Christian Reimer
YOU?
Author Swipe
View article: A large-scale multitrait meta-analysis of 11 health and 22 conformation traits in German Holstein cows
A large-scale multitrait meta-analysis of 11 health and 22 conformation traits in German Holstein cows Open
In dairy cattle farming, many traits are included in the breeding goal simultaneously to maximize economic value. The phenomenon of genetic correlations can both enhance and hinder the response to selection and has to be taken into account…
View article: Substrate stiffness modifies gene expression and transcriptional response of equine endometrial fibroblasts to TGF-β1
Substrate stiffness modifies gene expression and transcriptional response of equine endometrial fibroblasts to TGF-β1 Open
Equine endometrial fibrosis is a leading cause of subfertility in aging mares. Fibrosis is a reparative response involving excess deposition of extracellular matrix (ECM) and increasing tissue stiffness. Augmented rigidity itself can drive…
View article: Sequence-based genome-wide association study and fine-mapping in German Holstein reveal new quantitative trait loci for health traits
Sequence-based genome-wide association study and fine-mapping in German Holstein reveal new quantitative trait loci for health traits Open
We conducted a large GWAS of 11 health traits belonging to 3 trait complexes: (1) metabolic diseases, (2) infectious and noninfectious feet and claw disorders, and (3) udder-related traits in 100,809 to 180,217 German Holstein cows to inve…
View article: Genomic analysis of three medieval parchments from German monasteries
Genomic analysis of three medieval parchments from German monasteries Open
In the last two decades there has been growing interest in the analysis of ancient DNA obtained from the parchment used in historic documents. The genetic insight that this data provides makes collections of historic documents an invaluabl…
View article: Genomic evidence for the suitability of Göttingen Minipigs with a rare seizure phenotype as a model for human epilepsy
Genomic evidence for the suitability of Göttingen Minipigs with a rare seizure phenotype as a model for human epilepsy Open
Epilepsy is a complex genetic disorder that affects about 2% of the global population. Although the frequency and severity of epileptic seizures can be reduced by a range of pharmacological interventions, there are no disease-modifying tre…
View article: Supplementary Material for: Fourth Report on Chicken Genes and Chromosomes 2022
Supplementary Material for: Fourth Report on Chicken Genes and Chromosomes 2022 Open
none
View article: Feeding green: Spirulina ( <i>Arthrospira platensis</i> ) induced changes in production performance and quality of salmonid species
Feeding green: Spirulina ( <i>Arthrospira platensis</i> ) induced changes in production performance and quality of salmonid species Open
\nSpirulina is an interesting candidate for fish nutrition. This study aims to investigate the effect of the complete replacement of fishmeal with spirulina (Arthrospira platensis) in the diets of brook trout (Salvelinus fontinalis), rainb…
View article: Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations
Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations Open
Background Structural variants (SV) are causative for some prominent phenotypic traits of livestock as different comb types in chickens or color patterns in pigs. Their effects on production traits are also increasingly studied. Neverthele…
View article: Additional file 2 of Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations
Additional file 2 of Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations Open
Additional file 2. MultiQC report.
View article: Fourth Report on Chicken Genes and Chromosomes 2022
Fourth Report on Chicken Genes and Chromosomes 2022 Open
View article: Additional file 3 of Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations
Additional file 3 of Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations Open
Additional file 3. Observer concordance of the visual filtering step.
View article: Supplementary material for: "Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations"
Supplementary material for: "Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations" Open
Supplementary material for the publication "Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations" The realated preprint can be found at Resear…
View article: Supplementary material for: "Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations"
Supplementary material for: "Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations" Open
Supplementary material for the publication "Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations" The realated preprint can be found at Resear…
View article: The Modular Breeding Program Simulator (MoBPS) allows efficient simulation of complex breeding programs
The Modular Breeding Program Simulator (MoBPS) allows efficient simulation of complex breeding programs Open
Context Breeding programs aim at improving the genetic characteristics of livestock populations with respect to productivity, fitness and adaptation, while controlling negative effects such as inbreeding or health and welfare issues. As br…
View article: Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations
Assessment of linkage disequilibrium patterns between structural variants and single nucleotide polymorphisms in three commercial chicken populations Open
BackgroundStructural variants (SV) are causative for some prominent phenotypic traits of livestock as different comb types in chickens or color patterns in pigs. Their effects on production traits are also increasingly studied. Nevertheles…
View article: How imputation can mitigate SNP ascertainment Bias
How imputation can mitigate SNP ascertainment Bias Open
Background Population genetic studies based on genotyped single nucleotide polymorphisms (SNPs) are influenced by a non-random selection of the SNPs included in the used genotyping arrays. The resulting bias in the estimation of allele fre…
View article: Genetic diversity in global chicken breeds in relation to their genetic distances to wild populations
Genetic diversity in global chicken breeds in relation to their genetic distances to wild populations Open
Background Migration of a population from its founder population is expected to cause a reduction of its genetic diversity and facilitates differentiation between the population and its founder population, as predicted by the theory of gen…
View article: How array design creates SNP ascertainment bias
How array design creates SNP ascertainment bias Open
Single nucleotide polymorphisms (SNPs), genotyped with arrays, have become a widely used marker type in population genetic analyses over the last 10 years. However, compared to whole genome re-sequencing data, arrays are known to lack a su…
View article: 4CPS-382 Impact of a clinical pharmacist at transition of care: a prospective study in an orthopaedic ward of a regional hospital
4CPS-382 Impact of a clinical pharmacist at transition of care: a prospective study in an orthopaedic ward of a regional hospital Open
Background and importance Transition of care (TOC) is a high risk period for medication errors. Discrepancies and incomplete medication information are common on hospital admission and discharge, potentially leading to drug related problem…
View article: How Imputation Can Mitigate Ascertainment Bias
How Imputation Can Mitigate Ascertainment Bias Open
Background Population genetic studies based on genotyped single nucleotide polymorphisms (SNPs) are influenced by a non-random selection of the SNPs included in the used genotyping arrays. The resulting bias relative to whole genome sequen…
View article: Additional file 1 of How imputation can mitigate SNP ascertainment Bias
Additional file 1 of How imputation can mitigate SNP ascertainment Bias Open
Additional file 1: Supplementary File 1. Accession Information of raw data per sample.
View article: Additional file 3 of Genetic diversity in global chicken breeds in relation to their genetic distances to wild populations
Additional file 3 of Genetic diversity in global chicken breeds in relation to their genetic distances to wild populations Open
Additional file 3: Table S3. Title: R2 and slope values of the relationship between observed heterozygosity and genetic distance to Gallus gallus ssp. estimated from the 6303 genes.
View article: Data for "How Array Design Creates SNP Ascertainement Bias"
Data for "How Array Design Creates SNP Ascertainement Bias" Open
The repository contains the raw SNP data in vcf format for the publication "How Array Design Creates SNP Ascertainment Bias". Note that the variants are not filtered at this timepoint. Samples starting with pl_ are pooled sequences of ~10 …
View article: Data for "How Array Design Creates SNP Ascertainement Bias"
Data for "How Array Design Creates SNP Ascertainement Bias" Open
The repository contains the raw SNP data in vcf format for the publication "How Array Design Creates SNP Ascertainment Bias". Note that the variants are not filtered at this timepoint. Samples starting with pl_ are pooled sequences of ~10 …