Charles L. Perrin
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View article: Nonradical Reactions of <i>p</i>-Benzyne Diradicals
Nonradical Reactions of <i>p</i>-Benzyne Diradicals Open
Enediynes undergo electrocyclization to p-benzyne diradicals. Although such diradicals ordinarily react by radical pathways, they can also be trapped by nucleophilic addition, a pathway supported by computations. The product of that…
View article: Automerization of an Enediyne via a Symmetrical <i>p</i>-Benzyne Diradical Intermediate
Automerization of an Enediyne via a Symmetrical <i>p</i>-Benzyne Diradical Intermediate Open
Automerization is defined as a rearrangement reaction that yields a degenerate form of the starting material. We now report that cyclohexeno[3,4]cyclodeca-1,5-diyne-3-ene rearranges to its automer, via a D2h-symmetric …
View article: airGR: Suite of GR Hydrological Models for Precipitation-Runoff Modelling (v. 1.7.6)
airGR: Suite of GR Hydrological Models for Precipitation-Runoff Modelling (v. 1.7.6) Open
View article: Symmetry of Hydrogen Bonds: Application of NMR Method of Isotopic Perturbation and Relevance of Solvatomers
Symmetry of Hydrogen Bonds: Application of NMR Method of Isotopic Perturbation and Relevance of Solvatomers Open
Short, strong, symmetric, low-barrier hydrogen bonds (H-bonds) are thought to be of special significance. We have been searching for symmetric H-bonds by using the NMR technique of isotopic perturbation. Various dicarboxylate monoanions, a…
View article: Nucleophilic Addition of Enolates to 1,4-Dehydrobenzene Diradicals Derived from Enediynes: Synthesis of Functionalized Aromatics
Nucleophilic Addition of Enolates to 1,4-Dehydrobenzene Diradicals Derived from Enediynes: Synthesis of Functionalized Aromatics Open
Alkylation of aromatics and formation of a new C-C bond is usually achieved by the electrophilic attack of an activated carbon species on an electron-rich aromatic ring. Herein, we report an alternative method for alkylation of aromatics v…
View article: Glossary of terms used in physical organic chemistry (IUPAC Recommendations 2021)
Glossary of terms used in physical organic chemistry (IUPAC Recommendations 2021) Open
This Glossary contains definitions, explanatory notes, and sources for terms used in physical organic chemistry. Its aim is to provide guidance on the terminology of physical organic chemistry, with a view to achieving a consensus on the m…
View article: Enthalpic and entropic contributions to the basicity of cycloalkylamines
Enthalpic and entropic contributions to the basicity of cycloalkylamines Open
Large-ring cycloalkylamines are slightly less basic than other cycloalkylamines such as cyclohexylamine, even though all have tetrahedral carbons and are strain-free.
View article: Polynomial coefficients. Application to spin–spin splitting by <i>N</i> equivalent nuclei of spin <i>I</i> > 1/2
Polynomial coefficients. Application to spin–spin splitting by <i>N</i> equivalent nuclei of spin <i>I</i> > 1/2 Open
The NMR intensity pattern of a nucleus split by N identical nuclei of spin 1/2 is given by the familiar binomial coefficients. These are conveniently obtained from Pascal's Triangle, equivalent to the chemist's branching diagram. Much less…
View article: Approach control. Stereoelectronic origin of geometric constraints on N-to-S and N-to-O acyl shifts in peptides
Approach control. Stereoelectronic origin of geometric constraints on N-to-S and N-to-O acyl shifts in peptides Open
Intramolecular N-to-S or N-to-O acyl shifts in peptides are of fundamental and practical importance, as they constitute the first step in protein splicing and can be used for the synthesis of thioester-modified peptides required for native…
View article: Linear or Nonlinear Least-Squares Analysis of Kinetic Data?
Linear or Nonlinear Least-Squares Analysis of Kinetic Data? Open
ADVERTISEMENT RETURN TO ISSUECommentaryNEXTLinear or Nonlinear Least-Squares Analysis of Kinetic Data?Charles L. Perrin*View Author Information Department of Chemistry, University of California—San Diego, La Jolla, California 92093-0358, U…
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Issue Information Open
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View article: Protein-like proton exchange in a synthetic host cavity
Protein-like proton exchange in a synthetic host cavity Open
Significance Water drives molecular interactions central to the chemistry of life. Critical to life’s metabolic machinery, enzymes catalyze reactions with remarkable selectivities and efficiencies resulting from noncovalent interactions be…
View article: CCDC 1426953: Experimental Crystal Structure Determination
CCDC 1426953: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1426749: Experimental Crystal Structure Determination
CCDC 1426749: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1426954: Experimental Crystal Structure Determination
CCDC 1426954: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1426846: Experimental Crystal Structure Determination
CCDC 1426846: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1426955: Experimental Crystal Structure Determination
CCDC 1426955: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …