Rinku Majumder
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View article: Genome‐wide study links cardiometabolic factors to cognition via <i>APOA4‐APOA5‐ZPR1‐BUD13</i> and other loci in rural Indians
Genome‐wide study links cardiometabolic factors to cognition via <i>APOA4‐APOA5‐ZPR1‐BUD13</i> and other loci in rural Indians Open
INTRODUCTION Cardiometabolic risks affect cognition during aging, yet genetic basis for both remain understudied in Indians. METHODS This study constructs an ancestry‐matched Indian haplotype reference panel for genotype imputation of 5111…
View article: Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease
Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease Open
Atherosclerosis and cardiovascular disease are associated with high morbidity and mortality in industrialized nations. The Tyro3, Axl, and Mer (TAM) family of receptor tyrosine kinases is involved in the amplification or resolution of athe…
View article: SARS-CoV-2 Vaccine Improved Hemostasis of a Patient with Protein S Deficiency: A Case Report
SARS-CoV-2 Vaccine Improved Hemostasis of a Patient with Protein S Deficiency: A Case Report Open
A 16-year-old patient, while an infant, incurred right-sided hemiparesis and had difficulty breast feeding. She was later diagnosed with a neonatal stroke and her genetic testing showed a missense mutation in her PROS1 (Protein S) gene. Bo…
View article: Functions of TAM Receptors and Their Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease
Functions of TAM Receptors and Their Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease Open
Atherosclerosis and cardiovascular disease are associated with high morbidity and mortality in industrialized nations. The Tyro3, Axl, and Mer (TAM) family of receptor tyrosine kinases is involved in amplification or resolution of atherosc…
View article: A novel one-step purification of mouse factor IX
A novel one-step purification of mouse factor IX Open
View article: Pancreatic Cancer and Venous Thromboembolism
Pancreatic Cancer and Venous Thromboembolism Open
Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic cancers and is the most fatal of all cancers. The treatment response from combination chemotherapies is far from satisfactory and surgery remains the main…
View article: Sickle cell anemia: hepatic macrophages to the rescue
Sickle cell anemia: hepatic macrophages to the rescue Open
View article: PB0550 Novel Variants of PROS1 Gene Related to Protein S Deficiency
PB0550 Novel Variants of PROS1 Gene Related to Protein S Deficiency Open
View article: PB1091 A Novel Function of Protein S in Clot Retraction
PB1091 A Novel Function of Protein S in Clot Retraction Open
View article: PB1098 Regulation of Protein S Gene Expression by Hypoxia Inducible Factor 1 α and Estrogen Receptor
PB1098 Regulation of Protein S Gene Expression by Hypoxia Inducible Factor 1 α and Estrogen Receptor Open
inpatient hospitalizations) when fully adjusting for demographics and comorbidities.Conclusion(s): Patients with ESKD experience a higher rate of healthcare encounters and incur substantially higher inpatient costs both during and in the y…
View article: PB0575 Novel Variants of PROS1 Gene Related to Protein S Deficiency
PB0575 Novel Variants of PROS1 Gene Related to Protein S Deficiency Open
View article: PB1100 Effects of COVID-19 Vaccination on Pro-Coagulant State of a Protein S-Deficient Pediatric Patient: New Hope for Treatment of the Deficiency
PB1100 Effects of COVID-19 Vaccination on Pro-Coagulant State of a Protein S-Deficient Pediatric Patient: New Hope for Treatment of the Deficiency Open
View article: Protein S antibody as an adjunct therapy for hemophilia B
Protein S antibody as an adjunct therapy for hemophilia B Open
Hemophilia B (HB) is caused by an inherited deficiency of plasma coagulation factor IX (FIX). Approximately 60% of pediatric patients with HB possess a severe form of FIX deficiency (<1% FIX activity). Treatment typically requires repla…
View article: Systemic Review of Clot Retraction Modulators
Systemic Review of Clot Retraction Modulators Open
Through a process termed clot retraction, platelets cause thrombi to shrink and become more stable. After platelets are activated via inside-out signaling, glycoprotein αIIbβIII binds to fibrinogen and initiates a cascade of intracellular …
View article: Not so fast, antithrombin!
Not so fast, antithrombin! Open
newborn, which may be difficult to attribute to alloimmunization given concurrent maternal autoantibodies.Corticosteroids, IVIG, and transfusion were sufficient to stabilize all patients in this series, allowing other therapies to be defer…
View article: Targeting Hypoxic Tumor Microenvironment in Pancreatic Cancer: An Emerging Innovative Concept
Targeting Hypoxic Tumor Microenvironment in Pancreatic Cancer: An Emerging Innovative Concept Open
Novel Approaches in Cancer Study Targeting Hypoxic Tumor Microenvironment in Pancreatic Cancer: An Emerging Innovative Concept Rinku Majumder1*, Tanusree Sengupta2 and Samarpan Majumder3* 1Department of Biochemistry & Molecular Biology, LS…
View article: Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells
Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells Open
COVID-19 ranges from asymptomatic in 35% of cases to severe in 20% of patients. Differences in the type and degree of inflammation appear to determine the severity of the disease. Recent reports show an increase in circulating monocytic-my…
View article: Localization of Phosphatidylserine Binding Sites to Structural Domains of Factor X a
Localization of Phosphatidylserine Binding Sites to Structural Domains of Factor X a Open
Binding of short chain phosphatidylserine (C6PS) enhances the proteolytic activity of factor X(a) by 60-fold (Koppaka, V., Wang, J., Banerjee, M., and Lentz, B. R. (1996) Biochemistry 35, 7482-7491). In the present study, we locate three C…
View article: Protein S: function, regulation, and clinical perspectives
Protein S: function, regulation, and clinical perspectives Open
Purpose of review Protein S (PS) is an essential natural anticoagulant. PS deficiency is a major contributor to acquired hypercoagulability. Acquired hypercoagulability causes myocardial infarction, stroke, and deep vein thrombosis in mill…
View article: Transcriptome and Functions of Granulocytic Myeloid-Derived Suppressor Cells Determine their Association with Disease Severity of COVID-19
Transcriptome and Functions of Granulocytic Myeloid-Derived Suppressor Cells Determine their Association with Disease Severity of COVID-19 Open
COVID-19 ranges from asymptomatic in 35% of cases to severe in 20% of patients. Differences in the type and degree of inflammation appear to determine the severity of the disease. Recent reports show an increase in circulating monocytic-my…
View article: Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives
Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives Open
View article: Phosphatidylserine and phosphatidylethanolamine regulate the structure and function of FVIIa and its interaction with soluble tissue factor
Phosphatidylserine and phosphatidylethanolamine regulate the structure and function of FVIIa and its interaction with soluble tissue factor Open
Cell membranes have important functions in many steps of the blood coagulation cascade, including the activation of factor X (FX) by the factor VIIa (FVIIa)-tissue factor (TF) complex (extrinsic Xase). FVIIa shares structural similarity wi…
View article: Modulation of Prothrombinase Assembly and Activity by Phosphatidylethanolamine
Modulation of Prothrombinase Assembly and Activity by Phosphatidylethanolamine Open
Constituents of platelet membranes regulate the activity of the prothrombinase complex. We demonstrate that membranes containing phosphatidylcholine and phosphatidylethanolamine (PE) bind factor Va with high affinity (Kd = ∼10 nm) in the a…
View article: Soluble Phosphatidylserine Binds to Two Sites on Human Factor IXa in a Ca2+ Dependent Fashion to Specifically Regulate Structure and Activity
Soluble Phosphatidylserine Binds to Two Sites on Human Factor IXa in a Ca2+ Dependent Fashion to Specifically Regulate Structure and Activity Open
Clinical studies have demonstrated a correlation between elevated levels of FIX and the risk of coronary heart disease, while reduced plasma FIX causes hemophilia B. FIXa interacts with FVIIIa in the presence of Ca2+ and phosphatidylserine…
View article: Functional and Structural Characterization of Factor Xa Dimer in Solution
Functional and Structural Characterization of Factor Xa Dimer in Solution Open
Previous studies showed that binding of water-soluble phosphatidylserine (C6PS) to bovine factor Xa (FXa) leads to Ca2+-dependent dimerization in solution. We report the effects of Ca2+, C6PS, and dimerization on the activity and structure…
View article: Factor Xa Binding to Phosphatidylserine-Containing Membranes Produces an Inactive Membrane-Bound Dimer
Factor Xa Binding to Phosphatidylserine-Containing Membranes Produces an Inactive Membrane-Bound Dimer Open
Factor Xa (FXa) has a prominent role in amplifying both inflammation and the coagulation cascade. In the coagulation cascade, its main role is catalyzing the proteolytic activation of prothrombin to thrombin. Efficient proteolysis is well …
View article: Ca 2+ switches the effect of PS-containing membranes on Factor Xa from activating to inhibiting: implications for initiation of blood coagulation
Ca 2+ switches the effect of PS-containing membranes on Factor Xa from activating to inhibiting: implications for initiation of blood coagulation Open
Calcium (Ca2+) plays a pivotal role in cellular and organismal physiology. The Ca2+ ion has an intermediate protein-binding affinity, thus it can serve as an on/off switch in regulation of different biochemical processes. The serum level o…
View article: Effects of Water Soluble Phosphotidylserine on Bovine Factor Xa: Functional and Structural Changes Plus Dimerization
Effects of Water Soluble Phosphotidylserine on Bovine Factor Xa: Functional and Structural Changes Plus Dimerization Open
Previous work has shown that two molecules of a soluble form of phosphatidylserine, C6PS, bind to human and bovine factor Xa. Activity measurements along with the fluorescence of active-site-labeled human factor Xa showed that two linked s…
View article: Phosphatidylserine and FVa regulate FXa structure
Phosphatidylserine and FVa regulate FXa structure Open
Human coagulation factor Xa (FXa) plays a key role in blood coagulation by activating prothrombin to thrombin on “stimulated” platelet membranes in the presence of its cofactor factor Va (FVa). Phosphatidylserine (PS) exposure on activated…