Robert E. Spiller
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Length of the Adult Human Colon in Health and Constipation Measured Using Magnetic Resonance Imaging Open
Background Quantitative data on colon length in adult chronic constipation (CC) are lacking. This study aimed to measure the length of the colon in CC, in the undisturbed state and after an osmotic laxative challenge, using magnetic resona…
View article: Normalization of Gastrointestinal Symptoms in Adults With Constipation With Daily Green Kiwifruit Consumption: Protocol for an Open-Label Intervention Study
Normalization of Gastrointestinal Symptoms in Adults With Constipation With Daily Green Kiwifruit Consumption: Protocol for an Open-Label Intervention Study Open
Background Irritable bowel syndrome with constipation (IBS-C) and functional constipation (FC) have significant personal, health care, and social impacts, affecting patients’ quality of life. Treatment of these conditions is challenging. W…
Clinical Characteristics and Outcomes of Rome <span>IV</span> Diarrhea‐Predominant Irritable Bowel Syndrome and Functional Diarrhea Prescribed With Ondansetron: A Real‐World Study Open
Background 5‐HT3 receptor antagonists, such as ondansetron, are effective in the management of irritable bowel syndrome‐diarrhea predominant (IBS‐D). However, real‐world data and evidence exploring the response to ondansetron in patients w…
Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea Open
Background Insulin-like peptide 5 (INSL5) is an enteroendocrine hormone expressed in distal colonic ‘L cells’. Bile acid receptor agonists are known to stimulate INSL5 secretion in primary cell culture, and administration of an INSL5 analo…
View article: Normalization of gastrointestinal symptoms in adults with constipation with daily green kiwifruit consumption: protocol for an open-label intervention study. (Preprint)
Normalization of gastrointestinal symptoms in adults with constipation with daily green kiwifruit consumption: protocol for an open-label intervention study. (Preprint) Open
BACKGROUND Constipation-predominant irritable bowel syndrome (IBS-C) and functional constipation (FC) have significant personal, healthcare, and social impacts, affecting patients’ quality of life. Treatment for these conditions is challen…
View article: Assessing Water Content of the Human Colonic Chyme Using the <scp>MRI</scp> Parameter <scp>T1</scp>: A Key Biomarker of Colonic Function
Assessing Water Content of the Human Colonic Chyme Using the <span>MRI</span> Parameter <span>T1</span>: A Key Biomarker of Colonic Function Open
Background The human colon receives 2 L of fluid daily. Small changes in the efficacy of absorption can lead to altered stool consistency with diarrhea or constipation. Drugs and formulations can also alter colonic water, which can be asse…
View article: Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo‐controlled Trial in Constipation
Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo‐controlled Trial in Constipation Open
Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo‐controlled cross‐over trials were performed, one using…
View article: Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study
Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study Open
Background Colonic motility in constipation can be assessed non-invasively using MRI. Objective To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response. Design Part 1: 44 healthy volunteers (HVs), 43 …
View article: Experimental Measurements of the Length of the Human Colon: A Systematic Review and Meta-Analysis
Experimental Measurements of the Length of the Human Colon: A Systematic Review and Meta-Analysis Open
Purpose: Knowledge of the length of the colon is relevant to understanding physiological and pathological function. It also has implications for diagnostic and clinical interventions, as well as for the design of delayed-release drug formu…
View article: A longitudinal study assessing the impact of elexacaftor/tezacaftor/ivacaftor on gut transit and function in people with cystic fibrosis using magnetic resonance imaging (MRI)
A longitudinal study assessing the impact of elexacaftor/tezacaftor/ivacaftor on gut transit and function in people with cystic fibrosis using magnetic resonance imaging (MRI) Open
Our findings suggest an improvement in small bowel transit, small bowel response to food and a reduction in colonic volume after starting ETI. These effects may relate to CFTR activation in the small bowel. To our knowledge this is the fir…
View article: Intra‐ and interindividual variability in fasted gastric content volume
Intra‐ and interindividual variability in fasted gastric content volume Open
Background Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra‐ and interi…
View article: One year of gluten free diet impacts gut function and microbiome in celiac disease
One year of gluten free diet impacts gut function and microbiome in celiac disease Open
BACKGROUND & AIMS Currently, the main treatment option for coeliac disease (CD) is a gluten free diet (GFD). This observational cohort study investigated the impact of CD and 1 year of GFD on gut function and microbiome. METHODS 36 newly d…
View article: A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study.
A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study. Open
Background People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve …
View article: Intra- and interindividual variability in fasted gastric content volume
Intra- and interindividual variability in fasted gastric content volume Open
2 Abstract Background Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra-…
View article: Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the <scp>5‐HT<sub>3</sub></scp> receptor antagonist, ondansetron
Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the <span>5‐HT<sub>3</sub></span> receptor antagonist, ondansetron Open
Background Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti‐diarrheal actions of ondansetron. Methods A double‐bl…
View article: Colon length in pediatric health and constipation measured using magnetic resonance imaging and three dimensional skeletonization
Colon length in pediatric health and constipation measured using magnetic resonance imaging and three dimensional skeletonization Open
Recent magnetic resonance imaging (MRI) studies showed that colonic volumes in children are different between health and functional constipation. The length of the colon has however been rarely measured and principally using unphysiologica…
View article: A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes.
A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes. Open
Background People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve …
View article: Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial
Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial Open
Background Irritable bowel syndrome with diarrhoea is characterised by frequent, loose or watery stools with associated urgency, resulting in marked reduction of quality of life. Ondansetron, a 5-hydroxytryptamine-3 receptor antagonist, ha…
Editorial: Interaction between fibre and colonic fermentation assessed with a novel gas‐sensing capsule Open
LINKED CONTENT This article is linked to So et al papers. To view these articles, visit https://doi.org/10.1111/apt.17629 and https://doi.org/10.1111/apt.17704
In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans Open
Summary: The presence of a ‘magenstrasse’, a central ‘stomach road’ for flow and mixing of foods and drinks in the stomach had been predicted from hydrodynamic modelling. Here a magnetic resonance imaging (MRI) tagging technique was used t…
View article: Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis
Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis Open
GI-related symptoms, complications, and comorbidities in CF are common. More consistent characterization and recording of these symptoms in clinical studies may help achieve the priority of reducing the burden of GI disease in CF.
View article: <scp>MRI</scp> tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time
<span>MRI</span> tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time Open
Background Magnetic resonance imaging (MRI) tagging techniques have been applied to the GI tract to assess bowel contractions and content mixing. We aimed to evaluate the dependence of a tagging measurement (for assessing chyme mixing) on …
Editorial: ondansetron for patients with <span>IBS‐D</span> and bowel‐predominant symptoms—authors' reply Open
LINKED CONTENT This article is linked to Gunn et al papers. To view these articles, visit https://doi.org/10.1111/apt.17426 and https://doi.org/10.1111/apt.17462
Randomised, placebo‐controlled trial and meta‐analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The <span>TRITON</span> trial Open
Summary Background Ondansetron may be beneficial in irritable bowel syndrome with diarrhoea (IBS‐D). Aim To conduct a 12‐week parallel group, randomised, double‐blind, placebo‐controlled trial of ondansetron 4 mg o.d. (titrated up to 8 mg …
Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis Open
Gastrointestinal (GI)-related symptoms, complications, and comorbidities in cystic fibrosis (CF) are common and research to reduce their burden is a priority for the CF community. To enable future research, this review aimed to summarize t…