Chandragouda R. Patil
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View article: Exploring disulfiram mechanisms in renal fibrosis: insights from biological data and computational approaches
Exploring disulfiram mechanisms in renal fibrosis: insights from biological data and computational approaches Open
Background Disulfiram (DSF) is an anti-alcoholic drug that has been reported to inhibit the epithelial-to-mesenchymal transition and crosslinking during fibrosis, pyroptosis, and inflammatory NF-κB and Nrf-2 signaling pathways. However, th…
View article: CoviWall, a whole-virion-inactivated B.1.617.2 vaccine candidate, induces potent humoral and Th1 cell response in mice and protects against B.1.617.2 strain challenge in Syrian hamsters
CoviWall, a whole-virion-inactivated B.1.617.2 vaccine candidate, induces potent humoral and Th1 cell response in mice and protects against B.1.617.2 strain challenge in Syrian hamsters Open
Rapid development of coronavirus disease 2019 (COVID-19) vaccines and antiviral drugs have significantly reduced morbidity and mortality worldwide. Although most of the vaccines were developed initially with the ancestral Wuhan antigen, he…
View article: Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice
Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice Open
Objective: To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis (IPF) and to explore its underlying mechanisms using network pharmacology. Methods: IPF was induced in C57BL/6 mice by a single intratrach…
View article: Oroxylin A: Nature's arsenal against liver fibrosis, cancer, and inflammatory diseases
Oroxylin A: Nature's arsenal against liver fibrosis, cancer, and inflammatory diseases Open
Oroxylin A (ORA), a natural compound found in plants, has emerged as a promising therapeutic agent against liver fibrosis, cancer, and inflammatory diseases. Chronic inflammation fuels cancer development and progression by promoting cellul…
View article: Potential role of biopeptides in the treatment of idiopathic pulmonary fibrosis
Potential role of biopeptides in the treatment of idiopathic pulmonary fibrosis Open
Purpose of Review: Idiopathic pulmonary fibrosis (IPF) is chronic interstitial pneumonia with an unclear etiology. Abnormal production of inflammatory chemokines, cytokines, and growth factors together with altered cellular recruitment int…
View article: Acute Biochemical alterations during Phototherapy of Neonatal Icterus: Systematic Review and Meta-analysis
Acute Biochemical alterations during Phototherapy of Neonatal Icterus: Systematic Review and Meta-analysis Open
Purpose Phototherapy is used in the treatment of neonatal hyperbilirubinemia. There are contravening reports on its its adverse effect. This meta-analysis was conducted to substantiate the impact of phototherapy on the parameters indicatin…
View article: Active constituents of herbal medicines for breast cancer: Current status
Active constituents of herbal medicines for breast cancer: Current status Open
Estimation of phytochemicals and antimicrobial activities of mentha spicata from southern districts of KPKNaseem Ullah, Muhammad Khurram, Farhat Ali Khan, Sahibzada Umar Khayyam, Muhammad Usman Amin, Saleem Ullah, Umberin Najeeb, Said Muha…
View article: Identification of vaccine candidate against Omicron variant of SARS-CoV-2 using immunoinformatic approaches
Identification of vaccine candidate against Omicron variant of SARS-CoV-2 using immunoinformatic approaches Open
View article: Thymoquinone Produces Cardioprotective Effect in β-Receptor Stimulated Myocardial Infarcted Rats via Subsiding Oxidative Stress and Inflammation
Thymoquinone Produces Cardioprotective Effect in β-Receptor Stimulated Myocardial Infarcted Rats via Subsiding Oxidative Stress and Inflammation Open
Earlier studies reported that long-term treatment with thymoquinone (TQ) at a high dose (20 mg/kg) exerts a cardioprotective effect against isoproterenol (ISO)-triggered myocardial infarction (MI) in rats. In the present study, we tested t…
View article: Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors
Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors Open
Molecular docking revealed curcumin as a potent CB2 cannabinoid receptor (CB2R) agonist. Since CB2R is involved in cardioprotective functions, we explored its role in ameliorative actions of curcumin against myocardial damage triggered by …
View article: Phloretin-induced suppression of oxidative and nitrosative stress attenuates doxorubicin-induced cardiotoxicity in rats
Phloretin-induced suppression of oxidative and nitrosative stress attenuates doxorubicin-induced cardiotoxicity in rats Open
Objective: To compare the cardioprotective efficacy of equimolar doses (50 mM/kg, p.o.) of phloretin and genistein against doxorubicin-induced cardiotoxicity in rats. Methods: Cardiotoxicity was induced in rats by intraperitoneal injection…
View article: Can We Use <i>Terminalia Arjuna (Roxb.) Wight and Arn</i> in Place of Novel Oral Anticoagulants (NOACs) in Post-COVID-19Cardiac Conditions?
Can We Use <i>Terminalia Arjuna (Roxb.) Wight and Arn</i> in Place of Novel Oral Anticoagulants (NOACs) in Post-COVID-19Cardiac Conditions? Open
View article: Ghrelin alleviates depression-like behaviour in rats subjected to high-fat diet and diurnal rhythm disturbance.
Ghrelin alleviates depression-like behaviour in rats subjected to high-fat diet and diurnal rhythm disturbance. Open
Overall, this study confirmed the ameliorative effect of ghrelin in HFD- and DDR-induced depression-like behaviour.
View article: Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders
Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders Open
View article: Role of ACE2-Ang (1–7)-Mas axis in post-COVID-19 complications and its dietary modulation
Role of ACE2-Ang (1–7)-Mas axis in post-COVID-19 complications and its dietary modulation Open
View article: Homeopathic drug standardization through biological evaluations: An untrodden avenue
Homeopathic drug standardization through biological evaluations: An untrodden avenue Open
Background: There is a dearth of chemico-analytical or instrumental methods for standardization and quality control of higher dilutions of homeopathic drugs.
Aim: This review highlights the challenges in standardization of anti-inflammat…
View article: Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19
Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19 Open
Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19
View article: β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19
β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19 Open
Coronavirus disease (COVID-19), caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic and presents a public health emergency. It has affected millions of people and continues to affect more, d…
View article: Aloin attenuates chronic constriction injury-induced neuropathic pain in rats by inhibiting inflammatory cytokines and oxidative stress
Aloin attenuates chronic constriction injury-induced neuropathic pain in rats by inhibiting inflammatory cytokines and oxidative stress Open
Objective: To investigate the effect of aloin against chronic constriction injury (CCI)-induced neuropathic pain in rats. Methods: Rats were randomly divided into 7 groups: Group I (normal control), Group II (sham-operated), Group III (CCI…
View article: Ezetimibe-Loaded Nanostructured Lipid Carrier Based Formulation Ameliorates Hyperlipidaemia in an Experimental Model of High Fat Diet
Ezetimibe-Loaded Nanostructured Lipid Carrier Based Formulation Ameliorates Hyperlipidaemia in an Experimental Model of High Fat Diet Open
Ezetimibe (EZE) possesses low aqueous solubility and poor bioavailability and in addition, its extensive hepatic metabolism supports the notion of developing a novel carrier system for EZE. Ezetimibe was encapsulated into nanostructured li…
View article: Plant-derived natural therapeutics targeting cannabinoid receptors in metabolic syndrome and its complications: A review
Plant-derived natural therapeutics targeting cannabinoid receptors in metabolic syndrome and its complications: A review Open
View article: Protective effect of Barringtonia racemosa Ethyl Acetate Fraction against Cisplatin-induced Nephrotoxicity in Rats
Protective effect of Barringtonia racemosa Ethyl Acetate Fraction against Cisplatin-induced Nephrotoxicity in Rats Open
Cisplatin is a major antineoplastic drug for the treatment of solid tumors. Nephrotoxicity is dose- limiting side effect associated with clinical use of cisplatin. The present study was executed to determine whether bartogenic acid contain…
View article: Mechanistic Investigation on Anti-Nociceptive Potential of Bartogenic Acid Containing Barringtonia racemosa Fraction in Experimental Models of Pain
Mechanistic Investigation on Anti-Nociceptive Potential of Bartogenic Acid Containing Barringtonia racemosa Fraction in Experimental Models of Pain Open
Barringtonia racemosa (B. racemosa) is a tropical medicinal plant possessing interesting biological activities. B. racemosa fruits are traditionally used in India for the treatment of pain, inflammation, and rheumatic conditions. Earlier, …
View article: Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals
Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals Open
Inflammation is one of the common events in the majority of acute as well as chronic debilitating diseases and represent a chief cause of morbidity in today’s era of modern lifestyle. If unchecked, inflammation leads to development of rheu…
View article: Retraction Note: Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS- mediated neuropathic pain in rats
Retraction Note: Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS- mediated neuropathic pain in rats Open
This paper has been retracted.
View article: Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury
Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury Open
Acetaminophen (APAP), which is also known as paracetamol or N-acetyl-p-aminophenol is a safe and potent drug for fever, pain and inflammation when used at its normal therapeutic doses. It is available as over-the-counter drug and used by a…
View article: RETRACTED ARTICLE: Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS- mediated neuropathic pain in rats
RETRACTED ARTICLE: Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS- mediated neuropathic pain in rats Open
Despite the availability of multiple therapeutic agents, the search for novel pain management of neuropathic pain is still a challenge. Oxidative stress and inflammatory signaling are prominently involved in clinical manifestation of neuro…
View article: Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise
Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise Open
Asiatic acid (AA) is a naturally occurring aglycone of ursane type pentacyclic triterpenoids. It is abundantly present in many edible and medicinal plants including Centella asiatica that is a reputed herb in many traditional medici…
View article: Eplerenone attenuates myocardial infarction in diabetic rats via modulation of the PI3K-Akt pathway and phosphorylation of GSK-3β.
Eplerenone attenuates myocardial infarction in diabetic rats via modulation of the PI3K-Akt pathway and phosphorylation of GSK-3β. Open
We investigated the effect of eplerenone on myocardial infarcted diabetic rats via modulation of the PI3K/Akt pathway and its downstream target GSK-3β. Diabetes was induced by administration of a single dose of streptozotocin (55 mg/kg IP)…
View article: Therapeutic Potential and Pharmaceutical Development of Thymoquinone: A Multitargeted Molecule of Natural Origin
Therapeutic Potential and Pharmaceutical Development of Thymoquinone: A Multitargeted Molecule of Natural Origin Open
Thymoquinone, a monoterpene molecule is chemically known as 2-methyl-5-isopropyl-1, 4-benzoquinone. It is abundantly present in seeds of Nigella sativa L. that is popularly known as black cumin or black seed and belongs to the famil…