recurrence: Rationale, Design and Protocol for a Prospective Cohort Study (The PLACEBO Trial)
Exploring the Feasibility of Integrating Cardiopulmonary Exercise Testing, Echocardiography, and Biomarkers for Predicting Atrial Fibrillation Recurrence: Rationale, Design and Protocol for a Prospective Cohort Study (The PLACEBO Trial) Open
Background: Paroxysmal atrial fibrillation (PAF) presents significant challenges in management due to its unpredictable recurrence and associated complications. Current prognostic tools lack precision in predicting PAF outcomes, highlighti…
View article: Ferric carboxymaltose reduces the burden of arrhythmic events in heart failure with reduced ejection fraction: the role of the non-invasive arrhythmic biomarkers
Ferric carboxymaltose reduces the burden of arrhythmic events in heart failure with reduced ejection fraction: the role of the non-invasive arrhythmic biomarkers Open
Our study provides real-world evidence that IV FCM led to statistically significant reduction in ventricular arrhythmic episodes, as well as an improvement in non-invasive arrhythmic markers.
View article: The Role of Sodium Glucose Co-Transporter 2 Inhibitors in Atrial Fibrillation: A Comprehensive Review
The Role of Sodium Glucose Co-Transporter 2 Inhibitors in Atrial Fibrillation: A Comprehensive Review Open
Atrial fibrillation (AF) is the most prevalent arrhythmia among adults worldwide, frequently co-occurring with comorbidities such as Heart Failure (HF) and Type 2 Diabetes Mellitus (T2DM). This association contributes to increased morbidit…
View article: #1767 Effect of heart failure and atrial fibrillation on cardiorespiratory fitness in hemodialysis patients
#1767 Effect of heart failure and atrial fibrillation on cardiorespiratory fitness in hemodialysis patients Open
Background and Aims Heart failure (HF) and atrial fibrillation (AF) are highly prevalent in hemodialysis. They are well-known significant modifiers of the disease associations with cardiovascular outcomes, but there is a lack of evidence r…
View article: #1555 The effects of different interdialytic intervals on cardiorespiratory fitness assessed with CPET in hemodialysis patients
#1555 The effects of different interdialytic intervals on cardiorespiratory fitness assessed with CPET in hemodialysis patients Open
Background and Aims Long interdialytic interval in thrice-weekly hemodialysis is associated with excess cardiovascular and all-cause mortality risk. Impaired cardiorespiratory fitness is a strong predictor of mortality in hemodialysis. Thi…
View article: Classical and Novel Lipid-Lowering Therapies for Diabetic Patients with Established Coronary Artery Disease or High Risk of Coronary Artery Disease—A Narrative Clinical Review
Classical and Novel Lipid-Lowering Therapies for Diabetic Patients with Established Coronary Artery Disease or High Risk of Coronary Artery Disease—A Narrative Clinical Review Open
Diabetic atherosclerosis is a complex process that is characterized by diffuse and unstable lesions increasing 2–4-fold the risk of adverse cardiovascular (CV) events. Diabetic dyslipidemia has a predominant role in coronary artery disease…
View article: Different Interdialytic Intervals and Cardiorespiratory Fitness in Patients Undergoing Hemodialysis
Different Interdialytic Intervals and Cardiorespiratory Fitness in Patients Undergoing Hemodialysis Open
Key Points This is the first study exploring differences in cardiorespiratory fitness assessed with cardiopulmonary exercise testing between the 2-day and the 3-day interdialytic interval. The 3-day interdialytic interval was associated wi…
View article: The role of patient-oriented mHealth interventions in improving heart failure outcomes: A systematic review of the literature
The role of patient-oriented mHealth interventions in improving heart failure outcomes: A systematic review of the literature Open
Heart failure (HF) is a debilitating disease with 26 million patients worldwide. Consistent and complex self-care is required on the part of patients to adequately adhere to medication and to the lifestyle changes that the disease necessit…
View article: The effect of iron deficiency treatment with intravenous ferric carboxymaltose on the arrhythmic burden of patients with HFrEF and cardiac implantable electronic devices
The effect of iron deficiency treatment with intravenous ferric carboxymaltose on the arrhythmic burden of patients with HFrEF and cardiac implantable electronic devices Open
Background The deleterious effect of iron deficiency (ID) on cardiomyocyte electrochemical stability is well-documented. In patients with heart failure and reduced ejection fraction (HFrEF), ID represents a key comorbidity associated with …
View article: Serum magnesium and phosphorus values are lower among patients with paroxysmal atrial fibrillation: insights from the PLACEBO study
Serum magnesium and phosphorus values are lower among patients with paroxysmal atrial fibrillation: insights from the PLACEBO study Open
Background Magnesium and phosphorus comprise micronutrients in circulating blood, while associated disorders have been linked with increased risk of cardiovascular disease (CVD). Low serum magnesium has been connected to atrial fibrillatio…
View article: #6754 THE EFFECT OF REDUCED RENAL FUNCTION ON SEXUAL DYSFUNCTION IN PATIENTS WITH HEART FAILURE
#6754 THE EFFECT OF REDUCED RENAL FUNCTION ON SEXUAL DYSFUNCTION IN PATIENTS WITH HEART FAILURE Open
Background and Aims Sexual Dysfunction is a common and often undiagnosed complication in patients with Heart Failure (HF) or Chronic Kidney Disease (CKD). Sexual dysfunction presents a strong association with cardiovascular disease and dea…
View article: The Impact of Metabolic Syndrome Components on Erectile Function in Patients with Type 2 Diabetes
The Impact of Metabolic Syndrome Components on Erectile Function in Patients with Type 2 Diabetes Open
Erectile dysfunction is commonly encountered in diabetic patients and in patients with metabolic syndrome; however, only a few studies have assessed patients with metabolic syndrome and type 2 diabetes mellitus (T2DM) regarding their sexua…
View article: Iron therapy and severe arrhythmias in HFrEF: rationale, study design, and baseline results of the RESAFE‐HF trial
Iron therapy and severe arrhythmias in HFrEF: rationale, study design, and baseline results of the RESAFE‐HF trial Open
Aims The Iron Intravenous Therapy in Reducing the burden of Severe Arrhythmias in HFrEF (RESAFE‐HF) registry study aims to provide real‐word evidence on the impact of intravenous ferric carboxymaltose (FCM) on the arrhythmic burden of pati…