C. Patrick Collier
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View article: Electromechanically induced membrane restructuring enables learning and memory
Electromechanically induced membrane restructuring enables learning and memory Open
Human neural networks of interconnected neurons have evolved to be remarkably efficient and are capable of learning and memory through the brain’s synaptic plasticity, including short-term plasticity (STP), and long-term potentiation (LTP)…
View article: Curvature Memory in Electrically Stimulated Lipid Membranes
Curvature Memory in Electrically Stimulated Lipid Membranes Open
We demonstrate, using non-equilibrium molecular dynamics simulations, that lipid membrane capacitance varies with surface charge accumulation linked to membrane shape and curvature changes. Specifically, we show that lipid membranes exhibi…
View article: Neuronal Plasma Membranes as Supramolecular Assemblies for Biological Memory
Neuronal Plasma Membranes as Supramolecular Assemblies for Biological Memory Open
Biological memory is the ability to develop, retain, and retrieve information over time. Currently, it is widely accepted that memories are stored in synapses (i.e., connections between brain cells throughout the brain) through a process k…
View article: Heterosynaptic plasticity in memristive and memcapacitive lipid bilayers: A snapshot review
Heterosynaptic plasticity in memristive and memcapacitive lipid bilayers: A snapshot review Open
Synaptic plasticity refers to activity-dependent synaptic strengthening or weakening between neurons. It is usually associated with homosynaptic plasticity, which refers to a synaptic junction controlled by interactions between specific ne…
View article: Modulating Leidenfrost-like Prompt Jumping of Sessile Droplets on Microstructured Surfaces
Modulating Leidenfrost-like Prompt Jumping of Sessile Droplets on Microstructured Surfaces Open
The Leidenfrost effect, namely the levitation and hovering of liquid drops on hot solid surfaces, generally requires a sufficiently high substrate temperature to activate the intense liquid vaporization. Here we report the agile modulation…
View article: Cations Control Lipid Bilayer Memcapacitance Associated with Long-Term Potentiation
Cations Control Lipid Bilayer Memcapacitance Associated with Long-Term Potentiation Open
Phospholipid bilayers can be described as capacitors whose capacitance per unit area (specific capacitance, Cm) is determined by their thickness and dielectric constant─independent of applied voltage. It is also widely assumed that the Cm …
View article: Real Space and Time Imaging of Collective Headgroup Dipole Motions in Zwitterionic Lipid Bilayers
Real Space and Time Imaging of Collective Headgroup Dipole Motions in Zwitterionic Lipid Bilayers Open
Lipid bilayers are supramolecular structures responsible for a range of processes, such as transmembrane transport of ions and solutes, and sorting and replication of genetic materials, to name just a few. Some of these processes are trans…
View article: Laser ablation sampling system and method
Laser ablation sampling system and method Open
A method and system for sampling a solid sample material can include the step of mounting the sample material on a support. A sample surface is coated with a surface treatment composition in a dry deposition process. A solvent supply condu…
View article: Reversible, on-demand generation of aqueous two-phase microdroplets
Reversible, on-demand generation of aqueous two-phase microdroplets Open
The present invention provides methods of on-demand, reversible generation of aqueous two-phase microdroplets core-shell microbeads, microparticle preparations comprising the core-shell microbeads, and drug delivery formulation comprising …
View article: Modulating Leidenfrost-like Prompt Jumping of Sessile Droplets on Microstructured Surfaces NPformat
Modulating Leidenfrost-like Prompt Jumping of Sessile Droplets on Microstructured Surfaces NPformat Open
The Leidenfrost effect, namely the levitation and hovering of liquid drops on hot solid surfaces, generally requires a sufficiently high substrate temperature to activate the intense liquid vaporization. Here we report the agile modulation…
View article: Evidence for long-term potentiation in phospholipid membranes
Evidence for long-term potentiation in phospholipid membranes Open
Biological supramolecular assemblies, such as phospholipid bilayer membranes, have been used to demonstrate signal processing via short-term synaptic plasticity (STP) in the form of paired pulse facilitation and depression, emulating the b…
View article: The Unexpected Role of Cations in the Self-Assembly of Positively Charged Amphiphiles at Liquid/Liquid Interfaces
The Unexpected Role of Cations in the Self-Assembly of Positively Charged Amphiphiles at Liquid/Liquid Interfaces Open
Conventional wisdom suggests that cations play a minimal role in the assembly of cationic amphiphiles. Here, we show that at liquid/liquid (L/L) interfaces, specific cation effects can modulate the assemblies of hydrophobic tails in an oil…
View article: Crowding-Induced Spatial Organization of Gene Expression in Cell-Sized Vesicles
Crowding-Induced Spatial Organization of Gene Expression in Cell-Sized Vesicles Open
Cell-free protein synthesis is an important tool for studying gene expression and harnessing it for applications. In cells, gene expression is regulated in part by the spatial organization of transcription and translation. Unfortunately, c…
View article: Gold Ion Beam Milled Gold Zero-Mode Waveguides
Gold Ion Beam Milled Gold Zero-Mode Waveguides Open
Zero-mode waveguides (ZMWs) are widely used in single molecule fluorescence microscopy for their enhancement of emitted light and the ability to study samples at physiological concentrations. ZMWs are typically produced using photo or elec…
View article: Disentangling Memristive and Memcapacitive Effects in Droplet Interface Bilayers Using Dynamic Impedance Spectroscopy
Disentangling Memristive and Memcapacitive Effects in Droplet Interface Bilayers Using Dynamic Impedance Spectroscopy Open
The underlying principles for generating intelligent behavior in living organisms are fundamentally different from those in traditional solid‐state circuits. Biomimetic neuromorphic equivalents based on biological membranes offer novel imp…
View article: Ion Pairing and Molecular Orientation at Liquid/Liquid Interfaces: Self-Assembly and Function
Ion Pairing and Molecular Orientation at Liquid/Liquid Interfaces: Self-Assembly and Function Open
Molecular orientation plays a pivotal role in defining the functionality and chemistry of interfaces, yet accurate measurements probing this important feature are few, due, in part, to technical and analytical limitations in extracting inf…
View article: Squeezing Out Interfacial Solvation: The Role of Hydrogen-Bonding in the Structural and Orientational Freedom of Molecular Self-Assembly
Squeezing Out Interfacial Solvation: The Role of Hydrogen-Bonding in the Structural and Orientational Freedom of Molecular Self-Assembly Open
Bioinspired membrane molecules with improved physical properties and enhanced stability can serve as functional models for conventional lipid or amphiphilic species. Importantly, these molecules can also provide new insights into emergent …