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View article: Identification of novel collagen breakdown products by human osteoclasts in vitro and in vivo
Identification of novel collagen breakdown products by human osteoclasts in vitro and in vivo Open
Bone resorption involves dissolution of minerals and enzymatic degradation of bone matrix. The primary enzyme is cathepsin K but other proteases including matrix metalloproteinases are involved. Some cathepsin K cleavage products have been…
View article: Functional Profiling Demonstrates That a Sulfide-Reducing Diet Achieves Microenvironmental Targets in Ulcerative Colitis
Functional Profiling Demonstrates That a Sulfide-Reducing Diet Achieves Microenvironmental Targets in Ulcerative Colitis Open
Background As a dietary approach to reducing inflammation in ulcerative colitis, the 4-SURE (4 Strategies to Sulfide Reduction) diet was designed to correct pathogenic alterations of excessive protein fermentation and hydrogen sulfide (H2S…
View article: Management of diarrhoea in patients with stable ulcerative colitis with low FODMAP diet, amitriptyline, ondansetron or loperamide: the MODULATE RCT
Management of diarrhoea in patients with stable ulcerative colitis with low FODMAP diet, amitriptyline, ondansetron or loperamide: the MODULATE RCT Open
Background Many patients with ulcerative colitis report ongoing diarrhoea even when their disease is stable and in remission. Design MODULATE was a pragmatic, multicentre, seamless, adaptive, phase 2/3 open-label, parallel-group, multiarm …
View article: Distinct Profiles of Fecal Volatile Organic Compounds Discriminate Ulcerative Colitis Patients With an Ileoanal Pouch From Those With an Intact Colon
Distinct Profiles of Fecal Volatile Organic Compounds Discriminate Ulcerative Colitis Patients With an Ileoanal Pouch From Those With an Intact Colon Open
Fecal volatile organic compounds (VOCs) offer insights into gut microbiota function that may drive the pathogenesis of ulcerative colitis (UC). This cross‐sectional study aimed to compare dietary intake and VOC patterns in UC patients with…
View article: Recent advances in measuring the effects of diet on gastrointestinal physiology: Sniffing luminal gases and fecal volatile organic compounds
Recent advances in measuring the effects of diet on gastrointestinal physiology: Sniffing luminal gases and fecal volatile organic compounds Open
Despite the huge pool of ideas on how diet can be manipulated to ameliorate or prevent illnesses, our understanding of how specific changes in diet influence the gastrointestinal tract is limited. This review aims to describe two innovativ…
View article: Identification of novel bone-resorption markers by osteoclasts<i>in vitro</i>and<i>in vivo</i>
Identification of novel bone-resorption markers by osteoclasts<i>in vitro</i>and<i>in vivo</i> Open
Bone resorption involves dissolution of mineral and enzymatic degradation of bone matrix. The primary enzyme is cathepsin K but other proteases including matrix metalloproteinases are involved. Some cleavage products of cathepsin K have be…
View article: Machine learning enabled prediction of digital biomarkers from whole slide histopathology images
Machine learning enabled prediction of digital biomarkers from whole slide histopathology images Open
Current predictive biomarkers generally leverage technologies such as immunohis-tochemistry or genetic analysis, which may require specialized equipment, be time-intensive to deploy, or incur human error. In this paper, we present an alter…
View article: EmbedGEM: a framework to evaluate the utility of embeddings for genetic discovery
EmbedGEM: a framework to evaluate the utility of embeddings for genetic discovery Open
Summary Machine learning-derived embeddings are a compressed representation of high content data modalities. Embeddings can capture detailed information about disease states and have been qualitatively shown to be useful in genetic discove…
View article: EmbedGEM: A framework to evaluate the utility of embeddings for genetic discovery
EmbedGEM: A framework to evaluate the utility of embeddings for genetic discovery Open
Machine learning (ML)-derived embeddings are a compressed representation of high content data modalities. Embeddings can capture detailed information about disease states and have been qualitatively shown to be useful in genetic discovery.…
View article: OP33 Results of a randomised controlled trial to evaluate Interleukin 1 blockade with anakinra in patients with acute severe ulcerative colitis (IASO)
OP33 Results of a randomised controlled trial to evaluate Interleukin 1 blockade with anakinra in patients with acute severe ulcerative colitis (IASO) Open
Background Acute severe ulcerative colitis (ASUC) is a severe manifestation of ulcerative colitis (UC) that requires hospitalisation. Despite significant advances in therapeutic options for UC and in the medical management of steroid-refra…
View article: Patient preferences and current practice for adults with steroid-resistant ulcerative colitis: POPSTER mixed-methods study
Patient preferences and current practice for adults with steroid-resistant ulcerative colitis: POPSTER mixed-methods study Open
Background Corticosteroids are a mainstay of the treatment of moderately severe relapses of ulcerative colitis, yet almost 50% of patients do not respond fully to these and risk prolonged steroid use and side effects. There is a lack of cl…
View article: Almonds and Their Impact on Gastrointestinal Physiology, Luminal Microbiology and Gastrointestinal Function: A Randomized Controlled Trial
Almonds and Their Impact on Gastrointestinal Physiology, Luminal Microbiology and Gastrointestinal Function: A Randomized Controlled Trial Open
OBJECTIVES: The objective of this study was to investigate the impact of almonds, and almond form (whole, ground) on fecal Bifidobacteria (primary outcome) and gut microbiology, physiology, and symptoms in healthy adults. METHODS: Eighty-s…
View article: Efficacy and Safety of Elective Switching from Intravenous to Subcutaneous Infliximab [CT-P13]: A Multicentre Cohort Study
Efficacy and Safety of Elective Switching from Intravenous to Subcutaneous Infliximab [CT-P13]: A Multicentre Cohort Study Open
Background Intravenous [IV] infliximab is a well-established therapy for inflammatory bowel diseases [IBD] patients. A subcutaneous [SC] formulation of infliximab [CT-P13] has recently been shown to be as effective as IV infliximab after t…
View article: Patient preferences for treatment in steroid resistant ulcerative colitis – a discrete-choice experiment
Patient preferences for treatment in steroid resistant ulcerative colitis – a discrete-choice experiment Open
Understanding treatment preferences in those patients who are not responding to corticosteroids for ulcerative colitis is important in informing treatment choices. This study aimed to assess the relative importance of treatment characteris…
View article: Almonds and their impact on gastrointestinal physiology, luminal microbiology and gastrointestinal function: a randomised controlled trial
Almonds and their impact on gastrointestinal physiology, luminal microbiology and gastrointestinal function: a randomised controlled trial Open
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View article: PMO-28 Efficacy of subcutaneous infliximab in perianal crohn’s disease
PMO-28 Efficacy of subcutaneous infliximab in perianal crohn’s disease Open
Background A new subcutaneous (SC) formulation of infliximab has recently been approved for the management of inflammatory bowel diseases (IBD). In the registration clinical trial, the efficacy of SC IFX was comparable to intravenous (IV) …
View article: PMO-16 Efficacy and safety of elective switching from intravenous to subcutaneous infliximab: A multi-centre cohort study
PMO-16 Efficacy and safety of elective switching from intravenous to subcutaneous infliximab: A multi-centre cohort study Open
Introduction Intravenous (IV) infliximab is a well-established therapy for inflammatory bowel diseases (IBD) patients. A subcutaneous (SC) formulation of infliximab has recently been shown to be as effective as IV infliximab in a randomise…
View article: Lactoferrin impact on gut microbiota in preterm infants with late-onset sepsis or necrotising enterocolitis: the MAGPIE mechanisms of action study
Lactoferrin impact on gut microbiota in preterm infants with late-onset sepsis or necrotising enterocolitis: the MAGPIE mechanisms of action study Open
Background Preterm infants have high rates of morbidity, especially from late-onset sepsis and necrotising enterocolitis. Lactoferrin is an anti-infective milk protein that may act through effects on gut bacteria, metabolites and epithelia…
View article: P496 Efficacy and safety of elective switching of inflammatory bowel disease patients from intravenous to subcutaneous infliximab (IFX): a multi-centre cohort study
P496 Efficacy and safety of elective switching of inflammatory bowel disease patients from intravenous to subcutaneous infliximab (IFX): a multi-centre cohort study Open
Background A subcutaneous (SC) formulation of IFX has recently been shown to be as effective as intravenous (IV) IFX in a randomised trial but there are no real world data to support elective switching. We aimed to assess the effectiveness…
View article: P244 Clinician preferences in treating steroid resistant ulcerative colitis: a discrete-choice experiment (DCE) survey
P244 Clinician preferences in treating steroid resistant ulcerative colitis: a discrete-choice experiment (DCE) survey Open
Background The optimum treatment for steroid resistant ulcerative colitis (SRUC) is not clear and a range of options can be considered. The aim of this study was to quantify the relative importance of different treatment characteristics to…
View article: P176 Patient preferences in steroid resistant ulcerative colitis – a discrete choice experiment survey
P176 Patient preferences in steroid resistant ulcerative colitis – a discrete choice experiment survey Open
Background Understanding patient preferences in those who are not responding to steroids for ulcerative colitis is important in informing treatment choices. This study aimed to understand the relative importance of treatment characteristic…
View article: P97 Management of steroid resistant ulcerative colitis – a national survey of UK practice
P97 Management of steroid resistant ulcerative colitis – a national survey of UK practice Open
Introduction Corticosteroids are a mainstay in the treatment of moderately severe relapses of ulcerative colitis (UC), yet almost 50% of patients do not respond fully, with the risk of prolonged steroid use and side-effects. There is insuf…
View article: P88 The impact of NOD2 deficiency on the gut mycobiota in crohn’s disease patients in remission
P88 The impact of NOD2 deficiency on the gut mycobiota in crohn’s disease patients in remission Open
Introduction Crohn's disease (CD) is strongly associated with risk variants in Nod2 and an imbalanced gut microbiome. Historical and emerging data indicate that gut fungi play an important role in CD pathogenesis, however a causal link bet…
View article: P96 Factors influencing treatment preferences in steroid resistant ulcerative colitis – a qualitative interview study
P96 Factors influencing treatment preferences in steroid resistant ulcerative colitis – a qualitative interview study Open
Background The best treatment option for people whose ulcerative colitis (UC) is resistant to steroids is not clear. Importantly, understanding of patient preferences for available treatments in this setting is also limited. Therefore, the…
View article: Inter-kingdom relationships in Crohn’s disease explored using a multi-omics approach
Inter-kingdom relationships in Crohn’s disease explored using a multi-omics approach Open
The etiology of Crohn's disease (CD) is multifactorial. Bacterial and fungal microbiota are involved in the onset and/or progression of the disease. A bacterial dysbiosis in CD patients is accepted; however, less is known about the mycobio…