Campbell S.D. Roxburgh
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View article: Resecting Beyond the Central Pelvic Compartment in Pelvic Exenterations for Gynaecological Malignancies: Outcomes From a Tertiary Unit
Resecting Beyond the Central Pelvic Compartment in Pelvic Exenterations for Gynaecological Malignancies: Outcomes From a Tertiary Unit Open
Background Pelvic exenterations (PE) in solid organ gynaecological malignancies have historically been confined to the central pelvic compartment but an expansion of resection extent to include the lateral compartment is now technically fe…
View article: Gluteal Flap Reconstruction Following Complex Rectal Cancer Surgery: A Large Consecutive Series of Perineal Wounds Exploring Risk Factors for Complications
Gluteal Flap Reconstruction Following Complex Rectal Cancer Surgery: A Large Consecutive Series of Perineal Wounds Exploring Risk Factors for Complications Open
Aim To determine whether high complexity pelvic exenterations alter perineal wound morbidity and to assess risk factors for perineal flap complications following complex rectal cancer surgery. Methods A retrospective analysis of consecutiv…
View article: Self-Supervised AI Reveals a Hidden Landscape of Prognostic Spatial Patterns in Multiplex Immunofluorescence Images
Self-Supervised AI Reveals a Hidden Landscape of Prognostic Spatial Patterns in Multiplex Immunofluorescence Images Open
Modern spatial proteomic methods, such as multiplex immunofluorescence (mIF) imaging, offer a data-rich view of spatial biology in intact tissues. However, interpreting its complexity is a major bottleneck, limiting its potential for biolo…
View article: The <scp>ACPGBI AI</scp> taskforce report: A mixed‐methods roadmap for <scp>AI</scp> in colorectal surgery
The <span>ACPGBI AI</span> taskforce report: A mixed‐methods roadmap for <span>AI</span> in colorectal surgery Open
Aim The ACPGBI has commissioned a taskforce to devise a strategy for integrating artificial intelligence (AI) into colorectal surgery. This report aims to (i) map current AI adoption amongst UK colorectal surgeons; (ii) evaluate knowledge,…
View article: Risk assessment tools for predicting transfusion in surgery: a systematic review and meta-analysis
Risk assessment tools for predicting transfusion in surgery: a systematic review and meta-analysis Open
Background United Kingdom blood shortages necessitate better prediction of surgical blood requirement. We sought to assess the predictive accuracy of tools designed to identify those patients requiring blood transfusion within the perioper…
View article: Longitudinal association between statins and changes in CT‐derived body composition in patients with abdominal aortic aneurysm
Longitudinal association between statins and changes in CT‐derived body composition in patients with abdominal aortic aneurysm Open
Background Loss of skeletal muscle mass and systemic inflammation may offer prognostic value in patients with abdominal aortic aneurysm (AAA). The longitudinal progression of abnormal body composition parameters and their determinants is p…
View article: The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer
The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer Open
Background Systemic inflammation has prognostic value in cancer and is considered aetiological of cachexia by the Global Leadership Initiative on Malnutrition (GLIM). Lactate dehydrogenase (LDH) also has recognized prognostic value. The pr…
View article: The characteristic of epithelial-specific phenotypes and immunosuppressive microenvironment in the context of tumour budding in colorectal cancer
The characteristic of epithelial-specific phenotypes and immunosuppressive microenvironment in the context of tumour budding in colorectal cancer Open
Background A small cluster of up to four cells, defined as tumour budding (TB), has been well studied as an independent promising prognostic marker in CRC. However, its underlying mechanism in CRC is unclear. Methods Multi-omic approaches …
View article: Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections?
Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Open
Obesity (BMI > 30 kg/m 2 ) is rapidly increasing worldwide with 26% of the UK population being obese and 38% being overweight. Obesity is intimately related to several life-limiting conditions including colorectal cancer (CRC). Obese patie…
View article: The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer
The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer Open
Background In cancer cachexia the relationship between the tumour, its environment and the systemic inflammatory response is not clear. This study aims to examine this relationship in greater detail. Methods Host characteristics included t…
View article: IL6 and IL6R as Prognostic Biomarkers in Colorectal Cancer
IL6 and IL6R as Prognostic Biomarkers in Colorectal Cancer Open
Colorectal cancer is the third most diagnosed malignancy worldwide and survival outcomes remain poor. Research is focused on the identification of novel prognostic and predictive biomarkers to improve clinical practice. There is robust evi…
View article: The Relationship Between Peri-Operative Systemic Inflammation and Survival in Patients With Abdominal Aortic Aneurysm
The Relationship Between Peri-Operative Systemic Inflammation and Survival in Patients With Abdominal Aortic Aneurysm Open
Preoperative and postoperative markers of systemic inflammation were independently associated with inferior survival following emergency and elective repair of AAA, respectively. Further investigation of the perioperative systemic inflamma…
View article: Relationship between CT-derived cervical muscle mass and quality, systemic inflammation, and survival in symptomatic patients undergoing carotid endarterectomy
Relationship between CT-derived cervical muscle mass and quality, systemic inflammation, and survival in symptomatic patients undergoing carotid endarterectomy Open
Background Sarcopenia appears to be associated with inferior outcomes in surgical conditions. Chronic systemic inflammation confers an inferior long-term prognosis in cardiovascular disease and is associated with the development of sarcope…
View article: SP5.10 - Statin use during neoadjuvant therapy is an independent marker for a favourable Neoadjuvant Rectal (NAR) score in locally advanced rectal cancer when analysing common concomitant medications
SP5.10 - Statin use during neoadjuvant therapy is an independent marker for a favourable Neoadjuvant Rectal (NAR) score in locally advanced rectal cancer when analysing common concomitant medications Open
Aim The extent of neoadjuvant therapy (NAT) response is an important prognosticator in locally advanced rectal cancer (LARC). The Neoadjuvant Rectal (NAR) is validated as a pseudo-continuous measurement of response, and a surrogate marker …
View article: Clinical effectiveness of robotic versus laparoscopic and open surgery: an overview of systematic reviews
Clinical effectiveness of robotic versus laparoscopic and open surgery: an overview of systematic reviews Open
Objective To undertake a review of systematic reviews on the clinical outcomes of robotic-assisted surgery across a mix of intracavity procedures, using evidence mapping to inform the decision makers on the best utilisation of robotic-assi…
View article: A systematic review of the role of systemic inflammation-based prognostic scores in patients with abdominal aortic aneurysm
A systematic review of the role of systemic inflammation-based prognostic scores in patients with abdominal aortic aneurysm Open
CRD42022363765.
View article: Sarcopenia is independently associated with poor preoperative physical fitness in patients undergoing colorectal cancer surgery
Sarcopenia is independently associated with poor preoperative physical fitness in patients undergoing colorectal cancer surgery Open
Background Accurate preoperative risk assessment for major colorectal cancer (CRC) surgery remains challenging. Body composition (BC) and cardiopulmonary exercise testing (CPET) can be used to evaluate risk. The relationship between BC and…
View article: The Glasgow Microenvironment Score: an exemplar of contemporary biomarker evolution in colorectal cancer
The Glasgow Microenvironment Score: an exemplar of contemporary biomarker evolution in colorectal cancer Open
Colorectal cancer remains a leading cause of mortality worldwide. Significant variation in response to treatment and survival is evident among patients with similar stage disease. Molecular profiling has highlighted the heterogeneity of co…
View article: The relationship between LDH and GLIM criteria for cancer cachexia: Systematic review and meta-analysis
The relationship between LDH and GLIM criteria for cancer cachexia: Systematic review and meta-analysis Open
Current literature suggests elevated serum LDH is associated with inflammation in cancer (an aetiologic GLIM criterion), however more work is required to establish the relationship between LDH and the phenotypic components of GLIM. Additio…
View article: The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer Does tumour necrosis drive cachexia?
The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer Does tumour necrosis drive cachexia? Open
Background: In cancer cachexia the relationship between the tumour, its environment and the systemic inflammatory response is not clear. This study aims to examine this relationship in greater detail. Methods: Host characteristics included…
View article: Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer
Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer Open
Colorectal cancer (CRC) is a heterogenous malignancy and research is focused on identifying novel ways to subtype patients. In this study, a novel classification system, tumour microenvironment score (TMS), was devised based on Klintrup–Mä…
View article: CT-derived body composition: Differential association with disease, age and inflammation in a retrospective cohort study
CT-derived body composition: Differential association with disease, age and inflammation in a retrospective cohort study Open
Background Low skeletal muscle mass and density, as assessed by CT-body composition (CT-BC), are recognised to have prognostic value in non-cancer and cancer patients. The aim of the present study was to compare CT-BC parameters between no…