Explanipedia

The Use of E-mail in Primary Care: Characterization of the Reality of a Family Health Unit Open

Adriana Maria da Silva, Paulo do Nascimento, Andréia Bicalho Henriques, Luis Valmor Portela, Diogo B. Almeida , et al. · 2025

Introduction The progressive digitalization of healthcare has fostered the utilization of e-mail as a communication tool between users and family physicians. This modality has the potential to enhance accessibility, ensure continuity of ca…

Why should lymphocytes immune profile matter in sepsis? Open

Wagner Luís Nedel, Lílian Rodrigues Henrique, Luis Valmor Portela · 2025

The global incidence of critical illness has been steadily increasing, resulting in higher mortality rates thereby presenting substantial challenges for clinical management. Among these conditions, sepsis stands out as the leading cause of…

Assessment of mitochondrial function and its prognostic role in sepsis: a literature review Open

Wagner Luís Nedel, Nathan Ryzewski Strogulski, Afonso Kopczynski, Luis Valmor Portela · 2024

Sepsis is characterized by a dysregulated and excessive systemic inflammatory response to infection, associated with vascular and metabolic abnormalities that ultimately lead to organ dysfunction. In immune cells, both non-oxidative and ox…

Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury Open

Ilaria Lisi, Federico Moro, Edoardo Mazzone, Niklas Marklund, Francesca Pischiutta , et al. · 2024

Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translat…

Nandrolone Abuse Prior to Head Trauma Mitigates Endoplasmic Reticulum Stress, Mitochondrial Bioenergetic Deficits, and Markers of Neurodegeneration Open

Marcelo Salimen Rodolphi, Nathan Ryzewski Strogulski, Afonso Kopczynski, Mônia Sartor, Gabriela Soares , et al. · 2024

Neurogenic potential of NG2 in neurotrauma: a systematic review Open

Yuri R. Rigo, Radharani Benvenutti, Luis Valmor Portela, Nathan Ryzewski Strogulski · 2024

Regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of research. This is reflected in a large disparity between the …

Translating from mice to humans: using preclinical blood-based biomarkers for the prognosis and treatment of traumatic brain injury Open

Ilaria Lisi, Federico Moro, Edoardo Mazzone, Niklas Marklund, Francesca Pischiutta , et al. · 2023

Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing potential new therapeutic interventions for this devastating neurological disorder. However, the failure rate for th…

Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury Open

Nathan Ryzewski Strogulski, Luis Valmor Portela, Brian M. Polster, David J. Loane · 2023

Traumatic brain injury (TBI) is a devastating neurological disorder caused by a physical impact to the brain that promotes diffuse damage and chronic neurodegeneration. Key mechanisms believed to support secondary brain injury include mito…

Sepsis-induced mitochondrial dysfunction: A narrative review Open

Wagner Luís Nedel, Caroline Deutschendorf, Luis Valmor Portela · 2023

Sepsis represents a deranged and exaggerated systemic inflammatory response to infection and is associated with vascular and metabolic abnormalities that trigger systemic organic dysfunction. Mitochondrial function has been shown to be sev…

Effectiveness of regional health polyclinics in the state of bahia, brazil Open

Érika Aragão, Vinícius Mendes, Diana Gonzaga, Kécia Miranda, Samilly Miranda , et al. · 2023

Population Medicine considers the following types of articles:• Research Papers -reports of data from original research or secondary dataset analyses.• Review Papers -comprehensive, authoritative, reviews within the journal's scope.These i…

Capsicum baccatum Red Pepper Prevents Cardiometabolic Risk in Rats Fed with an Ultra-Processed Diet Open

Aline Rigon Zimmer, Bianca Franco Leonardi, Eduardo R. Zimmer, A. Müller, Grace Gosmann , et al. · 2023

Metabolic syndrome is a serious health condition reaching epidemic proportions worldwide and is closely linked to an increased risk of cardiovascular problems. The lack of appropriate treatment paves the way for developing new therapeutic …

Lower and higher volumes of physical exercise build up brain reserves against memory deficits triggered by a head injury in mice Open

Afonso Kopczynski, Randhall Bruce Carteri, Marcelo Salimen Rodolphi, Jean Pierre Oses, Luiz Osorio C Portela , et al. · 2023

Long-term cyclosporine A treatment promotes anxiety-like behavior: Possible relation with glutamate signaling in rat hippocampus Open

Marina M. Cararo-Lopes, Débora Guerini de Souza, Marcelo Ganzella, Gisele Hansel, Vanessa Kazlauckas , et al. · 2022

Cerebrospinal fluid purinomics as a biomarker approach to predict outcome after severe traumatic brain injury Open

Nathan Ryzewski Strogulski, Marco Antônio Stefani, Ana Elisa Böhmer, Gisele Hansel, Marcelo Salimen Rodolphi , et al. · 2022

Severe traumatic brain injury (TBI) is associated with high rates of mortality and long‐term disability linked to neurochemical abnormalities. Although purine derivatives play important roles in TBI pathogenesis in preclinical models, litt…

BDNF Levels According to Variations in the CACNA1C Gene: Sex-Based Disparity Open

Clarissa Ribeiro Bastos, Janaína Xavier, Laísa Camerini, Samantha Seibt Dewes, Fernanda Pedrotti Moreira , et al. · 2022

Cerebrospinal fluid purinomics as a biomarker approach to predict outcome after severe traumatic brain injury Open

Nathan Ryzewski Strogulski, Marco Antônio Stefani, Ana Elisa Böhmer, Gisele Hansel, Marcelo Salimen Rodolphi , et al. · 2021

Severe traumatic brain injury (TBI) is associated with high rates of mortality and long-term disability linked to neurochemical abnormalities. Although purine-derivatives play important roles in TBI pathogenesis in preclinical models, litt…

Nandrolone supplementation promotes AMPK activation and divergent<sup>18</sup>[FDG] PET brain connectivity in adult and aged mice Open

Nathan Ryzewski Strogulski, A Kopczinski, Vitória Girelli de Oliveira, Randhall Bruce Carteri, Gisele Hansel , et al. · 2021

Decreased anabolic androgen levels are followed by impaired brain energy support and sensing with loss of neural connectivity during physiological aging, providing a neurobiological basis for hormone supplementation. Here, we investigated …

Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study Open

Wagner Luís Nedel, Afonso Kopczynski, Marcelo Salimen Rodolphi, Nathan Ryzewski Strogulski, Marco De Bastiani , et al. · 2021

Efeitos da nandrolona e da ceftriaxona na homeostasia glutamatérgica e mitocondrial e no comportamento agressivo Open

Marcelo Salimen Rodolphi, Mônia Sartor, Afonso Kopczynski de Carvalho, Nathan Ryzewski Strogulski, Marceli Feldmann Gonçalves , et al. · 2020

Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus Open

Clarissa Branco Haas, Afonso Kopczynski de Carvalho, A. Müller, Bart J. L. Eggen, Luis Valmor Portela · 2020

Testosterone Administration after Traumatic Brain Injury Reduces Mitochondrial Dysfunction and Neurodegeneration Open

Randhall Bruce Carteri, Afonso Kopczynski, Marcelo Salimen Rodolphi, Nathan Ryzewski Strogulski, Mônia Sartor , et al. · 2019

Traumatic brain injury (TBI) increases Ca²⁺ influx into neurons and desynchronizes mitochondrial function leading to energy depletion and apoptosis. This process may be influenced by brain testosterone (TS) levels, which are kno…

Uso do índice de celularidade no líquor para diagnóstico precoce de infecção no sistema nervoso central após drenagem ventricular externa Open

Luciano Werle Lunardi, Samir dos Santos, Jóice Merzoni, Eduardo R. Zimmer, Luis Valmor Portela , et al. · 2018

Introdução: O uso de Derivação Ventricular Externa (DVE) é necessário para o tratamento de muitas doenças, como Traumatismo Cranioencefálico (TCE) e Hemorragia Subaracnoide (HSA). As meningites e ventriculites são complicações frequentes d…

Gender differences of cannabis smoking on serum leptin levels: population-based study Open

Fernanda Pedrotti Moreira, Carolina David Wiener, Jacqueline Flores de Oliveira, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva , et al. · 2018

Cannabis smoking was linked to leptin levels in men, suggesting that the response to biological signals may be different between men and women.

A suplementação com decanoato de nandrolona melhora eficiência bioenergética e fluxo autofágico cerebral de camundongos envelhecidos Open

Nathan Ryzewski Strogulski, Wanda Osório Dorneles, Afonso Kopczynski de Carvalho, Mônia Sartor, Randhall Bruce Carteri , et al. · 2018

Peripheral Oxidative Stress Biomarkers in Spinocerebellar Ataxia Type 3/Machado–Joseph Disease Open

Adriano Martimbianco de Assis, Jonas Alex Morales Saute, Aline Longoni, Clarissa Branco Haas, Vitor Rocco Torrez , et al. · 2017

Early/moderate stage SCA3/MJD patients presented a decreased antioxidant capacity and increased ROS generation. GSH-Px activity was the most promising oxidative stress disease biomarker in SCA3/MJD. Further longitudinal studies are necessa…

Efeitos do diabetes em um modelo animal de traumatismo craniano Open

Mônia Sartor, Gisele Hansel, Randhall Bruce Carteri, Marcelo Salimen Rodolphi, Afonso Kopczynski de Carvalho , et al. · 2017

Mood disorder, anxiety, and suicide risk among subjects with alcohol abuse and/or dependence: a population-based study Open

Carolina David Wiener, Fernanda Pedrotti Moreira, Alethea Zago, Luciano M. Souza, Jerônimo Costa Branco , et al. · 2017

These findings suggest that alcohol abuse and/or dependence are consistently associated with a higher prevalence of psychiatric comorbidities, could be considered important predictors of other psychiatric disorders, and deserve greater pub…

Elevated glutamate and lactate predict brain death after severe head trauma Open

Marco Antônio Stefani, Rafael Modkovski, Gisele Hansel, Eduardo R. Zimmer, Afonso Kopczynski , et al. · 2017

Objective Clinical neurological assessment is challenging for severe traumatic brain injury ( TBI ) patients in the acute setting. Waves of neurochemical abnormalities that follow TBI may serve as fluid biomarkers of neurological status. W…

S100B protein and neuron-specific enolase as predictors of cognitive dysfunction after coronary artery bypass graft surgery Open

Fernando P. Silva, André P. Schmidt, Lívia Stocco Sanches Valentin, Kátia Osternack Pinto, Suely Pereira Zeferino , et al. · 2016

NCT01550159.

Effects of Single Low Dose of Dexamethasone before Noncardiac and Nonneurologic Surgery and General Anesthesia on Postoperative Cognitive Dysfunction—A Phase III Double Blind, Randomized Clinical Trial Open

Lívia Stocco Sanches Valentin, Valéria Fontenelle Angelim Pereira, Ricardo Pietrobon, André P. Schmidt, Jean Pierre Oses , et al. · 2016

www.clinicaltrials.gov NCT01332812.

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